Human papillomavirus 68

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 7

Average proteome isoelectric point is 6.68

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q7KYK8|Q7KYK8_HPV68 Protein E6 OS=Human papillomavirus 68 OX=45240 GN=E6 PE=2 SV=1
MM1 pKa = 7.64HH2 pKa = 7.27GPKK5 pKa = 8.88PTVQEE10 pKa = 4.31IVLEE14 pKa = 4.08LCPCNEE20 pKa = 4.31IEE22 pKa = 5.21PVDD25 pKa = 4.23LVCHH29 pKa = 5.58EE30 pKa = 4.3QLGDD34 pKa = 3.61SDD36 pKa = 5.81DD37 pKa = 5.31EE38 pKa = 4.66IDD40 pKa = 4.52EE41 pKa = 4.7PDD43 pKa = 3.48HH44 pKa = 6.87AVNHH48 pKa = 6.19HH49 pKa = 4.59QHH51 pKa = 5.46QLLARR56 pKa = 11.84RR57 pKa = 11.84DD58 pKa = 3.49EE59 pKa = 4.38QQRR62 pKa = 11.84HH63 pKa = 5.59TIQCTCCKK71 pKa = 10.19CNNLLQLVVEE81 pKa = 4.81ASRR84 pKa = 11.84EE85 pKa = 4.01NLRR88 pKa = 11.84KK89 pKa = 9.54LQLLFMDD96 pKa = 4.93SLNFVCPWCATEE108 pKa = 4.13TQQ110 pKa = 3.39

Molecular weight: 12.7 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|T2A701|T2A701_HPV68 Regulatory protein E2 OS=Human papillomavirus 68 OX=45240 GN=E2 PE=3 SV=1
MM1 pKa = 7.32IVLVFLVWFCVCMYY15 pKa = 9.99ICCTVPLLQSMHH27 pKa = 5.29VCVYY31 pKa = 8.54VWILVFVFILVRR43 pKa = 11.84TTPLEE48 pKa = 3.98VFAVYY53 pKa = 10.26ILFFLLPMWVLHH65 pKa = 5.52SFARR69 pKa = 11.84YY70 pKa = 9.51RR71 pKa = 11.84MPP73 pKa = 4.9

Molecular weight: 8.79 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2325

73

640

332.1

37.39

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.505 ± 0.458

3.14 ± 0.754

6.194 ± 0.815

4.516 ± 0.598

3.871 ± 0.596

5.505 ± 0.64

2.495 ± 0.404

5.29 ± 0.347

5.118 ± 0.824

7.828 ± 0.62

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.151 ± 0.408

4.645 ± 0.624

6.022 ± 1.206

4.086 ± 0.428

4.946 ± 0.568

7.226 ± 0.686

8.989 ± 1.172

6.71 ± 0.85

1.634 ± 0.417

4.129 ± 0.614
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski