Amino acid dipepetide frequency for Tremblaya princeps

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.292AlaAla: 15.292 ± 0.883
4.714AlaCys: 4.714 ± 0.379
3.801AlaAsp: 3.801 ± 0.283
4.596AlaGlu: 4.596 ± 0.382
2.829AlaPhe: 2.829 ± 0.28
10.283AlaGly: 10.283 ± 0.555
3.978AlaHis: 3.978 ± 0.32
5.657AlaIle: 5.657 ± 0.406
2.328AlaLys: 2.328 ± 0.369
12.404AlaLeu: 12.404 ± 0.662
5.421AlaMet: 5.421 ± 0.475
1.945AlaAsn: 1.945 ± 0.223
4.862AlaPro: 4.862 ± 0.439
3.624AlaGln: 3.624 ± 0.284
14.378AlaArg: 14.378 ± 0.728
9.605AlaSer: 9.605 ± 0.711
5.127AlaThr: 5.127 ± 0.323
9.487AlaVal: 9.487 ± 0.684
1.414AlaTrp: 1.414 ± 0.21
2.829AlaTyr: 2.829 ± 0.307
0.0AlaXaa: 0.0 ± 0.0
Cys
4.773CysAla: 4.773 ± 0.432
1.237CysCys: 1.237 ± 0.179
1.355CysAsp: 1.355 ± 0.206
0.884CysGlu: 0.884 ± 0.141
0.53CysPhe: 0.53 ± 0.12
3.329CysGly: 3.329 ± 0.369
0.884CysHis: 0.884 ± 0.168
1.355CysIle: 1.355 ± 0.205
0.737CysLys: 0.737 ± 0.147
2.77CysLeu: 2.77 ± 0.354
1.12CysMet: 1.12 ± 0.142
0.766CysAsn: 0.766 ± 0.152
1.031CysPro: 1.031 ± 0.182
0.678CysGln: 0.678 ± 0.122
2.416CysArg: 2.416 ± 0.274
2.711CysSer: 2.711 ± 0.355
2.033CysThr: 2.033 ± 0.213
2.18CysVal: 2.18 ± 0.267
0.265CysTrp: 0.265 ± 0.079
0.678CysTyr: 0.678 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
6.276AspAla: 6.276 ± 0.36
1.09AspCys: 1.09 ± 0.181
1.385AspAsp: 1.385 ± 0.177
1.473AspGlu: 1.473 ± 0.224
1.12AspPhe: 1.12 ± 0.182
3.889AspGly: 3.889 ± 0.346
0.825AspHis: 0.825 ± 0.152
2.77AspIle: 2.77 ± 0.338
1.267AspLys: 1.267 ± 0.195
3.094AspLeu: 3.094 ± 0.299
1.562AspMet: 1.562 ± 0.251
0.854AspAsn: 0.854 ± 0.177
1.237AspPro: 1.237 ± 0.206
0.678AspGln: 0.678 ± 0.142
3.742AspArg: 3.742 ± 0.379
2.298AspSer: 2.298 ± 0.249
1.856AspThr: 1.856 ± 0.215
4.979AspVal: 4.979 ± 0.422
0.383AspTrp: 0.383 ± 0.104
1.002AspTyr: 1.002 ± 0.18
0.0AspXaa: 0.0 ± 0.0
Glu
5.068GluAla: 5.068 ± 0.41
0.972GluCys: 0.972 ± 0.17
2.062GluAsp: 2.062 ± 0.296
1.208GluGlu: 1.208 ± 0.25
0.913GluPhe: 0.913 ± 0.175
3.094GluGly: 3.094 ± 0.377
1.65GluHis: 1.65 ± 0.193
1.208GluIle: 1.208 ± 0.228
0.678GluLys: 0.678 ± 0.178
4.302GluLeu: 4.302 ± 0.414
0.913GluMet: 0.913 ± 0.171
0.589GluAsn: 0.589 ± 0.136
1.532GluPro: 1.532 ± 0.222
1.09GluGln: 1.09 ± 0.187
3.801GluArg: 3.801 ± 0.323
2.033GluSer: 2.033 ± 0.298
1.208GluThr: 1.208 ± 0.2
3.536GluVal: 3.536 ± 0.382
0.295GluTrp: 0.295 ± 0.078
0.796GluTyr: 0.796 ± 0.148
0.0GluXaa: 0.0 ± 0.0
Phe
2.004PheAla: 2.004 ± 0.253
0.619PheCys: 0.619 ± 0.114
1.355PheAsp: 1.355 ± 0.179
0.825PheGlu: 0.825 ± 0.153
0.501PhePhe: 0.501 ± 0.132
1.738PheGly: 1.738 ± 0.217
0.766PheHis: 0.766 ± 0.14
0.972PheIle: 0.972 ± 0.151
0.471PheLys: 0.471 ± 0.107
1.503PheLeu: 1.503 ± 0.211
0.737PheMet: 0.737 ± 0.157
0.678PheAsn: 0.678 ± 0.144
0.56PhePro: 0.56 ± 0.137
0.383PheGln: 0.383 ± 0.103
1.856PheArg: 1.856 ± 0.237
1.473PheSer: 1.473 ± 0.213
0.56PheThr: 0.56 ± 0.121
1.503PheVal: 1.503 ± 0.202
0.118PheTrp: 0.118 ± 0.052
0.648PheTyr: 0.648 ± 0.123
0.0PheXaa: 0.0 ± 0.0
Gly
10.312GlyAla: 10.312 ± 0.552
3.241GlyCys: 3.241 ± 0.362
3.712GlyAsp: 3.712 ± 0.39
2.946GlyGlu: 2.946 ± 0.311
2.004GlyPhe: 2.004 ± 0.236
6.806GlyGly: 6.806 ± 0.61
2.681GlyHis: 2.681 ± 0.287
4.95GlyIle: 4.95 ± 0.39
2.121GlyLys: 2.121 ± 0.301
8.191GlyLeu: 8.191 ± 0.593
4.596GlyMet: 4.596 ± 0.387
1.65GlyAsn: 1.65 ± 0.233
2.445GlyPro: 2.445 ± 0.21
2.062GlyGln: 2.062 ± 0.247
8.044GlyArg: 8.044 ± 0.568
7.042GlySer: 7.042 ± 0.411
5.392GlyThr: 5.392 ± 0.393
7.661GlyVal: 7.661 ± 0.53
0.972GlyTrp: 0.972 ± 0.182
2.387GlyTyr: 2.387 ± 0.216
0.0GlyXaa: 0.0 ± 0.0
His
4.862HisAla: 4.862 ± 0.458
0.913HisCys: 0.913 ± 0.165
1.974HisAsp: 1.974 ± 0.275
1.179HisGlu: 1.179 ± 0.205
0.501HisPhe: 0.501 ± 0.121
5.097HisGly: 5.097 ± 0.35
0.678HisHis: 0.678 ± 0.162
2.121HisIle: 2.121 ± 0.277
0.589HisLys: 0.589 ± 0.146
1.886HisLeu: 1.886 ± 0.217
0.943HisMet: 0.943 ± 0.163
0.796HisAsn: 0.796 ± 0.17
1.562HisPro: 1.562 ± 0.194
0.619HisGln: 0.619 ± 0.139
3.153HisArg: 3.153 ± 0.267
2.298HisSer: 2.298 ± 0.228
1.591HisThr: 1.591 ± 0.208
2.799HisVal: 2.799 ± 0.291
0.177HisTrp: 0.177 ± 0.072
0.412HisTyr: 0.412 ± 0.094
0.0HisXaa: 0.0 ± 0.0
Ile
6.07IleAla: 6.07 ± 0.442
0.766IleCys: 0.766 ± 0.152
2.121IleAsp: 2.121 ± 0.252
2.387IleGlu: 2.387 ± 0.314
0.471IlePhe: 0.471 ± 0.121
4.478IleGly: 4.478 ± 0.351
1.12IleHis: 1.12 ± 0.145
1.679IleIle: 1.679 ± 0.216
0.972IleLys: 0.972 ± 0.186
3.948IleLeu: 3.948 ± 0.31
1.385IleMet: 1.385 ± 0.203
1.179IleAsn: 1.179 ± 0.173
2.033IlePro: 2.033 ± 0.278
0.766IleGln: 0.766 ± 0.162
4.184IleArg: 4.184 ± 0.385
3.447IleSer: 3.447 ± 0.346
2.858IleThr: 2.858 ± 0.327
3.801IleVal: 3.801 ± 0.319
0.206IleTrp: 0.206 ± 0.082
0.56IleTyr: 0.56 ± 0.166
0.0IleXaa: 0.0 ± 0.0
Lys
2.976LysAla: 2.976 ± 0.304
0.442LysCys: 0.442 ± 0.1
1.002LysAsp: 1.002 ± 0.234
0.825LysGlu: 0.825 ± 0.215
0.295LysPhe: 0.295 ± 0.099
2.151LysGly: 2.151 ± 0.261
1.002LysHis: 1.002 ± 0.133
0.766LysIle: 0.766 ± 0.162
0.501LysLys: 0.501 ± 0.163
1.709LysLeu: 1.709 ± 0.224
0.589LysMet: 0.589 ± 0.152
0.56LysAsn: 0.56 ± 0.138
1.149LysPro: 1.149 ± 0.169
0.619LysGln: 0.619 ± 0.125
2.622LysArg: 2.622 ± 0.336
1.267LysSer: 1.267 ± 0.183
0.972LysThr: 0.972 ± 0.16
1.915LysVal: 1.915 ± 0.314
0.118LysTrp: 0.118 ± 0.055
0.589LysTyr: 0.589 ± 0.155
0.0LysXaa: 0.0 ± 0.0
Leu
10.695LeuAla: 10.695 ± 0.652
3.565LeuCys: 3.565 ± 0.311
3.329LeuAsp: 3.329 ± 0.368
3.565LeuGlu: 3.565 ± 0.334
1.09LeuPhe: 1.09 ± 0.162
7.837LeuGly: 7.837 ± 0.442
3.388LeuHis: 3.388 ± 0.388
2.504LeuIle: 2.504 ± 0.296
1.797LeuLys: 1.797 ± 0.213
8.603LeuLeu: 8.603 ± 0.66
2.092LeuMet: 2.092 ± 0.232
2.062LeuAsn: 2.062 ± 0.287
4.243LeuPro: 4.243 ± 0.44
2.387LeuGln: 2.387 ± 0.249
12.728LeuArg: 12.728 ± 0.67
7.278LeuSer: 7.278 ± 0.516
4.302LeuThr: 4.302 ± 0.353
6.718LeuVal: 6.718 ± 0.55
0.943LeuTrp: 0.943 ± 0.175
2.151LeuTyr: 2.151 ± 0.233
0.0LeuXaa: 0.0 ± 0.0
Met
4.449MetAla: 4.449 ± 0.325
0.825MetCys: 0.825 ± 0.147
1.355MetAsp: 1.355 ± 0.189
1.768MetGlu: 1.768 ± 0.231
0.295MetPhe: 0.295 ± 0.082
3.3MetGly: 3.3 ± 0.317
1.532MetHis: 1.532 ± 0.202
0.972MetIle: 0.972 ± 0.175
0.648MetLys: 0.648 ± 0.15
3.477MetLeu: 3.477 ± 0.347
0.796MetMet: 0.796 ± 0.142
0.707MetAsn: 0.707 ± 0.144
2.21MetPro: 2.21 ± 0.268
1.12MetGln: 1.12 ± 0.159
3.654MetArg: 3.654 ± 0.309
2.681MetSer: 2.681 ± 0.249
1.473MetThr: 1.473 ± 0.201
2.946MetVal: 2.946 ± 0.267
0.295MetTrp: 0.295 ± 0.117
0.56MetTyr: 0.56 ± 0.118
0.0MetXaa: 0.0 ± 0.0
Asn
2.74AsnAla: 2.74 ± 0.337
0.412AsnCys: 0.412 ± 0.103
0.884AsnAsp: 0.884 ± 0.16
0.737AsnGlu: 0.737 ± 0.13
0.412AsnPhe: 0.412 ± 0.112
2.21AsnGly: 2.21 ± 0.23
0.471AsnHis: 0.471 ± 0.109
0.796AsnIle: 0.796 ± 0.148
0.678AsnLys: 0.678 ± 0.104
1.532AsnLeu: 1.532 ± 0.206
0.825AsnMet: 0.825 ± 0.179
0.589AsnAsn: 0.589 ± 0.158
1.237AsnPro: 1.237 ± 0.177
0.412AsnGln: 0.412 ± 0.137
1.856AsnArg: 1.856 ± 0.201
1.621AsnSer: 1.621 ± 0.204
1.179AsnThr: 1.179 ± 0.157
1.679AsnVal: 1.679 ± 0.202
0.088AsnTrp: 0.088 ± 0.056
0.354AsnTyr: 0.354 ± 0.095
0.0AsnXaa: 0.0 ± 0.0
Pro
4.302ProAla: 4.302 ± 0.308
2.239ProCys: 2.239 ± 0.22
1.503ProAsp: 1.503 ± 0.263
1.503ProGlu: 1.503 ± 0.229
0.825ProPhe: 0.825 ± 0.158
4.685ProGly: 4.685 ± 0.422
1.326ProHis: 1.326 ± 0.2
1.886ProIle: 1.886 ± 0.284
0.972ProLys: 0.972 ± 0.18
3.123ProLeu: 3.123 ± 0.308
2.269ProMet: 2.269 ± 0.274
0.619ProAsn: 0.619 ± 0.114
1.296ProPro: 1.296 ± 0.189
1.208ProGln: 1.208 ± 0.189
3.654ProArg: 3.654 ± 0.314
3.3ProSer: 3.3 ± 0.281
2.239ProThr: 2.239 ± 0.252
3.624ProVal: 3.624 ± 0.317
0.412ProTrp: 0.412 ± 0.124
1.237ProTyr: 1.237 ± 0.287
0.0ProXaa: 0.0 ± 0.0
Gln
2.858GlnAla: 2.858 ± 0.259
1.208GlnCys: 1.208 ± 0.184
1.503GlnAsp: 1.503 ± 0.204
0.913GlnGlu: 0.913 ± 0.186
0.56GlnPhe: 0.56 ± 0.123
2.829GlnGly: 2.829 ± 0.342
1.326GlnHis: 1.326 ± 0.23
0.796GlnIle: 0.796 ± 0.128
0.354GlnLys: 0.354 ± 0.101
1.945GlnLeu: 1.945 ± 0.23
0.648GlnMet: 0.648 ± 0.15
0.412GlnAsn: 0.412 ± 0.117
1.326GlnPro: 1.326 ± 0.195
0.648GlnGln: 0.648 ± 0.145
2.711GlnArg: 2.711 ± 0.294
1.679GlnSer: 1.679 ± 0.26
0.766GlnThr: 0.766 ± 0.134
1.679GlnVal: 1.679 ± 0.24
0.206GlnTrp: 0.206 ± 0.079
0.707GlnTyr: 0.707 ± 0.157
0.0GlnXaa: 0.0 ± 0.0
Arg
12.139ArgAla: 12.139 ± 0.606
3.035ArgCys: 3.035 ± 0.311
4.037ArgAsp: 4.037 ± 0.314
3.771ArgGlu: 3.771 ± 0.323
2.033ArgPhe: 2.033 ± 0.243
7.572ArgGly: 7.572 ± 0.506
4.184ArgHis: 4.184 ± 0.333
4.567ArgIle: 4.567 ± 0.405
2.711ArgLys: 2.711 ± 0.32
11.049ArgLeu: 11.049 ± 0.524
3.506ArgMet: 3.506 ± 0.399
2.18ArgAsn: 2.18 ± 0.288
4.361ArgPro: 4.361 ± 0.384
2.563ArgGln: 2.563 ± 0.274
12.493ArgArg: 12.493 ± 0.672
8.957ArgSer: 8.957 ± 0.492
4.626ArgThr: 4.626 ± 0.469
7.336ArgVal: 7.336 ± 0.494
0.678ArgTrp: 0.678 ± 0.144
2.858ArgTyr: 2.858 ± 0.221
0.0ArgXaa: 0.0 ± 0.0
Ser
9.399SerAla: 9.399 ± 0.561
2.21SerCys: 2.21 ± 0.318
2.77SerAsp: 2.77 ± 0.26
2.357SerGlu: 2.357 ± 0.241
1.768SerPhe: 1.768 ± 0.267
5.716SerGly: 5.716 ± 0.368
2.445SerHis: 2.445 ± 0.302
4.361SerIle: 4.361 ± 0.334
1.738SerLys: 1.738 ± 0.275
6.953SerLeu: 6.953 ± 0.44
2.887SerMet: 2.887 ± 0.253
1.444SerAsn: 1.444 ± 0.249
3.536SerPro: 3.536 ± 0.305
1.709SerGln: 1.709 ± 0.188
6.57SerArg: 6.57 ± 0.409
5.952SerSer: 5.952 ± 0.497
4.213SerThr: 4.213 ± 0.418
5.981SerVal: 5.981 ± 0.482
0.619SerTrp: 0.619 ± 0.142
1.974SerTyr: 1.974 ± 0.247
0.0SerXaa: 0.0 ± 0.0
Thr
5.804ThrAla: 5.804 ± 0.431
0.943ThrCys: 0.943 ± 0.175
2.21ThrAsp: 2.21 ± 0.255
1.621ThrGlu: 1.621 ± 0.227
0.913ThrPhe: 0.913 ± 0.181
3.948ThrGly: 3.948 ± 0.319
1.414ThrHis: 1.414 ± 0.22
2.475ThrIle: 2.475 ± 0.303
1.149ThrLys: 1.149 ± 0.192
4.449ThrLeu: 4.449 ± 0.342
1.709ThrMet: 1.709 ± 0.232
1.267ThrAsn: 1.267 ± 0.208
2.416ThrPro: 2.416 ± 0.202
1.797ThrGln: 1.797 ± 0.249
3.978ThrArg: 3.978 ± 0.321
3.388ThrSer: 3.388 ± 0.37
2.77ThrThr: 2.77 ± 0.343
4.478ThrVal: 4.478 ± 0.344
0.53ThrTrp: 0.53 ± 0.109
1.002ThrTyr: 1.002 ± 0.165
0.0ThrXaa: 0.0 ± 0.0
Val
9.959ValAla: 9.959 ± 0.578
2.298ValCys: 2.298 ± 0.262
3.948ValAsp: 3.948 ± 0.347
3.418ValGlu: 3.418 ± 0.367
1.503ValPhe: 1.503 ± 0.226
7.012ValGly: 7.012 ± 0.456
3.153ValHis: 3.153 ± 0.304
3.094ValIle: 3.094 ± 0.331
1.856ValLys: 1.856 ± 0.241
7.867ValLeu: 7.867 ± 0.485
2.18ValMet: 2.18 ± 0.257
1.65ValAsn: 1.65 ± 0.221
3.919ValPro: 3.919 ± 0.369
1.974ValGln: 1.974 ± 0.243
9.252ValArg: 9.252 ± 0.618
5.333ValSer: 5.333 ± 0.414
3.595ValThr: 3.595 ± 0.324
7.661ValVal: 7.661 ± 0.659
0.619ValTrp: 0.619 ± 0.122
1.709ValTyr: 1.709 ± 0.2
0.0ValXaa: 0.0 ± 0.0
Trp
1.061TrpAla: 1.061 ± 0.192
0.265TrpCys: 0.265 ± 0.089
0.295TrpAsp: 0.295 ± 0.099
0.177TrpGlu: 0.177 ± 0.075
0.177TrpPhe: 0.177 ± 0.072
0.648TrpGly: 0.648 ± 0.149
0.53TrpHis: 0.53 ± 0.12
0.354TrpIle: 0.354 ± 0.107
0.088TrpLys: 0.088 ± 0.056
0.854TrpLeu: 0.854 ± 0.15
0.206TrpMet: 0.206 ± 0.066
0.147TrpAsn: 0.147 ± 0.07
0.295TrpPro: 0.295 ± 0.09
0.383TrpGln: 0.383 ± 0.113
1.326TrpArg: 1.326 ± 0.23
0.737TrpSer: 0.737 ± 0.168
0.295TrpThr: 0.295 ± 0.091
0.471TrpVal: 0.471 ± 0.148
0.088TrpTrp: 0.088 ± 0.057
0.147TrpTyr: 0.147 ± 0.062
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.565TyrAla: 3.565 ± 0.368
0.737TyrCys: 0.737 ± 0.126
1.179TyrAsp: 1.179 ± 0.171
0.796TyrGlu: 0.796 ± 0.143
0.53TyrPhe: 0.53 ± 0.122
2.593TyrGly: 2.593 ± 0.282
0.796TyrHis: 0.796 ± 0.158
1.149TyrIle: 1.149 ± 0.205
0.412TyrLys: 0.412 ± 0.099
1.621TyrLeu: 1.621 ± 0.201
0.648TyrMet: 0.648 ± 0.161
0.619TyrAsn: 0.619 ± 0.128
0.972TyrPro: 0.972 ± 0.184
0.354TyrGln: 0.354 ± 0.113
2.239TyrArg: 2.239 ± 0.299
1.503TyrSer: 1.503 ± 0.204
1.208TyrThr: 1.208 ± 0.188
1.562TyrVal: 1.562 ± 0.222
0.118TyrTrp: 0.118 ± 0.072
0.825TyrTyr: 0.825 ± 0.151
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 134 proteins (33941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski