Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA385M02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.427AlaAla: 2.427 ± 0.517
0.479AlaCys: 0.479 ± 0.112
2.217AlaAsp: 2.217 ± 0.231
3.086AlaGlu: 3.086 ± 0.406
1.887AlaPhe: 1.887 ± 0.227
3.146AlaGly: 3.146 ± 0.49
0.839AlaHis: 0.839 ± 0.169
3.355AlaIle: 3.355 ± 0.356
4.434AlaLys: 4.434 ± 0.474
3.865AlaLeu: 3.865 ± 0.357
1.228AlaMet: 1.228 ± 0.175
2.217AlaAsn: 2.217 ± 0.223
1.438AlaPro: 1.438 ± 0.206
1.288AlaGln: 1.288 ± 0.212
1.947AlaArg: 1.947 ± 0.32
2.876AlaSer: 2.876 ± 0.318
3.206AlaThr: 3.206 ± 0.41
2.487AlaVal: 2.487 ± 0.299
0.719AlaTrp: 0.719 ± 0.163
1.588AlaTyr: 1.588 ± 0.217
0.0AlaXaa: 0.0 ± 0.0
Cys
0.33CysAla: 0.33 ± 0.086
0.3CysCys: 0.3 ± 0.094
0.659CysAsp: 0.659 ± 0.125
1.019CysGlu: 1.019 ± 0.191
0.509CysPhe: 0.509 ± 0.161
1.558CysGly: 1.558 ± 0.304
0.27CysHis: 0.27 ± 0.077
0.719CysIle: 0.719 ± 0.159
1.168CysLys: 1.168 ± 0.236
0.839CysLeu: 0.839 ± 0.137
0.419CysMet: 0.419 ± 0.114
0.839CysAsn: 0.839 ± 0.183
0.719CysPro: 0.719 ± 0.16
0.539CysGln: 0.539 ± 0.133
0.689CysArg: 0.689 ± 0.165
1.049CysSer: 1.049 ± 0.221
0.509CysThr: 0.509 ± 0.128
0.749CysVal: 0.749 ± 0.175
0.3CysTrp: 0.3 ± 0.109
0.539CysTyr: 0.539 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
2.547AspAla: 2.547 ± 0.284
0.929AspCys: 0.929 ± 0.185
3.835AspAsp: 3.835 ± 0.44
5.393AspGlu: 5.393 ± 0.542
2.576AspPhe: 2.576 ± 0.261
3.715AspGly: 3.715 ± 0.396
1.198AspHis: 1.198 ± 0.196
4.644AspIle: 4.644 ± 0.338
5.542AspLys: 5.542 ± 0.472
4.254AspLeu: 4.254 ± 0.33
1.768AspMet: 1.768 ± 0.257
4.344AspAsn: 4.344 ± 0.426
1.558AspPro: 1.558 ± 0.245
1.138AspGln: 1.138 ± 0.183
2.337AspArg: 2.337 ± 0.277
3.775AspSer: 3.775 ± 0.453
3.505AspThr: 3.505 ± 0.33
3.535AspVal: 3.535 ± 0.314
0.719AspTrp: 0.719 ± 0.156
3.655AspTyr: 3.655 ± 0.326
0.0AspXaa: 0.0 ± 0.0
Glu
3.775GluAla: 3.775 ± 0.461
1.019GluCys: 1.019 ± 0.191
4.614GluAsp: 4.614 ± 0.518
6.891GluGlu: 6.891 ± 0.513
2.786GluPhe: 2.786 ± 0.303
3.086GluGly: 3.086 ± 0.287
1.108GluHis: 1.108 ± 0.201
5.722GluIle: 5.722 ± 0.49
8.868GluLys: 8.868 ± 0.612
5.722GluLeu: 5.722 ± 0.564
2.427GluMet: 2.427 ± 0.268
5.243GluAsn: 5.243 ± 0.446
2.067GluPro: 2.067 ± 0.27
2.606GluGln: 2.606 ± 0.437
2.696GluArg: 2.696 ± 0.312
3.475GluSer: 3.475 ± 0.284
3.985GluThr: 3.985 ± 0.475
3.595GluVal: 3.595 ± 0.336
0.629GluTrp: 0.629 ± 0.133
3.655GluTyr: 3.655 ± 0.365
0.0GluXaa: 0.0 ± 0.0
Phe
1.977PheAla: 1.977 ± 0.231
0.449PheCys: 0.449 ± 0.102
2.576PheAsp: 2.576 ± 0.297
2.696PheGlu: 2.696 ± 0.325
1.648PhePhe: 1.648 ± 0.333
2.217PheGly: 2.217 ± 0.293
0.959PheHis: 0.959 ± 0.209
2.217PheIle: 2.217 ± 0.307
3.056PheLys: 3.056 ± 0.336
3.146PheLeu: 3.146 ± 0.318
1.258PheMet: 1.258 ± 0.184
2.576PheAsn: 2.576 ± 0.281
1.588PhePro: 1.588 ± 0.172
1.168PheGln: 1.168 ± 0.177
1.528PheArg: 1.528 ± 0.172
2.876PheSer: 2.876 ± 0.342
2.157PheThr: 2.157 ± 0.258
2.187PheVal: 2.187 ± 0.3
0.539PheTrp: 0.539 ± 0.125
1.648PheTyr: 1.648 ± 0.243
0.0PheXaa: 0.0 ± 0.0
Gly
2.696GlyAla: 2.696 ± 0.346
0.599GlyCys: 0.599 ± 0.133
3.176GlyAsp: 3.176 ± 0.373
4.554GlyGlu: 4.554 ± 0.451
2.337GlyPhe: 2.337 ± 0.321
4.584GlyGly: 4.584 ± 0.528
1.049GlyHis: 1.049 ± 0.166
4.314GlyIle: 4.314 ± 0.416
5.632GlyLys: 5.632 ± 0.538
4.704GlyLeu: 4.704 ± 0.395
1.588GlyMet: 1.588 ± 0.214
3.625GlyAsn: 3.625 ± 0.363
1.558GlyPro: 1.558 ± 0.194
1.738GlyGln: 1.738 ± 0.277
2.427GlyArg: 2.427 ± 0.3
4.494GlySer: 4.494 ± 0.508
3.655GlyThr: 3.655 ± 0.542
4.254GlyVal: 4.254 ± 0.384
0.869GlyTrp: 0.869 ± 0.198
3.086GlyTyr: 3.086 ± 0.296
0.0GlyXaa: 0.0 ± 0.0
His
0.839HisAla: 0.839 ± 0.15
0.389HisCys: 0.389 ± 0.147
1.168HisAsp: 1.168 ± 0.195
1.288HisGlu: 1.288 ± 0.172
0.629HisPhe: 0.629 ± 0.137
1.438HisGly: 1.438 ± 0.21
0.869HisHis: 0.869 ± 0.202
1.947HisIle: 1.947 ± 0.191
1.857HisLys: 1.857 ± 0.28
1.348HisLeu: 1.348 ± 0.197
0.599HisMet: 0.599 ± 0.153
1.198HisAsn: 1.198 ± 0.198
1.079HisPro: 1.079 ± 0.169
0.809HisGln: 0.809 ± 0.141
0.599HisArg: 0.599 ± 0.137
1.618HisSer: 1.618 ± 0.214
0.869HisThr: 0.869 ± 0.207
0.959HisVal: 0.959 ± 0.168
0.24HisTrp: 0.24 ± 0.078
1.228HisTyr: 1.228 ± 0.221
0.0HisXaa: 0.0 ± 0.0
Ile
3.146IleAla: 3.146 ± 0.342
1.049IleCys: 1.049 ± 0.198
5.423IleAsp: 5.423 ± 0.446
5.812IleGlu: 5.812 ± 0.47
2.786IlePhe: 2.786 ± 0.322
4.434IleGly: 4.434 ± 0.383
1.917IleHis: 1.917 ± 0.253
4.614IleIle: 4.614 ± 0.46
6.98IleLys: 6.98 ± 0.592
5.632IleLeu: 5.632 ± 0.407
1.768IleMet: 1.768 ± 0.281
4.224IleAsn: 4.224 ± 0.381
2.846IlePro: 2.846 ± 0.338
3.116IleGln: 3.116 ± 0.361
2.816IleArg: 2.816 ± 0.337
4.943IleSer: 4.943 ± 0.426
3.565IleThr: 3.565 ± 0.301
4.044IleVal: 4.044 ± 0.345
0.569IleTrp: 0.569 ± 0.154
3.445IleTyr: 3.445 ± 0.345
0.0IleXaa: 0.0 ± 0.0
Lys
3.985LysAla: 3.985 ± 0.382
1.198LysCys: 1.198 ± 0.213
4.853LysAsp: 4.853 ± 0.438
8.418LysGlu: 8.418 ± 0.636
2.636LysPhe: 2.636 ± 0.294
4.584LysGly: 4.584 ± 0.467
2.606LysHis: 2.606 ± 0.293
6.891LysIle: 6.891 ± 0.454
11.085LysLys: 11.085 ± 0.895
6.381LysLeu: 6.381 ± 0.609
2.906LysMet: 2.906 ± 0.313
6.771LysAsn: 6.771 ± 0.553
3.146LysPro: 3.146 ± 0.28
3.805LysGln: 3.805 ± 0.455
4.015LysArg: 4.015 ± 0.409
5.363LysSer: 5.363 ± 0.408
5.453LysThr: 5.453 ± 0.612
5.363LysVal: 5.363 ± 0.381
1.019LysTrp: 1.019 ± 0.166
4.164LysTyr: 4.164 ± 0.347
0.0LysXaa: 0.0 ± 0.0
Leu
3.355LeuAla: 3.355 ± 0.399
0.959LeuCys: 0.959 ± 0.193
4.644LeuAsp: 4.644 ± 0.298
5.063LeuGlu: 5.063 ± 0.391
2.936LeuPhe: 2.936 ± 0.254
4.015LeuGly: 4.015 ± 0.404
1.588LeuHis: 1.588 ± 0.245
4.704LeuIle: 4.704 ± 0.426
6.681LeuLys: 6.681 ± 0.468
5.812LeuLeu: 5.812 ± 0.514
2.157LeuMet: 2.157 ± 0.349
5.153LeuAsn: 5.153 ± 0.447
2.307LeuPro: 2.307 ± 0.24
3.116LeuGln: 3.116 ± 0.408
3.176LeuArg: 3.176 ± 0.336
5.872LeuSer: 5.872 ± 0.406
4.344LeuThr: 4.344 ± 0.322
4.164LeuVal: 4.164 ± 0.348
0.659LeuTrp: 0.659 ± 0.159
3.715LeuTyr: 3.715 ± 0.299
0.0LeuXaa: 0.0 ± 0.0
Met
1.438MetAla: 1.438 ± 0.241
0.27MetCys: 0.27 ± 0.091
2.127MetAsp: 2.127 ± 0.229
2.217MetGlu: 2.217 ± 0.266
1.318MetPhe: 1.318 ± 0.219
1.468MetGly: 1.468 ± 0.208
0.36MetHis: 0.36 ± 0.103
1.917MetIle: 1.917 ± 0.243
2.936MetLys: 2.936 ± 0.299
1.857MetLeu: 1.857 ± 0.221
1.108MetMet: 1.108 ± 0.201
2.067MetAsn: 2.067 ± 0.272
0.779MetPro: 0.779 ± 0.146
1.049MetGln: 1.049 ± 0.215
1.138MetArg: 1.138 ± 0.191
1.558MetSer: 1.558 ± 0.214
1.768MetThr: 1.768 ± 0.314
2.337MetVal: 2.337 ± 0.283
0.3MetTrp: 0.3 ± 0.1
1.258MetTyr: 1.258 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
2.007AsnAla: 2.007 ± 0.279
0.959AsnCys: 0.959 ± 0.164
4.134AsnAsp: 4.134 ± 0.385
4.314AsnGlu: 4.314 ± 0.371
1.857AsnPhe: 1.857 ± 0.205
4.164AsnGly: 4.164 ± 0.405
1.258AsnHis: 1.258 ± 0.263
5.752AsnIle: 5.752 ± 0.425
6.591AsnLys: 6.591 ± 0.616
4.584AsnLeu: 4.584 ± 0.406
2.247AsnMet: 2.247 ± 0.255
5.003AsnAsn: 5.003 ± 0.602
2.786AsnPro: 2.786 ± 0.307
2.966AsnGln: 2.966 ± 0.341
2.397AsnArg: 2.397 ± 0.26
3.835AsnSer: 3.835 ± 0.359
3.056AsnThr: 3.056 ± 0.316
3.325AsnVal: 3.325 ± 0.263
0.719AsnTrp: 0.719 ± 0.137
3.266AsnTyr: 3.266 ± 0.318
0.0AsnXaa: 0.0 ± 0.0
Pro
1.708ProAla: 1.708 ± 0.254
0.27ProCys: 0.27 ± 0.082
2.337ProAsp: 2.337 ± 0.273
2.487ProGlu: 2.487 ± 0.315
1.348ProPhe: 1.348 ± 0.217
1.498ProGly: 1.498 ± 0.188
0.689ProHis: 0.689 ± 0.166
2.996ProIle: 2.996 ± 0.314
2.547ProLys: 2.547 ± 0.27
2.367ProLeu: 2.367 ± 0.284
0.749ProMet: 0.749 ± 0.134
1.678ProAsn: 1.678 ± 0.253
1.648ProPro: 1.648 ± 0.257
0.959ProGln: 0.959 ± 0.221
1.558ProArg: 1.558 ± 0.235
2.606ProSer: 2.606 ± 0.268
2.457ProThr: 2.457 ± 0.398
2.127ProVal: 2.127 ± 0.253
0.389ProTrp: 0.389 ± 0.111
1.588ProTyr: 1.588 ± 0.205
0.0ProXaa: 0.0 ± 0.0
Gln
1.977GlnAla: 1.977 ± 0.3
0.419GlnCys: 0.419 ± 0.109
1.708GlnAsp: 1.708 ± 0.206
2.576GlnGlu: 2.576 ± 0.302
1.079GlnPhe: 1.079 ± 0.215
1.738GlnGly: 1.738 ± 0.239
0.869GlnHis: 0.869 ± 0.142
2.606GlnIle: 2.606 ± 0.282
3.385GlnLys: 3.385 ± 0.314
2.996GlnLeu: 2.996 ± 0.364
1.258GlnMet: 1.258 ± 0.191
2.007GlnAsn: 2.007 ± 0.271
1.977GlnPro: 1.977 ± 0.235
2.277GlnGln: 2.277 ± 0.428
1.528GlnArg: 1.528 ± 0.238
2.606GlnSer: 2.606 ± 0.324
1.768GlnThr: 1.768 ± 0.227
2.067GlnVal: 2.067 ± 0.253
0.449GlnTrp: 0.449 ± 0.124
1.768GlnTyr: 1.768 ± 0.246
0.0GlnXaa: 0.0 ± 0.0
Arg
2.127ArgAla: 2.127 ± 0.319
0.509ArgCys: 0.509 ± 0.116
2.097ArgAsp: 2.097 ± 0.268
3.325ArgGlu: 3.325 ± 0.385
1.857ArgPhe: 1.857 ± 0.213
2.846ArgGly: 2.846 ± 0.301
0.599ArgHis: 0.599 ± 0.128
3.565ArgIle: 3.565 ± 0.347
3.895ArgLys: 3.895 ± 0.442
3.086ArgLeu: 3.086 ± 0.408
1.378ArgMet: 1.378 ± 0.206
2.696ArgAsn: 2.696 ± 0.325
1.138ArgPro: 1.138 ± 0.225
1.768ArgGln: 1.768 ± 0.246
2.576ArgArg: 2.576 ± 0.319
1.708ArgSer: 1.708 ± 0.222
1.498ArgThr: 1.498 ± 0.17
2.427ArgVal: 2.427 ± 0.234
0.629ArgTrp: 0.629 ± 0.127
1.857ArgTyr: 1.857 ± 0.244
0.0ArgXaa: 0.0 ± 0.0
Ser
2.876SerAla: 2.876 ± 0.409
1.019SerCys: 1.019 ± 0.173
4.254SerAsp: 4.254 ± 0.393
3.775SerGlu: 3.775 ± 0.412
3.176SerPhe: 3.176 ± 0.325
4.913SerGly: 4.913 ± 0.417
1.468SerHis: 1.468 ± 0.216
5.063SerIle: 5.063 ± 0.383
4.853SerLys: 4.853 ± 0.533
4.674SerLeu: 4.674 ± 0.342
1.708SerMet: 1.708 ± 0.226
4.374SerAsn: 4.374 ± 0.366
2.007SerPro: 2.007 ± 0.268
2.636SerGln: 2.636 ± 0.385
2.756SerArg: 2.756 ± 0.372
5.512SerSer: 5.512 ± 0.545
3.745SerThr: 3.745 ± 0.389
3.236SerVal: 3.236 ± 0.335
0.869SerTrp: 0.869 ± 0.149
2.756SerTyr: 2.756 ± 0.326
0.0SerXaa: 0.0 ± 0.0
Thr
2.966ThrAla: 2.966 ± 0.415
0.749ThrCys: 0.749 ± 0.143
2.966ThrAsp: 2.966 ± 0.419
3.355ThrGlu: 3.355 ± 0.423
2.187ThrPhe: 2.187 ± 0.298
3.955ThrGly: 3.955 ± 0.416
1.438ThrHis: 1.438 ± 0.217
4.524ThrIle: 4.524 ± 0.401
4.973ThrLys: 4.973 ± 0.414
4.254ThrLeu: 4.254 ± 0.351
1.378ThrMet: 1.378 ± 0.177
3.745ThrAsn: 3.745 ± 0.387
1.917ThrPro: 1.917 ± 0.385
1.588ThrGln: 1.588 ± 0.22
2.037ThrArg: 2.037 ± 0.225
3.895ThrSer: 3.895 ± 0.363
3.056ThrThr: 3.056 ± 0.4
2.457ThrVal: 2.457 ± 0.404
0.749ThrTrp: 0.749 ± 0.165
2.936ThrTyr: 2.936 ± 0.275
0.0ThrXaa: 0.0 ± 0.0
Val
2.517ValAla: 2.517 ± 0.242
1.258ValCys: 1.258 ± 0.233
3.865ValAsp: 3.865 ± 0.344
3.655ValGlu: 3.655 ± 0.305
2.427ValPhe: 2.427 ± 0.256
3.835ValGly: 3.835 ± 0.382
0.959ValHis: 0.959 ± 0.164
3.116ValIle: 3.116 ± 0.34
5.153ValLys: 5.153 ± 0.34
4.734ValLeu: 4.734 ± 0.421
1.348ValMet: 1.348 ± 0.223
3.236ValAsn: 3.236 ± 0.251
1.738ValPro: 1.738 ± 0.217
2.097ValGln: 2.097 ± 0.255
2.307ValArg: 2.307 ± 0.256
4.104ValSer: 4.104 ± 0.362
3.146ValThr: 3.146 ± 0.352
3.895ValVal: 3.895 ± 0.433
0.479ValTrp: 0.479 ± 0.115
2.457ValTyr: 2.457 ± 0.298
0.0ValXaa: 0.0 ± 0.0
Trp
0.419TrpAla: 0.419 ± 0.112
0.33TrpCys: 0.33 ± 0.098
0.899TrpAsp: 0.899 ± 0.2
0.629TrpGlu: 0.629 ± 0.134
0.539TrpPhe: 0.539 ± 0.144
0.689TrpGly: 0.689 ± 0.155
0.24TrpHis: 0.24 ± 0.073
0.899TrpIle: 0.899 ± 0.176
1.288TrpLys: 1.288 ± 0.2
0.809TrpLeu: 0.809 ± 0.147
0.479TrpMet: 0.479 ± 0.122
0.719TrpAsn: 0.719 ± 0.123
0.21TrpPro: 0.21 ± 0.097
0.479TrpGln: 0.479 ± 0.129
0.539TrpArg: 0.539 ± 0.109
0.689TrpSer: 0.689 ± 0.15
0.419TrpThr: 0.419 ± 0.12
0.479TrpVal: 0.479 ± 0.118
0.21TrpTrp: 0.21 ± 0.081
0.779TrpTyr: 0.779 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.618TyrAla: 1.618 ± 0.203
0.569TyrCys: 0.569 ± 0.152
3.415TyrAsp: 3.415 ± 0.41
3.415TyrGlu: 3.415 ± 0.397
1.947TyrPhe: 1.947 ± 0.194
3.056TyrGly: 3.056 ± 0.336
0.689TyrHis: 0.689 ± 0.123
3.565TyrIle: 3.565 ± 0.354
3.715TyrLys: 3.715 ± 0.377
3.355TyrLeu: 3.355 ± 0.262
1.468TyrMet: 1.468 ± 0.195
3.535TyrAsn: 3.535 ± 0.251
1.498TyrPro: 1.498 ± 0.19
1.917TyrGln: 1.917 ± 0.248
2.517TyrArg: 2.517 ± 0.273
2.816TyrSer: 2.816 ± 0.299
2.966TyrThr: 2.966 ± 0.345
2.636TyrVal: 2.636 ± 0.341
0.689TyrTrp: 0.689 ± 0.136
2.666TyrTyr: 2.666 ± 0.36
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 156 proteins (33380 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski