Amino acid dipepetide frequency for Phialophora americana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.29AlaAla: 9.29 ± 0.057	1.103AlaCys: 1.103 ± 0.016	4.414AlaAsp: 4.414 ± 0.026	5.317AlaGlu: 5.317 ± 0.039	3.213AlaPhe: 3.213 ± 0.026	6.031AlaGly: 6.031 ± 0.029	1.853AlaHis: 1.853 ± 0.017	4.283AlaIle: 4.283 ± 0.029	4.058AlaLys: 4.058 ± 0.03	7.92AlaLeu: 7.92 ± 0.048	1.999AlaMet: 1.999 ± 0.021	2.936AlaAsn: 2.936 ± 0.028	4.835AlaPro: 4.835 ± 0.043	3.702AlaGln: 3.702 ± 0.024	5.373AlaArg: 5.373 ± 0.033	7.289AlaSer: 7.289 ± 0.04	5.538AlaThr: 5.538 ± 0.036	5.527AlaVal: 5.527 ± 0.036	1.168AlaTrp: 1.168 ± 0.015	2.193AlaTyr: 2.193 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.015	0.243CysCys: 0.243 ± 0.008	0.647CysAsp: 0.647 ± 0.011	0.563CysGlu: 0.563 ± 0.01	0.547CysPhe: 0.547 ± 0.01	0.891CysGly: 0.891 ± 0.014	0.334CysHis: 0.334 ± 0.008	0.656CysIle: 0.656 ± 0.012	0.483CysLys: 0.483 ± 0.011	1.283CysLeu: 1.283 ± 0.018	0.269CysMet: 0.269 ± 0.007	0.399CysAsn: 0.399 ± 0.01	0.651CysPro: 0.651 ± 0.011	0.461CysGln: 0.461 ± 0.008	0.793CysArg: 0.793 ± 0.013	0.866CysSer: 0.866 ± 0.015	0.688CysThr: 0.688 ± 0.01	0.791CysVal: 0.791 ± 0.014	0.208CysTrp: 0.208 ± 0.006	0.363CysTyr: 0.363 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.832AspAla: 4.832 ± 0.031	0.612AspCys: 0.612 ± 0.012	4.338AspAsp: 4.338 ± 0.039	4.507AspGlu: 4.507 ± 0.036	2.232AspPhe: 2.232 ± 0.02	4.049AspGly: 4.049 ± 0.025	1.344AspHis: 1.344 ± 0.016	2.883AspIle: 2.883 ± 0.026	2.319AspLys: 2.319 ± 0.024	5.2AspLeu: 5.2 ± 0.035	1.266AspMet: 1.266 ± 0.014	1.791AspAsn: 1.791 ± 0.019	3.492AspPro: 3.492 ± 0.022	2.035AspGln: 2.035 ± 0.022	3.227AspArg: 3.227 ± 0.031	3.948AspSer: 3.948 ± 0.031	2.977AspThr: 2.977 ± 0.023	3.831AspVal: 3.831 ± 0.027	0.892AspTrp: 0.892 ± 0.014	1.535AspTyr: 1.535 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.405GluAla: 5.405 ± 0.041	0.595GluCys: 0.595 ± 0.012	4.204GluAsp: 4.204 ± 0.039	5.065GluGlu: 5.065 ± 0.042	1.868GluPhe: 1.868 ± 0.018	3.699GluGly: 3.699 ± 0.028	1.463GluHis: 1.463 ± 0.018	2.956GluIle: 2.956 ± 0.025	3.558GluLys: 3.558 ± 0.032	5.095GluLeu: 5.095 ± 0.033	1.439GluMet: 1.439 ± 0.016	2.116GluAsn: 2.116 ± 0.021	2.794GluPro: 2.794 ± 0.028	2.623GluGln: 2.623 ± 0.022	4.001GluArg: 4.001 ± 0.029	4.12GluSer: 4.12 ± 0.031	3.417GluThr: 3.417 ± 0.025	3.622GluVal: 3.622 ± 0.026	0.851GluTrp: 0.851 ± 0.012	1.592GluTyr: 1.592 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.115PheAla: 3.115 ± 0.024	0.545PheCys: 0.545 ± 0.01	2.344PheAsp: 2.344 ± 0.022	2.151PheGlu: 2.151 ± 0.019	1.627PhePhe: 1.627 ± 0.019	2.844PheGly: 2.844 ± 0.031	0.879PheHis: 0.879 ± 0.012	1.702PheIle: 1.702 ± 0.019	1.42PheLys: 1.42 ± 0.014	3.465PheLeu: 3.465 ± 0.03	0.759PheMet: 0.759 ± 0.012	1.363PheAsn: 1.363 ± 0.015	1.949PhePro: 1.949 ± 0.021	1.438PheGln: 1.438 ± 0.016	2.013PheArg: 2.013 ± 0.021	2.9PheSer: 2.9 ± 0.022	2.077PheThr: 2.077 ± 0.021	2.459PheVal: 2.459 ± 0.022	0.645PheTrp: 0.645 ± 0.011	1.055PheTyr: 1.055 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.382GlyAla: 5.382 ± 0.034	0.825GlyCys: 0.825 ± 0.013	3.59GlyAsp: 3.59 ± 0.029	3.6GlyGlu: 3.6 ± 0.03	2.827GlyPhe: 2.827 ± 0.026	5.744GlyGly: 5.744 ± 0.049	1.788GlyHis: 1.788 ± 0.019	3.41GlyIle: 3.41 ± 0.026	3.32GlyLys: 3.32 ± 0.031	6.145GlyLeu: 6.145 ± 0.036	1.622GlyMet: 1.622 ± 0.019	2.393GlyAsn: 2.393 ± 0.021	3.491GlyPro: 3.491 ± 0.03	2.709GlyGln: 2.709 ± 0.024	4.325GlyArg: 4.325 ± 0.032	5.524GlySer: 5.524 ± 0.037	4.098GlyThr: 4.098 ± 0.029	4.384GlyVal: 4.384 ± 0.032	1.149GlyTrp: 1.149 ± 0.015	2.111GlyTyr: 2.111 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.026HisAla: 2.026 ± 0.018	0.321HisCys: 0.321 ± 0.008	1.441HisAsp: 1.441 ± 0.016	1.41HisGlu: 1.41 ± 0.017	0.957HisPhe: 0.957 ± 0.014	1.812HisGly: 1.812 ± 0.02	0.895HisHis: 0.895 ± 0.014	1.194HisIle: 1.194 ± 0.014	0.942HisLys: 0.942 ± 0.013	2.308HisLeu: 2.308 ± 0.021	0.496HisMet: 0.496 ± 0.01	0.822HisAsn: 0.822 ± 0.012	1.729HisPro: 1.729 ± 0.018	1.046HisGln: 1.046 ± 0.015	1.612HisArg: 1.612 ± 0.021	1.86HisSer: 1.86 ± 0.02	1.285HisThr: 1.285 ± 0.015	1.552HisVal: 1.552 ± 0.015	0.353HisTrp: 0.353 ± 0.008	0.691HisTyr: 0.691 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.165IleAla: 4.165 ± 0.031	0.759IleCys: 0.759 ± 0.012	2.784IleAsp: 2.784 ± 0.024	2.74IleGlu: 2.74 ± 0.024	1.906IlePhe: 1.906 ± 0.019	3.087IleGly: 3.087 ± 0.028	1.166IleHis: 1.166 ± 0.014	2.311IleIle: 2.311 ± 0.025	2.023IleLys: 2.023 ± 0.022	4.527IleLeu: 4.527 ± 0.033	0.966IleMet: 0.966 ± 0.013	1.702IleAsn: 1.702 ± 0.018	2.988IlePro: 2.988 ± 0.024	1.831IleGln: 1.831 ± 0.015	2.75IleArg: 2.75 ± 0.025	3.704IleSer: 3.704 ± 0.027	2.718IleThr: 2.718 ± 0.024	3.104IleVal: 3.104 ± 0.028	0.722IleTrp: 0.722 ± 0.01	1.369IleTyr: 1.369 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.195LysAla: 4.195 ± 0.034	0.489LysCys: 0.489 ± 0.01	2.759LysAsp: 2.759 ± 0.024	3.199LysGlu: 3.199 ± 0.03	1.406LysPhe: 1.406 ± 0.015	2.839LysGly: 2.839 ± 0.02	1.177LysHis: 1.177 ± 0.014	2.223LysIle: 2.223 ± 0.019	3.053LysLys: 3.053 ± 0.045	3.902LysLeu: 3.902 ± 0.034	1.009LysMet: 1.009 ± 0.015	1.596LysAsn: 1.596 ± 0.018	2.679LysPro: 2.679 ± 0.025	1.86LysGln: 1.86 ± 0.019	3.378LysArg: 3.378 ± 0.029	3.386LysSer: 3.386 ± 0.029	2.719LysThr: 2.719 ± 0.024	2.748LysVal: 2.748 ± 0.022	0.661LysTrp: 0.661 ± 0.011	1.336LysTyr: 1.336 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	8.087LeuAla: 8.087 ± 0.044	1.255LeuCys: 1.255 ± 0.015	5.227LeuAsp: 5.227 ± 0.033	5.488LeuGlu: 5.488 ± 0.038	3.294LeuPhe: 3.294 ± 0.028	5.983LeuGly: 5.983 ± 0.033	2.286LeuHis: 2.286 ± 0.021	3.782LeuIle: 3.782 ± 0.031	4.166LeuLys: 4.166 ± 0.034	8.388LeuLeu: 8.388 ± 0.055	1.778LeuMet: 1.778 ± 0.018	3.136LeuAsn: 3.136 ± 0.023	5.564LeuPro: 5.564 ± 0.032	3.94LeuGln: 3.94 ± 0.033	5.897LeuArg: 5.897 ± 0.034	7.258LeuSer: 7.258 ± 0.043	4.9LeuThr: 4.9 ± 0.03	5.478LeuVal: 5.478 ± 0.037	1.248LeuTrp: 1.248 ± 0.016	2.343LeuTyr: 2.343 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.267MetAla: 2.267 ± 0.02	0.256MetCys: 0.256 ± 0.007	1.209MetAsp: 1.209 ± 0.016	1.181MetGlu: 1.181 ± 0.014	0.748MetPhe: 0.748 ± 0.012	1.444MetGly: 1.444 ± 0.017	0.502MetHis: 0.502 ± 0.01	0.953MetIle: 0.953 ± 0.013	0.943MetLys: 0.943 ± 0.013	1.919MetLeu: 1.919 ± 0.022	0.56MetMet: 0.56 ± 0.009	0.764MetAsn: 0.764 ± 0.012	1.313MetPro: 1.313 ± 0.014	0.895MetGln: 0.895 ± 0.015	1.243MetArg: 1.243 ± 0.013	1.885MetSer: 1.885 ± 0.018	1.325MetThr: 1.325 ± 0.016	1.312MetVal: 1.312 ± 0.016	0.259MetTrp: 0.259 ± 0.007	0.518MetTyr: 0.518 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.154AsnAla: 3.154 ± 0.024	0.404AsnCys: 0.404 ± 0.009	1.894AsnAsp: 1.894 ± 0.018	1.904AsnGlu: 1.904 ± 0.018	1.31AsnPhe: 1.31 ± 0.018	2.907AsnGly: 2.907 ± 0.029	0.849AsnHis: 0.849 ± 0.013	1.896AsnIle: 1.896 ± 0.022	1.424AsnLys: 1.424 ± 0.017	3.196AsnLeu: 3.196 ± 0.024	0.77AsnMet: 0.77 ± 0.011	1.325AsnAsn: 1.325 ± 0.017	2.413AsnPro: 2.413 ± 0.025	1.295AsnGln: 1.295 ± 0.016	1.873AsnArg: 1.873 ± 0.018	2.575AsnSer: 2.575 ± 0.024	2.06AsnThr: 2.06 ± 0.02	2.281AsnVal: 2.281 ± 0.021	0.528AsnTrp: 0.528 ± 0.01	0.988AsnTyr: 0.988 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.49ProAla: 5.49 ± 0.045	0.518ProCys: 0.518 ± 0.011	3.372ProAsp: 3.372 ± 0.026	3.806ProGlu: 3.806 ± 0.029	2.091ProPhe: 2.091 ± 0.021	4.144ProGly: 4.144 ± 0.033	1.377ProHis: 1.377 ± 0.019	2.459ProIle: 2.459 ± 0.02	2.579ProLys: 2.579 ± 0.023	4.863ProLeu: 4.863 ± 0.03	1.096ProMet: 1.096 ± 0.016	2.175ProAsn: 2.175 ± 0.018	5.494ProPro: 5.494 ± 0.069	2.656ProGln: 2.656 ± 0.033	3.663ProArg: 3.663 ± 0.028	6.114ProSer: 6.114 ± 0.047	4.18ProThr: 4.18 ± 0.033	3.681ProVal: 3.681 ± 0.028	0.754ProTrp: 0.754 ± 0.011	1.518ProTyr: 1.518 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.75GlnAla: 3.75 ± 0.03	0.437GlnCys: 0.437 ± 0.009	2.169GlnAsp: 2.169 ± 0.019	2.461GlnGlu: 2.461 ± 0.024	1.322GlnPhe: 1.322 ± 0.015	2.508GlnGly: 2.508 ± 0.025	1.213GlnHis: 1.213 ± 0.017	1.956GlnIle: 1.956 ± 0.019	1.996GlnLys: 1.996 ± 0.02	3.509GlnLeu: 3.509 ± 0.026	0.923GlnMet: 0.923 ± 0.015	1.567GlnAsn: 1.567 ± 0.019	2.702GlnPro: 2.702 ± 0.032	2.537GlnGln: 2.537 ± 0.036	2.802GlnArg: 2.802 ± 0.024	3.294GlnSer: 3.294 ± 0.031	2.452GlnThr: 2.452 ± 0.022	2.259GlnVal: 2.259 ± 0.02	0.576GlnTrp: 0.576 ± 0.011	1.222GlnTyr: 1.222 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.935ArgAla: 4.935 ± 0.034	0.732ArgCys: 0.732 ± 0.013	3.534ArgAsp: 3.534 ± 0.034	3.855ArgGlu: 3.855 ± 0.029	2.076ArgPhe: 2.076 ± 0.018	3.814ArgGly: 3.814 ± 0.027	1.757ArgHis: 1.757 ± 0.021	2.852ArgIle: 2.852 ± 0.025	3.555ArgLys: 3.555 ± 0.03	5.745ArgLeu: 5.745 ± 0.039	1.314ArgMet: 1.314 ± 0.016	2.237ArgAsn: 2.237 ± 0.016	3.903ArgPro: 3.903 ± 0.032	2.868ArgGln: 2.868 ± 0.025	5.528ArgArg: 5.528 ± 0.044	4.979ArgSer: 4.979 ± 0.038	3.52ArgThr: 3.52 ± 0.027	3.394ArgVal: 3.394 ± 0.026	0.951ArgTrp: 0.951 ± 0.013	1.692ArgTyr: 1.692 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.789SerAla: 6.789 ± 0.042	0.841SerCys: 0.841 ± 0.013	4.173SerAsp: 4.173 ± 0.033	4.053SerGlu: 4.053 ± 0.033	2.916SerPhe: 2.916 ± 0.02	5.38SerGly: 5.38 ± 0.034	1.981SerHis: 1.981 ± 0.02	3.865SerIle: 3.865 ± 0.028	3.502SerLys: 3.502 ± 0.03	7.102SerLeu: 7.102 ± 0.041	1.729SerMet: 1.729 ± 0.018	2.86SerAsn: 2.86 ± 0.026	5.771SerPro: 5.771 ± 0.043	3.381SerGln: 3.381 ± 0.028	5.232SerArg: 5.232 ± 0.038	8.657SerSer: 8.657 ± 0.065	5.791SerThr: 5.791 ± 0.048	4.486SerVal: 4.486 ± 0.033	1.108SerTrp: 1.108 ± 0.014	1.995SerTyr: 1.995 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.459ThrAla: 5.459 ± 0.037	0.732ThrCys: 0.732 ± 0.013	2.89ThrAsp: 2.89 ± 0.023	3.042ThrGlu: 3.042 ± 0.024	2.274ThrPhe: 2.274 ± 0.02	4.215ThrGly: 4.215 ± 0.029	1.297ThrHis: 1.297 ± 0.016	3.039ThrIle: 3.039 ± 0.023	2.573ThrLys: 2.573 ± 0.023	5.227ThrLeu: 5.227 ± 0.035	1.244ThrMet: 1.244 ± 0.014	2.074ThrAsn: 2.074 ± 0.023	4.438ThrPro: 4.438 ± 0.04	2.15ThrGln: 2.15 ± 0.023	3.279ThrArg: 3.279 ± 0.025	5.608ThrSer: 5.608 ± 0.042	4.571ThrThr: 4.571 ± 0.062	3.797ThrVal: 3.797 ± 0.025	0.88ThrTrp: 0.88 ± 0.012	1.601ThrTyr: 1.601 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.423ValAla: 5.423 ± 0.036	0.83ValCys: 0.83 ± 0.014	3.824ValAsp: 3.824 ± 0.031	3.859ValGlu: 3.859 ± 0.025	2.419ValPhe: 2.419 ± 0.023	4.08ValGly: 4.08 ± 0.03	1.45ValHis: 1.45 ± 0.016	2.826ValIle: 2.826 ± 0.026	2.915ValLys: 2.915 ± 0.028	5.651ValLeu: 5.651 ± 0.038	1.306ValMet: 1.306 ± 0.014	2.155ValAsn: 2.155 ± 0.025	3.688ValPro: 3.688 ± 0.027	2.507ValGln: 2.507 ± 0.023	3.62ValArg: 3.62 ± 0.026	4.584ValSer: 4.584 ± 0.027	3.519ValThr: 3.519 ± 0.022	4.406ValVal: 4.406 ± 0.035	0.872ValTrp: 0.872 ± 0.013	1.658ValTyr: 1.658 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.109TrpAla: 1.109 ± 0.012	0.202TrpCys: 0.202 ± 0.005	0.853TrpAsp: 0.853 ± 0.014	0.802TrpGlu: 0.802 ± 0.012	0.551TrpPhe: 0.551 ± 0.011	0.888TrpGly: 0.888 ± 0.014	0.38TrpHis: 0.38 ± 0.008	0.764TrpIle: 0.764 ± 0.014	0.76TrpLys: 0.76 ± 0.011	1.383TrpLeu: 1.383 ± 0.018	0.368TrpMet: 0.368 ± 0.009	0.581TrpAsn: 0.581 ± 0.011	0.621TrpPro: 0.621 ± 0.01	0.599TrpGln: 0.599 ± 0.011	1.008TrpArg: 1.008 ± 0.012	1.099TrpSer: 1.099 ± 0.015	0.979TrpThr: 0.979 ± 0.012	0.868TrpVal: 0.868 ± 0.013	0.281TrpTrp: 0.281 ± 0.007	0.442TrpTyr: 0.442 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.201TyrAla: 2.201 ± 0.022	0.404TyrCys: 0.404 ± 0.009	1.642TyrAsp: 1.642 ± 0.019	1.481TyrGlu: 1.481 ± 0.017	1.167TyrPhe: 1.167 ± 0.014	2.075TyrGly: 2.075 ± 0.022	0.763TyrHis: 0.763 ± 0.011	1.311TyrIle: 1.311 ± 0.015	1.026TyrLys: 1.026 ± 0.013	2.671TyrLeu: 2.671 ± 0.025	0.582TyrMet: 0.582 ± 0.011	1.055TyrAsn: 1.055 ± 0.016	1.515TyrPro: 1.515 ± 0.018	1.119TyrGln: 1.119 ± 0.014	1.623TyrArg: 1.623 ± 0.016	1.962TyrSer: 1.962 ± 0.02	1.579TyrThr: 1.579 ± 0.02	1.614TyrVal: 1.614 ± 0.017	0.431TyrTrp: 0.431 ± 0.009	0.865TyrTyr: 0.865 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11503 proteins (5818011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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