Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA385D11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.197AlaAla: 4.197 ± 0.333
0.96AlaCys: 0.96 ± 0.128
3.457AlaAsp: 3.457 ± 0.245
5.857AlaGlu: 5.857 ± 0.309
2.469AlaPhe: 2.469 ± 0.211
5.13AlaGly: 5.13 ± 0.308
1.097AlaHis: 1.097 ± 0.117
4.238AlaIle: 4.238 ± 0.293
4.595AlaLys: 4.595 ± 0.283
5.953AlaLeu: 5.953 ± 0.388
1.591AlaMet: 1.591 ± 0.161
1.865AlaAsn: 1.865 ± 0.157
2.057AlaPro: 2.057 ± 0.207
1.481AlaGln: 1.481 ± 0.124
4.101AlaArg: 4.101 ± 0.301
4.074AlaSer: 4.074 ± 0.252
3.059AlaThr: 3.059 ± 0.194
4.965AlaVal: 4.965 ± 0.282
0.562AlaTrp: 0.562 ± 0.092
1.632AlaTyr: 1.632 ± 0.148
0.0AlaXaa: 0.0 ± 0.0
Cys
0.658CysAla: 0.658 ± 0.09
0.247CysCys: 0.247 ± 0.086
0.713CysAsp: 0.713 ± 0.127
1.015CysGlu: 1.015 ± 0.147
0.535CysPhe: 0.535 ± 0.091
1.152CysGly: 1.152 ± 0.15
0.219CysHis: 0.219 ± 0.056
0.576CysIle: 0.576 ± 0.099
0.686CysLys: 0.686 ± 0.119
0.919CysLeu: 0.919 ± 0.105
0.247CysMet: 0.247 ± 0.061
0.453CysAsn: 0.453 ± 0.097
0.823CysPro: 0.823 ± 0.144
0.302CysGln: 0.302 ± 0.064
0.713CysArg: 0.713 ± 0.094
0.796CysSer: 0.796 ± 0.119
0.549CysThr: 0.549 ± 0.085
0.48CysVal: 0.48 ± 0.1
0.151CysTrp: 0.151 ± 0.047
0.439CysTyr: 0.439 ± 0.092
0.0CysXaa: 0.0 ± 0.0
Asp
3.237AspAla: 3.237 ± 0.239
0.768AspCys: 0.768 ± 0.125
2.359AspAsp: 2.359 ± 0.222
5.226AspGlu: 5.226 ± 0.286
2.496AspPhe: 2.496 ± 0.191
4.074AspGly: 4.074 ± 0.288
0.988AspHis: 0.988 ± 0.126
4.17AspIle: 4.17 ± 0.214
3.347AspLys: 3.347 ± 0.215
6.762AspLeu: 6.762 ± 0.32
1.138AspMet: 1.138 ± 0.144
2.057AspAsn: 2.057 ± 0.287
2.949AspPro: 2.949 ± 0.232
1.468AspGln: 1.468 ± 0.16
3.155AspArg: 3.155 ± 0.215
3.566AspSer: 3.566 ± 0.257
2.702AspThr: 2.702 ± 0.355
4.142AspVal: 4.142 ± 0.282
0.631AspTrp: 0.631 ± 0.103
2.03AspTyr: 2.03 ± 0.173
0.0AspXaa: 0.0 ± 0.0
Glu
5.884GluAla: 5.884 ± 0.309
0.946GluCys: 0.946 ± 0.131
5.061GluAsp: 5.061 ± 0.293
10.987GluGlu: 10.987 ± 0.535
3.649GluPhe: 3.649 ± 0.248
6.844GluGly: 6.844 ± 0.333
1.33GluHis: 1.33 ± 0.134
7.709GluIle: 7.709 ± 0.393
9.409GluLys: 9.409 ± 0.539
8.669GluLeu: 8.669 ± 0.456
2.51GluMet: 2.51 ± 0.201
4.334GluAsn: 4.334 ± 0.328
2.606GluPro: 2.606 ± 0.195
1.536GluGln: 1.536 ± 0.153
6.213GluArg: 6.213 ± 0.384
4.814GluSer: 4.814 ± 0.271
3.745GluThr: 3.745 ± 0.247
6.488GluVal: 6.488 ± 0.333
0.892GluTrp: 0.892 ± 0.121
2.428GluTyr: 2.428 ± 0.191
0.0GluXaa: 0.0 ± 0.0
Phe
2.126PheAla: 2.126 ± 0.161
0.672PheCys: 0.672 ± 0.071
3.004PheAsp: 3.004 ± 0.197
3.141PheGlu: 3.141 ± 0.242
1.523PhePhe: 1.523 ± 0.181
2.62PheGly: 2.62 ± 0.214
0.535PheHis: 0.535 ± 0.077
2.153PheIle: 2.153 ± 0.194
2.538PheLys: 2.538 ± 0.189
4.005PheLeu: 4.005 ± 0.353
0.892PheMet: 0.892 ± 0.11
1.18PheAsn: 1.18 ± 0.183
1.495PhePro: 1.495 ± 0.14
1.056PheGln: 1.056 ± 0.134
2.085PheArg: 2.085 ± 0.187
2.839PheSer: 2.839 ± 0.213
1.715PheThr: 1.715 ± 0.182
2.579PheVal: 2.579 ± 0.193
0.549PheTrp: 0.549 ± 0.082
1.18PheTyr: 1.18 ± 0.124
0.0PheXaa: 0.0 ± 0.0
Gly
4.828GlyAla: 4.828 ± 0.338
1.07GlyCys: 1.07 ± 0.132
4.115GlyAsp: 4.115 ± 0.254
6.748GlyGlu: 6.748 ± 0.355
2.908GlyPhe: 2.908 ± 0.208
6.337GlyGly: 6.337 ± 0.372
1.344GlyHis: 1.344 ± 0.147
5.596GlyIle: 5.596 ± 0.324
6.296GlyLys: 6.296 ± 0.324
6.255GlyLeu: 6.255 ± 0.307
1.564GlyMet: 1.564 ± 0.18
2.688GlyAsn: 2.688 ± 0.257
2.044GlyPro: 2.044 ± 0.191
1.372GlyGln: 1.372 ± 0.159
4.334GlyArg: 4.334 ± 0.29
4.828GlySer: 4.828 ± 0.276
4.43GlyThr: 4.43 ± 0.378
5.294GlyVal: 5.294 ± 0.285
1.138GlyTrp: 1.138 ± 0.133
2.332GlyTyr: 2.332 ± 0.215
0.0GlyXaa: 0.0 ± 0.0
His
0.823HisAla: 0.823 ± 0.108
0.165HisCys: 0.165 ± 0.046
0.823HisAsp: 0.823 ± 0.113
1.385HisGlu: 1.385 ± 0.15
0.658HisPhe: 0.658 ± 0.093
1.33HisGly: 1.33 ± 0.146
0.411HisHis: 0.411 ± 0.087
1.221HisIle: 1.221 ± 0.144
1.015HisLys: 1.015 ± 0.148
1.742HisLeu: 1.742 ± 0.15
0.425HisMet: 0.425 ± 0.072
0.398HisAsn: 0.398 ± 0.063
1.193HisPro: 1.193 ± 0.114
0.508HisGln: 0.508 ± 0.086
0.892HisArg: 0.892 ± 0.117
0.878HisSer: 0.878 ± 0.11
0.796HisThr: 0.796 ± 0.089
1.234HisVal: 1.234 ± 0.127
0.165HisTrp: 0.165 ± 0.046
0.521HisTyr: 0.521 ± 0.082
0.0HisXaa: 0.0 ± 0.0
Ile
4.636IleAla: 4.636 ± 0.266
0.754IleCys: 0.754 ± 0.103
4.609IleAsp: 4.609 ± 0.238
6.543IleGlu: 6.543 ± 0.356
2.716IlePhe: 2.716 ± 0.241
5.377IleGly: 5.377 ± 0.327
1.029IleHis: 1.029 ± 0.126
4.087IleIle: 4.087 ± 0.311
4.801IleLys: 4.801 ± 0.267
5.953IleLeu: 5.953 ± 0.344
1.193IleMet: 1.193 ± 0.124
2.167IleAsn: 2.167 ± 0.189
3.127IlePro: 3.127 ± 0.22
1.715IleGln: 1.715 ± 0.141
3.923IleArg: 3.923 ± 0.239
5.048IleSer: 5.048 ± 0.303
3.402IleThr: 3.402 ± 0.296
4.842IleVal: 4.842 ± 0.244
0.508IleTrp: 0.508 ± 0.111
1.92IleTyr: 1.92 ± 0.169
0.0IleXaa: 0.0 ± 0.0
Lys
5.363LysAla: 5.363 ± 0.321
0.768LysCys: 0.768 ± 0.115
3.895LysAsp: 3.895 ± 0.257
8.34LysGlu: 8.34 ± 0.519
2.826LysPhe: 2.826 ± 0.18
5.308LysGly: 5.308 ± 0.291
1.344LysHis: 1.344 ± 0.131
6.337LysIle: 6.337 ± 0.327
7.709LysLys: 7.709 ± 0.448
6.886LysLeu: 6.886 ± 0.38
1.865LysMet: 1.865 ± 0.154
3.553LysAsn: 3.553 ± 0.23
2.551LysPro: 2.551 ± 0.206
1.468LysGln: 1.468 ± 0.196
4.842LysArg: 4.842 ± 0.368
4.129LysSer: 4.129 ± 0.25
3.141LysThr: 3.141 ± 0.236
5.13LysVal: 5.13 ± 0.286
0.864LysTrp: 0.864 ± 0.091
2.373LysTyr: 2.373 ± 0.191
0.0LysXaa: 0.0 ± 0.0
Leu
6.337LeuAla: 6.337 ± 0.403
0.7LeuCys: 0.7 ± 0.111
6.008LeuAsp: 6.008 ± 0.248
9.025LeuGlu: 9.025 ± 0.533
2.894LeuPhe: 2.894 ± 0.25
6.817LeuGly: 6.817 ± 0.343
1.372LeuHis: 1.372 ± 0.148
5.514LeuIle: 5.514 ± 0.317
7.846LeuLys: 7.846 ± 0.42
7.462LeuLeu: 7.462 ± 0.45
1.783LeuMet: 1.783 ± 0.161
3.717LeuAsn: 3.717 ± 0.208
3.786LeuPro: 3.786 ± 0.216
2.099LeuGln: 2.099 ± 0.2
5.198LeuArg: 5.198 ± 0.333
6.323LeuSer: 6.323 ± 0.276
4.362LeuThr: 4.362 ± 0.306
5.569LeuVal: 5.569 ± 0.3
0.946LeuTrp: 0.946 ± 0.1
2.057LeuTyr: 2.057 ± 0.168
0.0LeuXaa: 0.0 ± 0.0
Met
1.811MetAla: 1.811 ± 0.19
0.192MetCys: 0.192 ± 0.064
1.481MetAsp: 1.481 ± 0.147
1.948MetGlu: 1.948 ± 0.171
0.686MetPhe: 0.686 ± 0.106
1.632MetGly: 1.632 ± 0.177
0.219MetHis: 0.219 ± 0.049
1.55MetIle: 1.55 ± 0.136
1.838MetLys: 1.838 ± 0.181
1.564MetLeu: 1.564 ± 0.173
0.535MetMet: 0.535 ± 0.086
1.084MetAsn: 1.084 ± 0.126
0.905MetPro: 0.905 ± 0.121
0.274MetGln: 0.274 ± 0.071
1.426MetArg: 1.426 ± 0.128
1.577MetSer: 1.577 ± 0.142
1.001MetThr: 1.001 ± 0.11
1.646MetVal: 1.646 ± 0.143
0.247MetTrp: 0.247 ± 0.058
0.233MetTyr: 0.233 ± 0.059
0.0MetXaa: 0.0 ± 0.0
Asn
2.167AsnAla: 2.167 ± 0.199
0.7AsnCys: 0.7 ± 0.105
1.756AsnAsp: 1.756 ± 0.18
2.922AsnGlu: 2.922 ± 0.221
1.783AsnPhe: 1.783 ± 0.18
2.647AsnGly: 2.647 ± 0.24
0.796AsnHis: 0.796 ± 0.117
2.62AsnIle: 2.62 ± 0.255
2.387AsnLys: 2.387 ± 0.214
4.033AsnLeu: 4.033 ± 0.249
0.809AsnMet: 0.809 ± 0.117
1.207AsnAsn: 1.207 ± 0.146
2.14AsnPro: 2.14 ± 0.168
0.905AsnGln: 0.905 ± 0.107
2.167AsnArg: 2.167 ± 0.188
2.099AsnSer: 2.099 ± 0.178
1.605AsnThr: 1.605 ± 0.269
3.031AsnVal: 3.031 ± 0.299
0.617AsnTrp: 0.617 ± 0.106
1.577AsnTyr: 1.577 ± 0.247
0.0AsnXaa: 0.0 ± 0.0
Pro
2.51ProAla: 2.51 ± 0.191
0.315ProCys: 0.315 ± 0.082
2.51ProAsp: 2.51 ± 0.169
4.554ProGlu: 4.554 ± 0.277
1.564ProPhe: 1.564 ± 0.151
2.675ProGly: 2.675 ± 0.211
0.809ProHis: 0.809 ± 0.112
2.592ProIle: 2.592 ± 0.204
2.661ProLys: 2.661 ± 0.182
3.511ProLeu: 3.511 ± 0.264
0.796ProMet: 0.796 ± 0.123
1.413ProAsn: 1.413 ± 0.129
1.783ProPro: 1.783 ± 0.155
1.166ProGln: 1.166 ± 0.155
1.989ProArg: 1.989 ± 0.168
2.976ProSer: 2.976 ± 0.231
1.934ProThr: 1.934 ± 0.221
2.579ProVal: 2.579 ± 0.172
0.453ProTrp: 0.453 ± 0.078
1.495ProTyr: 1.495 ± 0.136
0.0ProXaa: 0.0 ± 0.0
Gln
1.523GlnAla: 1.523 ± 0.142
0.206GlnCys: 0.206 ± 0.079
1.193GlnAsp: 1.193 ± 0.129
2.195GlnGlu: 2.195 ± 0.214
0.7GlnPhe: 0.7 ± 0.124
1.523GlnGly: 1.523 ± 0.158
0.398GlnHis: 0.398 ± 0.086
1.756GlnIle: 1.756 ± 0.162
1.948GlnLys: 1.948 ± 0.161
2.03GlnLeu: 2.03 ± 0.19
0.439GlnMet: 0.439 ± 0.088
0.946GlnAsn: 0.946 ± 0.128
0.754GlnPro: 0.754 ± 0.101
0.562GlnGln: 0.562 ± 0.077
1.481GlnArg: 1.481 ± 0.144
1.166GlnSer: 1.166 ± 0.111
1.221GlnThr: 1.221 ± 0.174
1.687GlnVal: 1.687 ± 0.136
0.247GlnTrp: 0.247 ± 0.082
0.686GlnTyr: 0.686 ± 0.099
0.0GlnXaa: 0.0 ± 0.0
Arg
3.717ArgAla: 3.717 ± 0.239
0.631ArgCys: 0.631 ± 0.099
3.155ArgAsp: 3.155 ± 0.191
6.063ArgGlu: 6.063 ± 0.365
2.208ArgPhe: 2.208 ± 0.176
4.183ArgGly: 4.183 ± 0.289
0.713ArgHis: 0.713 ± 0.102
4.54ArgIle: 4.54 ± 0.275
5.391ArgLys: 5.391 ± 0.39
4.595ArgLeu: 4.595 ± 0.331
1.495ArgMet: 1.495 ± 0.139
2.236ArgAsn: 2.236 ± 0.191
2.167ArgPro: 2.167 ± 0.172
1.262ArgGln: 1.262 ± 0.13
4.403ArgArg: 4.403 ± 0.323
3.429ArgSer: 3.429 ± 0.25
2.634ArgThr: 2.634 ± 0.201
4.43ArgVal: 4.43 ± 0.301
0.604ArgTrp: 0.604 ± 0.098
1.495ArgTyr: 1.495 ± 0.135
0.0ArgXaa: 0.0 ± 0.0
Ser
3.635SerAla: 3.635 ± 0.237
0.576SerCys: 0.576 ± 0.082
3.978SerAsp: 3.978 ± 0.248
6.268SerGlu: 6.268 ± 0.288
2.675SerPhe: 2.675 ± 0.163
5.157SerGly: 5.157 ± 0.279
1.111SerHis: 1.111 ± 0.129
4.472SerIle: 4.472 ± 0.264
4.664SerLys: 4.664 ± 0.246
5.336SerLeu: 5.336 ± 0.265
1.344SerMet: 1.344 ± 0.122
2.524SerAsn: 2.524 ± 0.222
2.565SerPro: 2.565 ± 0.165
1.66SerGln: 1.66 ± 0.158
3.388SerArg: 3.388 ± 0.255
4.375SerSer: 4.375 ± 0.378
3.402SerThr: 3.402 ± 0.3
4.334SerVal: 4.334 ± 0.244
0.823SerTrp: 0.823 ± 0.13
2.071SerTyr: 2.071 ± 0.197
0.0SerXaa: 0.0 ± 0.0
Thr
2.867ThrAla: 2.867 ± 0.229
0.576ThrCys: 0.576 ± 0.117
2.51ThrAsp: 2.51 ± 0.27
3.621ThrGlu: 3.621 ± 0.213
1.605ThrPhe: 1.605 ± 0.192
4.526ThrGly: 4.526 ± 0.321
0.782ThrHis: 0.782 ± 0.118
3.059ThrIle: 3.059 ± 0.237
2.976ThrLys: 2.976 ± 0.209
4.06ThrLeu: 4.06 ± 0.205
1.166ThrMet: 1.166 ± 0.124
1.619ThrAsn: 1.619 ± 0.209
2.661ThrPro: 2.661 ± 0.209
1.152ThrGln: 1.152 ± 0.144
2.634ThrArg: 2.634 ± 0.186
3.429ThrSer: 3.429 ± 0.449
2.579ThrThr: 2.579 ± 0.322
3.703ThrVal: 3.703 ± 0.39
0.686ThrTrp: 0.686 ± 0.159
1.646ThrTyr: 1.646 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
4.993ValAla: 4.993 ± 0.289
0.796ValCys: 0.796 ± 0.114
4.307ValAsp: 4.307 ± 0.308
6.995ValGlu: 6.995 ± 0.339
2.277ValPhe: 2.277 ± 0.189
4.965ValGly: 4.965 ± 0.272
1.289ValHis: 1.289 ± 0.118
3.895ValIle: 3.895 ± 0.225
5.322ValLys: 5.322 ± 0.296
6.351ValLeu: 6.351 ± 0.307
1.399ValMet: 1.399 ± 0.142
2.839ValAsn: 2.839 ± 0.226
2.88ValPro: 2.88 ± 0.254
1.756ValGln: 1.756 ± 0.14
3.868ValArg: 3.868 ± 0.224
4.622ValSer: 4.622 ± 0.296
3.484ValThr: 3.484 ± 0.371
5.24ValVal: 5.24 ± 0.334
0.658ValTrp: 0.658 ± 0.106
1.907ValTyr: 1.907 ± 0.183
0.0ValXaa: 0.0 ± 0.0
Trp
0.672TrpAla: 0.672 ± 0.108
0.082TrpCys: 0.082 ± 0.033
0.631TrpAsp: 0.631 ± 0.122
0.796TrpGlu: 0.796 ± 0.107
0.411TrpPhe: 0.411 ± 0.087
0.713TrpGly: 0.713 ± 0.102
0.192TrpHis: 0.192 ± 0.047
0.837TrpIle: 0.837 ± 0.101
1.056TrpLys: 1.056 ± 0.126
0.85TrpLeu: 0.85 ± 0.095
0.343TrpMet: 0.343 ± 0.066
0.562TrpAsn: 0.562 ± 0.115
0.48TrpPro: 0.48 ± 0.077
0.261TrpGln: 0.261 ± 0.065
0.741TrpArg: 0.741 ± 0.099
0.919TrpSer: 0.919 ± 0.142
0.576TrpThr: 0.576 ± 0.099
0.562TrpVal: 0.562 ± 0.09
0.165TrpTrp: 0.165 ± 0.049
0.357TrpTyr: 0.357 ± 0.087
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.358TyrAla: 1.358 ± 0.146
0.549TyrCys: 0.549 ± 0.097
1.701TyrAsp: 1.701 ± 0.179
2.428TyrGlu: 2.428 ± 0.17
1.303TyrPhe: 1.303 ± 0.114
2.51TyrGly: 2.51 ± 0.15
0.604TyrHis: 0.604 ± 0.1
1.426TyrIle: 1.426 ± 0.137
2.208TyrLys: 2.208 ± 0.229
2.88TyrLeu: 2.88 ± 0.245
0.302TyrMet: 0.302 ± 0.056
1.125TyrAsn: 1.125 ± 0.234
1.317TyrPro: 1.317 ± 0.136
0.658TyrGln: 0.658 ± 0.106
1.797TyrArg: 1.797 ± 0.173
2.469TyrSer: 2.469 ± 0.245
1.523TyrThr: 1.523 ± 0.208
1.907TyrVal: 1.907 ± 0.16
0.302TyrTrp: 0.302 ± 0.065
1.084TyrTyr: 1.084 ± 0.143
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 299 proteins (72907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski