Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-4518 (FW-2643)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.98AlaAla: 9.98 ± 0.064	1.082AlaCys: 1.082 ± 0.015	4.465AlaAsp: 4.465 ± 0.031	5.41AlaGlu: 5.41 ± 0.041	3.128AlaPhe: 3.128 ± 0.024	6.147AlaGly: 6.147 ± 0.037	1.748AlaHis: 1.748 ± 0.021	4.616AlaIle: 4.616 ± 0.036	4.365AlaLys: 4.365 ± 0.037	7.915AlaLeu: 7.915 ± 0.043	2.007AlaMet: 2.007 ± 0.019	3.114AlaAsn: 3.114 ± 0.024	5.122AlaPro: 5.122 ± 0.046	3.421AlaGln: 3.421 ± 0.032	4.827AlaArg: 4.827 ± 0.037	7.249AlaSer: 7.249 ± 0.042	5.638AlaThr: 5.638 ± 0.034	5.659AlaVal: 5.659 ± 0.039	1.137AlaTrp: 1.137 ± 0.017	2.23AlaTyr: 2.23 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.983CysAla: 0.983 ± 0.015	0.246CysCys: 0.246 ± 0.007	0.668CysAsp: 0.668 ± 0.013	0.607CysGlu: 0.607 ± 0.01	0.521CysPhe: 0.521 ± 0.01	1.011CysGly: 1.011 ± 0.017	0.32CysHis: 0.32 ± 0.009	0.716CysIle: 0.716 ± 0.011	0.517CysLys: 0.517 ± 0.011	1.195CysLeu: 1.195 ± 0.015	0.264CysMet: 0.264 ± 0.007	0.448CysAsn: 0.448 ± 0.01	0.631CysPro: 0.631 ± 0.013	0.432CysGln: 0.432 ± 0.009	0.693CysArg: 0.693 ± 0.013	0.913CysSer: 0.913 ± 0.014	0.701CysThr: 0.701 ± 0.011	0.772CysVal: 0.772 ± 0.012	0.203CysTrp: 0.203 ± 0.007	0.362CysTyr: 0.362 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.886AspAla: 4.886 ± 0.029	0.625AspCys: 0.625 ± 0.01	4.063AspAsp: 4.063 ± 0.042	4.451AspGlu: 4.451 ± 0.04	2.2AspPhe: 2.2 ± 0.023	4.313AspGly: 4.313 ± 0.031	1.125AspHis: 1.125 ± 0.014	3.228AspIle: 3.228 ± 0.026	2.423AspLys: 2.423 ± 0.023	4.901AspLeu: 4.901 ± 0.031	1.227AspMet: 1.227 ± 0.015	1.994AspAsn: 1.994 ± 0.02	3.057AspPro: 3.057 ± 0.024	1.723AspGln: 1.723 ± 0.018	2.892AspArg: 2.892 ± 0.026	4.099AspSer: 4.099 ± 0.031	3.006AspThr: 3.006 ± 0.021	3.775AspVal: 3.775 ± 0.03	0.875AspTrp: 0.875 ± 0.012	1.593AspTyr: 1.593 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.78GluAla: 5.78 ± 0.045	0.627GluCys: 0.627 ± 0.011	4.196GluAsp: 4.196 ± 0.04	5.637GluGlu: 5.637 ± 0.064	1.966GluPhe: 1.966 ± 0.018	4.325GluGly: 4.325 ± 0.033	1.283GluHis: 1.283 ± 0.017	3.18GluIle: 3.18 ± 0.024	3.632GluLys: 3.632 ± 0.033	5.189GluLeu: 5.189 ± 0.041	1.5GluMet: 1.5 ± 0.016	2.27GluAsn: 2.27 ± 0.022	2.688GluPro: 2.688 ± 0.033	2.31GluGln: 2.31 ± 0.026	3.957GluArg: 3.957 ± 0.038	4.273GluSer: 4.273 ± 0.032	3.469GluThr: 3.469 ± 0.027	3.877GluVal: 3.877 ± 0.03	0.891GluTrp: 0.891 ± 0.013	1.705GluTyr: 1.705 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.067PheAla: 3.067 ± 0.028	0.548PheCys: 0.548 ± 0.009	2.217PheAsp: 2.217 ± 0.021	2.143PheGlu: 2.143 ± 0.02	1.542PhePhe: 1.542 ± 0.02	2.877PheGly: 2.877 ± 0.023	0.807PheHis: 0.807 ± 0.012	1.862PheIle: 1.862 ± 0.02	1.573PheLys: 1.573 ± 0.02	3.283PheLeu: 3.283 ± 0.028	0.783PheMet: 0.783 ± 0.013	1.433PheAsn: 1.433 ± 0.018	1.886PhePro: 1.886 ± 0.018	1.364PheGln: 1.364 ± 0.015	1.815PheArg: 1.815 ± 0.017	2.9PheSer: 2.9 ± 0.027	2.151PheThr: 2.151 ± 0.021	2.358PheVal: 2.358 ± 0.023	0.619PheTrp: 0.619 ± 0.011	1.089PheTyr: 1.089 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.937GlyAla: 5.937 ± 0.04	0.937GlyCys: 0.937 ± 0.015	3.869GlyAsp: 3.869 ± 0.032	4.154GlyGlu: 4.154 ± 0.034	2.854GlyPhe: 2.854 ± 0.028	6.797GlyGly: 6.797 ± 0.067	1.711GlyHis: 1.711 ± 0.023	3.756GlyIle: 3.756 ± 0.026	3.766GlyLys: 3.766 ± 0.028	6.173GlyLeu: 6.173 ± 0.037	1.661GlyMet: 1.661 ± 0.018	2.694GlyAsn: 2.694 ± 0.028	3.325GlyPro: 3.325 ± 0.029	2.57GlyGln: 2.57 ± 0.029	4.204GlyArg: 4.204 ± 0.034	5.764GlySer: 5.764 ± 0.042	4.138GlyThr: 4.138 ± 0.033	4.715GlyVal: 4.715 ± 0.034	1.206GlyTrp: 1.206 ± 0.014	2.164GlyTyr: 2.164 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.754HisAla: 1.754 ± 0.018	0.305HisCys: 0.305 ± 0.008	1.236HisAsp: 1.236 ± 0.017	1.267HisGlu: 1.267 ± 0.018	0.876HisPhe: 0.876 ± 0.015	1.673HisGly: 1.673 ± 0.018	0.736HisHis: 0.736 ± 0.013	1.254HisIle: 1.254 ± 0.014	0.904HisLys: 0.904 ± 0.014	2.108HisLeu: 2.108 ± 0.021	0.444HisMet: 0.444 ± 0.009	0.856HisAsn: 0.856 ± 0.014	1.536HisPro: 1.536 ± 0.016	0.9HisGln: 0.9 ± 0.012	1.384HisArg: 1.384 ± 0.017	1.729HisSer: 1.729 ± 0.021	1.268HisThr: 1.268 ± 0.014	1.353HisVal: 1.353 ± 0.015	0.327HisTrp: 0.327 ± 0.009	0.682HisTyr: 0.682 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.465IleAla: 4.465 ± 0.03	0.774IleCys: 0.774 ± 0.012	2.985IleAsp: 2.985 ± 0.026	3.027IleGlu: 3.027 ± 0.024	2.04IlePhe: 2.04 ± 0.024	3.446IleGly: 3.446 ± 0.028	1.164IleHis: 1.164 ± 0.014	2.783IleIle: 2.783 ± 0.025	2.336IleLys: 2.336 ± 0.021	4.64IleLeu: 4.64 ± 0.034	1.072IleMet: 1.072 ± 0.014	1.936IleAsn: 1.936 ± 0.018	3.092IlePro: 3.092 ± 0.018	1.923IleGln: 1.923 ± 0.017	2.75IleArg: 2.75 ± 0.024	4.053IleSer: 4.053 ± 0.027	3.091IleThr: 3.091 ± 0.028	3.291IleVal: 3.291 ± 0.027	0.733IleTrp: 0.733 ± 0.012	1.503IleTyr: 1.503 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.508LysAla: 4.508 ± 0.042	0.524LysCys: 0.524 ± 0.011	2.795LysAsp: 2.795 ± 0.024	3.512LysGlu: 3.512 ± 0.037	1.511LysPhe: 1.511 ± 0.016	3.225LysGly: 3.225 ± 0.03	1.103LysHis: 1.103 ± 0.014	2.376LysIle: 2.376 ± 0.023	3.265LysLys: 3.265 ± 0.049	4.222LysLeu: 4.222 ± 0.032	1.02LysMet: 1.02 ± 0.014	1.789LysAsn: 1.789 ± 0.018	2.664LysPro: 2.664 ± 0.027	1.732LysGln: 1.732 ± 0.02	3.281LysArg: 3.281 ± 0.029	3.635LysSer: 3.635 ± 0.026	2.876LysThr: 2.876 ± 0.025	2.935LysVal: 2.935 ± 0.029	0.682LysTrp: 0.682 ± 0.012	1.425LysTyr: 1.425 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.886LeuAla: 7.886 ± 0.042	1.185LeuCys: 1.185 ± 0.015	5.075LeuAsp: 5.075 ± 0.037	5.535LeuGlu: 5.535 ± 0.039	3.182LeuPhe: 3.182 ± 0.03	6.051LeuGly: 6.051 ± 0.044	2.121LeuHis: 2.121 ± 0.021	3.991LeuIle: 3.991 ± 0.032	4.285LeuLys: 4.285 ± 0.035	8.411LeuLeu: 8.411 ± 0.06	1.695LeuMet: 1.695 ± 0.016	3.13LeuAsn: 3.13 ± 0.024	5.39LeuPro: 5.39 ± 0.034	3.781LeuGln: 3.781 ± 0.031	5.461LeuArg: 5.461 ± 0.042	7.22LeuSer: 7.22 ± 0.04	4.813LeuThr: 4.813 ± 0.031	5.307LeuVal: 5.307 ± 0.04	1.185LeuTrp: 1.185 ± 0.017	2.334LeuTyr: 2.334 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.205MetAla: 2.205 ± 0.02	0.225MetCys: 0.225 ± 0.006	1.257MetAsp: 1.257 ± 0.015	1.308MetGlu: 1.308 ± 0.017	0.741MetPhe: 0.741 ± 0.013	1.553MetGly: 1.553 ± 0.018	0.475MetHis: 0.475 ± 0.009	0.98MetIle: 0.98 ± 0.015	1.028MetLys: 1.028 ± 0.013	1.79MetLeu: 1.79 ± 0.018	0.561MetMet: 0.561 ± 0.011	0.766MetAsn: 0.766 ± 0.012	1.188MetPro: 1.188 ± 0.016	0.813MetGln: 0.813 ± 0.013	1.245MetArg: 1.245 ± 0.013	1.833MetSer: 1.833 ± 0.019	1.209MetThr: 1.209 ± 0.014	1.329MetVal: 1.329 ± 0.014	0.255MetTrp: 0.255 ± 0.007	0.511MetTyr: 0.511 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.257AsnAla: 3.257 ± 0.03	0.478AsnCys: 0.478 ± 0.011	1.956AsnAsp: 1.956 ± 0.02	2.073AsnGlu: 2.073 ± 0.016	1.407AsnPhe: 1.407 ± 0.016	3.175AsnGly: 3.175 ± 0.03	0.801AsnHis: 0.801 ± 0.012	2.209AsnIle: 2.209 ± 0.021	1.577AsnLys: 1.577 ± 0.018	3.244AsnLeu: 3.244 ± 0.023	0.835AsnMet: 0.835 ± 0.014	1.572AsnAsn: 1.572 ± 0.022	2.437AsnPro: 2.437 ± 0.022	1.295AsnGln: 1.295 ± 0.017	1.914AsnArg: 1.914 ± 0.02	2.917AsnSer: 2.917 ± 0.026	2.263AsnThr: 2.263 ± 0.022	2.307AsnVal: 2.307 ± 0.023	0.564AsnTrp: 0.564 ± 0.01	1.096AsnTyr: 1.096 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.225ProAla: 5.225 ± 0.044	0.498ProCys: 0.498 ± 0.009	2.975ProAsp: 2.975 ± 0.025	3.636ProGlu: 3.636 ± 0.031	1.931ProPhe: 1.931 ± 0.021	3.836ProGly: 3.836 ± 0.03	1.287ProHis: 1.287 ± 0.016	2.642ProIle: 2.642 ± 0.023	2.719ProLys: 2.719 ± 0.027	4.758ProLeu: 4.758 ± 0.032	1.015ProMet: 1.015 ± 0.017	2.236ProAsn: 2.236 ± 0.021	4.935ProPro: 4.935 ± 0.064	2.402ProGln: 2.402 ± 0.032	3.269ProArg: 3.269 ± 0.031	5.695ProSer: 5.695 ± 0.046	4.219ProThr: 4.219 ± 0.037	3.422ProVal: 3.422 ± 0.029	0.726ProTrp: 0.726 ± 0.013	1.468ProTyr: 1.468 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.346GlnAla: 3.346 ± 0.029	0.413GlnCys: 0.413 ± 0.008	1.939GlnAsp: 1.939 ± 0.02	2.304GlnGlu: 2.304 ± 0.023	1.251GlnPhe: 1.251 ± 0.015	2.52GlnGly: 2.52 ± 0.026	0.998GlnHis: 0.998 ± 0.017	1.871GlnIle: 1.871 ± 0.019	1.901GlnLys: 1.901 ± 0.021	3.405GlnLeu: 3.405 ± 0.028	0.81GlnMet: 0.81 ± 0.013	1.545GlnAsn: 1.545 ± 0.021	2.389GlnPro: 2.389 ± 0.038	2.342GlnGln: 2.342 ± 0.057	2.499GlnArg: 2.499 ± 0.022	2.942GlnSer: 2.942 ± 0.03	2.251GlnThr: 2.251 ± 0.022	2.081GlnVal: 2.081 ± 0.022	0.567GlnTrp: 0.567 ± 0.012	1.171GlnTyr: 1.171 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.738ArgAla: 4.738 ± 0.035	0.693ArgCys: 0.693 ± 0.013	3.314ArgAsp: 3.314 ± 0.03	3.811ArgGlu: 3.811 ± 0.037	1.941ArgPhe: 1.941 ± 0.02	3.927ArgGly: 3.927 ± 0.032	1.48ArgHis: 1.48 ± 0.017	2.872ArgIle: 2.872 ± 0.026	3.286ArgLys: 3.286 ± 0.029	5.096ArgLeu: 5.096 ± 0.034	1.218ArgMet: 1.218 ± 0.016	2.192ArgAsn: 2.192 ± 0.021	3.257ArgPro: 3.257 ± 0.03	2.462ArgGln: 2.462 ± 0.023	4.81ArgArg: 4.81 ± 0.048	4.451ArgSer: 4.451 ± 0.037	3.18ArgThr: 3.18 ± 0.03	3.298ArgVal: 3.298 ± 0.026	0.851ArgTrp: 0.851 ± 0.013	1.552ArgTyr: 1.552 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.67SerAla: 6.67 ± 0.037	0.883SerCys: 0.883 ± 0.014	4.192SerAsp: 4.192 ± 0.032	4.137SerGlu: 4.137 ± 0.032	2.923SerPhe: 2.923 ± 0.023	5.699SerGly: 5.699 ± 0.042	1.825SerHis: 1.825 ± 0.019	4.211SerIle: 4.211 ± 0.029	3.8SerLys: 3.8 ± 0.033	7.065SerLeu: 7.065 ± 0.041	1.647SerMet: 1.647 ± 0.018	3.091SerAsn: 3.091 ± 0.029	5.349SerPro: 5.349 ± 0.052	3.146SerGln: 3.146 ± 0.027	4.714SerArg: 4.714 ± 0.04	8.092SerSer: 8.092 ± 0.064	5.625SerThr: 5.625 ± 0.041	4.508SerVal: 4.508 ± 0.031	1.097SerTrp: 1.097 ± 0.014	2.099SerTyr: 2.099 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.5ThrAla: 5.5 ± 0.032	0.76ThrCys: 0.76 ± 0.014	2.891ThrAsp: 2.891 ± 0.024	3.19ThrGlu: 3.19 ± 0.028	2.241ThrPhe: 2.241 ± 0.018	4.282ThrGly: 4.282 ± 0.029	1.274ThrHis: 1.274 ± 0.014	3.303ThrIle: 3.303 ± 0.024	2.731ThrLys: 2.731 ± 0.021	5.246ThrLeu: 5.246 ± 0.032	1.231ThrMet: 1.231 ± 0.015	2.218ThrAsn: 2.218 ± 0.022	4.431ThrPro: 4.431 ± 0.034	2.067ThrGln: 2.067 ± 0.024	3.007ThrArg: 3.007 ± 0.026	5.386ThrSer: 5.386 ± 0.036	4.586ThrThr: 4.586 ± 0.039	3.76ThrVal: 3.76 ± 0.028	0.874ThrTrp: 0.874 ± 0.012	1.676ThrTyr: 1.676 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.682ValAla: 5.682 ± 0.038	0.781ValCys: 0.781 ± 0.012	3.817ValAsp: 3.817 ± 0.026	4.155ValGlu: 4.155 ± 0.038	2.368ValPhe: 2.368 ± 0.024	4.371ValGly: 4.371 ± 0.03	1.293ValHis: 1.293 ± 0.016	3.042ValIle: 3.042 ± 0.026	3.006ValLys: 3.006 ± 0.026	5.535ValLeu: 5.535 ± 0.037	1.329ValMet: 1.329 ± 0.014	2.254ValAsn: 2.254 ± 0.024	3.465ValPro: 3.465 ± 0.028	2.273ValGln: 2.273 ± 0.022	3.258ValArg: 3.258 ± 0.024	4.475ValSer: 4.475 ± 0.031	3.609ValThr: 3.609 ± 0.028	4.558ValVal: 4.558 ± 0.036	0.856ValTrp: 0.856 ± 0.011	1.689ValTyr: 1.689 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.204TrpAla: 1.204 ± 0.016	0.193TrpCys: 0.193 ± 0.006	0.897TrpAsp: 0.897 ± 0.014	0.864TrpGlu: 0.864 ± 0.012	0.52TrpPhe: 0.52 ± 0.01	0.986TrpGly: 0.986 ± 0.015	0.329TrpHis: 0.329 ± 0.008	0.75TrpIle: 0.75 ± 0.013	0.791TrpLys: 0.791 ± 0.013	1.282TrpLeu: 1.282 ± 0.015	0.352TrpMet: 0.352 ± 0.007	0.617TrpAsn: 0.617 ± 0.012	0.593TrpPro: 0.593 ± 0.01	0.528TrpGln: 0.528 ± 0.01	0.907TrpArg: 0.907 ± 0.013	1.033TrpSer: 1.033 ± 0.013	0.908TrpThr: 0.908 ± 0.016	0.905TrpVal: 0.905 ± 0.013	0.266TrpTrp: 0.266 ± 0.007	0.414TrpTyr: 0.414 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.188TyrAla: 2.188 ± 0.02	0.427TyrCys: 0.427 ± 0.01	1.65TyrAsp: 1.65 ± 0.017	1.533TyrGlu: 1.533 ± 0.016	1.175TyrPhe: 1.175 ± 0.016	2.182TyrGly: 2.182 ± 0.023	0.711TyrHis: 0.711 ± 0.012	1.464TyrIle: 1.464 ± 0.019	1.176TyrLys: 1.176 ± 0.016	2.579TyrLeu: 2.579 ± 0.022	0.601TyrMet: 0.601 ± 0.011	1.222TyrAsn: 1.222 ± 0.014	1.46TyrPro: 1.46 ± 0.019	1.059TyrGln: 1.059 ± 0.014	1.541TyrArg: 1.541 ± 0.017	2.115TyrSer: 2.115 ± 0.02	1.654TyrThr: 1.654 ± 0.017	1.604TyrVal: 1.604 ± 0.016	0.423TyrTrp: 0.423 ± 0.01	0.936TyrTyr: 0.936 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11618 proteins (5826161 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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