Amino acid dipepetide frequency for Nibricoccus aquaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.041AlaAla: 15.041 ± 0.165
1.031AlaCys: 1.031 ± 0.031
5.996AlaAsp: 5.996 ± 0.065
6.928AlaGlu: 6.928 ± 0.1
4.416AlaPhe: 4.416 ± 0.054
9.322AlaGly: 9.322 ± 0.109
2.319AlaHis: 2.319 ± 0.046
5.23AlaIle: 5.23 ± 0.07
4.955AlaLys: 4.955 ± 0.085
12.568AlaLeu: 12.568 ± 0.136
2.33AlaMet: 2.33 ± 0.043
3.19AlaAsn: 3.19 ± 0.059
5.532AlaPro: 5.532 ± 0.086
4.058AlaGln: 4.058 ± 0.064
7.887AlaArg: 7.887 ± 0.091
7.15AlaSer: 7.15 ± 0.106
7.111AlaThr: 7.111 ± 0.115
7.819AlaVal: 7.819 ± 0.099
1.699AlaTrp: 1.699 ± 0.042
2.434AlaTyr: 2.434 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.033CysAla: 1.033 ± 0.031
0.111CysCys: 0.111 ± 0.009
0.46CysAsp: 0.46 ± 0.018
0.468CysGlu: 0.468 ± 0.02
0.35CysPhe: 0.35 ± 0.015
0.79CysGly: 0.79 ± 0.025
0.221CysHis: 0.221 ± 0.013
0.396CysIle: 0.396 ± 0.016
0.207CysLys: 0.207 ± 0.014
0.817CysLeu: 0.817 ± 0.023
0.124CysMet: 0.124 ± 0.008
0.197CysAsn: 0.197 ± 0.013
0.436CysPro: 0.436 ± 0.017
0.214CysGln: 0.214 ± 0.014
0.594CysArg: 0.594 ± 0.02
0.509CysSer: 0.509 ± 0.021
0.428CysThr: 0.428 ± 0.017
0.701CysVal: 0.701 ± 0.028
0.126CysTrp: 0.126 ± 0.01
0.199CysTyr: 0.199 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.073AspAla: 6.073 ± 0.062
0.411AspCys: 0.411 ± 0.019
2.624AspAsp: 2.624 ± 0.049
3.174AspGlu: 3.174 ± 0.059
2.478AspPhe: 2.478 ± 0.043
4.446AspGly: 4.446 ± 0.068
1.077AspHis: 1.077 ± 0.03
2.222AspIle: 2.222 ± 0.039
1.697AspLys: 1.697 ± 0.038
5.247AspLeu: 5.247 ± 0.067
0.712AspMet: 0.712 ± 0.025
1.388AspAsn: 1.388 ± 0.034
2.833AspPro: 2.833 ± 0.044
1.585AspGln: 1.585 ± 0.034
3.27AspArg: 3.27 ± 0.045
2.689AspSer: 2.689 ± 0.056
2.688AspThr: 2.688 ± 0.056
3.49AspVal: 3.49 ± 0.049
0.899AspTrp: 0.899 ± 0.027
1.587AspTyr: 1.587 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
6.296GluAla: 6.296 ± 0.096
0.397GluCys: 0.397 ± 0.017
2.234GluAsp: 2.234 ± 0.044
2.944GluGlu: 2.944 ± 0.051
2.176GluPhe: 2.176 ± 0.044
3.557GluGly: 3.557 ± 0.058
1.119GluHis: 1.119 ± 0.03
3.517GluIle: 3.517 ± 0.056
3.537GluLys: 3.537 ± 0.07
6.139GluLeu: 6.139 ± 0.085
1.194GluMet: 1.194 ± 0.033
2.073GluAsn: 2.073 ± 0.04
2.376GluPro: 2.376 ± 0.038
2.048GluGln: 2.048 ± 0.044
4.271GluArg: 4.271 ± 0.075
3.065GluSer: 3.065 ± 0.051
3.518GluThr: 3.518 ± 0.052
3.72GluVal: 3.72 ± 0.062
0.782GluTrp: 0.782 ± 0.025
1.204GluTyr: 1.204 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.647PheAla: 4.647 ± 0.05
0.416PheCys: 0.416 ± 0.015
2.442PheAsp: 2.442 ± 0.042
2.226PheGlu: 2.226 ± 0.042
1.941PhePhe: 1.941 ± 0.04
3.339PheGly: 3.339 ± 0.054
0.826PheHis: 0.826 ± 0.023
1.863PheIle: 1.863 ± 0.039
1.395PheLys: 1.395 ± 0.032
3.908PheLeu: 3.908 ± 0.054
0.715PheMet: 0.715 ± 0.023
1.465PheAsn: 1.465 ± 0.03
1.936PhePro: 1.936 ± 0.037
1.23PheGln: 1.23 ± 0.028
2.421PheArg: 2.421 ± 0.044
2.998PheSer: 2.998 ± 0.055
2.878PheThr: 2.878 ± 0.047
2.785PheVal: 2.785 ± 0.046
0.623PheTrp: 0.623 ± 0.022
1.114PheTyr: 1.114 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
7.803GlyAla: 7.803 ± 0.1
0.748GlyCys: 0.748 ± 0.028
3.734GlyAsp: 3.734 ± 0.057
4.357GlyGlu: 4.357 ± 0.062
3.453GlyPhe: 3.453 ± 0.053
6.775GlyGly: 6.775 ± 0.104
1.71GlyHis: 1.71 ± 0.037
3.951GlyIle: 3.951 ± 0.057
3.774GlyLys: 3.774 ± 0.06
7.926GlyLeu: 7.926 ± 0.087
1.628GlyMet: 1.628 ± 0.033
2.364GlyAsn: 2.364 ± 0.053
2.83GlyPro: 2.83 ± 0.049
2.558GlyGln: 2.558 ± 0.051
5.079GlyArg: 5.079 ± 0.064
4.658GlySer: 4.658 ± 0.077
4.736GlyThr: 4.736 ± 0.097
5.855GlyVal: 5.855 ± 0.076
1.483GlyTrp: 1.483 ± 0.035
2.266GlyTyr: 2.266 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.573HisAla: 2.573 ± 0.049
0.233HisCys: 0.233 ± 0.014
1.143HisAsp: 1.143 ± 0.03
1.219HisGlu: 1.219 ± 0.033
1.038HisPhe: 1.038 ± 0.025
1.778HisGly: 1.778 ± 0.038
0.65HisHis: 0.65 ± 0.024
0.888HisIle: 0.888 ± 0.025
0.532HisLys: 0.532 ± 0.021
2.281HisLeu: 2.281 ± 0.043
0.298HisMet: 0.298 ± 0.013
0.597HisAsn: 0.597 ± 0.021
1.446HisPro: 1.446 ± 0.036
0.623HisGln: 0.623 ± 0.022
1.501HisArg: 1.501 ± 0.033
1.077HisSer: 1.077 ± 0.032
1.2HisThr: 1.2 ± 0.034
1.347HisVal: 1.347 ± 0.029
0.417HisTrp: 0.417 ± 0.021
0.584HisTyr: 0.584 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.143IleAla: 6.143 ± 0.072
0.44IleCys: 0.44 ± 0.017
3.12IleAsp: 3.12 ± 0.054
3.141IleGlu: 3.141 ± 0.049
1.929IlePhe: 1.929 ± 0.038
4.023IleGly: 4.023 ± 0.061
1.075IleHis: 1.075 ± 0.03
2.185IleIle: 2.185 ± 0.045
1.731IleLys: 1.731 ± 0.037
4.353IleLeu: 4.353 ± 0.066
0.649IleMet: 0.649 ± 0.023
1.615IleAsn: 1.615 ± 0.032
2.492IlePro: 2.492 ± 0.049
1.403IleGln: 1.403 ± 0.031
2.973IleArg: 2.973 ± 0.047
2.999IleSer: 2.999 ± 0.05
3.368IleThr: 3.368 ± 0.07
3.732IleVal: 3.732 ± 0.053
0.547IleTrp: 0.547 ± 0.021
1.202IleTyr: 1.202 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.354LysAla: 4.354 ± 0.079
0.197LysCys: 0.197 ± 0.012
1.973LysAsp: 1.973 ± 0.047
2.122LysGlu: 2.122 ± 0.044
1.48LysPhe: 1.48 ± 0.032
2.491LysGly: 2.491 ± 0.048
0.823LysHis: 0.823 ± 0.025
2.611LysIle: 2.611 ± 0.047
2.475LysLys: 2.475 ± 0.053
4.274LysLeu: 4.274 ± 0.072
0.976LysMet: 0.976 ± 0.023
1.713LysAsn: 1.713 ± 0.04
2.527LysPro: 2.527 ± 0.049
1.329LysGln: 1.329 ± 0.032
2.653LysArg: 2.653 ± 0.051
2.512LysSer: 2.512 ± 0.045
2.886LysThr: 2.886 ± 0.043
2.48LysVal: 2.48 ± 0.051
0.518LysTrp: 0.518 ± 0.021
0.852LysTyr: 0.852 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
12.984LeuAla: 12.984 ± 0.129
0.997LeuCys: 0.997 ± 0.025
5.179LeuAsp: 5.179 ± 0.078
5.321LeuGlu: 5.321 ± 0.081
3.881LeuPhe: 3.881 ± 0.058
7.99LeuGly: 7.99 ± 0.083
2.247LeuHis: 2.247 ± 0.043
4.844LeuIle: 4.844 ± 0.064
4.412LeuLys: 4.412 ± 0.074
10.244LeuLeu: 10.244 ± 0.129
1.875LeuMet: 1.875 ± 0.044
3.171LeuAsn: 3.171 ± 0.052
5.886LeuPro: 5.886 ± 0.076
2.947LeuGln: 2.947 ± 0.049
7.585LeuArg: 7.585 ± 0.083
6.433LeuSer: 6.433 ± 0.085
6.831LeuThr: 6.831 ± 0.083
6.901LeuVal: 6.901 ± 0.077
1.402LeuTrp: 1.402 ± 0.037
2.032LeuTyr: 2.032 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.863MetAla: 1.863 ± 0.042
0.143MetCys: 0.143 ± 0.011
0.871MetAsp: 0.871 ± 0.029
0.952MetGlu: 0.952 ± 0.027
0.563MetPhe: 0.563 ± 0.022
1.232MetGly: 1.232 ± 0.032
0.37MetHis: 0.37 ± 0.017
1.034MetIle: 1.034 ± 0.03
1.121MetLys: 1.121 ± 0.033
1.778MetLeu: 1.778 ± 0.039
0.397MetMet: 0.397 ± 0.017
0.793MetAsn: 0.793 ± 0.023
1.265MetPro: 1.265 ± 0.033
0.584MetGln: 0.584 ± 0.022
1.297MetArg: 1.297 ± 0.035
1.435MetSer: 1.435 ± 0.032
1.24MetThr: 1.24 ± 0.033
1.085MetVal: 1.085 ± 0.03
0.206MetTrp: 0.206 ± 0.014
0.285MetTyr: 0.285 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.468AsnAla: 3.468 ± 0.061
0.266AsnCys: 0.266 ± 0.014
1.514AsnAsp: 1.514 ± 0.038
1.427AsnGlu: 1.427 ± 0.035
1.317AsnPhe: 1.317 ± 0.033
2.607AsnGly: 2.607 ± 0.057
0.651AsnHis: 0.651 ± 0.024
1.472AsnIle: 1.472 ± 0.039
0.927AsnLys: 0.927 ± 0.03
3.178AsnLeu: 3.178 ± 0.056
0.412AsnMet: 0.412 ± 0.019
1.126AsnAsn: 1.126 ± 0.036
2.283AsnPro: 2.283 ± 0.04
0.993AsnGln: 0.993 ± 0.032
1.853AsnArg: 1.853 ± 0.037
1.76AsnSer: 1.76 ± 0.04
1.887AsnThr: 1.887 ± 0.05
2.154AsnVal: 2.154 ± 0.048
0.514AsnTrp: 0.514 ± 0.022
0.98AsnTyr: 0.98 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
7.438ProAla: 7.438 ± 0.098
0.313ProCys: 0.313 ± 0.016
3.064ProAsp: 3.064 ± 0.041
3.509ProGlu: 3.509 ± 0.059
2.061ProPhe: 2.061 ± 0.046
4.237ProGly: 4.237 ± 0.063
1.206ProHis: 1.206 ± 0.029
2.078ProIle: 2.078 ± 0.041
1.982ProLys: 1.982 ± 0.045
4.947ProLeu: 4.947 ± 0.069
0.999ProMet: 0.999 ± 0.027
1.323ProAsn: 1.323 ± 0.033
2.875ProPro: 2.875 ± 0.065
1.585ProGln: 1.585 ± 0.039
2.9ProArg: 2.9 ± 0.052
3.407ProSer: 3.407 ± 0.068
2.97ProThr: 2.97 ± 0.052
4.214ProVal: 4.214 ± 0.061
0.786ProTrp: 0.786 ± 0.024
1.104ProTyr: 1.104 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.354GlnAla: 3.354 ± 0.061
0.199GlnCys: 0.199 ± 0.011
1.157GlnAsp: 1.157 ± 0.029
1.52GlnGlu: 1.52 ± 0.039
1.248GlnPhe: 1.248 ± 0.033
1.96GlnGly: 1.96 ± 0.04
0.712GlnHis: 0.712 ± 0.023
1.932GlnIle: 1.932 ± 0.041
1.553GlnLys: 1.553 ± 0.041
3.769GlnLeu: 3.769 ± 0.061
0.667GlnMet: 0.667 ± 0.023
1.024GlnAsn: 1.024 ± 0.028
2.061GlnPro: 2.061 ± 0.042
1.321GlnGln: 1.321 ± 0.044
2.438GlnArg: 2.438 ± 0.047
1.997GlnSer: 1.997 ± 0.037
1.926GlnThr: 1.926 ± 0.039
1.97GlnVal: 1.97 ± 0.043
0.476GlnTrp: 0.476 ± 0.02
0.631GlnTyr: 0.631 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.423ArgAla: 7.423 ± 0.083
0.543ArgCys: 0.543 ± 0.021
3.579ArgAsp: 3.579 ± 0.057
4.564ArgGlu: 4.564 ± 0.067
2.942ArgPhe: 2.942 ± 0.049
4.444ArgGly: 4.444 ± 0.064
1.606ArgHis: 1.606 ± 0.037
3.609ArgIle: 3.609 ± 0.052
2.455ArgLys: 2.455 ± 0.046
7.156ArgLeu: 7.156 ± 0.083
1.462ArgMet: 1.462 ± 0.034
1.835ArgAsn: 1.835 ± 0.039
3.201ArgPro: 3.201 ± 0.053
2.181ArgGln: 2.181 ± 0.039
4.691ArgArg: 4.691 ± 0.07
3.673ArgSer: 3.673 ± 0.052
3.664ArgThr: 3.664 ± 0.049
4.88ArgVal: 4.88 ± 0.062
1.192ArgTrp: 1.192 ± 0.034
1.83ArgTyr: 1.83 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.445SerAla: 7.445 ± 0.096
0.429SerCys: 0.429 ± 0.019
2.949SerAsp: 2.949 ± 0.054
3.187SerGlu: 3.187 ± 0.056
2.516SerPhe: 2.516 ± 0.051
5.61SerGly: 5.61 ± 0.088
1.229SerHis: 1.229 ± 0.035
2.76SerIle: 2.76 ± 0.048
2.014SerLys: 2.014 ± 0.039
6.54SerLeu: 6.54 ± 0.081
1.128SerMet: 1.128 ± 0.027
1.638SerAsn: 1.638 ± 0.043
3.67SerPro: 3.67 ± 0.064
1.818SerGln: 1.818 ± 0.042
3.843SerArg: 3.843 ± 0.06
4.27SerSer: 4.27 ± 0.081
3.771SerThr: 3.771 ± 0.078
4.295SerVal: 4.295 ± 0.07
0.873SerTrp: 0.873 ± 0.026
1.544SerTyr: 1.544 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.333ThrAla: 7.333 ± 0.116
0.388ThrCys: 0.388 ± 0.018
3.133ThrAsp: 3.133 ± 0.06
2.952ThrGlu: 2.952 ± 0.053
2.451ThrPhe: 2.451 ± 0.047
5.512ThrGly: 5.512 ± 0.093
1.387ThrHis: 1.387 ± 0.033
2.916ThrIle: 2.916 ± 0.064
2.129ThrLys: 2.129 ± 0.045
6.879ThrLeu: 6.879 ± 0.086
0.876ThrMet: 0.876 ± 0.025
1.765ThrAsn: 1.765 ± 0.051
4.188ThrPro: 4.188 ± 0.071
1.882ThrGln: 1.882 ± 0.038
3.789ThrArg: 3.789 ± 0.056
3.767ThrSer: 3.767 ± 0.077
3.96ThrThr: 3.96 ± 0.087
4.461ThrVal: 4.461 ± 0.075
0.91ThrTrp: 0.91 ± 0.03
1.586ThrTyr: 1.586 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
7.87ValAla: 7.87 ± 0.094
0.733ValCys: 0.733 ± 0.022
3.213ValAsp: 3.213 ± 0.052
4.12ValGlu: 4.12 ± 0.07
3.08ValPhe: 3.08 ± 0.045
4.782ValGly: 4.782 ± 0.065
1.277ValHis: 1.277 ± 0.033
3.915ValIle: 3.915 ± 0.053
2.93ValLys: 2.93 ± 0.051
6.863ValLeu: 6.863 ± 0.078
1.358ValMet: 1.358 ± 0.037
2.207ValAsn: 2.207 ± 0.046
3.361ValPro: 3.361 ± 0.051
1.99ValGln: 1.99 ± 0.039
4.686ValArg: 4.686 ± 0.067
4.67ValSer: 4.67 ± 0.061
4.781ValThr: 4.781 ± 0.084
5.352ValVal: 5.352 ± 0.09
1.011ValTrp: 1.011 ± 0.028
1.551ValTyr: 1.551 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.294TrpAla: 1.294 ± 0.038
0.175TrpCys: 0.175 ± 0.012
0.73TrpAsp: 0.73 ± 0.026
0.765TrpGlu: 0.765 ± 0.027
0.68TrpPhe: 0.68 ± 0.021
0.897TrpGly: 0.897 ± 0.028
0.36TrpHis: 0.36 ± 0.015
0.805TrpIle: 0.805 ± 0.026
0.684TrpLys: 0.684 ± 0.025
1.856TrpLeu: 1.856 ± 0.047
0.365TrpMet: 0.365 ± 0.016
0.514TrpAsn: 0.514 ± 0.02
0.694TrpPro: 0.694 ± 0.024
0.621TrpGln: 0.621 ± 0.021
1.244TrpArg: 1.244 ± 0.034
1.039TrpSer: 1.039 ± 0.03
0.909TrpThr: 0.909 ± 0.028
0.921TrpVal: 0.921 ± 0.025
0.332TrpTrp: 0.332 ± 0.016
0.344TrpTyr: 0.344 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.582TyrAla: 2.582 ± 0.051
0.211TyrCys: 0.211 ± 0.012
1.474TyrAsp: 1.474 ± 0.037
1.274TyrGlu: 1.274 ± 0.033
1.172TyrPhe: 1.172 ± 0.026
1.897TyrGly: 1.897 ± 0.039
0.56TyrHis: 0.56 ± 0.023
0.889TyrIle: 0.889 ± 0.027
0.735TyrLys: 0.735 ± 0.027
2.439TyrLeu: 2.439 ± 0.043
0.346TyrMet: 0.346 ± 0.018
0.793TyrAsn: 0.793 ± 0.028
1.107TyrPro: 1.107 ± 0.031
0.943TyrGln: 0.943 ± 0.032
1.958TyrArg: 1.958 ± 0.042
1.419TyrSer: 1.419 ± 0.034
1.512TyrThr: 1.512 ± 0.042
1.588TyrVal: 1.588 ± 0.03
0.432TyrTrp: 0.432 ± 0.019
0.782TyrTyr: 0.782 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3760 proteins (1409849 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski