Amino acid dipepetide frequency for Halopiger salifodinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.197AlaAla: 14.197 ± 0.175	0.696AlaCys: 0.696 ± 0.026	10.969AlaAsp: 10.969 ± 0.13	8.552AlaGlu: 8.552 ± 0.113	3.861AlaPhe: 3.861 ± 0.067	9.462AlaGly: 9.462 ± 0.093	1.734AlaHis: 1.734 ± 0.039	5.575AlaIle: 5.575 ± 0.079	1.704AlaLys: 1.704 ± 0.041	10.105AlaLeu: 10.105 ± 0.113	2.137AlaMet: 2.137 ± 0.043	2.491AlaAsn: 2.491 ± 0.045	4.007AlaPro: 4.007 ± 0.06	2.084AlaGln: 2.084 ± 0.044	6.083AlaArg: 6.083 ± 0.082	5.312AlaSer: 5.312 ± 0.077	7.207AlaThr: 7.207 ± 0.098	10.428AlaVal: 10.428 ± 0.126	1.208AlaTrp: 1.208 ± 0.03	2.662AlaTyr: 2.662 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.598CysAla: 0.598 ± 0.023	0.104CysCys: 0.104 ± 0.01	0.606CysAsp: 0.606 ± 0.023	0.654CysGlu: 0.654 ± 0.025	0.192CysPhe: 0.192 ± 0.013	0.887CysGly: 0.887 ± 0.03	0.201CysHis: 0.201 ± 0.014	0.277CysIle: 0.277 ± 0.015	0.142CysLys: 0.142 ± 0.012	0.575CysLeu: 0.575 ± 0.022	0.111CysMet: 0.111 ± 0.011	0.193CysAsn: 0.193 ± 0.013	0.54CysPro: 0.54 ± 0.022	0.177CysGln: 0.177 ± 0.011	0.528CysArg: 0.528 ± 0.023	0.467CysSer: 0.467 ± 0.023	0.446CysThr: 0.446 ± 0.024	0.484CysVal: 0.484 ± 0.023	0.11CysTrp: 0.11 ± 0.008	0.254CysTyr: 0.254 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	10.629AspAla: 10.629 ± 0.123	0.696AspCys: 0.696 ± 0.027	8.577AspAsp: 8.577 ± 0.126	9.43AspGlu: 9.43 ± 0.123	1.958AspPhe: 1.958 ± 0.043	8.79AspGly: 8.79 ± 0.113	1.972AspHis: 1.972 ± 0.05	2.799AspIle: 2.799 ± 0.054	0.873AspLys: 0.873 ± 0.03	7.356AspLeu: 7.356 ± 0.088	1.22AspMet: 1.22 ± 0.035	1.292AspAsn: 1.292 ± 0.043	4.951AspPro: 4.951 ± 0.071	1.988AspGln: 1.988 ± 0.044	7.575AspArg: 7.575 ± 0.098	3.613AspSer: 3.613 ± 0.064	3.704AspThr: 3.704 ± 0.06	8.157AspVal: 8.157 ± 0.089	0.998AspTrp: 0.998 ± 0.033	1.987AspTyr: 1.987 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.344GluAla: 8.344 ± 0.104	0.573GluCys: 0.573 ± 0.027	6.286GluAsp: 6.286 ± 0.088	6.913GluGlu: 6.913 ± 0.102	3.076GluPhe: 3.076 ± 0.058	5.649GluGly: 5.649 ± 0.065	1.969GluHis: 1.969 ± 0.046	4.431GluIle: 4.431 ± 0.073	1.794GluLys: 1.794 ± 0.05	7.714GluLeu: 7.714 ± 0.102	1.754GluMet: 1.754 ± 0.038	2.57GluAsn: 2.57 ± 0.051	4.746GluPro: 4.746 ± 0.077	2.465GluGln: 2.465 ± 0.054	8.265GluArg: 8.265 ± 0.106	5.658GluSer: 5.658 ± 0.087	7.282GluThr: 7.282 ± 0.108	5.237GluVal: 5.237 ± 0.069	1.182GluTrp: 1.182 ± 0.037	2.993GluTyr: 2.993 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.681PheAla: 3.681 ± 0.059	0.288PheCys: 0.288 ± 0.016	3.39PheAsp: 3.39 ± 0.05	3.177PheGlu: 3.177 ± 0.057	1.028PhePhe: 1.028 ± 0.038	3.06PheGly: 3.06 ± 0.054	0.632PheHis: 0.632 ± 0.023	1.03PheIle: 1.03 ± 0.031	0.433PheLys: 0.433 ± 0.018	2.702PheLeu: 2.702 ± 0.055	0.488PheMet: 0.488 ± 0.02	0.699PheAsn: 0.699 ± 0.026	1.291PhePro: 1.291 ± 0.033	0.757PheGln: 0.757 ± 0.02	1.756PheArg: 1.756 ± 0.045	1.527PheSer: 1.527 ± 0.035	1.769PheThr: 1.769 ± 0.035	3.207PheVal: 3.207 ± 0.058	0.43PheTrp: 0.43 ± 0.018	0.842PheTyr: 0.842 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.188GlyAla: 8.188 ± 0.103	0.783GlyCys: 0.783 ± 0.027	7.396GlyAsp: 7.396 ± 0.095	7.073GlyGlu: 7.073 ± 0.085	2.985GlyPhe: 2.985 ± 0.051	7.167GlyGly: 7.167 ± 0.111	1.648GlyHis: 1.648 ± 0.036	4.408GlyIle: 4.408 ± 0.065	1.713GlyLys: 1.713 ± 0.036	7.515GlyLeu: 7.515 ± 0.103	1.659GlyMet: 1.659 ± 0.039	1.977GlyAsn: 1.977 ± 0.048	3.463GlyPro: 3.463 ± 0.06	2.056GlyGln: 2.056 ± 0.05	4.962GlyArg: 4.962 ± 0.07	5.028GlySer: 5.028 ± 0.071	5.963GlyThr: 5.963 ± 0.067	7.034GlyVal: 7.034 ± 0.083	1.062GlyTrp: 1.062 ± 0.033	2.695GlyTyr: 2.695 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.883HisAla: 1.883 ± 0.04	0.234HisCys: 0.234 ± 0.015	1.781HisAsp: 1.781 ± 0.042	1.689HisGlu: 1.689 ± 0.037	0.557HisPhe: 0.557 ± 0.021	1.929HisGly: 1.929 ± 0.044	0.492HisHis: 0.492 ± 0.023	0.648HisIle: 0.648 ± 0.025	0.296HisLys: 0.296 ± 0.017	1.666HisLeu: 1.666 ± 0.037	0.301HisMet: 0.301 ± 0.016	0.411HisAsn: 0.411 ± 0.021	1.211HisPro: 1.211 ± 0.033	0.481HisGln: 0.481 ± 0.017	1.269HisArg: 1.269 ± 0.032	0.835HisSer: 0.835 ± 0.029	0.991HisThr: 0.991 ± 0.028	1.872HisVal: 1.872 ± 0.044	0.226HisTrp: 0.226 ± 0.015	0.613HisTyr: 0.613 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.361IleAla: 5.361 ± 0.077	0.313IleCys: 0.313 ± 0.015	4.516IleAsp: 4.516 ± 0.061	4.643IleGlu: 4.643 ± 0.075	1.03IlePhe: 1.03 ± 0.036	4.266IleGly: 4.266 ± 0.07	0.806IleHis: 0.806 ± 0.024	1.378IleIle: 1.378 ± 0.041	0.666IleLys: 0.666 ± 0.025	3.006IleLeu: 3.006 ± 0.063	0.534IleMet: 0.534 ± 0.021	0.959IleAsn: 0.959 ± 0.033	2.142IlePro: 2.142 ± 0.041	1.001IleGln: 1.001 ± 0.032	2.592IleArg: 2.592 ± 0.052	2.166IleSer: 2.166 ± 0.046	2.455IleThr: 2.455 ± 0.044	4.168IleVal: 4.168 ± 0.067	0.362IleTrp: 0.362 ± 0.018	0.964IleTyr: 0.964 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	1.671LysAla: 1.671 ± 0.04	0.112LysCys: 0.112 ± 0.011	1.019LysAsp: 1.019 ± 0.029	1.265LysGlu: 1.265 ± 0.034	0.485LysPhe: 0.485 ± 0.021	1.236LysGly: 1.236 ± 0.034	0.441LysHis: 0.441 ± 0.021	0.768LysIle: 0.768 ± 0.028	0.448LysLys: 0.448 ± 0.023	1.568LysLeu: 1.568 ± 0.041	0.331LysMet: 0.331 ± 0.018	0.485LysAsn: 0.485 ± 0.021	0.888LysPro: 0.888 ± 0.03	0.598LysGln: 0.598 ± 0.023	1.514LysArg: 1.514 ± 0.039	1.07LysSer: 1.07 ± 0.03	1.176LysThr: 1.176 ± 0.034	1.054LysVal: 1.054 ± 0.033	0.2LysTrp: 0.2 ± 0.012	0.572LysTyr: 0.572 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	11.277LeuAla: 11.277 ± 0.134	0.632LeuCys: 0.632 ± 0.024	6.863LeuAsp: 6.863 ± 0.084	9.002LeuGlu: 9.002 ± 0.098	3.065LeuPhe: 3.065 ± 0.062	7.223LeuGly: 7.223 ± 0.091	1.416LeuHis: 1.416 ± 0.03	3.169LeuIle: 3.169 ± 0.057	1.369LeuLys: 1.369 ± 0.037	8.153LeuLeu: 8.153 ± 0.12	1.237LeuMet: 1.237 ± 0.035	1.662LeuAsn: 1.662 ± 0.04	4.057LeuPro: 4.057 ± 0.062	1.994LeuGln: 1.994 ± 0.042	5.092LeuArg: 5.092 ± 0.074	5.258LeuSer: 5.258 ± 0.066	4.982LeuThr: 4.982 ± 0.07	7.98LeuVal: 7.98 ± 0.116	0.861LeuTrp: 0.861 ± 0.028	2.15LeuTyr: 2.15 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.866MetAla: 1.866 ± 0.041	0.117MetCys: 0.117 ± 0.01	1.172MetAsp: 1.172 ± 0.035	1.047MetGlu: 1.047 ± 0.031	0.496MetPhe: 0.496 ± 0.022	1.402MetGly: 1.402 ± 0.036	0.327MetHis: 0.327 ± 0.015	0.739MetIle: 0.739 ± 0.025	0.396MetLys: 0.396 ± 0.018	1.45MetLeu: 1.45 ± 0.037	0.324MetMet: 0.324 ± 0.02	0.59MetAsn: 0.59 ± 0.021	0.796MetPro: 0.796 ± 0.026	0.48MetGln: 0.48 ± 0.022	1.06MetArg: 1.06 ± 0.03	1.475MetSer: 1.475 ± 0.033	1.57MetThr: 1.57 ± 0.036	1.232MetVal: 1.232 ± 0.033	0.167MetTrp: 0.167 ± 0.013	0.41MetTyr: 0.41 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.583AsnAla: 2.583 ± 0.047	0.248AsnCys: 0.248 ± 0.017	1.712AsnAsp: 1.712 ± 0.044	2.029AsnGlu: 2.029 ± 0.047	0.659AsnPhe: 0.659 ± 0.024	2.154AsnGly: 2.154 ± 0.045	0.49AsnHis: 0.49 ± 0.021	0.838AsnIle: 0.838 ± 0.029	0.43AsnLys: 0.43 ± 0.023	1.869AsnLeu: 1.869 ± 0.045	0.379AsnMet: 0.379 ± 0.018	0.559AsnAsn: 0.559 ± 0.027	1.52AsnPro: 1.52 ± 0.037	0.623AsnGln: 0.623 ± 0.022	1.684AsnArg: 1.684 ± 0.039	0.953AsnSer: 0.953 ± 0.03	1.197AsnThr: 1.197 ± 0.032	2.218AsnVal: 2.218 ± 0.049	0.33AsnTrp: 0.33 ± 0.017	0.661AsnTyr: 0.661 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.867ProAla: 4.867 ± 0.072	0.251ProCys: 0.251 ± 0.015	5.247ProAsp: 5.247 ± 0.068	4.49ProGlu: 4.49 ± 0.062	1.615ProPhe: 1.615 ± 0.039	3.881ProGly: 3.881 ± 0.059	0.911ProHis: 0.911 ± 0.026	2.296ProIle: 2.296 ± 0.042	0.813ProLys: 0.813 ± 0.025	3.773ProLeu: 3.773 ± 0.06	0.888ProMet: 0.888 ± 0.028	1.244ProAsn: 1.244 ± 0.035	2.194ProPro: 2.194 ± 0.047	0.958ProGln: 0.958 ± 0.028	2.323ProArg: 2.323 ± 0.044	2.773ProSer: 2.773 ± 0.052	3.217ProThr: 3.217 ± 0.055	3.961ProVal: 3.961 ± 0.059	0.554ProTrp: 0.554 ± 0.022	1.157ProTyr: 1.157 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.812GlnAla: 2.812 ± 0.047	0.172GlnCys: 0.172 ± 0.012	1.276GlnAsp: 1.276 ± 0.035	1.734GlnGlu: 1.734 ± 0.043	0.985GlnPhe: 0.985 ± 0.028	1.594GlnGly: 1.594 ± 0.042	0.496GlnHis: 0.496 ± 0.024	1.031GlnIle: 1.031 ± 0.027	0.513GlnLys: 0.513 ± 0.023	2.341GlnLeu: 2.341 ± 0.048	0.51GlnMet: 0.51 ± 0.024	0.679GlnAsn: 0.679 ± 0.025	1.107GlnPro: 1.107 ± 0.031	1.002GlnGln: 1.002 ± 0.047	1.99GlnArg: 1.99 ± 0.046	1.526GlnSer: 1.526 ± 0.043	1.44GlnThr: 1.44 ± 0.038	1.653GlnVal: 1.653 ± 0.04	0.361GlnTrp: 0.361 ± 0.016	0.77GlnTyr: 0.77 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.336ArgAla: 6.336 ± 0.083	0.517ArgCys: 0.517 ± 0.023	5.493ArgAsp: 5.493 ± 0.081	6.837ArgGlu: 6.837 ± 0.091	2.284ArgPhe: 2.284 ± 0.04	4.49ArgGly: 4.49 ± 0.071	1.138ArgHis: 1.138 ± 0.033	3.236ArgIle: 3.236 ± 0.056	1.319ArgLys: 1.319 ± 0.036	6.158ArgLeu: 6.158 ± 0.073	1.291ArgMet: 1.291 ± 0.036	1.608ArgAsn: 1.608 ± 0.041	2.774ArgPro: 2.774 ± 0.056	1.825ArgGln: 1.825 ± 0.041	5.193ArgArg: 5.193 ± 0.083	3.774ArgSer: 3.774 ± 0.064	4.312ArgThr: 4.312 ± 0.068	5.03ArgVal: 5.03 ± 0.073	0.788ArgTrp: 0.788 ± 0.028	2.069ArgTyr: 2.069 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.279SerAla: 5.279 ± 0.072	0.316SerCys: 0.316 ± 0.018	4.697SerAsp: 4.697 ± 0.067	4.52SerGlu: 4.52 ± 0.079	1.794SerPhe: 1.794 ± 0.033	5.131SerGly: 5.131 ± 0.079	1.029SerHis: 1.029 ± 0.032	2.706SerIle: 2.706 ± 0.05	1.087SerLys: 1.087 ± 0.034	4.785SerLeu: 4.785 ± 0.079	1.05SerMet: 1.05 ± 0.03	1.405SerAsn: 1.405 ± 0.04	2.539SerPro: 2.539 ± 0.053	1.339SerGln: 1.339 ± 0.036	3.156SerArg: 3.156 ± 0.051	3.136SerSer: 3.136 ± 0.061	3.392SerThr: 3.392 ± 0.06	4.623SerVal: 4.623 ± 0.072	0.6SerTrp: 0.6 ± 0.023	1.405SerTyr: 1.405 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.183ThrAla: 7.183 ± 0.09	0.413ThrCys: 0.413 ± 0.022	6.068ThrAsp: 6.068 ± 0.089	4.94ThrGlu: 4.94 ± 0.063	2.003ThrPhe: 2.003 ± 0.04	5.872ThrGly: 5.872 ± 0.081	1.153ThrHis: 1.153 ± 0.034	3.34ThrIle: 3.34 ± 0.059	0.965ThrLys: 0.965 ± 0.033	5.401ThrLeu: 5.401 ± 0.079	1.044ThrMet: 1.044 ± 0.03	1.508ThrAsn: 1.508 ± 0.04	3.071ThrPro: 3.071 ± 0.051	1.285ThrGln: 1.285 ± 0.037	3.163ThrArg: 3.163 ± 0.057	2.873ThrSer: 2.873 ± 0.044	3.997ThrThr: 3.997 ± 0.064	6.798ThrVal: 6.798 ± 0.088	0.649ThrTrp: 0.649 ± 0.024	1.632ThrTyr: 1.632 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.942ValAla: 9.942 ± 0.115	0.694ValCys: 0.694 ± 0.024	7.831ValAsp: 7.831 ± 0.094	7.371ValGlu: 7.371 ± 0.082	2.833ValPhe: 2.833 ± 0.059	7.376ValGly: 7.376 ± 0.095	1.621ValHis: 1.621 ± 0.039	3.351ValIle: 3.351 ± 0.058	1.256ValLys: 1.256 ± 0.033	7.623ValLeu: 7.623 ± 0.097	1.274ValMet: 1.274 ± 0.036	1.808ValAsn: 1.808 ± 0.043	4.339ValPro: 4.339 ± 0.06	1.774ValGln: 1.774 ± 0.041	5.421ValArg: 5.421 ± 0.087	4.772ValSer: 4.772 ± 0.056	6.04ValThr: 6.04 ± 0.079	8.139ValVal: 8.139 ± 0.107	0.799ValTrp: 0.799 ± 0.028	2.13ValTyr: 2.13 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.932TrpAla: 0.932 ± 0.03	0.097TrpCys: 0.097 ± 0.009	0.858TrpAsp: 0.858 ± 0.03	0.873TrpGlu: 0.873 ± 0.032	0.44TrpPhe: 0.44 ± 0.019	0.811TrpGly: 0.811 ± 0.024	0.256TrpHis: 0.256 ± 0.015	0.54TrpIle: 0.54 ± 0.019	0.284TrpLys: 0.284 ± 0.017	1.277TrpLeu: 1.277 ± 0.039	0.216TrpMet: 0.216 ± 0.013	0.391TrpAsn: 0.391 ± 0.021	0.48TrpPro: 0.48 ± 0.019	0.356TrpGln: 0.356 ± 0.018	0.869TrpArg: 0.869 ± 0.032	0.594TrpSer: 0.594 ± 0.03	0.789TrpThr: 0.789 ± 0.025	0.802TrpVal: 0.802 ± 0.027	0.199TrpTrp: 0.199 ± 0.014	0.368TrpTyr: 0.368 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.847TyrAla: 2.847 ± 0.046	0.286TyrCys: 0.286 ± 0.014	2.808TyrAsp: 2.808 ± 0.055	2.663TyrGlu: 2.663 ± 0.05	0.841TyrPhe: 0.841 ± 0.029	2.396TyrGly: 2.396 ± 0.048	0.652TyrHis: 0.652 ± 0.024	0.771TyrIle: 0.771 ± 0.026	0.401TyrLys: 0.401 ± 0.017	2.403TyrLeu: 2.403 ± 0.052	0.37TyrMet: 0.37 ± 0.017	0.605TyrAsn: 0.605 ± 0.023	1.296TyrPro: 1.296 ± 0.035	0.748TyrGln: 0.748 ± 0.027	1.978TyrArg: 1.978 ± 0.041	1.178TyrSer: 1.178 ± 0.03	1.43TyrThr: 1.43 ± 0.031	2.314TyrVal: 2.314 ± 0.047	0.349TyrTrp: 0.349 ± 0.019	0.866TyrTyr: 0.866 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4090 proteins (1200987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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