Amino acid dipepetide frequency for Papilio xuthus (Asian swallowtail butterfly)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.202AlaAla: 8.202 ± 0.084	1.444AlaCys: 1.444 ± 0.02	3.424AlaAsp: 3.424 ± 0.024	4.284AlaGlu: 4.284 ± 0.035	2.275AlaPhe: 2.275 ± 0.023	4.776AlaGly: 4.776 ± 0.043	2.015AlaHis: 2.015 ± 0.022	3.277AlaIle: 3.277 ± 0.025	3.48AlaLys: 3.48 ± 0.028	7.348AlaLeu: 7.348 ± 0.062	1.591AlaMet: 1.591 ± 0.018	2.583AlaAsn: 2.583 ± 0.022	4.601AlaPro: 4.601 ± 0.05	2.604AlaGln: 2.604 ± 0.026	4.654AlaArg: 4.654 ± 0.043	5.028AlaSer: 5.028 ± 0.041	3.967AlaThr: 3.967 ± 0.028	4.803AlaVal: 4.803 ± 0.04	0.791AlaTrp: 0.791 ± 0.013	1.892AlaTyr: 1.892 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.577CysAla: 1.577 ± 0.022	0.512CysCys: 0.512 ± 0.011	1.185CysAsp: 1.185 ± 0.02	1.263CysGlu: 1.263 ± 0.02	0.693CysPhe: 0.693 ± 0.011	1.552CysGly: 1.552 ± 0.024	0.489CysHis: 0.489 ± 0.01	1.018CysIle: 1.018 ± 0.014	1.077CysLys: 1.077 ± 0.015	1.765CysLeu: 1.765 ± 0.02	0.406CysMet: 0.406 ± 0.009	0.907CysAsn: 0.907 ± 0.015	1.072CysPro: 1.072 ± 0.022	0.706CysGln: 0.706 ± 0.012	1.235CysArg: 1.235 ± 0.018	1.536CysSer: 1.536 ± 0.02	1.081CysThr: 1.081 ± 0.014	1.434CysVal: 1.434 ± 0.021	0.228CysTrp: 0.228 ± 0.006	0.613CysTyr: 0.613 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	3.465AspAla: 3.465 ± 0.03	1.045AspCys: 1.045 ± 0.016	3.844AspAsp: 3.844 ± 0.037	4.095AspGlu: 4.095 ± 0.034	2.093AspPhe: 2.093 ± 0.021	3.092AspGly: 3.092 ± 0.031	1.124AspHis: 1.124 ± 0.016	3.459AspIle: 3.459 ± 0.029	3.519AspLys: 3.519 ± 0.031	4.777AspLeu: 4.777 ± 0.031	1.316AspMet: 1.316 ± 0.015	2.852AspAsn: 2.852 ± 0.03	2.485AspPro: 2.485 ± 0.026	1.553AspGln: 1.553 ± 0.022	2.727AspArg: 2.727 ± 0.026	4.137AspSer: 4.137 ± 0.038	3.121AspThr: 3.121 ± 0.026	3.795AspVal: 3.795 ± 0.027	0.622AspTrp: 0.622 ± 0.011	1.883AspTyr: 1.883 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.386GluAla: 4.386 ± 0.033	1.259GluCys: 1.259 ± 0.018	3.951GluAsp: 3.951 ± 0.029	5.813GluGlu: 5.813 ± 0.056	2.037GluPhe: 2.037 ± 0.025	3.258GluGly: 3.258 ± 0.034	1.505GluHis: 1.505 ± 0.015	3.711GluIle: 3.711 ± 0.031	4.747GluLys: 4.747 ± 0.052	5.746GluLeu: 5.746 ± 0.042	1.553GluMet: 1.553 ± 0.018	3.521GluAsn: 3.521 ± 0.033	2.906GluPro: 2.906 ± 0.033	2.573GluGln: 2.573 ± 0.024	4.078GluArg: 4.078 ± 0.037	4.406GluSer: 4.406 ± 0.038	3.614GluThr: 3.614 ± 0.044	3.981GluVal: 3.981 ± 0.031	0.715GluTrp: 0.715 ± 0.011	2.013GluTyr: 2.013 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	2.182PheAla: 2.182 ± 0.02	0.742PheCys: 0.742 ± 0.013	2.01PheAsp: 2.01 ± 0.023	2.049PheGlu: 2.049 ± 0.022	1.376PhePhe: 1.376 ± 0.018	2.255PheGly: 2.255 ± 0.023	0.864PheHis: 0.864 ± 0.012	2.033PheIle: 2.033 ± 0.021	2.085PheLys: 2.085 ± 0.02	3.208PheLeu: 3.208 ± 0.032	0.799PheMet: 0.799 ± 0.011	1.766PheAsn: 1.766 ± 0.018	1.561PhePro: 1.561 ± 0.016	1.218PheGln: 1.218 ± 0.014	1.779PheArg: 1.779 ± 0.019	2.649PheSer: 2.649 ± 0.023	2.119PheThr: 2.119 ± 0.023	2.373PheVal: 2.373 ± 0.024	0.417PheTrp: 0.417 ± 0.009	1.327PheTyr: 1.327 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.813GlyAla: 4.813 ± 0.045	1.101GlyCys: 1.101 ± 0.019	3.029GlyAsp: 3.029 ± 0.028	3.429GlyGlu: 3.429 ± 0.035	2.105GlyPhe: 2.105 ± 0.019	5.104GlyGly: 5.104 ± 0.08	1.486GlyHis: 1.486 ± 0.023	2.734GlyIle: 2.734 ± 0.024	3.089GlyLys: 3.089 ± 0.028	4.672GlyLeu: 4.672 ± 0.04	1.141GlyMet: 1.141 ± 0.015	2.377GlyAsn: 2.377 ± 0.023	2.622GlyPro: 2.622 ± 0.044	1.99GlyGln: 1.99 ± 0.03	3.465GlyArg: 3.465 ± 0.034	4.38GlySer: 4.38 ± 0.036	3.061GlyThr: 3.061 ± 0.027	3.912GlyVal: 3.912 ± 0.032	0.749GlyTrp: 0.749 ± 0.014	2.039GlyTyr: 2.039 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.871HisAla: 1.871 ± 0.023	0.589HisCys: 0.589 ± 0.011	1.212HisAsp: 1.212 ± 0.013	1.373HisGlu: 1.373 ± 0.015	0.953HisPhe: 0.953 ± 0.012	1.433HisGly: 1.433 ± 0.019	1.021HisHis: 1.021 ± 0.027	1.352HisIle: 1.352 ± 0.015	1.409HisLys: 1.409 ± 0.018	2.377HisLeu: 2.377 ± 0.02	0.64HisMet: 0.64 ± 0.012	1.18HisAsn: 1.18 ± 0.014	1.375HisPro: 1.375 ± 0.019	0.958HisGln: 0.958 ± 0.013	1.517HisArg: 1.517 ± 0.018	1.903HisSer: 1.903 ± 0.021	1.521HisThr: 1.521 ± 0.021	1.593HisVal: 1.593 ± 0.017	0.323HisTrp: 0.323 ± 0.007	0.937HisTyr: 0.937 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.433IleAla: 3.433 ± 0.025	1.146IleCys: 1.146 ± 0.016	3.105IleAsp: 3.105 ± 0.029	3.533IleGlu: 3.533 ± 0.032	2.016IlePhe: 2.016 ± 0.024	2.674IleGly: 2.674 ± 0.026	1.235IleHis: 1.235 ± 0.014	3.133IleIle: 3.133 ± 0.026	3.657IleLys: 3.657 ± 0.031	4.75IleLeu: 4.75 ± 0.037	1.135IleMet: 1.135 ± 0.013	2.814IleAsn: 2.814 ± 0.023	2.642IlePro: 2.642 ± 0.023	2.039IleGln: 2.039 ± 0.021	2.525IleArg: 2.525 ± 0.022	4.002IleSer: 4.002 ± 0.031	3.174IleThr: 3.174 ± 0.031	3.426IleVal: 3.426 ± 0.029	0.514IleTrp: 0.514 ± 0.01	1.711IleTyr: 1.711 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.352LysAla: 3.352 ± 0.025	1.185LysCys: 1.185 ± 0.017	3.457LysAsp: 3.457 ± 0.035	4.747LysGlu: 4.747 ± 0.042	2.022LysPhe: 2.022 ± 0.019	2.651LysGly: 2.651 ± 0.029	1.524LysHis: 1.524 ± 0.018	3.651LysIle: 3.651 ± 0.033	5.32LysLys: 5.32 ± 0.066	5.472LysLeu: 5.472 ± 0.037	1.492LysMet: 1.492 ± 0.016	3.218LysAsn: 3.218 ± 0.042	3.117LysPro: 3.117 ± 0.034	2.493LysGln: 2.493 ± 0.024	3.591LysArg: 3.591 ± 0.031	4.491LysSer: 4.491 ± 0.047	3.561LysThr: 3.561 ± 0.044	3.579LysVal: 3.579 ± 0.03	0.62LysTrp: 0.62 ± 0.01	2.209LysTyr: 2.209 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	7.027LeuAla: 7.027 ± 0.052	1.901LeuCys: 1.901 ± 0.02	4.851LeuAsp: 4.851 ± 0.036	5.827LeuGlu: 5.827 ± 0.045	3.073LeuPhe: 3.073 ± 0.029	4.62LeuGly: 4.62 ± 0.039	2.436LeuHis: 2.436 ± 0.024	4.171LeuIle: 4.171 ± 0.037	5.702LeuLys: 5.702 ± 0.04	8.998LeuLeu: 8.998 ± 0.067	1.977LeuMet: 1.977 ± 0.019	4.177LeuAsn: 4.177 ± 0.029	5.003LeuPro: 5.003 ± 0.036	4.221LeuGln: 4.221 ± 0.031	5.722LeuArg: 5.722 ± 0.042	6.876LeuSer: 6.876 ± 0.034	5.025LeuThr: 5.025 ± 0.031	5.43LeuVal: 5.43 ± 0.038	0.977LeuTrp: 0.977 ± 0.014	2.782LeuTyr: 2.782 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.658MetAla: 1.658 ± 0.017	0.446MetCys: 0.446 ± 0.008	1.238MetAsp: 1.238 ± 0.013	1.52MetGlu: 1.52 ± 0.016	0.896MetPhe: 0.896 ± 0.012	1.128MetGly: 1.128 ± 0.017	0.542MetHis: 0.542 ± 0.009	1.017MetIle: 1.017 ± 0.014	1.45MetLys: 1.45 ± 0.017	2.037MetLeu: 2.037 ± 0.023	0.607MetMet: 0.607 ± 0.01	1.037MetAsn: 1.037 ± 0.019	1.121MetPro: 1.121 ± 0.015	0.932MetGln: 0.932 ± 0.014	1.276MetArg: 1.276 ± 0.016	1.846MetSer: 1.846 ± 0.019	1.245MetThr: 1.245 ± 0.014	1.247MetVal: 1.247 ± 0.014	0.261MetTrp: 0.261 ± 0.006	0.719MetTyr: 0.719 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.766AsnAla: 2.766 ± 0.023	0.884AsnCys: 0.884 ± 0.014	2.627AsnAsp: 2.627 ± 0.026	3.217AsnGlu: 3.217 ± 0.03	1.802AsnPhe: 1.802 ± 0.018	2.761AsnGly: 2.761 ± 0.027	0.979AsnHis: 0.979 ± 0.013	3.37AsnIle: 3.37 ± 0.028	3.352AsnLys: 3.352 ± 0.034	4.151AsnLeu: 4.151 ± 0.034	1.192AsnMet: 1.192 ± 0.02	3.004AsnAsn: 3.004 ± 0.035	2.15AsnPro: 2.15 ± 0.022	1.654AsnGln: 1.654 ± 0.021	2.141AsnArg: 2.141 ± 0.019	3.5AsnSer: 3.5 ± 0.032	2.877AsnThr: 2.877 ± 0.034	3.224AsnVal: 3.224 ± 0.025	0.485AsnTrp: 0.485 ± 0.01	1.7AsnTyr: 1.7 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.598ProAla: 4.598 ± 0.047	0.865ProCys: 0.865 ± 0.02	2.853ProAsp: 2.853 ± 0.022	3.505ProGlu: 3.505 ± 0.03	1.644ProPhe: 1.644 ± 0.022	2.99ProGly: 2.99 ± 0.053	1.613ProHis: 1.613 ± 0.024	2.508ProIle: 2.508 ± 0.027	2.929ProLys: 2.929 ± 0.03	4.573ProLeu: 4.573 ± 0.035	0.998ProMet: 0.998 ± 0.015	2.246ProAsn: 2.246 ± 0.023	5.277ProPro: 5.277 ± 0.083	2.292ProGln: 2.292 ± 0.031	3.181ProArg: 3.181 ± 0.034	4.099ProSer: 4.099 ± 0.037	3.231ProThr: 3.231 ± 0.033	3.477ProVal: 3.477 ± 0.032	0.519ProTrp: 0.519 ± 0.009	1.67ProTyr: 1.67 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.509GlnAla: 2.509 ± 0.024	0.807GlnCys: 0.807 ± 0.013	1.773GlnAsp: 1.773 ± 0.017	2.491GlnGlu: 2.491 ± 0.028	1.294GlnPhe: 1.294 ± 0.016	1.758GlnGly: 1.758 ± 0.024	1.175GlnHis: 1.175 ± 0.017	2.077GlnIle: 2.077 ± 0.026	2.305GlnLys: 2.305 ± 0.022	3.754GlnLeu: 3.754 ± 0.034	0.983GlnMet: 0.983 ± 0.016	2.01GlnAsn: 2.01 ± 0.022	2.194GlnPro: 2.194 ± 0.029	2.196GlnGln: 2.196 ± 0.04	2.448GlnArg: 2.448 ± 0.024	2.664GlnSer: 2.664 ± 0.027	2.128GlnThr: 2.128 ± 0.023	2.198GlnVal: 2.198 ± 0.021	0.471GlnTrp: 0.471 ± 0.008	1.353GlnTyr: 1.353 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.705ArgAla: 4.705 ± 0.048	1.284ArgCys: 1.284 ± 0.019	3.162ArgAsp: 3.162 ± 0.036	3.582ArgGlu: 3.582 ± 0.032	1.833ArgPhe: 1.833 ± 0.016	3.368ArgGly: 3.368 ± 0.038	1.705ArgHis: 1.705 ± 0.018	2.651ArgIle: 2.651 ± 0.022	3.484ArgLys: 3.484 ± 0.027	5.419ArgLeu: 5.419 ± 0.039	1.17ArgMet: 1.17 ± 0.014	2.64ArgAsn: 2.64 ± 0.021	3.197ArgPro: 3.197 ± 0.03	2.247ArgGln: 2.247 ± 0.021	5.088ArgArg: 5.088 ± 0.047	4.29ArgSer: 4.29 ± 0.042	2.989ArgThr: 2.989 ± 0.023	3.421ArgVal: 3.421 ± 0.029	0.707ArgTrp: 0.707 ± 0.012	1.818ArgTyr: 1.818 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	5.229SerAla: 5.229 ± 0.038	1.47SerCys: 1.47 ± 0.019	4.378SerAsp: 4.378 ± 0.049	4.797SerGlu: 4.797 ± 0.039	2.505SerPhe: 2.505 ± 0.026	4.745SerGly: 4.745 ± 0.036	1.747SerHis: 1.747 ± 0.02	3.722SerIle: 3.722 ± 0.032	4.335SerLys: 4.335 ± 0.041	6.615SerLeu: 6.615 ± 0.033	1.557SerMet: 1.557 ± 0.015	3.64SerAsn: 3.64 ± 0.035	4.588SerPro: 4.588 ± 0.054	2.771SerGln: 2.771 ± 0.025	4.143SerArg: 4.143 ± 0.039	7.105SerSer: 7.105 ± 0.076	4.496SerThr: 4.496 ± 0.038	4.686SerVal: 4.686 ± 0.032	0.821SerTrp: 0.821 ± 0.013	2.24SerTyr: 2.24 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	3.969ThrAla: 3.969 ± 0.024	1.166ThrCys: 1.166 ± 0.018	3.044ThrAsp: 3.044 ± 0.031	3.696ThrGlu: 3.696 ± 0.039	2.103ThrPhe: 2.103 ± 0.018	3.111ThrGly: 3.111 ± 0.029	1.387ThrHis: 1.387 ± 0.018	3.112ThrIle: 3.112 ± 0.027	3.445ThrLys: 3.445 ± 0.049	5.201ThrLeu: 5.201 ± 0.036	1.246ThrMet: 1.246 ± 0.02	2.739ThrAsn: 2.739 ± 0.026	3.714ThrPro: 3.714 ± 0.035	2.098ThrGln: 2.098 ± 0.025	2.83ThrArg: 2.83 ± 0.024	4.71ThrSer: 4.71 ± 0.042	4.12ThrThr: 4.12 ± 0.08	3.79ThrVal: 3.79 ± 0.027	0.616ThrTrp: 0.616 ± 0.011	1.782ThrTyr: 1.782 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.656ValAla: 4.656 ± 0.032	1.499ValCys: 1.499 ± 0.019	3.399ValAsp: 3.399 ± 0.029	3.925ValGlu: 3.925 ± 0.033	2.334ValPhe: 2.334 ± 0.023	3.37ValGly: 3.37 ± 0.032	1.558ValHis: 1.558 ± 0.015	3.326ValIle: 3.326 ± 0.026	3.764ValLys: 3.764 ± 0.027	5.879ValLeu: 5.879 ± 0.041	1.376ValMet: 1.376 ± 0.016	2.878ValAsn: 2.878 ± 0.022	3.435ValPro: 3.435 ± 0.027	2.386ValGln: 2.386 ± 0.021	3.667ValArg: 3.667 ± 0.036	4.771ValSer: 4.771 ± 0.033	4.052ValThr: 4.052 ± 0.029	4.447ValVal: 4.447 ± 0.039	0.764ValTrp: 0.764 ± 0.012	1.984ValTyr: 1.984 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.737TrpAla: 0.737 ± 0.012	0.268TrpCys: 0.268 ± 0.007	0.608TrpAsp: 0.608 ± 0.01	0.627TrpGlu: 0.627 ± 0.01	0.419TrpPhe: 0.419 ± 0.008	0.658TrpGly: 0.658 ± 0.012	0.277TrpHis: 0.277 ± 0.007	0.555TrpIle: 0.555 ± 0.009	0.632TrpLys: 0.632 ± 0.011	1.145TrpLeu: 1.145 ± 0.015	0.287TrpMet: 0.287 ± 0.006	0.521TrpAsn: 0.521 ± 0.009	0.478TrpPro: 0.478 ± 0.009	0.445TrpGln: 0.445 ± 0.008	0.888TrpArg: 0.888 ± 0.012	0.848TrpSer: 0.848 ± 0.012	0.591TrpThr: 0.591 ± 0.011	0.633TrpVal: 0.633 ± 0.011	0.207TrpTrp: 0.207 ± 0.006	0.386TrpTyr: 0.386 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.905TyrAla: 1.905 ± 0.019	0.74TyrCys: 0.74 ± 0.012	1.854TyrAsp: 1.854 ± 0.017	2.001TyrGlu: 2.001 ± 0.02	1.336TyrPhe: 1.336 ± 0.015	1.994TyrGly: 1.994 ± 0.023	0.856TyrHis: 0.856 ± 0.012	1.786TyrIle: 1.786 ± 0.018	1.97TyrLys: 1.97 ± 0.018	2.908TyrLeu: 2.908 ± 0.024	0.755TyrMet: 0.755 ± 0.01	1.725TyrAsn: 1.725 ± 0.018	1.53TyrPro: 1.53 ± 0.02	1.213TyrGln: 1.213 ± 0.016	1.808TyrArg: 1.808 ± 0.017	2.349TyrSer: 2.349 ± 0.022	1.906TyrThr: 1.906 ± 0.025	2.018TyrVal: 2.018 ± 0.02	0.403TyrTrp: 0.403 ± 0.009	1.293TyrTyr: 1.293 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 15265 proteins (6989348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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