Amino acid dipepetide frequency for Janthinobacterium sp. CG23_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.486AlaAla: 18.486 ± 0.161	1.411AlaCys: 1.411 ± 0.029	6.896AlaAsp: 6.896 ± 0.062	5.858AlaGlu: 5.858 ± 0.083	3.905AlaPhe: 3.905 ± 0.046	11.222AlaGly: 11.222 ± 0.098	2.714AlaHis: 2.714 ± 0.04	5.704AlaIle: 5.704 ± 0.059	4.0AlaLys: 4.0 ± 0.067	14.501AlaLeu: 14.501 ± 0.13	3.558AlaMet: 3.558 ± 0.039	3.631AlaAsn: 3.631 ± 0.07	6.826AlaPro: 6.826 ± 0.087	5.4AlaGln: 5.4 ± 0.064	9.091AlaArg: 9.091 ± 0.082	7.514AlaSer: 7.514 ± 0.071	6.135AlaThr: 6.135 ± 0.06	8.202AlaVal: 8.202 ± 0.071	1.726AlaTrp: 1.726 ± 0.03	2.928AlaTyr: 2.928 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.38CysAla: 1.38 ± 0.03	0.146CysCys: 0.146 ± 0.009	0.538CysAsp: 0.538 ± 0.015	0.469CysGlu: 0.469 ± 0.016	0.322CysPhe: 0.322 ± 0.012	0.96CysGly: 0.96 ± 0.024	0.267CysHis: 0.267 ± 0.013	0.424CysIle: 0.424 ± 0.014	0.289CysLys: 0.289 ± 0.012	0.86CysLeu: 0.86 ± 0.021	0.218CysMet: 0.218 ± 0.01	0.255CysAsn: 0.255 ± 0.011	0.433CysPro: 0.433 ± 0.014	0.27CysGln: 0.27 ± 0.011	0.587CysArg: 0.587 ± 0.017	0.509CysSer: 0.509 ± 0.014	0.456CysThr: 0.456 ± 0.017	0.666CysVal: 0.666 ± 0.02	0.13CysTrp: 0.13 ± 0.007	0.255CysTyr: 0.255 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.508AspAla: 7.508 ± 0.189	0.49AspCys: 0.49 ± 0.015	3.204AspAsp: 3.204 ± 0.046	3.053AspGlu: 3.053 ± 0.042	2.093AspPhe: 2.093 ± 0.03	5.292AspGly: 5.292 ± 0.076	1.093AspHis: 1.093 ± 0.023	2.744AspIle: 2.744 ± 0.045	2.249AspLys: 2.249 ± 0.041	5.186AspLeu: 5.186 ± 0.055	1.408AspMet: 1.408 ± 0.025	1.669AspAsn: 1.669 ± 0.035	3.054AspPro: 3.054 ± 0.043	1.936AspGln: 1.936 ± 0.035	2.814AspArg: 2.814 ± 0.042	2.898AspSer: 2.898 ± 0.034	2.899AspThr: 2.899 ± 0.039	3.887AspVal: 3.887 ± 0.05	0.884AspTrp: 0.884 ± 0.023	1.599AspTyr: 1.599 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.842GluAla: 5.842 ± 0.072	0.406GluCys: 0.406 ± 0.015	1.92GluAsp: 1.92 ± 0.033	2.382GluGlu: 2.382 ± 0.041	1.74GluPhe: 1.74 ± 0.029	3.223GluGly: 3.223 ± 0.045	1.305GluHis: 1.305 ± 0.025	2.473GluIle: 2.473 ± 0.041	2.033GluLys: 2.033 ± 0.036	5.528GluLeu: 5.528 ± 0.067	1.277GluMet: 1.277 ± 0.028	1.422GluAsn: 1.422 ± 0.027	2.12GluPro: 2.12 ± 0.041	2.723GluGln: 2.723 ± 0.04	4.458GluArg: 4.458 ± 0.059	2.407GluSer: 2.407 ± 0.033	2.486GluThr: 2.486 ± 0.038	3.448GluVal: 3.448 ± 0.046	0.666GluTrp: 0.666 ± 0.018	1.167GluTyr: 1.167 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.189PheAla: 4.189 ± 0.048	0.394PheCys: 0.394 ± 0.013	2.597PheAsp: 2.597 ± 0.038	1.843PheGlu: 1.843 ± 0.035	1.33PhePhe: 1.33 ± 0.028	3.355PheGly: 3.355 ± 0.043	0.77PheHis: 0.77 ± 0.02	1.609PheIle: 1.609 ± 0.035	1.334PheLys: 1.334 ± 0.027	2.962PheLeu: 2.962 ± 0.043	0.832PheMet: 0.832 ± 0.023	1.226PheAsn: 1.226 ± 0.027	1.48PhePro: 1.48 ± 0.03	1.078PheGln: 1.078 ± 0.024	1.878PheArg: 1.878 ± 0.033	2.445PheSer: 2.445 ± 0.038	2.028PheThr: 2.028 ± 0.032	2.452PheVal: 2.452 ± 0.035	0.473PheTrp: 0.473 ± 0.017	1.041PheTyr: 1.041 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.356GlyAla: 10.356 ± 0.077	0.836GlyCys: 0.836 ± 0.024	4.184GlyAsp: 4.184 ± 0.056	4.077GlyGlu: 4.077 ± 0.05	3.138GlyPhe: 3.138 ± 0.038	7.027GlyGly: 7.027 ± 0.095	1.858GlyHis: 1.858 ± 0.043	3.968GlyIle: 3.968 ± 0.051	3.988GlyLys: 3.988 ± 0.057	7.496GlyLeu: 7.496 ± 0.069	2.51GlyMet: 2.51 ± 0.038	2.983GlyAsn: 2.983 ± 0.173	2.866GlyPro: 2.866 ± 0.041	3.234GlyGln: 3.234 ± 0.04	4.919GlyArg: 4.919 ± 0.057	4.956GlySer: 4.956 ± 0.066	4.525GlyThr: 4.525 ± 0.066	6.027GlyVal: 6.027 ± 0.058	1.276GlyTrp: 1.276 ± 0.029	2.409GlyTyr: 2.409 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.954HisAla: 2.954 ± 0.042	0.269HisCys: 0.269 ± 0.012	1.276HisAsp: 1.276 ± 0.025	1.093HisGlu: 1.093 ± 0.023	0.934HisPhe: 0.934 ± 0.021	2.037HisGly: 2.037 ± 0.033	0.593HisHis: 0.593 ± 0.019	0.972HisIle: 0.972 ± 0.022	0.64HisLys: 0.64 ± 0.018	2.151HisLeu: 2.151 ± 0.032	0.524HisMet: 0.524 ± 0.016	0.594HisAsn: 0.594 ± 0.017	1.33HisPro: 1.33 ± 0.026	0.783HisGln: 0.783 ± 0.019	1.217HisArg: 1.217 ± 0.026	1.115HisSer: 1.115 ± 0.023	1.084HisThr: 1.084 ± 0.023	1.474HisVal: 1.474 ± 0.024	0.353HisTrp: 0.353 ± 0.013	0.693HisTyr: 0.693 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.425IleAla: 6.425 ± 0.068	0.436IleCys: 0.436 ± 0.015	3.694IleAsp: 3.694 ± 0.041	2.992IleGlu: 2.992 ± 0.047	1.319IlePhe: 1.319 ± 0.027	4.569IleGly: 4.569 ± 0.055	0.89IleHis: 0.89 ± 0.022	1.831IleIle: 1.831 ± 0.037	1.823IleLys: 1.823 ± 0.032	3.638IleLeu: 3.638 ± 0.048	0.903IleMet: 0.903 ± 0.023	1.667IleAsn: 1.667 ± 0.031	1.964IlePro: 1.964 ± 0.036	1.115IleGln: 1.115 ± 0.023	2.603IleArg: 2.603 ± 0.036	2.681IleSer: 2.681 ± 0.036	2.536IleThr: 2.536 ± 0.036	3.672IleVal: 3.672 ± 0.041	0.446IleTrp: 0.446 ± 0.015	1.051IleTyr: 1.051 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.183LysAla: 4.183 ± 0.058	0.223LysCys: 0.223 ± 0.01	1.865LysAsp: 1.865 ± 0.031	1.743LysGlu: 1.743 ± 0.034	1.132LysPhe: 1.132 ± 0.025	2.552LysGly: 2.552 ± 0.043	0.742LysHis: 0.742 ± 0.02	1.822LysIle: 1.822 ± 0.034	1.654LysLys: 1.654 ± 0.037	3.857LysLeu: 3.857 ± 0.049	1.069LysMet: 1.069 ± 0.024	1.326LysAsn: 1.326 ± 0.031	2.112LysPro: 2.112 ± 0.04	1.453LysGln: 1.453 ± 0.032	2.343LysArg: 2.343 ± 0.035	2.01LysSer: 2.01 ± 0.035	2.152LysThr: 2.152 ± 0.035	2.767LysVal: 2.767 ± 0.039	0.397LysTrp: 0.397 ± 0.015	0.831LysTyr: 0.831 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.572LeuAla: 14.572 ± 0.132	1.004LeuCys: 1.004 ± 0.021	6.058LeuAsp: 6.058 ± 0.054	4.795LeuGlu: 4.795 ± 0.064	3.392LeuPhe: 3.392 ± 0.05	7.754LeuGly: 7.754 ± 0.073	2.279LeuHis: 2.279 ± 0.035	4.422LeuIle: 4.422 ± 0.053	3.606LeuLys: 3.606 ± 0.047	10.358LeuLeu: 10.358 ± 0.127	2.458LeuMet: 2.458 ± 0.038	2.96LeuAsn: 2.96 ± 0.04	5.606LeuPro: 5.606 ± 0.067	3.513LeuGln: 3.513 ± 0.049	7.207LeuArg: 7.207 ± 0.083	6.196LeuSer: 6.196 ± 0.059	5.54LeuThr: 5.54 ± 0.05	6.97LeuVal: 6.97 ± 0.064	1.134LeuTrp: 1.134 ± 0.03	2.207LeuTyr: 2.207 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.099MetAla: 3.099 ± 0.04	0.179MetCys: 0.179 ± 0.009	1.184MetAsp: 1.184 ± 0.025	1.129MetGlu: 1.129 ± 0.022	0.832MetPhe: 0.832 ± 0.018	1.776MetGly: 1.776 ± 0.03	0.607MetHis: 0.607 ± 0.017	1.175MetIle: 1.175 ± 0.024	1.086MetLys: 1.086 ± 0.025	2.933MetLeu: 2.933 ± 0.043	0.706MetMet: 0.706 ± 0.02	1.011MetAsn: 1.011 ± 0.022	1.531MetPro: 1.531 ± 0.03	1.141MetGln: 1.141 ± 0.023	1.802MetArg: 1.802 ± 0.031	1.745MetSer: 1.745 ± 0.03	1.632MetThr: 1.632 ± 0.027	1.744MetVal: 1.744 ± 0.029	0.226MetTrp: 0.226 ± 0.01	0.498MetTyr: 0.498 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.719AsnAla: 3.719 ± 0.053	0.291AsnCys: 0.291 ± 0.012	1.685AsnAsp: 1.685 ± 0.034	1.344AsnGlu: 1.344 ± 0.022	1.077AsnPhe: 1.077 ± 0.023	2.974AsnGly: 2.974 ± 0.091	0.588AsnHis: 0.588 ± 0.015	1.492AsnIle: 1.492 ± 0.027	1.151AsnLys: 1.151 ± 0.025	2.994AsnLeu: 2.994 ± 0.044	0.743AsnMet: 0.743 ± 0.019	1.111AsnAsn: 1.111 ± 0.032	1.885AsnPro: 1.885 ± 0.033	1.069AsnGln: 1.069 ± 0.03	1.962AsnArg: 1.962 ± 0.102	1.587AsnSer: 1.587 ± 0.031	1.734AsnThr: 1.734 ± 0.039	2.313AsnVal: 2.313 ± 0.049	0.46AsnTrp: 0.46 ± 0.014	0.913AsnTyr: 0.913 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.483ProAla: 7.483 ± 0.087	0.39ProCys: 0.39 ± 0.013	3.255ProAsp: 3.255 ± 0.041	2.821ProGlu: 2.821 ± 0.043	1.704ProPhe: 1.704 ± 0.032	4.491ProGly: 4.491 ± 0.059	1.074ProHis: 1.074 ± 0.025	1.787ProIle: 1.787 ± 0.035	1.497ProLys: 1.497 ± 0.031	4.859ProLeu: 4.859 ± 0.061	1.271ProMet: 1.271 ± 0.025	1.326ProAsn: 1.326 ± 0.026	2.538ProPro: 2.538 ± 0.053	1.832ProGln: 1.832 ± 0.03	2.575ProArg: 2.575 ± 0.039	2.676ProSer: 2.676 ± 0.039	2.388ProThr: 2.388 ± 0.054	4.072ProVal: 4.072 ± 0.057	0.625ProTrp: 0.625 ± 0.017	1.121ProTyr: 1.121 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.204GlnAla: 5.204 ± 0.064	0.307GlnCys: 0.307 ± 0.011	1.623GlnAsp: 1.623 ± 0.027	1.609GlnGlu: 1.609 ± 0.028	1.473GlnPhe: 1.473 ± 0.03	2.757GlnGly: 2.757 ± 0.042	0.946GlnHis: 0.946 ± 0.022	1.763GlnIle: 1.763 ± 0.028	1.261GlnLys: 1.261 ± 0.026	4.185GlnLeu: 4.185 ± 0.05	1.029GlnMet: 1.029 ± 0.022	1.026GlnAsn: 1.026 ± 0.027	1.852GlnPro: 1.852 ± 0.032	1.893GlnGln: 1.893 ± 0.037	3.03GlnArg: 3.03 ± 0.039	1.989GlnSer: 1.989 ± 0.031	1.896GlnThr: 1.896 ± 0.04	2.874GlnVal: 2.874 ± 0.038	0.54GlnTrp: 0.54 ± 0.017	0.917GlnTyr: 0.917 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.947ArgAla: 7.947 ± 0.088	0.598ArgCys: 0.598 ± 0.019	3.489ArgAsp: 3.489 ± 0.041	3.482ArgGlu: 3.482 ± 0.051	2.731ArgPhe: 2.731 ± 0.037	4.187ArgGly: 4.187 ± 0.05	1.747ArgHis: 1.747 ± 0.035	3.67ArgIle: 3.67 ± 0.049	2.255ArgLys: 2.255 ± 0.029	7.104ArgLeu: 7.104 ± 0.072	1.933ArgMet: 1.933 ± 0.031	1.941ArgAsn: 1.941 ± 0.029	2.772ArgPro: 2.772 ± 0.039	2.879ArgGln: 2.879 ± 0.043	4.437ArgArg: 4.437 ± 0.058	3.359ArgSer: 3.359 ± 0.041	3.235ArgThr: 3.235 ± 0.055	4.442ArgVal: 4.442 ± 0.056	0.97ArgTrp: 0.97 ± 0.025	1.957ArgTyr: 1.957 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.487SerAla: 7.487 ± 0.072	0.52SerCys: 0.52 ± 0.016	3.049SerAsp: 3.049 ± 0.031	2.627SerGlu: 2.627 ± 0.036	2.189SerPhe: 2.189 ± 0.032	5.768SerGly: 5.768 ± 0.067	1.203SerHis: 1.203 ± 0.021	2.643SerIle: 2.643 ± 0.039	1.914SerLys: 1.914 ± 0.033	5.663SerLeu: 5.663 ± 0.064	1.569SerMet: 1.569 ± 0.03	1.776SerAsn: 1.776 ± 0.033	2.643SerPro: 2.643 ± 0.041	1.879SerGln: 1.879 ± 0.032	3.154SerArg: 3.154 ± 0.037	3.53SerSer: 3.53 ± 0.053	3.318SerThr: 3.318 ± 0.064	4.037SerVal: 4.037 ± 0.043	0.778SerTrp: 0.778 ± 0.02	1.695SerTyr: 1.695 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	5.91ThrAla: 5.91 ± 0.056	0.432ThrCys: 0.432 ± 0.015	2.841ThrAsp: 2.841 ± 0.107	2.285ThrGlu: 2.285 ± 0.036	1.819ThrPhe: 1.819 ± 0.03	4.638ThrGly: 4.638 ± 0.065	1.098ThrHis: 1.098 ± 0.023	2.725ThrIle: 2.725 ± 0.045	1.483ThrLys: 1.483 ± 0.032	6.048ThrLeu: 6.048 ± 0.064	1.369ThrMet: 1.369 ± 0.028	1.474ThrAsn: 1.474 ± 0.034	3.434ThrPro: 3.434 ± 0.058	1.8ThrGln: 1.8 ± 0.036	3.329ThrArg: 3.329 ± 0.051	3.125ThrSer: 3.125 ± 0.073	3.083ThrThr: 3.083 ± 0.103	4.46ThrVal: 4.46 ± 0.058	0.676ThrTrp: 0.676 ± 0.017	1.489ThrTyr: 1.489 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	8.916ValAla: 8.916 ± 0.084	0.674ValCys: 0.674 ± 0.016	4.065ValAsp: 4.065 ± 0.047	3.64ValGlu: 3.64 ± 0.043	2.597ValPhe: 2.597 ± 0.039	5.175ValGly: 5.175 ± 0.059	1.449ValHis: 1.449 ± 0.027	3.392ValIle: 3.392 ± 0.038	2.601ValLys: 2.601 ± 0.048	7.47ValLeu: 7.47 ± 0.078	1.748ValMet: 1.748 ± 0.035	2.331ValAsn: 2.331 ± 0.036	3.574ValPro: 3.574 ± 0.048	2.44ValGln: 2.44 ± 0.034	4.756ValArg: 4.756 ± 0.053	4.386ValSer: 4.386 ± 0.047	4.242ValThr: 4.242 ± 0.085	5.317ValVal: 5.317 ± 0.061	0.866ValTrp: 0.866 ± 0.021	1.727ValTyr: 1.727 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.115TrpAla: 1.115 ± 0.026	0.154TrpCys: 0.154 ± 0.009	0.644TrpAsp: 0.644 ± 0.02	0.558TrpGlu: 0.558 ± 0.017	0.521TrpPhe: 0.521 ± 0.019	0.806TrpGly: 0.806 ± 0.02	0.345TrpHis: 0.345 ± 0.014	0.678TrpIle: 0.678 ± 0.021	0.507TrpLys: 0.507 ± 0.017	1.635TrpLeu: 1.635 ± 0.038	0.406TrpMet: 0.406 ± 0.016	0.507TrpAsn: 0.507 ± 0.015	0.588TrpPro: 0.588 ± 0.019	0.676TrpGln: 0.676 ± 0.019	1.109TrpArg: 1.109 ± 0.022	0.825TrpSer: 0.825 ± 0.022	0.736TrpThr: 0.736 ± 0.019	0.832TrpVal: 0.832 ± 0.022	0.231TrpTrp: 0.231 ± 0.011	0.339TrpTyr: 0.339 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.929TyrAla: 2.929 ± 0.044	0.272TyrCys: 0.272 ± 0.012	1.891TyrAsp: 1.891 ± 0.208	1.226TyrGlu: 1.226 ± 0.022	1.067TyrPhe: 1.067 ± 0.023	2.07TyrGly: 2.07 ± 0.033	0.522TyrHis: 0.522 ± 0.015	0.962TyrIle: 0.962 ± 0.023	0.862TyrLys: 0.862 ± 0.022	2.602TyrLeu: 2.602 ± 0.038	0.505TyrMet: 0.505 ± 0.016	0.856TyrAsn: 0.856 ± 0.027	1.178TyrPro: 1.178 ± 0.028	1.062TyrGln: 1.062 ± 0.023	1.865TyrArg: 1.865 ± 0.032	1.487TyrSer: 1.487 ± 0.029	1.414TyrThr: 1.414 ± 0.038	1.711TyrVal: 1.711 ± 0.03	0.356TyrTrp: 0.356 ± 0.013	0.714TyrTyr: 0.714 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7002 proteins (2239087 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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