Amino acid dipepetide frequency for Caenorhabditis remanei (Caenorhabditis vulgaris)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.71AlaAla: 4.71 ± 0.037	1.02AlaCys: 1.02 ± 0.01	2.899AlaAsp: 2.899 ± 0.017	3.98AlaGlu: 3.98 ± 0.034	2.531AlaPhe: 2.531 ± 0.017	2.967AlaGly: 2.967 ± 0.021	1.259AlaHis: 1.259 ± 0.01	3.649AlaIle: 3.649 ± 0.018	3.614AlaLys: 3.614 ± 0.023	5.008AlaLeu: 5.008 ± 0.026	1.528AlaMet: 1.528 ± 0.012	2.506AlaAsn: 2.506 ± 0.017	3.346AlaPro: 3.346 ± 0.045	2.295AlaGln: 2.295 ± 0.021	2.918AlaArg: 2.918 ± 0.022	4.328AlaSer: 4.328 ± 0.028	3.641AlaThr: 3.641 ± 0.02	4.035AlaVal: 4.035 ± 0.02	0.548AlaTrp: 0.548 ± 0.007	1.668AlaTyr: 1.668 ± 0.013	0.001AlaXaa: 0.001 ± 0.0
Cys	1.101CysAla: 1.101 ± 0.012	0.525CysCys: 0.525 ± 0.011	1.073CysAsp: 1.073 ± 0.016	1.197CysGlu: 1.197 ± 0.014	1.008CysPhe: 1.008 ± 0.009	1.237CysGly: 1.237 ± 0.014	0.5CysHis: 0.5 ± 0.008	1.148CysIle: 1.148 ± 0.013	1.065CysLys: 1.065 ± 0.012	1.761CysLeu: 1.761 ± 0.018	0.441CysMet: 0.441 ± 0.006	0.879CysAsn: 0.879 ± 0.009	1.041CysPro: 1.041 ± 0.016	0.827CysGln: 0.827 ± 0.011	1.08CysArg: 1.08 ± 0.012	1.69CysSer: 1.69 ± 0.017	1.042CysThr: 1.042 ± 0.012	1.221CysVal: 1.221 ± 0.015	0.222CysTrp: 0.222 ± 0.004	0.673CysTyr: 0.673 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.042AspAla: 3.042 ± 0.025	1.001AspCys: 1.001 ± 0.013	3.836AspAsp: 3.836 ± 0.029	4.507AspGlu: 4.507 ± 0.031	2.586AspPhe: 2.586 ± 0.017	3.352AspGly: 3.352 ± 0.053	1.144AspHis: 1.144 ± 0.011	3.172AspIle: 3.172 ± 0.016	2.834AspLys: 2.834 ± 0.019	4.427AspLeu: 4.427 ± 0.024	1.321AspMet: 1.321 ± 0.011	2.288AspAsn: 2.288 ± 0.015	2.289AspPro: 2.289 ± 0.018	1.919AspGln: 1.919 ± 0.015	2.572AspArg: 2.572 ± 0.019	4.079AspSer: 4.079 ± 0.022	2.544AspThr: 2.544 ± 0.015	3.624AspVal: 3.624 ± 0.019	0.663AspTrp: 0.663 ± 0.007	1.885AspTyr: 1.885 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	3.772GluAla: 3.772 ± 0.029	1.143GluCys: 1.143 ± 0.016	4.071GluAsp: 4.071 ± 0.025	6.862GluGlu: 6.862 ± 0.055	2.767GluPhe: 2.767 ± 0.015	2.683GluGly: 2.683 ± 0.02	1.475GluHis: 1.475 ± 0.014	4.407GluIle: 4.407 ± 0.023	6.267GluLys: 6.267 ± 0.041	5.443GluLeu: 5.443 ± 0.032	2.171GluMet: 2.171 ± 0.014	3.973GluAsn: 3.973 ± 0.02	2.466GluPro: 2.466 ± 0.025	2.718GluGln: 2.718 ± 0.041	3.518GluArg: 3.518 ± 0.023	4.547GluSer: 4.547 ± 0.036	4.01GluThr: 4.01 ± 0.044	3.917GluVal: 3.917 ± 0.025	0.781GluTrp: 0.781 ± 0.008	2.168GluTyr: 2.168 ± 0.015	0.001GluXaa: 0.001 ± 0.0
Phe	2.553PheAla: 2.553 ± 0.018	1.091PheCys: 1.091 ± 0.01	2.742PheAsp: 2.742 ± 0.018	2.998PheGlu: 2.998 ± 0.019	2.645PhePhe: 2.645 ± 0.02	2.818PheGly: 2.818 ± 0.018	1.186PheHis: 1.186 ± 0.01	2.922PheIle: 2.922 ± 0.018	2.542PheLys: 2.542 ± 0.018	4.645PheLeu: 4.645 ± 0.026	1.152PheMet: 1.152 ± 0.01	2.259PheAsn: 2.259 ± 0.014	2.095PhePro: 2.095 ± 0.014	2.011PheGln: 2.011 ± 0.014	2.336PheArg: 2.336 ± 0.018	3.873PheSer: 3.873 ± 0.023	2.427PheThr: 2.427 ± 0.015	3.077PheVal: 3.077 ± 0.021	0.608PheTrp: 0.608 ± 0.007	1.779PheTyr: 1.779 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	3.116GlyAla: 3.116 ± 0.026	1.068GlyCys: 1.068 ± 0.013	2.604GlyAsp: 2.604 ± 0.018	3.071GlyGlu: 3.071 ± 0.024	2.519GlyPhe: 2.519 ± 0.02	3.836GlyGly: 3.836 ± 0.049	1.2GlyHis: 1.2 ± 0.012	3.168GlyIle: 3.168 ± 0.017	3.363GlyLys: 3.363 ± 0.024	3.862GlyLeu: 3.862 ± 0.022	1.309GlyMet: 1.309 ± 0.012	2.628GlyAsn: 2.628 ± 0.026	2.118GlyPro: 2.118 ± 0.028	1.889GlyGln: 1.889 ± 0.02	2.713GlyArg: 2.713 ± 0.022	3.966GlySer: 3.966 ± 0.027	2.994GlyThr: 2.994 ± 0.023	3.292GlyVal: 3.292 ± 0.019	0.6GlyTrp: 0.6 ± 0.008	1.951GlyTyr: 1.951 ± 0.017	0.001GlyXaa: 0.001 ± 0.0
His	1.154HisAla: 1.154 ± 0.012	0.502HisCys: 0.502 ± 0.007	1.062HisAsp: 1.062 ± 0.01	1.291HisGlu: 1.291 ± 0.012	1.345HisPhe: 1.345 ± 0.012	1.237HisGly: 1.237 ± 0.011	0.855HisHis: 0.855 ± 0.015	1.361HisIle: 1.361 ± 0.012	1.144HisLys: 1.144 ± 0.011	2.246HisLeu: 2.246 ± 0.015	0.57HisMet: 0.57 ± 0.007	0.999HisAsn: 0.999 ± 0.009	1.218HisPro: 1.218 ± 0.011	1.088HisGln: 1.088 ± 0.011	1.393HisArg: 1.393 ± 0.011	1.783HisSer: 1.783 ± 0.012	1.063HisThr: 1.063 ± 0.009	1.522HisVal: 1.522 ± 0.015	0.326HisTrp: 0.326 ± 0.005	0.818HisTyr: 0.818 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.656IleAla: 3.656 ± 0.019	1.319IleCys: 1.319 ± 0.012	3.647IleAsp: 3.647 ± 0.019	4.176IleGlu: 4.176 ± 0.022	3.206IlePhe: 3.206 ± 0.021	3.344IleGly: 3.344 ± 0.019	1.526IleHis: 1.526 ± 0.012	3.785IleIle: 3.785 ± 0.022	3.27IleLys: 3.27 ± 0.02	5.733IleLeu: 5.733 ± 0.027	1.377IleMet: 1.377 ± 0.011	2.793IleAsn: 2.793 ± 0.017	3.337IlePro: 3.337 ± 0.018	2.608IleGln: 2.608 ± 0.017	3.452IleArg: 3.452 ± 0.017	4.964IleSer: 4.964 ± 0.026	3.334IleThr: 3.334 ± 0.02	4.013IleVal: 4.013 ± 0.023	0.7IleTrp: 0.7 ± 0.009	2.008IleTyr: 2.008 ± 0.017	0.001IleXaa: 0.001 ± 0.0
Lys	3.345LysAla: 3.345 ± 0.023	1.41LysCys: 1.41 ± 0.017	3.135LysAsp: 3.135 ± 0.02	4.998LysGlu: 4.998 ± 0.035	2.708LysPhe: 2.708 ± 0.017	2.436LysGly: 2.436 ± 0.017	1.363LysHis: 1.363 ± 0.012	4.133LysIle: 4.133 ± 0.025	6.404LysLys: 6.404 ± 0.047	5.787LysLeu: 5.787 ± 0.031	2.119LysMet: 2.119 ± 0.015	3.646LysAsn: 3.646 ± 0.018	2.709LysPro: 2.709 ± 0.026	2.439LysGln: 2.439 ± 0.017	3.84LysArg: 3.84 ± 0.021	4.831LysSer: 4.831 ± 0.024	4.172LysThr: 4.172 ± 0.021	3.645LysVal: 3.645 ± 0.021	0.85LysTrp: 0.85 ± 0.009	2.185LysTyr: 2.185 ± 0.014	0.001LysXaa: 0.001 ± 0.0
Leu	5.255LeuAla: 5.255 ± 0.023	1.65LeuCys: 1.65 ± 0.013	4.43LeuAsp: 4.43 ± 0.023	5.997LeuGlu: 5.997 ± 0.035	4.379LeuPhe: 4.379 ± 0.024	3.867LeuGly: 3.867 ± 0.022	2.057LeuHis: 2.057 ± 0.015	5.426LeuIle: 5.426 ± 0.025	6.269LeuLys: 6.269 ± 0.031	8.27LeuLeu: 8.27 ± 0.036	2.208LeuMet: 2.208 ± 0.015	4.314LeuAsn: 4.314 ± 0.024	4.347LeuPro: 4.347 ± 0.036	3.459LeuGln: 3.459 ± 0.021	4.661LeuArg: 4.661 ± 0.025	6.709LeuSer: 6.709 ± 0.026	4.766LeuThr: 4.766 ± 0.024	5.182LeuVal: 5.182 ± 0.023	0.86LeuTrp: 0.86 ± 0.009	2.502LeuTyr: 2.502 ± 0.017	0.001LeuXaa: 0.001 ± 0.0
Met	1.669MetAla: 1.669 ± 0.012	0.487MetCys: 0.487 ± 0.007	1.49MetAsp: 1.49 ± 0.013	1.941MetGlu: 1.941 ± 0.011	1.203MetPhe: 1.203 ± 0.011	1.129MetGly: 1.129 ± 0.012	0.535MetHis: 0.535 ± 0.007	1.66MetIle: 1.66 ± 0.011	2.037MetLys: 2.037 ± 0.015	2.068MetLeu: 2.068 ± 0.015	0.856MetMet: 0.856 ± 0.01	1.465MetAsn: 1.465 ± 0.012	1.117MetPro: 1.117 ± 0.011	0.909MetGln: 0.909 ± 0.008	1.416MetArg: 1.416 ± 0.011	2.237MetSer: 2.237 ± 0.015	1.685MetThr: 1.685 ± 0.012	1.439MetVal: 1.439 ± 0.011	0.251MetTrp: 0.251 ± 0.004	0.765MetTyr: 0.765 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.747AsnAla: 2.747 ± 0.015	1.043AsnCys: 1.043 ± 0.011	2.536AsnAsp: 2.536 ± 0.014	3.257AsnGlu: 3.257 ± 0.018	2.386AsnPhe: 2.386 ± 0.017	3.261AsnGly: 3.261 ± 0.022	1.149AsnHis: 1.149 ± 0.011	2.919AsnIle: 2.919 ± 0.015	2.666AsnLys: 2.666 ± 0.017	4.316AsnLeu: 4.316 ± 0.019	1.283AsnMet: 1.283 ± 0.012	2.58AsnAsn: 2.58 ± 0.019	2.336AsnPro: 2.336 ± 0.016	2.178AsnGln: 2.178 ± 0.017	2.632AsnArg: 2.632 ± 0.015	3.997AsnSer: 3.997 ± 0.022	2.552AsnThr: 2.552 ± 0.015	3.159AsnVal: 3.159 ± 0.019	0.629AsnTrp: 0.629 ± 0.008	1.762AsnTyr: 1.762 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	3.096ProAla: 3.096 ± 0.037	0.664ProCys: 0.664 ± 0.013	2.363ProAsp: 2.363 ± 0.031	3.263ProGlu: 3.263 ± 0.029	2.078ProPhe: 2.078 ± 0.015	2.54ProGly: 2.54 ± 0.036	1.003ProHis: 1.003 ± 0.011	3.074ProIle: 3.074 ± 0.02	2.89ProLys: 2.89 ± 0.023	3.803ProLeu: 3.803 ± 0.03	1.126ProMet: 1.126 ± 0.011	2.263ProAsn: 2.263 ± 0.014	3.906ProPro: 3.906 ± 0.044	1.921ProGln: 1.921 ± 0.02	2.365ProArg: 2.365 ± 0.02	4.199ProSer: 4.199 ± 0.028	3.323ProThr: 3.323 ± 0.04	3.214ProVal: 3.214 ± 0.056	0.424ProTrp: 0.424 ± 0.006	1.378ProTyr: 1.378 ± 0.01	0.001ProXaa: 0.001 ± 0.0
Gln	2.088GlnAla: 2.088 ± 0.027	0.837GlnCys: 0.837 ± 0.012	1.555GlnAsp: 1.555 ± 0.014	2.522GlnGlu: 2.522 ± 0.031	1.905GlnPhe: 1.905 ± 0.013	1.61GlnGly: 1.61 ± 0.017	0.985GlnHis: 0.985 ± 0.011	2.455GlnIle: 2.455 ± 0.014	3.112GlnLys: 3.112 ± 0.02	3.809GlnLeu: 3.809 ± 0.021	1.338GlnMet: 1.338 ± 0.013	2.276GlnAsn: 2.276 ± 0.017	1.942GlnPro: 1.942 ± 0.022	2.58GlnGln: 2.58 ± 0.048	2.179GlnArg: 2.179 ± 0.017	2.767GlnSer: 2.767 ± 0.019	2.165GlnThr: 2.165 ± 0.015	2.193GlnVal: 2.193 ± 0.014	0.486GlnTrp: 0.486 ± 0.007	1.314GlnTyr: 1.314 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	2.856ArgAla: 2.856 ± 0.018	0.994ArgCys: 0.994 ± 0.012	2.64ArgAsp: 2.64 ± 0.018	3.479ArgGlu: 3.479 ± 0.022	2.479ArgPhe: 2.479 ± 0.015	2.558ArgGly: 2.558 ± 0.022	1.341ArgHis: 1.341 ± 0.011	3.393ArgIle: 3.393 ± 0.018	4.131ArgLys: 4.131 ± 0.024	4.564ArgLeu: 4.564 ± 0.021	1.461ArgMet: 1.461 ± 0.011	2.935ArgAsn: 2.935 ± 0.018	2.305ArgPro: 2.305 ± 0.019	2.189ArgGln: 2.189 ± 0.014	4.137ArgArg: 4.137 ± 0.027	3.864ArgSer: 3.864 ± 0.028	2.768ArgThr: 2.768 ± 0.017	3.082ArgVal: 3.082 ± 0.02	0.561ArgTrp: 0.561 ± 0.007	1.633ArgTyr: 1.633 ± 0.011	0.001ArgXaa: 0.001 ± 0.0
Ser	4.588SerAla: 4.588 ± 0.023	1.452SerCys: 1.452 ± 0.017	4.293SerAsp: 4.293 ± 0.021	5.099SerGlu: 5.099 ± 0.032	3.657SerPhe: 3.657 ± 0.021	4.191SerGly: 4.191 ± 0.028	1.682SerHis: 1.682 ± 0.012	4.957SerIle: 4.957 ± 0.024	4.689SerLys: 4.689 ± 0.025	6.588SerLeu: 6.588 ± 0.032	1.901SerMet: 1.901 ± 0.013	3.817SerAsn: 3.817 ± 0.023	3.884SerPro: 3.884 ± 0.029	2.998SerGln: 2.998 ± 0.018	4.004SerArg: 4.004 ± 0.024	8.448SerSer: 8.448 ± 0.067	5.43SerThr: 5.43 ± 0.047	4.828SerVal: 4.828 ± 0.025	0.816SerTrp: 0.816 ± 0.009	2.284SerTyr: 2.284 ± 0.016	0.001SerXaa: 0.001 ± 0.0
Thr	3.568ThrAla: 3.568 ± 0.018	1.218ThrCys: 1.218 ± 0.015	2.918ThrAsp: 2.918 ± 0.043	3.603ThrGlu: 3.603 ± 0.042	2.683ThrPhe: 2.683 ± 0.016	2.984ThrGly: 2.984 ± 0.02	1.19ThrHis: 1.19 ± 0.009	3.902ThrIle: 3.902 ± 0.02	3.281ThrLys: 3.281 ± 0.018	4.771ThrLeu: 4.771 ± 0.019	1.413ThrMet: 1.413 ± 0.012	2.634ThrAsn: 2.634 ± 0.017	3.468ThrPro: 3.468 ± 0.036	1.948ThrGln: 1.948 ± 0.015	2.717ThrArg: 2.717 ± 0.017	5.233ThrSer: 5.233 ± 0.041	4.916ThrThr: 4.916 ± 0.07	4.2ThrVal: 4.2 ± 0.026	0.638ThrTrp: 0.638 ± 0.007	1.641ThrTyr: 1.641 ± 0.013	0.001ThrXaa: 0.001 ± 0.0
Val	3.877ValAla: 3.877 ± 0.02	1.276ValCys: 1.276 ± 0.012	3.487ValAsp: 3.487 ± 0.018	4.364ValGlu: 4.364 ± 0.026	3.291ValPhe: 3.291 ± 0.019	2.883ValGly: 2.883 ± 0.018	1.441ValHis: 1.441 ± 0.012	3.938ValIle: 3.938 ± 0.024	3.841ValLys: 3.841 ± 0.021	5.56ValLeu: 5.56 ± 0.027	1.578ValMet: 1.578 ± 0.013	2.838ValAsn: 2.838 ± 0.016	3.115ValPro: 3.115 ± 0.03	2.349ValGln: 2.349 ± 0.025	3.02ValArg: 3.02 ± 0.019	4.757ValSer: 4.757 ± 0.018	3.755ValThr: 3.755 ± 0.028	4.31ValVal: 4.31 ± 0.022	0.692ValTrp: 0.692 ± 0.008	2.044ValTyr: 2.044 ± 0.013	0.001ValXaa: 0.001 ± 0.0
Trp	0.567TrpAla: 0.567 ± 0.007	0.223TrpCys: 0.223 ± 0.005	0.542TrpAsp: 0.542 ± 0.007	0.604TrpGlu: 0.604 ± 0.008	0.573TrpPhe: 0.573 ± 0.007	0.43TrpGly: 0.43 ± 0.007	0.235TrpHis: 0.235 ± 0.004	0.884TrpIle: 0.884 ± 0.009	1.003TrpLys: 1.003 ± 0.011	0.983TrpLeu: 0.983 ± 0.009	0.389TrpMet: 0.389 ± 0.006	0.753TrpAsn: 0.753 ± 0.008	0.42TrpPro: 0.42 ± 0.007	0.415TrpGln: 0.415 ± 0.007	0.647TrpArg: 0.647 ± 0.008	0.815TrpSer: 0.815 ± 0.009	0.689TrpThr: 0.689 ± 0.008	0.573TrpVal: 0.573 ± 0.008	0.153TrpTrp: 0.153 ± 0.004	0.369TrpTyr: 0.369 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.689TyrAla: 1.689 ± 0.012	0.811TyrCys: 0.811 ± 0.009	1.76TyrAsp: 1.76 ± 0.012	1.948TyrGlu: 1.948 ± 0.014	1.808TyrPhe: 1.808 ± 0.016	1.908TyrGly: 1.908 ± 0.014	0.852TyrHis: 0.852 ± 0.009	1.894TyrIle: 1.894 ± 0.015	1.735TyrLys: 1.735 ± 0.013	2.965TyrLeu: 2.965 ± 0.02	0.817TyrMet: 0.817 ± 0.009	1.544TyrAsn: 1.544 ± 0.012	1.436TyrPro: 1.436 ± 0.018	1.379TyrGln: 1.379 ± 0.012	1.773TyrArg: 1.773 ± 0.014	2.518TyrSer: 2.518 ± 0.018	1.648TyrThr: 1.648 ± 0.013	1.89TyrVal: 1.89 ± 0.014	0.453TyrTrp: 0.453 ± 0.007	1.288TyrTyr: 1.288 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.085XaaXaa: 0.085 ± 0.034

Statistics based on 31252 proteins (12547433 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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