Amino acid dipepetide frequency for Tomato leaf curl purple vein virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.742AlaAla: 5.742 ± 1.755
0.957AlaCys: 0.957 ± 0.839
1.914AlaAsp: 1.914 ± 1.278
2.871AlaGlu: 2.871 ± 1.291
0.957AlaPhe: 0.957 ± 0.916
1.914AlaGly: 1.914 ± 1.169
0.0AlaHis: 0.0 ± 0.0
0.957AlaIle: 0.957 ± 0.909
5.742AlaLys: 5.742 ± 2.133
7.656AlaLeu: 7.656 ± 2.615
0.0AlaMet: 0.0 ± 0.0
1.914AlaAsn: 1.914 ± 1.299
3.828AlaPro: 3.828 ± 1.049
2.871AlaGln: 2.871 ± 1.307
3.828AlaArg: 3.828 ± 1.999
4.785AlaSer: 4.785 ± 1.329
2.871AlaThr: 2.871 ± 1.703
0.957AlaVal: 0.957 ± 0.916
0.957AlaTrp: 0.957 ± 0.839
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.957CysCys: 0.957 ± 1.31
0.957CysAsp: 0.957 ± 1.31
0.957CysGlu: 0.957 ± 0.839
0.0CysPhe: 0.0 ± 0.0
0.957CysGly: 0.957 ± 0.909
1.914CysHis: 1.914 ± 0.919
0.957CysIle: 0.957 ± 0.839
2.871CysLys: 2.871 ± 1.225
0.0CysLeu: 0.0 ± 0.0
0.957CysMet: 0.957 ± 1.31
1.914CysAsn: 1.914 ± 1.278
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.914CysArg: 1.914 ± 1.299
1.914CysSer: 1.914 ± 0.919
2.871CysThr: 2.871 ± 0.877
0.957CysVal: 0.957 ± 0.839
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.871AspAla: 2.871 ± 1.948
0.0AspCys: 0.0 ± 0.0
2.871AspAsp: 2.871 ± 1.307
0.957AspGlu: 0.957 ± 0.839
3.828AspPhe: 3.828 ± 1.778
2.871AspGly: 2.871 ± 1.307
0.0AspHis: 0.0 ± 0.0
2.871AspIle: 2.871 ± 1.617
0.957AspLys: 0.957 ± 0.995
6.699AspLeu: 6.699 ± 2.671
0.957AspMet: 0.957 ± 0.602
2.871AspAsn: 2.871 ± 0.877
0.957AspPro: 0.957 ± 0.916
1.914AspGln: 1.914 ± 1.282
2.871AspArg: 2.871 ± 1.703
5.742AspSer: 5.742 ± 1.098
0.957AspThr: 0.957 ± 0.649
2.871AspVal: 2.871 ± 1.532
0.957AspTrp: 0.957 ± 0.649
1.914AspTyr: 1.914 ± 1.299
0.0AspXaa: 0.0 ± 0.0
Glu
3.828GluAla: 3.828 ± 1.778
0.0GluCys: 0.0 ± 0.0
1.914GluAsp: 1.914 ± 1.665
6.699GluGlu: 6.699 ± 2.962
0.0GluPhe: 0.0 ± 0.0
3.828GluGly: 3.828 ± 1.778
2.871GluHis: 2.871 ± 2.985
1.914GluIle: 1.914 ± 1.751
1.914GluLys: 1.914 ± 1.299
3.828GluLeu: 3.828 ± 1.407
0.957GluMet: 0.957 ± 0.649
6.699GluAsn: 6.699 ± 2.191
2.871GluPro: 2.871 ± 1.225
2.871GluGln: 2.871 ± 1.532
0.957GluArg: 0.957 ± 0.649
1.914GluSer: 1.914 ± 0.919
0.957GluThr: 0.957 ± 0.649
0.957GluVal: 0.957 ± 1.31
2.871GluTrp: 2.871 ± 1.307
0.957GluTyr: 0.957 ± 0.649
0.0GluXaa: 0.0 ± 0.0
Phe
1.914PheAla: 1.914 ± 1.079
0.957PheCys: 0.957 ± 0.839
1.914PheAsp: 1.914 ± 0.825
0.957PheGlu: 0.957 ± 0.649
1.914PhePhe: 1.914 ± 1.299
0.957PheGly: 0.957 ± 0.839
0.0PheHis: 0.0 ± 0.0
1.914PheIle: 1.914 ± 0.911
1.914PheLys: 1.914 ± 1.282
5.742PheLeu: 5.742 ± 2.581
0.0PheMet: 0.0 ± 0.0
2.871PheAsn: 2.871 ± 0.843
0.957PhePro: 0.957 ± 0.649
4.785PheGln: 4.785 ± 0.876
2.871PheArg: 2.871 ± 1.503
0.957PheSer: 0.957 ± 0.839
1.914PheThr: 1.914 ± 0.919
2.871PheVal: 2.871 ± 1.51
2.871PheTrp: 2.871 ± 1.725
1.914PheTyr: 1.914 ± 1.678
0.0PheXaa: 0.0 ± 0.0
Gly
0.957GlyAla: 0.957 ± 0.649
1.914GlyCys: 1.914 ± 1.094
3.828GlyAsp: 3.828 ± 2.597
2.871GlyGlu: 2.871 ± 1.291
1.914GlyPhe: 1.914 ± 1.817
5.742GlyGly: 5.742 ± 1.376
0.957GlyHis: 0.957 ± 0.649
2.871GlyIle: 2.871 ± 0.973
5.742GlyLys: 5.742 ± 2.474
1.914GlyLeu: 1.914 ± 1.99
0.957GlyMet: 0.957 ± 0.839
2.871GlyAsn: 2.871 ± 1.617
1.914GlyPro: 1.914 ± 1.678
3.828GlyGln: 3.828 ± 1.65
3.828GlyArg: 3.828 ± 1.37
5.742GlySer: 5.742 ± 2.377
3.828GlyThr: 3.828 ± 1.742
3.828GlyVal: 3.828 ± 2.662
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
1.914HisAla: 1.914 ± 0.825
0.957HisCys: 0.957 ± 0.909
1.914HisAsp: 1.914 ± 0.825
0.0HisGlu: 0.0 ± 0.0
0.957HisPhe: 0.957 ± 0.649
2.871HisGly: 2.871 ± 1.894
3.828HisHis: 3.828 ± 1.861
1.914HisIle: 1.914 ± 1.282
1.914HisLys: 1.914 ± 1.079
3.828HisLeu: 3.828 ± 2.014
0.957HisMet: 0.957 ± 1.31
5.742HisAsn: 5.742 ± 2.047
3.828HisPro: 3.828 ± 1.99
0.957HisGln: 0.957 ± 0.839
2.871HisArg: 2.871 ± 1.827
0.957HisSer: 0.957 ± 0.916
3.828HisThr: 3.828 ± 1.889
4.785HisVal: 4.785 ± 2.287
0.957HisTrp: 0.957 ± 0.649
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.957IleAla: 0.957 ± 1.31
0.957IleCys: 0.957 ± 1.31
2.871IleAsp: 2.871 ± 1.307
1.914IleGlu: 1.914 ± 1.299
3.828IlePhe: 3.828 ± 1.624
1.914IleGly: 1.914 ± 1.007
0.957IleHis: 0.957 ± 1.31
2.871IleIle: 2.871 ± 1.948
4.785IleLys: 4.785 ± 0.876
3.828IleLeu: 3.828 ± 2.939
0.957IleMet: 0.957 ± 1.31
1.914IleAsn: 1.914 ± 1.282
2.871IlePro: 2.871 ± 2.506
0.957IleGln: 0.957 ± 0.916
4.785IleArg: 4.785 ± 1.57
6.699IleSer: 6.699 ± 2.13
4.785IleThr: 4.785 ± 2.425
2.871IleVal: 2.871 ± 1.894
0.957IleTrp: 0.957 ± 0.916
4.785IleTyr: 4.785 ± 2.846
0.0IleXaa: 0.0 ± 0.0
Lys
3.828LysAla: 3.828 ± 1.823
0.957LysCys: 0.957 ± 0.649
1.914LysAsp: 1.914 ± 1.299
2.871LysGlu: 2.871 ± 1.948
2.871LysPhe: 2.871 ± 1.225
1.914LysGly: 1.914 ± 0.825
0.957LysHis: 0.957 ± 0.649
1.914LysIle: 1.914 ± 1.079
1.914LysLys: 1.914 ± 0.919
1.914LysLeu: 1.914 ± 1.678
1.914LysMet: 1.914 ± 0.839
3.828LysAsn: 3.828 ± 1.65
3.828LysPro: 3.828 ± 1.299
0.957LysGln: 0.957 ± 0.649
3.828LysArg: 3.828 ± 1.45
2.871LysSer: 2.871 ± 1.225
2.871LysThr: 2.871 ± 1.894
6.699LysVal: 6.699 ± 4.011
0.0LysTrp: 0.0 ± 0.0
4.785LysTyr: 4.785 ± 1.528
0.0LysXaa: 0.0 ± 0.0
Leu
1.914LeuAla: 1.914 ± 1.663
0.957LeuCys: 0.957 ± 0.649
6.699LeuAsp: 6.699 ± 1.449
3.828LeuGlu: 3.828 ± 1.609
0.957LeuPhe: 0.957 ± 0.909
3.828LeuGly: 3.828 ± 1.049
6.699LeuHis: 6.699 ± 1.077
3.828LeuIle: 3.828 ± 1.825
4.785LeuLys: 4.785 ± 1.505
5.742LeuLeu: 5.742 ± 1.477
0.0LeuMet: 0.0 ± 0.0
4.785LeuAsn: 4.785 ± 1.58
4.785LeuPro: 4.785 ± 3.352
4.785LeuGln: 4.785 ± 2.479
5.742LeuArg: 5.742 ± 1.477
6.699LeuSer: 6.699 ± 2.038
2.871LeuThr: 2.871 ± 1.503
6.699LeuVal: 6.699 ± 2.848
0.0LeuTrp: 0.0 ± 0.0
4.785LeuTyr: 4.785 ± 2.41
0.0LeuXaa: 0.0 ± 0.0
Met
0.957MetAla: 0.957 ± 0.839
0.957MetCys: 0.957 ± 0.839
2.871MetAsp: 2.871 ± 1.703
0.957MetGlu: 0.957 ± 1.31
2.871MetPhe: 2.871 ± 1.694
1.914MetGly: 1.914 ± 1.751
0.0MetHis: 0.0 ± 0.0
0.957MetIle: 0.957 ± 1.31
0.957MetLys: 0.957 ± 0.649
0.957MetLeu: 0.957 ± 0.909
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.871MetPro: 2.871 ± 2.506
0.957MetGln: 0.957 ± 0.649
0.0MetArg: 0.0 ± 0.0
1.914MetSer: 1.914 ± 1.678
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.957MetTrp: 0.957 ± 0.649
0.957MetTyr: 0.957 ± 0.839
0.0MetXaa: 0.0 ± 0.0
Asn
3.828AsnAla: 3.828 ± 1.778
3.828AsnCys: 3.828 ± 1.839
2.871AsnAsp: 2.871 ± 1.225
1.914AsnGlu: 1.914 ± 1.678
1.914AsnPhe: 1.914 ± 1.079
3.828AsnGly: 3.828 ± 0.883
6.699AsnHis: 6.699 ± 3.218
1.914AsnIle: 1.914 ± 1.079
0.957AsnLys: 0.957 ± 0.649
5.742AsnLeu: 5.742 ± 3.459
1.914AsnMet: 1.914 ± 1.531
2.871AsnAsn: 2.871 ± 2.024
2.871AsnPro: 2.871 ± 0.843
0.957AsnGln: 0.957 ± 0.909
1.914AsnArg: 1.914 ± 1.261
4.785AsnSer: 4.785 ± 1.134
3.828AsnThr: 3.828 ± 2.161
4.785AsnVal: 4.785 ± 2.422
0.957AsnTrp: 0.957 ± 0.649
1.914AsnTyr: 1.914 ± 1.299
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
1.914ProCys: 1.914 ± 1.261
0.957ProAsp: 0.957 ± 0.839
4.785ProGlu: 4.785 ± 1.785
0.957ProPhe: 0.957 ± 0.649
0.957ProGly: 0.957 ± 0.649
2.871ProHis: 2.871 ± 1.188
0.957ProIle: 0.957 ± 0.649
5.742ProLys: 5.742 ± 1.946
3.828ProLeu: 3.828 ± 1.823
2.871ProMet: 2.871 ± 1.854
1.914ProAsn: 1.914 ± 1.663
5.742ProPro: 5.742 ± 1.993
6.699ProGln: 6.699 ± 2.866
2.871ProArg: 2.871 ± 1.694
6.699ProSer: 6.699 ± 1.79
0.0ProThr: 0.0 ± 0.0
5.742ProVal: 5.742 ± 1.221
1.914ProTrp: 1.914 ± 0.825
1.914ProTyr: 1.914 ± 1.169
0.0ProXaa: 0.0 ± 0.0
Gln
2.871GlnAla: 2.871 ± 0.843
0.0GlnCys: 0.0 ± 0.0
1.914GlnAsp: 1.914 ± 1.817
3.828GlnGlu: 3.828 ± 1.778
0.957GlnPhe: 0.957 ± 0.649
1.914GlnGly: 1.914 ± 1.007
1.914GlnHis: 1.914 ± 1.299
3.828GlnIle: 3.828 ± 1.829
0.957GlnLys: 0.957 ± 0.649
6.699GlnLeu: 6.699 ± 2.925
0.0GlnMet: 0.0 ± 0.0
0.957GlnAsn: 0.957 ± 0.995
2.871GlnPro: 2.871 ± 1.709
1.914GlnGln: 1.914 ± 0.919
3.828GlnArg: 3.828 ± 1.65
4.785GlnSer: 4.785 ± 1.589
1.914GlnThr: 1.914 ± 1.278
2.871GlnVal: 2.871 ± 1.703
0.0GlnTrp: 0.0 ± 0.0
1.914GlnTyr: 1.914 ± 0.825
0.0GlnXaa: 0.0 ± 0.0
Arg
3.828ArgAla: 3.828 ± 1.938
0.0ArgCys: 0.0 ± 0.0
3.828ArgAsp: 3.828 ± 1.65
1.914ArgGlu: 1.914 ± 0.919
8.612ArgPhe: 8.612 ± 3.286
3.828ArgGly: 3.828 ± 1.585
1.914ArgHis: 1.914 ± 0.825
6.699ArgIle: 6.699 ± 0.872
1.914ArgLys: 1.914 ± 1.079
0.0ArgLeu: 0.0 ± 0.0
0.957ArgMet: 0.957 ± 1.156
0.0ArgAsn: 0.0 ± 0.0
3.828ArgPro: 3.828 ± 1.65
0.957ArgGln: 0.957 ± 1.31
6.699ArgArg: 6.699 ± 3.622
8.612ArgSer: 8.612 ± 3.211
3.828ArgThr: 3.828 ± 1.144
7.656ArgVal: 7.656 ± 1.589
0.0ArgTrp: 0.0 ± 0.0
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
3.828SerAla: 3.828 ± 1.173
0.957SerCys: 0.957 ± 0.649
3.828SerAsp: 3.828 ± 1.005
0.0SerGlu: 0.0 ± 0.0
1.914SerPhe: 1.914 ± 0.825
4.785SerGly: 4.785 ± 1.264
1.914SerHis: 1.914 ± 0.825
8.612SerIle: 8.612 ± 1.724
5.742SerLys: 5.742 ± 1.888
4.785SerLeu: 4.785 ± 1.589
0.0SerMet: 0.0 ± 0.0
7.656SerAsn: 7.656 ± 2.392
7.656SerPro: 7.656 ± 1.556
1.914SerGln: 1.914 ± 1.299
4.785SerArg: 4.785 ± 1.543
12.44SerSer: 12.44 ± 5.78
6.699SerThr: 6.699 ± 3.752
2.871SerVal: 2.871 ± 1.725
0.0SerTrp: 0.0 ± 0.0
3.828SerTyr: 3.828 ± 1.049
0.0SerXaa: 0.0 ± 0.0
Thr
3.828ThrAla: 3.828 ± 1.556
0.957ThrCys: 0.957 ± 1.31
0.957ThrAsp: 0.957 ± 0.916
3.828ThrGlu: 3.828 ± 2.7
0.0ThrPhe: 0.0 ± 0.0
5.742ThrGly: 5.742 ± 2.023
5.742ThrHis: 5.742 ± 2.701
2.871ThrIle: 2.871 ± 2.059
0.0ThrLys: 0.0 ± 0.0
4.785ThrLeu: 4.785 ± 1.369
0.957ThrMet: 0.957 ± 0.649
3.828ThrAsn: 3.828 ± 1.173
5.742ThrPro: 5.742 ± 1.221
0.0ThrGln: 0.0 ± 0.0
2.871ThrArg: 2.871 ± 1.278
2.871ThrSer: 2.871 ± 1.949
1.914ThrThr: 1.914 ± 1.832
2.871ThrVal: 2.871 ± 1.354
0.0ThrTrp: 0.0 ± 0.0
2.871ThrTyr: 2.871 ± 1.225
0.0ThrXaa: 0.0 ± 0.0
Val
1.914ValAla: 1.914 ± 1.007
2.871ValCys: 2.871 ± 1.948
0.0ValAsp: 0.0 ± 0.0
4.785ValGlu: 4.785 ± 2.984
2.871ValPhe: 2.871 ± 1.278
2.871ValGly: 2.871 ± 1.725
4.785ValHis: 4.785 ± 3.473
5.742ValIle: 5.742 ± 3.345
1.914ValLys: 1.914 ± 1.678
4.785ValLeu: 4.785 ± 1.709
2.871ValMet: 2.871 ± 1.694
4.785ValAsn: 4.785 ± 1.329
1.914ValPro: 1.914 ± 0.825
4.785ValGln: 4.785 ± 1.42
3.828ValArg: 3.828 ± 1.831
1.914ValSer: 1.914 ± 1.007
3.828ValThr: 3.828 ± 2.329
0.0ValVal: 0.0 ± 0.0
1.914ValTrp: 1.914 ± 1.079
4.785ValTyr: 4.785 ± 1.317
0.0ValXaa: 0.0 ± 0.0
Trp
2.871TrpAla: 2.871 ± 1.948
0.0TrpCys: 0.0 ± 0.0
0.957TrpAsp: 0.957 ± 0.909
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.957TrpGly: 0.957 ± 0.649
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.957TrpLys: 0.957 ± 0.649
0.957TrpLeu: 0.957 ± 0.839
0.957TrpMet: 0.957 ± 0.839
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.914TrpGln: 1.914 ± 0.911
2.871TrpArg: 2.871 ± 1.725
0.0TrpSer: 0.0 ± 0.0
1.914TrpThr: 1.914 ± 0.911
0.957TrpVal: 0.957 ± 0.839
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.871TyrAla: 2.871 ± 1.532
0.0TyrCys: 0.0 ± 0.0
0.957TyrAsp: 0.957 ± 0.839
2.871TyrGlu: 2.871 ± 1.532
2.871TyrPhe: 2.871 ± 0.843
1.914TyrGly: 1.914 ± 0.825
0.957TyrHis: 0.957 ± 0.916
2.871TyrIle: 2.871 ± 1.225
0.957TyrLys: 0.957 ± 0.649
6.699TyrLeu: 6.699 ± 2.651
1.914TyrMet: 1.914 ± 1.049
2.871TyrAsn: 2.871 ± 0.843
0.957TyrPro: 0.957 ± 0.649
1.914TyrGln: 1.914 ± 1.007
1.914TyrArg: 1.914 ± 1.678
1.914TyrSer: 1.914 ± 0.825
0.957TyrThr: 0.957 ± 0.916
1.914TyrVal: 1.914 ± 0.911
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1046 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski