Amino acid dipepetide frequency for Tenacibaculum phage JQ

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.067AlaAla: 2.067 ± 0.584
0.27AlaCys: 0.27 ± 0.163
1.977AlaAsp: 1.977 ± 0.468
2.876AlaGlu: 2.876 ± 0.404
1.438AlaPhe: 1.438 ± 0.326
2.876AlaGly: 2.876 ± 0.65
0.629AlaHis: 0.629 ± 0.313
3.595AlaIle: 3.595 ± 0.468
4.763AlaLys: 4.763 ± 0.919
4.583AlaLeu: 4.583 ± 0.655
1.078AlaMet: 1.078 ± 0.356
3.595AlaAsn: 3.595 ± 0.601
0.899AlaPro: 0.899 ± 0.248
1.078AlaGln: 1.078 ± 0.444
1.528AlaArg: 1.528 ± 0.361
3.055AlaSer: 3.055 ± 0.575
3.325AlaThr: 3.325 ± 0.536
2.786AlaVal: 2.786 ± 0.514
0.809AlaTrp: 0.809 ± 0.226
1.797AlaTyr: 1.797 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
0.27CysAla: 0.27 ± 0.146
0.629CysCys: 0.629 ± 0.356
0.899CysAsp: 0.899 ± 0.352
0.899CysGlu: 0.899 ± 0.325
0.629CysPhe: 0.629 ± 0.262
0.809CysGly: 0.809 ± 0.287
0.27CysHis: 0.27 ± 0.173
0.988CysIle: 0.988 ± 0.298
2.876CysLys: 2.876 ± 0.684
0.719CysLeu: 0.719 ± 0.212
0.27CysMet: 0.27 ± 0.155
1.078CysAsn: 1.078 ± 0.325
0.27CysPro: 0.27 ± 0.165
0.09CysGln: 0.09 ± 0.081
0.719CysArg: 0.719 ± 0.266
0.988CysSer: 0.988 ± 0.345
0.359CysThr: 0.359 ± 0.237
0.18CysVal: 0.18 ± 0.108
0.09CysTrp: 0.09 ± 0.082
0.359CysTyr: 0.359 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
3.595AspAla: 3.595 ± 0.636
1.168AspCys: 1.168 ± 0.339
2.606AspAsp: 2.606 ± 0.484
4.763AspGlu: 4.763 ± 0.89
3.505AspPhe: 3.505 ± 0.622
2.876AspGly: 2.876 ± 0.491
0.449AspHis: 0.449 ± 0.215
4.763AspIle: 4.763 ± 0.647
5.032AspLys: 5.032 ± 0.731
7.189AspLeu: 7.189 ± 0.768
1.078AspMet: 1.078 ± 0.322
4.673AspAsn: 4.673 ± 0.649
0.809AspPro: 0.809 ± 0.259
0.629AspGln: 0.629 ± 0.278
1.977AspArg: 1.977 ± 0.472
3.595AspSer: 3.595 ± 0.686
2.606AspThr: 2.606 ± 0.508
4.942AspVal: 4.942 ± 0.816
0.988AspTrp: 0.988 ± 0.304
3.684AspTyr: 3.684 ± 0.528
0.0AspXaa: 0.0 ± 0.0
Glu
3.415GluAla: 3.415 ± 0.725
0.449GluCys: 0.449 ± 0.178
5.931GluAsp: 5.931 ± 0.859
4.853GluGlu: 4.853 ± 0.739
4.224GluPhe: 4.224 ± 0.799
2.516GluGly: 2.516 ± 0.395
1.168GluHis: 1.168 ± 0.343
7.189GluIle: 7.189 ± 0.959
6.29GluLys: 6.29 ± 0.907
9.166GluLeu: 9.166 ± 0.968
1.528GluMet: 1.528 ± 0.378
5.122GluAsn: 5.122 ± 0.677
1.977GluPro: 1.977 ± 0.398
2.336GluGln: 2.336 ± 0.428
3.595GluArg: 3.595 ± 0.695
3.595GluSer: 3.595 ± 0.547
3.864GluThr: 3.864 ± 0.466
4.403GluVal: 4.403 ± 0.673
1.348GluTrp: 1.348 ± 0.374
3.774GluTyr: 3.774 ± 0.554
0.0GluXaa: 0.0 ± 0.0
Phe
1.887PheAla: 1.887 ± 0.349
0.988PheCys: 0.988 ± 0.306
3.325PheAsp: 3.325 ± 0.669
4.224PheGlu: 4.224 ± 0.535
1.887PhePhe: 1.887 ± 0.508
2.067PheGly: 2.067 ± 0.481
0.449PheHis: 0.449 ± 0.2
3.415PheIle: 3.415 ± 0.656
4.493PheLys: 4.493 ± 0.557
2.336PheLeu: 2.336 ± 0.476
1.258PheMet: 1.258 ± 0.313
3.235PheAsn: 3.235 ± 0.596
0.899PhePro: 0.899 ± 0.283
0.899PheGln: 0.899 ± 0.314
2.606PheArg: 2.606 ± 0.542
2.786PheSer: 2.786 ± 0.55
1.528PheThr: 1.528 ± 0.364
2.336PheVal: 2.336 ± 0.408
0.719PheTrp: 0.719 ± 0.311
2.876PheTyr: 2.876 ± 0.461
0.0PheXaa: 0.0 ± 0.0
Gly
3.055GlyAla: 3.055 ± 0.542
0.539GlyCys: 0.539 ± 0.179
2.876GlyAsp: 2.876 ± 0.526
2.426GlyGlu: 2.426 ± 0.563
3.774GlyPhe: 3.774 ± 0.472
3.145GlyGly: 3.145 ± 0.676
0.09GlyHis: 0.09 ± 0.075
4.673GlyIle: 4.673 ± 0.774
4.044GlyLys: 4.044 ± 0.644
4.942GlyLeu: 4.942 ± 0.529
0.988GlyMet: 0.988 ± 0.346
3.684GlyAsn: 3.684 ± 0.666
0.0GlyPro: 0.0 ± 0.0
1.977GlyGln: 1.977 ± 0.458
1.438GlyArg: 1.438 ± 0.369
2.876GlySer: 2.876 ± 0.557
2.965GlyThr: 2.965 ± 0.57
3.684GlyVal: 3.684 ± 0.629
0.449GlyTrp: 0.449 ± 0.197
2.336GlyTyr: 2.336 ± 0.48
0.0GlyXaa: 0.0 ± 0.0
His
0.27HisAla: 0.27 ± 0.149
0.18HisCys: 0.18 ± 0.11
0.449HisAsp: 0.449 ± 0.187
1.348HisGlu: 1.348 ± 0.347
0.809HisPhe: 0.809 ± 0.26
0.539HisGly: 0.539 ± 0.258
0.359HisHis: 0.359 ± 0.21
0.629HisIle: 0.629 ± 0.338
1.528HisLys: 1.528 ± 0.351
1.078HisLeu: 1.078 ± 0.281
0.359HisMet: 0.359 ± 0.176
0.629HisAsn: 0.629 ± 0.222
0.629HisPro: 0.629 ± 0.214
0.809HisGln: 0.809 ± 0.242
0.809HisArg: 0.809 ± 0.295
0.719HisSer: 0.719 ± 0.368
0.809HisThr: 0.809 ± 0.306
1.168HisVal: 1.168 ± 0.444
0.18HisTrp: 0.18 ± 0.128
1.348HisTyr: 1.348 ± 0.322
0.0HisXaa: 0.0 ± 0.0
Ile
2.696IleAla: 2.696 ± 0.701
0.719IleCys: 0.719 ± 0.316
5.661IleAsp: 5.661 ± 0.59
6.83IleGlu: 6.83 ± 0.737
2.876IlePhe: 2.876 ± 0.492
3.954IleGly: 3.954 ± 0.538
0.629IleHis: 0.629 ± 0.248
5.122IleIle: 5.122 ± 0.763
8.627IleLys: 8.627 ± 1.282
5.032IleLeu: 5.032 ± 0.809
1.707IleMet: 1.707 ± 0.38
8.986IleAsn: 8.986 ± 0.861
2.247IlePro: 2.247 ± 0.405
2.696IleGln: 2.696 ± 0.444
2.336IleArg: 2.336 ± 0.476
5.302IleSer: 5.302 ± 0.776
5.302IleThr: 5.302 ± 0.854
4.134IleVal: 4.134 ± 0.586
0.719IleTrp: 0.719 ± 0.239
3.415IleTyr: 3.415 ± 0.591
0.0IleXaa: 0.0 ± 0.0
Lys
5.032LysAla: 5.032 ± 0.592
2.336LysCys: 2.336 ± 0.508
7.279LysAsp: 7.279 ± 0.977
11.592LysGlu: 11.592 ± 1.667
2.965LysPhe: 2.965 ± 0.576
5.572LysGly: 5.572 ± 0.622
2.696LysHis: 2.696 ± 0.569
7.279LysIle: 7.279 ± 0.986
8.986LysLys: 8.986 ± 1.201
9.615LysLeu: 9.615 ± 1.22
2.067LysMet: 2.067 ± 0.45
5.032LysAsn: 5.032 ± 0.671
2.426LysPro: 2.426 ± 0.524
4.763LysGln: 4.763 ± 0.658
4.493LysArg: 4.493 ± 0.748
4.583LysSer: 4.583 ± 0.8
4.493LysThr: 4.493 ± 0.55
4.763LysVal: 4.763 ± 0.79
1.168LysTrp: 1.168 ± 0.33
4.403LysTyr: 4.403 ± 0.9
0.0LysXaa: 0.0 ± 0.0
Leu
3.954LeuAla: 3.954 ± 0.621
1.078LeuCys: 1.078 ± 0.312
6.111LeuAsp: 6.111 ± 0.954
5.751LeuGlu: 5.751 ± 0.683
3.595LeuPhe: 3.595 ± 0.654
3.595LeuGly: 3.595 ± 0.567
1.887LeuHis: 1.887 ± 0.581
7.099LeuIle: 7.099 ± 0.731
10.155LeuLys: 10.155 ± 1.047
6.29LeuLeu: 6.29 ± 0.939
1.887LeuMet: 1.887 ± 0.339
6.56LeuAsn: 6.56 ± 0.769
2.426LeuPro: 2.426 ± 0.444
3.235LeuGln: 3.235 ± 0.553
2.516LeuArg: 2.516 ± 0.437
4.044LeuSer: 4.044 ± 0.541
6.29LeuThr: 6.29 ± 0.758
5.032LeuVal: 5.032 ± 0.77
0.988LeuTrp: 0.988 ± 0.286
2.876LeuTyr: 2.876 ± 0.381
0.0LeuXaa: 0.0 ± 0.0
Met
1.528MetAla: 1.528 ± 0.3
0.18MetCys: 0.18 ± 0.118
1.348MetAsp: 1.348 ± 0.357
1.348MetGlu: 1.348 ± 0.241
0.449MetPhe: 0.449 ± 0.178
1.078MetGly: 1.078 ± 0.273
0.27MetHis: 0.27 ± 0.158
0.899MetIle: 0.899 ± 0.281
2.786MetLys: 2.786 ± 0.56
2.067MetLeu: 2.067 ± 0.437
0.539MetMet: 0.539 ± 0.232
1.168MetAsn: 1.168 ± 0.328
0.899MetPro: 0.899 ± 0.26
1.438MetGln: 1.438 ± 0.378
0.899MetArg: 0.899 ± 0.263
1.258MetSer: 1.258 ± 0.289
0.809MetThr: 0.809 ± 0.272
0.988MetVal: 0.988 ± 0.281
0.18MetTrp: 0.18 ± 0.139
1.168MetTyr: 1.168 ± 0.303
0.0MetXaa: 0.0 ± 0.0
Asn
3.145AsnAla: 3.145 ± 0.43
0.539AsnCys: 0.539 ± 0.212
3.864AsnAsp: 3.864 ± 0.536
6.56AsnGlu: 6.56 ± 0.729
2.516AsnPhe: 2.516 ± 0.464
4.493AsnGly: 4.493 ± 0.679
1.528AsnHis: 1.528 ± 0.37
6.111AsnIle: 6.111 ± 0.84
7.459AsnLys: 7.459 ± 0.93
5.392AsnLeu: 5.392 ± 0.601
1.977AsnMet: 1.977 ± 0.435
6.56AsnAsn: 6.56 ± 0.688
1.977AsnPro: 1.977 ± 0.427
2.516AsnGln: 2.516 ± 0.465
2.696AsnArg: 2.696 ± 0.475
5.572AsnSer: 5.572 ± 0.939
4.583AsnThr: 4.583 ± 0.57
4.763AsnVal: 4.763 ± 0.591
0.719AsnTrp: 0.719 ± 0.219
4.853AsnTyr: 4.853 ± 0.746
0.0AsnXaa: 0.0 ± 0.0
Pro
0.988ProAla: 0.988 ± 0.314
0.449ProCys: 0.449 ± 0.258
1.618ProAsp: 1.618 ± 0.441
1.348ProGlu: 1.348 ± 0.405
1.528ProPhe: 1.528 ± 0.394
0.27ProGly: 0.27 ± 0.203
0.09ProHis: 0.09 ± 0.104
2.336ProIle: 2.336 ± 0.473
2.336ProLys: 2.336 ± 0.547
2.067ProLeu: 2.067 ± 0.385
0.719ProMet: 0.719 ± 0.242
2.247ProAsn: 2.247 ± 0.577
0.539ProPro: 0.539 ± 0.197
0.809ProGln: 0.809 ± 0.295
0.809ProArg: 0.809 ± 0.289
1.348ProSer: 1.348 ± 0.281
1.348ProThr: 1.348 ± 0.375
1.168ProVal: 1.168 ± 0.363
0.0ProTrp: 0.0 ± 0.0
1.078ProTyr: 1.078 ± 0.288
0.0ProXaa: 0.0 ± 0.0
Gln
1.528GlnAla: 1.528 ± 0.412
0.449GlnCys: 0.449 ± 0.216
1.258GlnAsp: 1.258 ± 0.337
2.336GlnGlu: 2.336 ± 0.474
1.168GlnPhe: 1.168 ± 0.27
1.438GlnGly: 1.438 ± 0.31
0.629GlnHis: 0.629 ± 0.207
2.965GlnIle: 2.965 ± 0.418
4.134GlnLys: 4.134 ± 0.599
3.325GlnLeu: 3.325 ± 0.637
0.18GlnMet: 0.18 ± 0.12
2.516GlnAsn: 2.516 ± 0.393
0.539GlnPro: 0.539 ± 0.22
1.168GlnGln: 1.168 ± 0.357
1.528GlnArg: 1.528 ± 0.412
1.977GlnSer: 1.977 ± 0.401
2.516GlnThr: 2.516 ± 0.516
1.438GlnVal: 1.438 ± 0.325
0.27GlnTrp: 0.27 ± 0.133
1.348GlnTyr: 1.348 ± 0.374
0.0GlnXaa: 0.0 ± 0.0
Arg
2.067ArgAla: 2.067 ± 0.439
0.809ArgCys: 0.809 ± 0.353
2.067ArgAsp: 2.067 ± 0.476
3.055ArgGlu: 3.055 ± 0.609
1.707ArgPhe: 1.707 ± 0.395
1.887ArgGly: 1.887 ± 0.345
0.27ArgHis: 0.27 ± 0.148
3.595ArgIle: 3.595 ± 0.642
4.044ArgLys: 4.044 ± 0.621
3.055ArgLeu: 3.055 ± 0.429
1.258ArgMet: 1.258 ± 0.397
2.247ArgAsn: 2.247 ± 0.554
1.078ArgPro: 1.078 ± 0.261
1.348ArgGln: 1.348 ± 0.34
2.247ArgArg: 2.247 ± 0.505
1.887ArgSer: 1.887 ± 0.41
1.887ArgThr: 1.887 ± 0.33
2.067ArgVal: 2.067 ± 0.343
0.539ArgTrp: 0.539 ± 0.193
3.235ArgTyr: 3.235 ± 0.489
0.0ArgXaa: 0.0 ± 0.0
Ser
2.786SerAla: 2.786 ± 0.41
0.719SerCys: 0.719 ± 0.265
3.505SerAsp: 3.505 ± 0.623
4.403SerGlu: 4.403 ± 0.78
3.325SerPhe: 3.325 ± 0.538
3.325SerGly: 3.325 ± 0.656
1.078SerHis: 1.078 ± 0.305
5.661SerIle: 5.661 ± 0.712
6.83SerLys: 6.83 ± 1.072
4.403SerLeu: 4.403 ± 0.574
1.078SerMet: 1.078 ± 0.281
4.583SerAsn: 4.583 ± 0.739
1.078SerPro: 1.078 ± 0.303
1.977SerGln: 1.977 ± 0.55
1.618SerArg: 1.618 ± 0.373
3.145SerSer: 3.145 ± 0.69
2.876SerThr: 2.876 ± 0.449
3.505SerVal: 3.505 ± 0.693
0.18SerTrp: 0.18 ± 0.133
2.876SerTyr: 2.876 ± 0.575
0.0SerXaa: 0.0 ± 0.0
Thr
2.426ThrAla: 2.426 ± 0.407
0.539ThrCys: 0.539 ± 0.192
4.313ThrAsp: 4.313 ± 0.587
3.595ThrGlu: 3.595 ± 0.57
1.977ThrPhe: 1.977 ± 0.503
4.403ThrGly: 4.403 ± 0.789
0.809ThrHis: 0.809 ± 0.261
4.044ThrIle: 4.044 ± 0.594
5.751ThrLys: 5.751 ± 0.922
4.224ThrLeu: 4.224 ± 0.621
0.27ThrMet: 0.27 ± 0.203
5.032ThrAsn: 5.032 ± 0.898
1.977ThrPro: 1.977 ± 0.48
1.618ThrGln: 1.618 ± 0.359
2.067ThrArg: 2.067 ± 0.618
3.595ThrSer: 3.595 ± 0.64
3.595ThrThr: 3.595 ± 0.701
2.965ThrVal: 2.965 ± 0.42
0.449ThrTrp: 0.449 ± 0.172
2.965ThrTyr: 2.965 ± 0.585
0.0ThrXaa: 0.0 ± 0.0
Val
2.426ValAla: 2.426 ± 0.385
0.539ValCys: 0.539 ± 0.219
2.696ValAsp: 2.696 ± 0.36
4.134ValGlu: 4.134 ± 0.626
2.606ValPhe: 2.606 ± 0.539
2.336ValGly: 2.336 ± 0.361
0.359ValHis: 0.359 ± 0.213
3.864ValIle: 3.864 ± 0.58
5.841ValLys: 5.841 ± 0.73
4.224ValLeu: 4.224 ± 0.596
1.078ValMet: 1.078 ± 0.332
5.212ValAsn: 5.212 ± 0.782
1.618ValPro: 1.618 ± 0.366
1.528ValGln: 1.528 ± 0.422
2.516ValArg: 2.516 ± 0.58
5.751ValSer: 5.751 ± 0.606
3.325ValThr: 3.325 ± 0.73
3.235ValVal: 3.235 ± 0.59
0.899ValTrp: 0.899 ± 0.284
1.528ValTyr: 1.528 ± 0.383
0.0ValXaa: 0.0 ± 0.0
Trp
0.629TrpAla: 0.629 ± 0.273
0.09TrpCys: 0.09 ± 0.103
0.809TrpAsp: 0.809 ± 0.296
0.809TrpGlu: 0.809 ± 0.246
0.719TrpPhe: 0.719 ± 0.285
0.719TrpGly: 0.719 ± 0.285
0.449TrpHis: 0.449 ± 0.195
0.629TrpIle: 0.629 ± 0.235
0.629TrpLys: 0.629 ± 0.197
1.528TrpLeu: 1.528 ± 0.353
0.539TrpMet: 0.539 ± 0.234
0.539TrpAsn: 0.539 ± 0.231
0.0TrpPro: 0.0 ± 0.0
0.629TrpGln: 0.629 ± 0.206
0.809TrpArg: 0.809 ± 0.279
0.359TrpSer: 0.359 ± 0.163
0.629TrpThr: 0.629 ± 0.231
0.18TrpVal: 0.18 ± 0.129
0.449TrpTrp: 0.449 ± 0.246
0.809TrpTyr: 0.809 ± 0.255
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.258TyrAla: 1.258 ± 0.323
0.719TyrCys: 0.719 ± 0.313
2.336TyrAsp: 2.336 ± 0.49
3.595TyrGlu: 3.595 ± 0.597
2.516TyrPhe: 2.516 ± 0.518
2.067TyrGly: 2.067 ± 0.476
0.539TyrHis: 0.539 ± 0.22
4.134TyrIle: 4.134 ± 0.494
4.942TyrLys: 4.942 ± 0.721
4.134TyrLeu: 4.134 ± 0.529
1.348TyrMet: 1.348 ± 0.335
5.212TyrAsn: 5.212 ± 0.67
0.809TyrPro: 0.809 ± 0.24
1.168TyrGln: 1.168 ± 0.324
3.145TyrArg: 3.145 ± 0.538
2.516TyrSer: 2.516 ± 0.513
3.505TyrThr: 3.505 ± 0.502
1.977TyrVal: 1.977 ± 0.392
0.809TyrTrp: 0.809 ± 0.266
3.954TyrTyr: 3.954 ± 0.729
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (11129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski