Amino acid dipepetide frequency for Candida auris (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.592AlaAla: 5.592 ± 0.076	0.761AlaCys: 0.761 ± 0.018	3.353AlaAsp: 3.353 ± 0.033	4.109AlaGlu: 4.109 ± 0.047	2.846AlaPhe: 2.846 ± 0.037	3.62AlaGly: 3.62 ± 0.056	1.395AlaHis: 1.395 ± 0.024	3.892AlaIle: 3.892 ± 0.047	4.586AlaLys: 4.586 ± 0.046	6.353AlaLeu: 6.353 ± 0.057	1.467AlaMet: 1.467 ± 0.025	3.126AlaAsn: 3.126 ± 0.039	3.112AlaPro: 3.112 ± 0.052	2.636AlaGln: 2.636 ± 0.032	3.139AlaArg: 3.139 ± 0.039	6.451AlaSer: 6.451 ± 0.065	3.847AlaThr: 3.847 ± 0.039	4.11AlaVal: 4.11 ± 0.046	0.626AlaTrp: 0.626 ± 0.018	1.973AlaTyr: 1.973 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.669CysAla: 0.669 ± 0.02	0.24CysCys: 0.24 ± 0.01	0.646CysAsp: 0.646 ± 0.018	0.637CysGlu: 0.637 ± 0.014	0.616CysPhe: 0.616 ± 0.016	0.805CysGly: 0.805 ± 0.021	0.312CysHis: 0.312 ± 0.011	0.76CysIle: 0.76 ± 0.017	0.66CysLys: 0.66 ± 0.018	1.212CysLeu: 1.212 ± 0.024	0.23CysMet: 0.23 ± 0.01	0.494CysAsn: 0.494 ± 0.014	0.497CysPro: 0.497 ± 0.018	0.37CysGln: 0.37 ± 0.012	0.473CysArg: 0.473 ± 0.012	0.918CysSer: 0.918 ± 0.021	0.551CysThr: 0.551 ± 0.016	0.776CysVal: 0.776 ± 0.019	0.141CysTrp: 0.141 ± 0.007	0.414CysTyr: 0.414 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.731AspAla: 3.731 ± 0.043	0.589AspCys: 0.589 ± 0.015	4.684AspAsp: 4.684 ± 0.06	5.263AspGlu: 5.263 ± 0.05	2.765AspPhe: 2.765 ± 0.032	3.014AspGly: 3.014 ± 0.039	1.278AspHis: 1.278 ± 0.021	3.544AspIle: 3.544 ± 0.04	3.529AspLys: 3.529 ± 0.039	5.69AspLeu: 5.69 ± 0.046	1.187AspMet: 1.187 ± 0.024	2.549AspAsn: 2.549 ± 0.031	2.675AspPro: 2.675 ± 0.033	1.825AspGln: 1.825 ± 0.028	2.238AspArg: 2.238 ± 0.033	5.091AspSer: 5.091 ± 0.066	2.849AspThr: 2.849 ± 0.038	3.796AspVal: 3.796 ± 0.043	0.617AspTrp: 0.617 ± 0.018	2.07AspTyr: 2.07 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	4.589GluAla: 4.589 ± 0.051	0.626GluCys: 0.626 ± 0.018	4.553GluAsp: 4.553 ± 0.056	6.584GluGlu: 6.584 ± 0.089	2.707GluPhe: 2.707 ± 0.034	3.153GluGly: 3.153 ± 0.039	1.432GluHis: 1.432 ± 0.023	3.872GluIle: 3.872 ± 0.045	5.441GluLys: 5.441 ± 0.063	6.273GluLeu: 6.273 ± 0.06	1.377GluMet: 1.377 ± 0.027	3.517GluAsn: 3.517 ± 0.041	2.455GluPro: 2.455 ± 0.037	2.672GluGln: 2.672 ± 0.045	3.291GluArg: 3.291 ± 0.041	5.56GluSer: 5.56 ± 0.055	3.481GluThr: 3.481 ± 0.048	4.011GluVal: 4.011 ± 0.035	0.662GluTrp: 0.662 ± 0.016	2.11GluTyr: 2.11 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	2.845PheAla: 2.845 ± 0.035	0.576PheCys: 0.576 ± 0.015	2.913PheAsp: 2.913 ± 0.037	2.84PheGlu: 2.84 ± 0.032	2.115PhePhe: 2.115 ± 0.04	2.89PheGly: 2.89 ± 0.054	1.058PheHis: 1.058 ± 0.021	2.451PheIle: 2.451 ± 0.037	2.738PheLys: 2.738 ± 0.036	3.972PheLeu: 3.972 ± 0.046	0.964PheMet: 0.964 ± 0.019	2.217PheAsn: 2.217 ± 0.031	1.788PhePro: 1.788 ± 0.031	1.622PheGln: 1.622 ± 0.024	1.817PheArg: 1.817 ± 0.03	3.72PheSer: 3.72 ± 0.042	2.441PheThr: 2.441 ± 0.044	2.957PheVal: 2.957 ± 0.037	0.545PheTrp: 0.545 ± 0.015	1.516PheTyr: 1.516 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	3.741GlyAla: 3.741 ± 0.06	0.714GlyCys: 0.714 ± 0.02	3.065GlyAsp: 3.065 ± 0.034	3.267GlyGlu: 3.267 ± 0.036	2.678GlyPhe: 2.678 ± 0.039	3.802GlyGly: 3.802 ± 0.074	1.288GlyHis: 1.288 ± 0.024	3.225GlyIle: 3.225 ± 0.035	3.635GlyLys: 3.635 ± 0.041	4.807GlyLeu: 4.807 ± 0.048	1.108GlyMet: 1.108 ± 0.02	2.622GlyAsn: 2.622 ± 0.035	2.115GlyPro: 2.115 ± 0.036	1.92GlyGln: 1.92 ± 0.035	2.419GlyArg: 2.419 ± 0.037	5.28GlySer: 5.28 ± 0.074	2.968GlyThr: 2.968 ± 0.036	3.655GlyVal: 3.655 ± 0.051	0.647GlyTrp: 0.647 ± 0.018	1.931GlyTyr: 1.931 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	1.256HisAla: 1.256 ± 0.021	0.294HisCys: 0.294 ± 0.011	1.3HisAsp: 1.3 ± 0.023	1.555HisGlu: 1.555 ± 0.024	1.076HisPhe: 1.076 ± 0.02	1.306HisGly: 1.306 ± 0.024	0.814HisHis: 0.814 ± 0.025	1.341HisIle: 1.341 ± 0.022	1.476HisLys: 1.476 ± 0.025	2.314HisLeu: 2.314 ± 0.033	0.465HisMet: 0.465 ± 0.014	1.089HisAsn: 1.089 ± 0.021	1.245HisPro: 1.245 ± 0.024	1.004HisGln: 1.004 ± 0.024	1.148HisArg: 1.148 ± 0.02	1.988HisSer: 1.988 ± 0.028	1.157HisThr: 1.157 ± 0.02	1.35HisVal: 1.35 ± 0.022	0.246HisTrp: 0.246 ± 0.012	0.848HisTyr: 0.848 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.82IleAla: 3.82 ± 0.045	0.714IleCys: 0.714 ± 0.016	3.691IleAsp: 3.691 ± 0.039	3.676IleGlu: 3.676 ± 0.038	2.495IlePhe: 2.495 ± 0.039	3.016IleGly: 3.016 ± 0.044	1.294IleHis: 1.294 ± 0.02	3.143IleIle: 3.143 ± 0.044	3.648IleLys: 3.648 ± 0.042	5.135IleLeu: 5.135 ± 0.057	1.153IleMet: 1.153 ± 0.021	2.766IleAsn: 2.766 ± 0.034	2.836IlePro: 2.836 ± 0.037	1.927IleGln: 1.927 ± 0.028	2.629IleArg: 2.629 ± 0.035	4.791IleSer: 4.791 ± 0.049	3.127IleThr: 3.127 ± 0.036	3.757IleVal: 3.757 ± 0.05	0.602IleTrp: 0.602 ± 0.016	1.805IleTyr: 1.805 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.54LysAla: 4.54 ± 0.052	0.689LysCys: 0.689 ± 0.019	3.972LysAsp: 3.972 ± 0.044	5.191LysGlu: 5.191 ± 0.059	2.724LysPhe: 2.724 ± 0.036	3.146LysGly: 3.146 ± 0.038	1.619LysHis: 1.619 ± 0.027	3.71LysIle: 3.71 ± 0.042	5.947LysLys: 5.947 ± 0.08	6.513LysLeu: 6.513 ± 0.053	1.351LysMet: 1.351 ± 0.023	3.393LysAsn: 3.393 ± 0.039	3.021LysPro: 3.021 ± 0.039	2.8LysGln: 2.8 ± 0.036	3.794LysArg: 3.794 ± 0.044	5.599LysSer: 5.599 ± 0.057	3.488LysThr: 3.488 ± 0.04	4.176LysVal: 4.176 ± 0.046	0.739LysTrp: 0.739 ± 0.016	2.37LysTyr: 2.37 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	6.496LeuAla: 6.496 ± 0.054	1.203LeuCys: 1.203 ± 0.022	5.299LeuAsp: 5.299 ± 0.04	5.93LeuGlu: 5.93 ± 0.067	3.868LeuPhe: 3.868 ± 0.048	4.91LeuGly: 4.91 ± 0.053	2.256LeuHis: 2.256 ± 0.033	4.988LeuIle: 4.988 ± 0.047	6.44LeuLys: 6.44 ± 0.054	8.719LeuLeu: 8.719 ± 0.085	1.927LeuMet: 1.927 ± 0.028	4.502LeuAsn: 4.502 ± 0.053	4.498LeuPro: 4.498 ± 0.043	3.959LeuGln: 3.959 ± 0.042	4.955LeuArg: 4.955 ± 0.048	8.254LeuSer: 8.254 ± 0.069	4.946LeuThr: 4.946 ± 0.052	5.716LeuVal: 5.716 ± 0.052	0.939LeuTrp: 0.939 ± 0.019	2.841LeuTyr: 2.841 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.583MetAla: 1.583 ± 0.024	0.246MetCys: 0.246 ± 0.009	1.174MetAsp: 1.174 ± 0.022	1.226MetGlu: 1.226 ± 0.021	0.882MetPhe: 0.882 ± 0.023	1.207MetGly: 1.207 ± 0.023	0.359MetHis: 0.359 ± 0.012	1.105MetIle: 1.105 ± 0.023	1.422MetLys: 1.422 ± 0.022	1.821MetLeu: 1.821 ± 0.029	0.488MetMet: 0.488 ± 0.013	1.103MetAsn: 1.103 ± 0.024	0.988MetPro: 0.988 ± 0.021	0.628MetGln: 0.628 ± 0.018	0.938MetArg: 0.938 ± 0.018	2.174MetSer: 2.174 ± 0.031	1.097MetThr: 1.097 ± 0.018	1.229MetVal: 1.229 ± 0.022	0.203MetTrp: 0.203 ± 0.008	0.629MetTyr: 0.629 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.154AsnAla: 3.154 ± 0.04	0.56AsnCys: 0.56 ± 0.015	3.009AsnAsp: 3.009 ± 0.038	3.412AsnGlu: 3.412 ± 0.043	2.174AsnPhe: 2.174 ± 0.03	2.979AsnGly: 2.979 ± 0.053	1.11AsnHis: 1.11 ± 0.021	2.726AsnIle: 2.726 ± 0.033	2.999AsnLys: 2.999 ± 0.04	4.481AsnLeu: 4.481 ± 0.05	0.993AsnMet: 0.993 ± 0.02	2.494AsnAsn: 2.494 ± 0.043	2.392AsnPro: 2.392 ± 0.034	1.744AsnGln: 1.744 ± 0.031	2.025AsnArg: 2.025 ± 0.03	4.247AsnSer: 4.247 ± 0.055	2.557AsnThr: 2.557 ± 0.036	3.021AsnVal: 3.021 ± 0.038	0.553AsnTrp: 0.553 ± 0.014	1.765AsnTyr: 1.765 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	2.944ProAla: 2.944 ± 0.049	0.374ProCys: 0.374 ± 0.013	2.455ProAsp: 2.455 ± 0.031	3.433ProGlu: 3.433 ± 0.041	1.93ProPhe: 1.93 ± 0.033	2.383ProGly: 2.383 ± 0.036	1.164ProHis: 1.164 ± 0.031	2.365ProIle: 2.365 ± 0.029	3.168ProLys: 3.168 ± 0.039	3.91ProLeu: 3.91 ± 0.048	0.824ProMet: 0.824 ± 0.021	2.156ProAsn: 2.156 ± 0.033	3.111ProPro: 3.111 ± 0.089	2.349ProGln: 2.349 ± 0.044	2.097ProArg: 2.097 ± 0.027	4.859ProSer: 4.859 ± 0.074	2.76ProThr: 2.76 ± 0.045	3.029ProVal: 3.029 ± 0.039	0.449ProTrp: 0.449 ± 0.013	1.446ProTyr: 1.446 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	2.529GlnAla: 2.529 ± 0.035	0.384GlnCys: 0.384 ± 0.012	1.845GlnAsp: 1.845 ± 0.028	2.612GlnGlu: 2.612 ± 0.039	1.674GlnPhe: 1.674 ± 0.03	1.938GlnGly: 1.938 ± 0.033	1.056GlnHis: 1.056 ± 0.024	2.117GlnIle: 2.117 ± 0.028	2.723GlnLys: 2.723 ± 0.037	3.752GlnLeu: 3.752 ± 0.047	0.898GlnMet: 0.898 ± 0.021	1.958GlnAsn: 1.958 ± 0.032	1.926GlnPro: 1.926 ± 0.046	2.73GlnGln: 2.73 ± 0.098	2.088GlnArg: 2.088 ± 0.031	3.221GlnSer: 3.221 ± 0.047	1.98GlnThr: 1.98 ± 0.032	2.18GlnVal: 2.18 ± 0.028	0.43GlnTrp: 0.43 ± 0.012	1.276GlnTyr: 1.276 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	3.114ArgAla: 3.114 ± 0.037	0.54ArgCys: 0.54 ± 0.014	2.59ArgAsp: 2.59 ± 0.031	3.076ArgGlu: 3.076 ± 0.04	2.137ArgPhe: 2.137 ± 0.025	2.372ArgGly: 2.372 ± 0.033	1.158ArgHis: 1.158 ± 0.021	2.65ArgIle: 2.65 ± 0.032	3.744ArgLys: 3.744 ± 0.042	4.533ArgLeu: 4.533 ± 0.046	0.981ArgMet: 0.981 ± 0.018	2.316ArgAsn: 2.316 ± 0.03	2.006ArgPro: 2.006 ± 0.032	1.981ArgGln: 1.981 ± 0.028	3.143ArgArg: 3.143 ± 0.05	4.173ArgSer: 4.173 ± 0.049	2.289ArgThr: 2.289 ± 0.033	2.721ArgVal: 2.721 ± 0.033	0.514ArgTrp: 0.514 ± 0.016	1.59ArgTyr: 1.59 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	5.808SerAla: 5.808 ± 0.061	0.883SerCys: 0.883 ± 0.021	5.106SerAsp: 5.106 ± 0.06	5.545SerGlu: 5.545 ± 0.054	3.926SerPhe: 3.926 ± 0.046	5.245SerGly: 5.245 ± 0.07	2.071SerHis: 2.071 ± 0.032	4.997SerIle: 4.997 ± 0.057	6.038SerLys: 6.038 ± 0.048	8.252SerLeu: 8.252 ± 0.061	1.9SerMet: 1.9 ± 0.03	4.303SerAsn: 4.303 ± 0.058	4.484SerPro: 4.484 ± 0.067	3.567SerGln: 3.567 ± 0.052	4.345SerArg: 4.345 ± 0.049	10.966SerSer: 10.966 ± 0.161	5.501SerThr: 5.501 ± 0.074	5.312SerVal: 5.312 ± 0.048	0.931SerTrp: 0.931 ± 0.022	2.593SerTyr: 2.593 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	3.536ThrAla: 3.536 ± 0.038	0.597ThrCys: 0.597 ± 0.016	2.775ThrAsp: 2.775 ± 0.055	3.196ThrGlu: 3.196 ± 0.039	2.471ThrPhe: 2.471 ± 0.044	3.172ThrGly: 3.172 ± 0.053	1.206ThrHis: 1.206 ± 0.021	3.149ThrIle: 3.149 ± 0.035	3.572ThrLys: 3.572 ± 0.037	4.938ThrLeu: 4.938 ± 0.048	1.011ThrMet: 1.011 ± 0.029	2.574ThrAsn: 2.574 ± 0.034	3.179ThrPro: 3.179 ± 0.05	1.908ThrGln: 1.908 ± 0.026	2.384ThrArg: 2.384 ± 0.035	5.424ThrSer: 5.424 ± 0.082	3.734ThrThr: 3.734 ± 0.166	3.362ThrVal: 3.362 ± 0.039	0.588ThrTrp: 0.588 ± 0.023	1.679ThrTyr: 1.679 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	4.442ValAla: 4.442 ± 0.054	0.795ValCys: 0.795 ± 0.019	3.832ValAsp: 3.832 ± 0.038	4.093ValGlu: 4.093 ± 0.042	2.783ValPhe: 2.783 ± 0.037	3.385ValGly: 3.385 ± 0.047	1.326ValHis: 1.326 ± 0.022	3.513ValIle: 3.513 ± 0.05	4.177ValLys: 4.177 ± 0.046	5.72ValLeu: 5.72 ± 0.059	1.271ValMet: 1.271 ± 0.022	2.944ValAsn: 2.944 ± 0.036	3.149ValPro: 3.149 ± 0.041	2.081ValGln: 2.081 ± 0.027	2.69ValArg: 2.69 ± 0.034	5.599ValSer: 5.599 ± 0.045	3.376ValThr: 3.376 ± 0.05	4.379ValVal: 4.379 ± 0.058	0.681ValTrp: 0.681 ± 0.018	1.934ValTyr: 1.934 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.674TrpAla: 0.674 ± 0.015	0.206TrpCys: 0.206 ± 0.008	0.649TrpAsp: 0.649 ± 0.017	0.606TrpGlu: 0.606 ± 0.016	0.522TrpPhe: 0.522 ± 0.015	0.583TrpGly: 0.583 ± 0.017	0.239TrpHis: 0.239 ± 0.01	0.609TrpIle: 0.609 ± 0.015	0.759TrpLys: 0.759 ± 0.016	1.065TrpLeu: 1.065 ± 0.019	0.223TrpMet: 0.223 ± 0.009	0.577TrpAsn: 0.577 ± 0.016	0.338TrpPro: 0.338 ± 0.012	0.361TrpGln: 0.361 ± 0.018	0.593TrpArg: 0.593 ± 0.016	0.852TrpSer: 0.852 ± 0.018	0.607TrpThr: 0.607 ± 0.022	0.647TrpVal: 0.647 ± 0.015	0.189TrpTrp: 0.189 ± 0.009	0.396TrpTyr: 0.396 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.931TyrAla: 1.931 ± 0.027	0.433TyrCys: 0.433 ± 0.013	2.077TyrAsp: 2.077 ± 0.029	2.116TyrGlu: 2.116 ± 0.028	1.594TyrPhe: 1.594 ± 0.028	1.959TyrGly: 1.959 ± 0.034	0.835TyrHis: 0.835 ± 0.018	1.865TyrIle: 1.865 ± 0.03	2.081TyrLys: 2.081 ± 0.029	3.185TyrLeu: 3.185 ± 0.037	0.683TyrMet: 0.683 ± 0.017	1.695TyrAsn: 1.695 ± 0.027	1.391TyrPro: 1.391 ± 0.025	1.233TyrGln: 1.233 ± 0.024	1.423TyrArg: 1.423 ± 0.022	2.605TyrSer: 2.605 ± 0.032	1.7TyrThr: 1.7 ± 0.034	1.988TyrVal: 1.988 ± 0.024	0.393TyrTrp: 0.393 ± 0.012	1.307TyrTyr: 1.307 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5409 proteins (2694904 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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