Amino acid dipepetide frequency for Thermoproteus tenax virus 1 (strain KRA1) (TTV1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.971AlaAla: 2.971 ± 0.985
0.914AlaCys: 0.914 ± 0.481
2.971AlaAsp: 2.971 ± 0.96
2.285AlaGlu: 2.285 ± 0.936
1.371AlaPhe: 1.371 ± 0.517
2.285AlaGly: 2.285 ± 0.625
0.229AlaHis: 0.229 ± 0.236
7.084AlaIle: 7.084 ± 1.073
2.285AlaLys: 2.285 ± 0.81
5.256AlaLeu: 5.256 ± 0.922
1.828AlaMet: 1.828 ± 0.699
3.656AlaAsn: 3.656 ± 1.067
1.828AlaPro: 1.828 ± 0.743
1.828AlaGln: 1.828 ± 0.925
1.143AlaArg: 1.143 ± 0.601
3.656AlaSer: 3.656 ± 1.049
1.828AlaThr: 1.828 ± 0.547
3.199AlaVal: 3.199 ± 0.801
0.914AlaTrp: 0.914 ± 0.376
4.342AlaTyr: 4.342 ± 0.944
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.457CysCys: 0.457 ± 0.272
1.371CysAsp: 1.371 ± 0.529
0.914CysGlu: 0.914 ± 0.469
1.371CysPhe: 1.371 ± 0.729
0.457CysGly: 0.457 ± 0.306
0.229CysHis: 0.229 ± 0.238
1.6CysIle: 1.6 ± 0.578
0.914CysLys: 0.914 ± 0.474
0.686CysLeu: 0.686 ± 0.378
0.457CysMet: 0.457 ± 0.344
0.914CysAsn: 0.914 ± 0.41
0.686CysPro: 0.686 ± 0.384
0.229CysGln: 0.229 ± 0.238
0.914CysArg: 0.914 ± 0.379
1.828CysSer: 1.828 ± 0.81
1.6CysThr: 1.6 ± 0.682
0.457CysVal: 0.457 ± 0.267
0.0CysTrp: 0.0 ± 0.0
1.6CysTyr: 1.6 ± 0.567
0.0CysXaa: 0.0 ± 0.0
Asp
2.742AspAla: 2.742 ± 0.804
0.686AspCys: 0.686 ± 0.344
0.914AspAsp: 0.914 ± 0.568
2.285AspGlu: 2.285 ± 0.899
3.656AspPhe: 3.656 ± 0.847
3.428AspGly: 3.428 ± 0.907
0.0AspHis: 0.0 ± 0.0
4.113AspIle: 4.113 ± 1.095
3.885AspLys: 3.885 ± 0.89
3.428AspLeu: 3.428 ± 0.995
1.6AspMet: 1.6 ± 0.562
1.143AspAsn: 1.143 ± 0.481
2.285AspPro: 2.285 ± 0.97
0.686AspGln: 0.686 ± 0.372
2.742AspArg: 2.742 ± 0.673
2.285AspSer: 2.285 ± 0.757
2.514AspThr: 2.514 ± 0.755
3.656AspVal: 3.656 ± 1.027
0.229AspTrp: 0.229 ± 0.229
2.057AspTyr: 2.057 ± 0.695
0.0AspXaa: 0.0 ± 0.0
Glu
1.828GluAla: 1.828 ± 0.611
0.457GluCys: 0.457 ± 0.307
2.742GluAsp: 2.742 ± 0.969
3.885GluGlu: 3.885 ± 1.37
1.828GluPhe: 1.828 ± 0.657
3.656GluGly: 3.656 ± 1.136
0.457GluHis: 0.457 ± 0.276
7.084GluIle: 7.084 ± 1.192
2.285GluLys: 2.285 ± 0.954
4.799GluLeu: 4.799 ± 1.344
2.971GluMet: 2.971 ± 0.941
2.057GluAsn: 2.057 ± 0.634
2.057GluPro: 2.057 ± 0.675
1.6GluGln: 1.6 ± 0.55
3.199GluArg: 3.199 ± 0.869
1.828GluSer: 1.828 ± 0.659
0.914GluThr: 0.914 ± 0.414
2.971GluVal: 2.971 ± 1.039
0.686GluTrp: 0.686 ± 0.405
2.742GluTyr: 2.742 ± 0.885
0.0GluXaa: 0.0 ± 0.0
Phe
2.514PheAla: 2.514 ± 0.861
0.457PheCys: 0.457 ± 0.305
2.057PheAsp: 2.057 ± 0.721
1.371PheGlu: 1.371 ± 0.537
1.6PhePhe: 1.6 ± 0.591
2.971PheGly: 2.971 ± 0.577
0.914PheHis: 0.914 ± 0.477
4.799PheIle: 4.799 ± 0.874
1.828PheLys: 1.828 ± 0.724
4.342PheLeu: 4.342 ± 0.83
2.057PheMet: 2.057 ± 0.608
1.828PheAsn: 1.828 ± 0.662
0.914PhePro: 0.914 ± 0.548
1.828PheGln: 1.828 ± 0.847
1.143PheArg: 1.143 ± 0.48
4.342PheSer: 4.342 ± 1.003
4.342PheThr: 4.342 ± 0.923
1.371PheVal: 1.371 ± 0.562
0.457PheTrp: 0.457 ± 0.316
2.971PheTyr: 2.971 ± 0.915
0.0PheXaa: 0.0 ± 0.0
Gly
2.742GlyAla: 2.742 ± 0.662
0.686GlyCys: 0.686 ± 0.44
2.057GlyAsp: 2.057 ± 0.522
2.742GlyGlu: 2.742 ± 0.859
2.971GlyPhe: 2.971 ± 0.674
5.027GlyGly: 5.027 ± 2.958
1.143GlyHis: 1.143 ± 0.426
6.627GlyIle: 6.627 ± 1.124
3.428GlyLys: 3.428 ± 1.431
6.627GlyLeu: 6.627 ± 1.135
2.057GlyMet: 2.057 ± 0.797
2.514GlyAsn: 2.514 ± 0.745
1.371GlyPro: 1.371 ± 0.558
2.285GlyGln: 2.285 ± 0.802
2.057GlyArg: 2.057 ± 0.694
5.027GlySer: 5.027 ± 1.183
3.428GlyThr: 3.428 ± 1.172
4.113GlyVal: 4.113 ± 0.794
0.457GlyTrp: 0.457 ± 0.295
3.199GlyTyr: 3.199 ± 0.901
0.0GlyXaa: 0.0 ± 0.0
His
0.686HisAla: 0.686 ± 0.405
0.686HisCys: 0.686 ± 0.522
0.686HisAsp: 0.686 ± 0.422
0.457HisGlu: 0.457 ± 0.279
0.686HisPhe: 0.686 ± 0.395
0.229HisGly: 0.229 ± 0.215
1.371HisHis: 1.371 ± 0.598
2.742HisIle: 2.742 ± 0.815
0.457HisLys: 0.457 ± 0.337
1.371HisLeu: 1.371 ± 0.522
0.229HisMet: 0.229 ± 0.21
1.6HisAsn: 1.6 ± 0.628
0.229HisPro: 0.229 ± 0.21
0.229HisGln: 0.229 ± 0.215
1.828HisArg: 1.828 ± 0.746
0.914HisSer: 0.914 ± 0.415
0.457HisThr: 0.457 ± 0.343
0.457HisVal: 0.457 ± 0.291
0.0HisTrp: 0.0 ± 0.0
1.143HisTyr: 1.143 ± 0.453
0.0HisXaa: 0.0 ± 0.0
Ile
4.57IleAla: 4.57 ± 1.158
1.371IleCys: 1.371 ± 0.621
6.17IleAsp: 6.17 ± 0.975
7.541IleGlu: 7.541 ± 1.603
5.941IlePhe: 5.941 ± 1.078
4.57IleGly: 4.57 ± 0.973
1.143IleHis: 1.143 ± 0.576
8.684IleIle: 8.684 ± 1.513
6.17IleLys: 6.17 ± 1.126
5.941IleLeu: 5.941 ± 0.906
2.057IleMet: 2.057 ± 0.907
4.342IleAsn: 4.342 ± 0.807
3.656IlePro: 3.656 ± 0.829
2.514IleGln: 2.514 ± 0.744
3.656IleArg: 3.656 ± 1.023
7.998IleSer: 7.998 ± 1.545
6.627IleThr: 6.627 ± 1.252
7.998IleVal: 7.998 ± 1.124
1.143IleTrp: 1.143 ± 0.446
5.941IleTyr: 5.941 ± 1.321
0.0IleXaa: 0.0 ± 0.0
Lys
2.514LysAla: 2.514 ± 0.926
1.143LysCys: 1.143 ± 0.619
2.285LysAsp: 2.285 ± 0.779
3.428LysGlu: 3.428 ± 1.275
2.742LysPhe: 2.742 ± 0.993
1.371LysGly: 1.371 ± 0.696
0.914LysHis: 0.914 ± 0.438
5.256LysIle: 5.256 ± 1.476
2.742LysLys: 2.742 ± 0.944
4.799LysLeu: 4.799 ± 0.899
1.6LysMet: 1.6 ± 0.606
1.371LysAsn: 1.371 ± 0.483
2.057LysPro: 2.057 ± 0.706
0.914LysGln: 0.914 ± 0.493
2.971LysArg: 2.971 ± 1.037
2.285LysSer: 2.285 ± 0.702
2.285LysThr: 2.285 ± 0.732
3.199LysVal: 3.199 ± 0.78
0.457LysTrp: 0.457 ± 0.343
5.027LysTyr: 5.027 ± 1.155
0.0LysXaa: 0.0 ± 0.0
Leu
4.113LeuAla: 4.113 ± 0.918
1.828LeuCys: 1.828 ± 0.737
3.656LeuAsp: 3.656 ± 0.735
4.113LeuGlu: 4.113 ± 0.91
3.885LeuPhe: 3.885 ± 1.014
5.484LeuGly: 5.484 ± 1.034
3.428LeuHis: 3.428 ± 0.925
5.256LeuIle: 5.256 ± 1.241
3.885LeuLys: 3.885 ± 0.851
10.055LeuLeu: 10.055 ± 1.812
2.971LeuMet: 2.971 ± 1.428
4.57LeuAsn: 4.57 ± 0.94
3.885LeuPro: 3.885 ± 1.123
1.828LeuGln: 1.828 ± 0.815
5.713LeuArg: 5.713 ± 1.326
8.227LeuSer: 8.227 ± 1.61
5.027LeuThr: 5.027 ± 0.968
4.113LeuVal: 4.113 ± 0.951
0.914LeuTrp: 0.914 ± 0.519
6.17LeuTyr: 6.17 ± 1.228
0.0LeuXaa: 0.0 ± 0.0
Met
1.828MetAla: 1.828 ± 0.65
0.914MetCys: 0.914 ± 0.453
1.143MetAsp: 1.143 ± 0.397
2.514MetGlu: 2.514 ± 0.894
1.371MetPhe: 1.371 ± 0.708
1.371MetGly: 1.371 ± 0.712
0.686MetHis: 0.686 ± 0.342
3.428MetIle: 3.428 ± 1.075
2.285MetLys: 2.285 ± 0.759
4.113MetLeu: 4.113 ± 1.309
1.143MetMet: 1.143 ± 0.438
0.914MetAsn: 0.914 ± 0.448
1.6MetPro: 1.6 ± 0.553
0.229MetGln: 0.229 ± 0.207
2.514MetArg: 2.514 ± 0.777
2.057MetSer: 2.057 ± 0.665
0.457MetThr: 0.457 ± 0.319
1.143MetVal: 1.143 ± 0.622
0.229MetTrp: 0.229 ± 0.205
1.6MetTyr: 1.6 ± 0.524
0.0MetXaa: 0.0 ± 0.0
Asn
2.971AsnAla: 2.971 ± 0.894
1.143AsnCys: 1.143 ± 0.544
2.057AsnAsp: 2.057 ± 0.62
2.971AsnGlu: 2.971 ± 0.937
1.143AsnPhe: 1.143 ± 0.424
2.514AsnGly: 2.514 ± 0.75
0.686AsnHis: 0.686 ± 0.416
5.713AsnIle: 5.713 ± 1.309
2.971AsnLys: 2.971 ± 0.844
3.656AsnLeu: 3.656 ± 0.834
0.914AsnMet: 0.914 ± 0.514
3.656AsnAsn: 3.656 ± 1.008
1.828AsnPro: 1.828 ± 0.774
1.6AsnGln: 1.6 ± 0.714
2.057AsnArg: 2.057 ± 0.614
1.828AsnSer: 1.828 ± 0.554
2.514AsnThr: 2.514 ± 0.735
3.199AsnVal: 3.199 ± 0.943
0.914AsnTrp: 0.914 ± 0.429
3.428AsnTyr: 3.428 ± 0.832
0.0AsnXaa: 0.0 ± 0.0
Pro
0.686ProAla: 0.686 ± 0.569
0.229ProCys: 0.229 ± 0.251
2.057ProAsp: 2.057 ± 0.517
1.371ProGlu: 1.371 ± 0.487
1.828ProPhe: 1.828 ± 0.629
2.971ProGly: 2.971 ± 0.902
0.457ProHis: 0.457 ± 0.355
3.656ProIle: 3.656 ± 0.916
0.686ProLys: 0.686 ± 0.373
4.113ProLeu: 4.113 ± 1.284
1.6ProMet: 1.6 ± 0.609
1.143ProAsn: 1.143 ± 0.485
1.371ProPro: 1.371 ± 0.517
0.686ProGln: 0.686 ± 0.345
2.971ProArg: 2.971 ± 0.994
3.885ProSer: 3.885 ± 1.49
8.912ProThr: 8.912 ± 5.953
1.371ProVal: 1.371 ± 0.473
1.143ProTrp: 1.143 ± 0.402
3.428ProTyr: 3.428 ± 0.81
0.0ProXaa: 0.0 ± 0.0
Gln
2.742GlnAla: 2.742 ± 1.339
0.686GlnCys: 0.686 ± 0.465
0.686GlnAsp: 0.686 ± 0.382
0.914GlnGlu: 0.914 ± 0.374
2.285GlnPhe: 2.285 ± 0.598
2.057GlnGly: 2.057 ± 0.983
0.457GlnHis: 0.457 ± 0.289
2.971GlnIle: 2.971 ± 0.852
1.143GlnLys: 1.143 ± 0.469
2.742GlnLeu: 2.742 ± 0.904
0.229GlnMet: 0.229 ± 0.201
1.6GlnAsn: 1.6 ± 0.6
1.143GlnPro: 1.143 ± 0.506
1.6GlnGln: 1.6 ± 0.856
0.914GlnArg: 0.914 ± 0.487
2.514GlnSer: 2.514 ± 0.821
1.371GlnThr: 1.371 ± 0.874
2.057GlnVal: 2.057 ± 0.606
0.0GlnTrp: 0.0 ± 0.0
0.686GlnTyr: 0.686 ± 0.329
0.0GlnXaa: 0.0 ± 0.0
Arg
2.057ArgAla: 2.057 ± 0.651
0.914ArgCys: 0.914 ± 0.426
3.199ArgAsp: 3.199 ± 1.008
3.428ArgGlu: 3.428 ± 0.912
1.828ArgPhe: 1.828 ± 0.51
4.113ArgGly: 4.113 ± 1.288
0.686ArgHis: 0.686 ± 0.309
4.113ArgIle: 4.113 ± 0.903
3.656ArgLys: 3.656 ± 1.201
5.484ArgLeu: 5.484 ± 1.092
1.371ArgMet: 1.371 ± 0.432
1.6ArgAsn: 1.6 ± 0.691
1.6ArgPro: 1.6 ± 0.56
1.6ArgGln: 1.6 ± 0.675
2.514ArgArg: 2.514 ± 0.847
2.514ArgSer: 2.514 ± 0.617
2.514ArgThr: 2.514 ± 0.65
2.514ArgVal: 2.514 ± 0.924
0.914ArgTrp: 0.914 ± 0.367
2.971ArgTyr: 2.971 ± 1.011
0.0ArgXaa: 0.0 ± 0.0
Ser
3.199SerAla: 3.199 ± 0.86
1.143SerCys: 1.143 ± 0.383
2.742SerAsp: 2.742 ± 0.726
1.828SerGlu: 1.828 ± 0.709
3.656SerPhe: 3.656 ± 1.127
4.799SerGly: 4.799 ± 0.992
1.6SerHis: 1.6 ± 0.712
6.627SerIle: 6.627 ± 1.337
2.057SerLys: 2.057 ± 0.918
7.084SerLeu: 7.084 ± 1.499
2.285SerMet: 2.285 ± 0.663
5.256SerAsn: 5.256 ± 1.018
4.342SerPro: 4.342 ± 1.728
2.057SerGln: 2.057 ± 0.76
5.941SerArg: 5.941 ± 1.298
7.998SerSer: 7.998 ± 2.953
5.027SerThr: 5.027 ± 1.655
3.428SerVal: 3.428 ± 0.78
0.457SerTrp: 0.457 ± 0.306
4.57SerTyr: 4.57 ± 1.164
0.0SerXaa: 0.0 ± 0.0
Thr
3.199ThrAla: 3.199 ± 0.937
0.914ThrCys: 0.914 ± 0.663
0.686ThrAsp: 0.686 ± 0.378
1.143ThrGlu: 1.143 ± 0.48
2.057ThrPhe: 2.057 ± 0.999
4.113ThrGly: 4.113 ± 0.805
0.686ThrHis: 0.686 ± 0.436
5.256ThrIle: 5.256 ± 0.969
2.971ThrLys: 2.971 ± 0.791
5.256ThrLeu: 5.256 ± 1.148
2.057ThrMet: 2.057 ± 0.636
2.971ThrAsn: 2.971 ± 0.929
8.227ThrPro: 8.227 ± 5.913
2.285ThrGln: 2.285 ± 0.952
1.6ThrArg: 1.6 ± 0.64
5.484ThrSer: 5.484 ± 1.153
3.656ThrThr: 3.656 ± 1.066
5.256ThrVal: 5.256 ± 1.253
0.0ThrTrp: 0.0 ± 0.0
4.113ThrTyr: 4.113 ± 1.32
0.0ThrXaa: 0.0 ± 0.0
Val
4.799ValAla: 4.799 ± 1.052
0.686ValCys: 0.686 ± 0.54
3.428ValAsp: 3.428 ± 0.854
3.199ValGlu: 3.199 ± 0.98
2.057ValPhe: 2.057 ± 0.794
4.342ValGly: 4.342 ± 1.073
0.686ValHis: 0.686 ± 0.414
5.027ValIle: 5.027 ± 0.966
2.971ValLys: 2.971 ± 0.803
4.799ValLeu: 4.799 ± 0.887
1.6ValMet: 1.6 ± 0.616
3.199ValAsn: 3.199 ± 0.966
1.828ValPro: 1.828 ± 0.583
2.057ValGln: 2.057 ± 0.606
2.514ValArg: 2.514 ± 0.777
5.027ValSer: 5.027 ± 0.979
2.285ValThr: 2.285 ± 0.923
6.17ValVal: 6.17 ± 1.434
0.457ValTrp: 0.457 ± 0.322
5.027ValTyr: 5.027 ± 1.027
0.0ValXaa: 0.0 ± 0.0
Trp
0.686TrpAla: 0.686 ± 0.347
0.229TrpCys: 0.229 ± 0.212
0.229TrpAsp: 0.229 ± 0.216
0.686TrpGlu: 0.686 ± 0.397
1.371TrpPhe: 1.371 ± 0.634
0.457TrpGly: 0.457 ± 0.331
0.0TrpHis: 0.0 ± 0.0
1.143TrpIle: 1.143 ± 0.591
0.457TrpLys: 0.457 ± 0.313
0.229TrpLeu: 0.229 ± 0.239
0.457TrpMet: 0.457 ± 0.276
0.229TrpAsn: 0.229 ± 0.214
0.914TrpPro: 0.914 ± 0.661
0.457TrpGln: 0.457 ± 0.286
0.457TrpArg: 0.457 ± 0.356
0.229TrpSer: 0.229 ± 0.212
0.686TrpThr: 0.686 ± 0.307
0.457TrpVal: 0.457 ± 0.282
0.686TrpTrp: 0.686 ± 0.324
0.686TrpTyr: 0.686 ± 0.339
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.027TyrAla: 5.027 ± 0.967
1.143TyrCys: 1.143 ± 0.459
3.199TyrAsp: 3.199 ± 0.914
2.971TyrGlu: 2.971 ± 0.863
0.457TyrPhe: 0.457 ± 0.295
4.57TyrGly: 4.57 ± 1.095
0.686TyrHis: 0.686 ± 0.429
6.856TyrIle: 6.856 ± 1.086
2.285TyrLys: 2.285 ± 0.606
4.342TyrLeu: 4.342 ± 1.165
1.828TyrMet: 1.828 ± 0.531
3.199TyrAsn: 3.199 ± 1.2
2.742TyrPro: 2.742 ± 0.81
2.285TyrGln: 2.285 ± 0.596
2.742TyrArg: 2.742 ± 0.865
6.17TyrSer: 6.17 ± 1.175
5.484TyrThr: 5.484 ± 1.137
5.027TyrVal: 5.027 ± 0.858
0.686TyrTrp: 0.686 ± 0.352
4.57TyrTyr: 4.57 ± 1.387
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 37 proteins (4377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski