Amino acid dipepetide frequency for Aquila chrysaetos chrysaetos

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.396AlaAla: 7.396 ± 0.048	1.386AlaCys: 1.386 ± 0.013	3.103AlaAsp: 3.103 ± 0.015	5.107AlaGlu: 5.107 ± 0.03	2.489AlaPhe: 2.489 ± 0.014	4.803AlaGly: 4.803 ± 0.031	1.392AlaHis: 1.392 ± 0.01	2.895AlaIle: 2.895 ± 0.017	3.677AlaLys: 3.677 ± 0.021	6.805AlaLeu: 6.805 ± 0.028	1.541AlaMet: 1.541 ± 0.01	2.202AlaAsn: 2.202 ± 0.013	3.595AlaPro: 3.595 ± 0.025	2.96AlaGln: 2.96 ± 0.017	3.438AlaArg: 3.438 ± 0.018	5.511AlaSer: 5.511 ± 0.023	3.446AlaThr: 3.446 ± 0.019	4.977AlaVal: 4.977 ± 0.023	0.777AlaTrp: 0.777 ± 0.009	1.552AlaTyr: 1.552 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.237CysAla: 1.237 ± 0.012	0.636CysCys: 0.636 ± 0.009	1.056CysAsp: 1.056 ± 0.012	1.325CysGlu: 1.325 ± 0.016	0.875CysPhe: 0.875 ± 0.009	1.519CysGly: 1.519 ± 0.017	0.648CysHis: 0.648 ± 0.008	1.084CysIle: 1.084 ± 0.012	1.256CysLys: 1.256 ± 0.01	2.168CysLeu: 2.168 ± 0.014	0.455CysMet: 0.455 ± 0.005	0.873CysAsn: 0.873 ± 0.009	1.346CysPro: 1.346 ± 0.015	1.095CysGln: 1.095 ± 0.014	1.32CysArg: 1.32 ± 0.012	2.03CysSer: 2.03 ± 0.015	1.183CysThr: 1.183 ± 0.012	1.304CysVal: 1.304 ± 0.012	0.296CysTrp: 0.296 ± 0.005	0.634CysTyr: 0.634 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.054AspAla: 3.054 ± 0.017	1.102AspCys: 1.102 ± 0.012	2.793AspAsp: 2.793 ± 0.016	3.663AspGlu: 3.663 ± 0.023	2.152AspPhe: 2.152 ± 0.013	3.408AspGly: 3.408 ± 0.022	1.128AspHis: 1.128 ± 0.008	2.797AspIle: 2.797 ± 0.018	2.695AspLys: 2.695 ± 0.015	4.973AspLeu: 4.973 ± 0.02	1.165AspMet: 1.165 ± 0.011	1.893AspAsn: 1.893 ± 0.014	2.719AspPro: 2.719 ± 0.016	1.84AspGln: 1.84 ± 0.011	2.401AspArg: 2.401 ± 0.014	4.161AspSer: 4.161 ± 0.02	2.537AspThr: 2.537 ± 0.014	3.154AspVal: 3.154 ± 0.019	0.631AspTrp: 0.631 ± 0.007	1.586AspTyr: 1.586 ± 0.011	0.0AspXaa: 0.0 ± 0.0
Glu	4.926GluAla: 4.926 ± 0.027	1.317GluCys: 1.317 ± 0.018	4.517GluAsp: 4.517 ± 0.023	8.174GluGlu: 8.174 ± 0.048	2.066GluPhe: 2.066 ± 0.012	4.143GluGly: 4.143 ± 0.021	1.557GluHis: 1.557 ± 0.01	3.436GluIle: 3.436 ± 0.021	5.662GluLys: 5.662 ± 0.035	6.576GluLeu: 6.576 ± 0.034	1.783GluMet: 1.783 ± 0.012	3.32GluAsn: 3.32 ± 0.02	2.849GluPro: 2.849 ± 0.018	3.328GluGln: 3.328 ± 0.022	4.099GluArg: 4.099 ± 0.025	4.567GluSer: 4.567 ± 0.022	3.578GluThr: 3.578 ± 0.019	4.286GluVal: 4.286 ± 0.02	0.72GluTrp: 0.72 ± 0.007	1.77GluTyr: 1.77 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.103PheAla: 2.103 ± 0.012	0.923PheCys: 0.923 ± 0.008	1.729PheAsp: 1.729 ± 0.011	2.047PheGlu: 2.047 ± 0.012	1.659PhePhe: 1.659 ± 0.014	2.162PheGly: 2.162 ± 0.013	1.026PheHis: 1.026 ± 0.009	1.882PheIle: 1.882 ± 0.014	1.852PheLys: 1.852 ± 0.014	3.938PheLeu: 3.938 ± 0.024	0.763PheMet: 0.763 ± 0.007	1.397PheAsn: 1.397 ± 0.011	1.912PhePro: 1.912 ± 0.012	1.745PheGln: 1.745 ± 0.011	1.811PheArg: 1.811 ± 0.012	3.294PheSer: 3.294 ± 0.016	2.064PheThr: 2.064 ± 0.013	2.229PheVal: 2.229 ± 0.014	0.5PheTrp: 0.5 ± 0.007	1.198PheTyr: 1.198 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	4.184GlyAla: 4.184 ± 0.028	1.302GlyCys: 1.302 ± 0.012	3.127GlyAsp: 3.127 ± 0.017	4.032GlyGlu: 4.032 ± 0.02	2.339GlyPhe: 2.339 ± 0.015	5.03GlyGly: 5.03 ± 0.037	1.555GlyHis: 1.555 ± 0.012	2.863GlyIle: 2.863 ± 0.016	3.825GlyLys: 3.825 ± 0.021	5.248GlyLeu: 5.248 ± 0.025	1.361GlyMet: 1.361 ± 0.012	2.48GlyAsn: 2.48 ± 0.016	3.207GlyPro: 3.207 ± 0.037	2.643GlyGln: 2.643 ± 0.016	3.721GlyArg: 3.721 ± 0.022	5.535GlySer: 5.535 ± 0.026	3.668GlyThr: 3.668 ± 0.02	3.469GlyVal: 3.469 ± 0.021	0.835GlyTrp: 0.835 ± 0.011	1.836GlyTyr: 1.836 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	1.395HisAla: 1.395 ± 0.011	0.72HisCys: 0.72 ± 0.008	0.934HisAsp: 0.934 ± 0.008	1.372HisGlu: 1.372 ± 0.01	1.038HisPhe: 1.038 ± 0.009	1.528HisGly: 1.528 ± 0.011	0.89HisHis: 0.89 ± 0.01	1.272HisIle: 1.272 ± 0.011	1.302HisLys: 1.302 ± 0.01	2.721HisLeu: 2.721 ± 0.015	0.557HisMet: 0.557 ± 0.006	0.933HisAsn: 0.933 ± 0.009	1.594HisPro: 1.594 ± 0.013	1.226HisGln: 1.226 ± 0.01	1.545HisArg: 1.545 ± 0.012	2.154HisSer: 2.154 ± 0.013	1.29HisThr: 1.29 ± 0.01	1.512HisVal: 1.512 ± 0.011	0.326HisTrp: 0.326 ± 0.005	0.837HisTyr: 0.837 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.869IleAla: 2.869 ± 0.014	1.139IleCys: 1.139 ± 0.011	2.214IleAsp: 2.214 ± 0.015	2.772IleGlu: 2.772 ± 0.017	1.929IlePhe: 1.929 ± 0.015	2.326IleGly: 2.326 ± 0.015	1.288IleHis: 1.288 ± 0.01	2.517IleIle: 2.517 ± 0.016	2.869IleLys: 2.869 ± 0.015	4.606IleLeu: 4.606 ± 0.025	1.025IleMet: 1.025 ± 0.008	2.061IleAsn: 2.061 ± 0.012	2.683IlePro: 2.683 ± 0.014	2.407IleGln: 2.407 ± 0.015	2.422IleArg: 2.422 ± 0.013	3.91IleSer: 3.91 ± 0.019	2.75IleThr: 2.75 ± 0.015	2.702IleVal: 2.702 ± 0.016	0.526IleTrp: 0.526 ± 0.007	1.463IleTyr: 1.463 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.024LysAla: 4.024 ± 0.023	1.168LysCys: 1.168 ± 0.011	3.332LysAsp: 3.332 ± 0.019	5.468LysGlu: 5.468 ± 0.028	1.765LysPhe: 1.765 ± 0.013	3.263LysGly: 3.263 ± 0.024	1.514LysHis: 1.514 ± 0.012	2.984LysIle: 2.984 ± 0.018	5.041LysLys: 5.041 ± 0.028	5.521LysLeu: 5.521 ± 0.028	1.538LysMet: 1.538 ± 0.012	2.609LysAsn: 2.609 ± 0.015	3.052LysPro: 3.052 ± 0.019	2.903LysGln: 2.903 ± 0.018	3.406LysArg: 3.406 ± 0.019	4.139LysSer: 4.139 ± 0.02	3.277LysThr: 3.277 ± 0.017	3.624LysVal: 3.624 ± 0.02	0.649LysTrp: 0.649 ± 0.008	1.737LysTyr: 1.737 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	6.482LeuAla: 6.482 ± 0.027	2.207LeuCys: 2.207 ± 0.017	4.725LeuAsp: 4.725 ± 0.023	7.134LeuGlu: 7.134 ± 0.036	3.351LeuPhe: 3.351 ± 0.021	5.282LeuGly: 5.282 ± 0.028	2.721LeuHis: 2.721 ± 0.015	4.002LeuIle: 4.002 ± 0.022	6.119LeuLys: 6.119 ± 0.031	10.348LeuLeu: 10.348 ± 0.044	2.001LeuMet: 2.001 ± 0.012	3.713LeuAsn: 3.713 ± 0.017	5.619LeuPro: 5.619 ± 0.027	5.797LeuGln: 5.797 ± 0.032	5.55LeuArg: 5.55 ± 0.022	7.771LeuSer: 7.771 ± 0.027	4.9LeuThr: 4.9 ± 0.021	5.276LeuVal: 5.276 ± 0.024	1.091LeuTrp: 1.091 ± 0.009	2.634LeuTyr: 2.634 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	1.796MetAla: 1.796 ± 0.011	0.414MetCys: 0.414 ± 0.006	1.27MetAsp: 1.27 ± 0.009	1.922MetGlu: 1.922 ± 0.011	0.779MetPhe: 0.779 ± 0.007	1.251MetGly: 1.251 ± 0.01	0.509MetHis: 0.509 ± 0.006	0.895MetIle: 0.895 ± 0.009	1.553MetLys: 1.553 ± 0.01	2.022MetLeu: 2.022 ± 0.011	0.582MetMet: 0.582 ± 0.008	0.966MetAsn: 0.966 ± 0.01	1.085MetPro: 1.085 ± 0.011	1.046MetGln: 1.046 ± 0.01	1.042MetArg: 1.042 ± 0.009	1.585MetSer: 1.585 ± 0.011	1.101MetThr: 1.101 ± 0.008	1.396MetVal: 1.396 ± 0.012	0.247MetTrp: 0.247 ± 0.004	0.621MetTyr: 0.621 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.333AsnAla: 2.333 ± 0.011	0.925AsnCys: 0.925 ± 0.01	1.683AsnAsp: 1.683 ± 0.013	2.494AsnGlu: 2.494 ± 0.015	1.529AsnPhe: 1.529 ± 0.012	2.698AsnGly: 2.698 ± 0.019	0.944AsnHis: 0.944 ± 0.008	2.317AsnIle: 2.317 ± 0.014	2.463AsnLys: 2.463 ± 0.016	3.837AsnLeu: 3.837 ± 0.02	0.97AsnMet: 0.97 ± 0.008	1.728AsnAsn: 1.728 ± 0.014	2.162AsnPro: 2.162 ± 0.015	1.716AsnGln: 1.716 ± 0.012	1.94AsnArg: 1.94 ± 0.013	3.296AsnSer: 3.296 ± 0.016	2.141AsnThr: 2.141 ± 0.013	2.388AsnVal: 2.388 ± 0.014	0.471AsnTrp: 0.471 ± 0.005	1.206AsnTyr: 1.206 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	4.692ProAla: 4.692 ± 0.028	1.153ProCys: 1.153 ± 0.015	2.668ProAsp: 2.668 ± 0.018	3.985ProGlu: 3.985 ± 0.021	1.836ProPhe: 1.836 ± 0.013	4.328ProGly: 4.328 ± 0.042	1.346ProHis: 1.346 ± 0.009	1.887ProIle: 1.887 ± 0.013	2.699ProLys: 2.699 ± 0.023	4.894ProLeu: 4.894 ± 0.024	0.975ProMet: 0.975 ± 0.01	1.838ProAsn: 1.838 ± 0.012	5.514ProPro: 5.514 ± 0.049	2.515ProGln: 2.515 ± 0.018	3.007ProArg: 3.007 ± 0.021	5.215ProSer: 5.215 ± 0.028	2.77ProThr: 2.77 ± 0.017	3.796ProVal: 3.796 ± 0.018	0.617ProTrp: 0.617 ± 0.008	1.413ProTyr: 1.413 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.243GlnAla: 3.243 ± 0.017	0.98GlnCys: 0.98 ± 0.01	2.261GlnAsp: 2.261 ± 0.013	3.785GlnGlu: 3.785 ± 0.023	1.413GlnPhe: 1.413 ± 0.011	2.588GlnGly: 2.588 ± 0.016	1.345GlnHis: 1.345 ± 0.01	2.159GlnIle: 2.159 ± 0.015	3.096GlnLys: 3.096 ± 0.019	4.738GlnLeu: 4.738 ± 0.025	1.136GlnMet: 1.136 ± 0.009	1.996GlnAsn: 1.996 ± 0.015	2.594GlnPro: 2.594 ± 0.02	3.206GlnGln: 3.206 ± 0.033	2.825GlnArg: 2.825 ± 0.016	3.275GlnSer: 3.275 ± 0.018	2.345GlnThr: 2.345 ± 0.014	2.733GlnVal: 2.733 ± 0.016	0.564GlnTrp: 0.564 ± 0.006	1.271GlnTyr: 1.271 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	3.644ArgAla: 3.644 ± 0.019	1.269ArgCys: 1.269 ± 0.012	2.731ArgAsp: 2.731 ± 0.017	3.865ArgGlu: 3.865 ± 0.019	1.83ArgPhe: 1.83 ± 0.012	3.407ArgGly: 3.407 ± 0.026	1.483ArgHis: 1.483 ± 0.01	2.483ArgIle: 2.483 ± 0.013	3.642ArgLys: 3.642 ± 0.017	5.167ArgLeu: 5.167 ± 0.023	1.189ArgMet: 1.189 ± 0.009	2.178ArgAsn: 2.178 ± 0.012	2.845ArgPro: 2.845 ± 0.018	2.645ArgGln: 2.645 ± 0.017	4.313ArgArg: 4.313 ± 0.025	4.228ArgSer: 4.228 ± 0.027	2.755ArgThr: 2.755 ± 0.014	3.015ArgVal: 3.015 ± 0.016	0.703ArgTrp: 0.703 ± 0.007	1.547ArgTyr: 1.547 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	5.393SerAla: 5.393 ± 0.022	1.875SerCys: 1.875 ± 0.015	4.047SerAsp: 4.047 ± 0.027	5.213SerGlu: 5.213 ± 0.026	3.007SerPhe: 3.007 ± 0.015	5.236SerGly: 5.236 ± 0.025	2.001SerHis: 2.001 ± 0.013	3.439SerIle: 3.439 ± 0.018	4.322SerLys: 4.322 ± 0.021	7.936SerLeu: 7.936 ± 0.028	1.644SerMet: 1.644 ± 0.009	2.944SerAsn: 2.944 ± 0.016	5.729SerPro: 5.729 ± 0.034	3.697SerGln: 3.697 ± 0.02	4.295SerArg: 4.295 ± 0.021	9.272SerSer: 9.272 ± 0.054	4.538SerThr: 4.538 ± 0.021	5.043SerVal: 5.043 ± 0.021	1.005SerTrp: 1.005 ± 0.009	2.123SerTyr: 2.123 ± 0.011	0.0SerXaa: 0.0 ± 0.0
Thr	3.956ThrAla: 3.956 ± 0.021	1.35ThrCys: 1.35 ± 0.017	2.678ThrAsp: 2.678 ± 0.016	3.753ThrGlu: 3.753 ± 0.019	2.055ThrPhe: 2.055 ± 0.013	3.536ThrGly: 3.536 ± 0.022	1.202ThrHis: 1.202 ± 0.009	2.458ThrIle: 2.458 ± 0.015	2.774ThrLys: 2.774 ± 0.016	5.084ThrLeu: 5.084 ± 0.02	1.103ThrMet: 1.103 ± 0.009	1.861ThrAsn: 1.861 ± 0.011	3.287ThrPro: 3.287 ± 0.026	2.15ThrGln: 2.15 ± 0.013	2.365ThrArg: 2.365 ± 0.014	4.613ThrSer: 4.613 ± 0.023	2.994ThrThr: 2.994 ± 0.021	4.029ThrVal: 4.029 ± 0.024	0.668ThrTrp: 0.668 ± 0.008	1.463ThrTyr: 1.463 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	4.126ValAla: 4.126 ± 0.019	1.508ValCys: 1.508 ± 0.013	2.96ValAsp: 2.96 ± 0.02	3.98ValGlu: 3.98 ± 0.019	2.441ValPhe: 2.441 ± 0.016	3.301ValGly: 3.301 ± 0.018	1.511ValHis: 1.511 ± 0.01	2.993ValIle: 2.993 ± 0.02	3.68ValLys: 3.68 ± 0.022	6.201ValLeu: 6.201 ± 0.026	1.344ValMet: 1.344 ± 0.01	2.502ValAsn: 2.502 ± 0.015	3.616ValPro: 3.616 ± 0.019	2.82ValGln: 2.82 ± 0.016	3.045ValArg: 3.045 ± 0.017	4.984ValSer: 4.984 ± 0.021	3.813ValThr: 3.813 ± 0.019	4.033ValVal: 4.033 ± 0.023	0.707ValTrp: 0.707 ± 0.008	1.703ValTyr: 1.703 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	0.711TrpAla: 0.711 ± 0.009	0.251TrpCys: 0.251 ± 0.005	0.653TrpAsp: 0.653 ± 0.008	0.811TrpGlu: 0.811 ± 0.008	0.428TrpPhe: 0.428 ± 0.005	0.749TrpGly: 0.749 ± 0.011	0.312TrpHis: 0.312 ± 0.004	0.596TrpIle: 0.596 ± 0.007	0.807TrpLys: 0.807 ± 0.008	1.227TrpLeu: 1.227 ± 0.011	0.323TrpMet: 0.323 ± 0.005	0.541TrpAsn: 0.541 ± 0.007	0.476TrpPro: 0.476 ± 0.006	0.56TrpGln: 0.56 ± 0.005	0.702TrpArg: 0.702 ± 0.007	0.897TrpSer: 0.897 ± 0.009	0.637TrpThr: 0.637 ± 0.008	0.676TrpVal: 0.676 ± 0.008	0.198TrpTrp: 0.198 ± 0.004	0.355TrpTyr: 0.355 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.487TyrAla: 1.487 ± 0.011	0.719TyrCys: 0.719 ± 0.008	1.37TyrAsp: 1.37 ± 0.012	1.774TyrGlu: 1.774 ± 0.011	1.252TyrPhe: 1.252 ± 0.01	1.702TyrGly: 1.702 ± 0.013	0.773TyrHis: 0.773 ± 0.008	1.518TyrIle: 1.518 ± 0.011	1.676TyrLys: 1.676 ± 0.024	2.712TyrLeu: 2.712 ± 0.016	0.624TyrMet: 0.624 ± 0.006	1.207TyrAsn: 1.207 ± 0.01	1.267TyrPro: 1.267 ± 0.012	1.254TyrGln: 1.254 ± 0.009	1.692TyrArg: 1.692 ± 0.014	2.322TyrSer: 2.322 ± 0.015	1.592TyrThr: 1.592 ± 0.012	1.625TyrVal: 1.625 ± 0.011	0.381TyrTrp: 0.381 ± 0.007	0.995TyrTyr: 0.995 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 24817 proteins (16571618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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