Amino acid dipepetide frequency for Suhomyces tanzawaensis NRRL Y-17324

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.673AlaAla: 4.673 ± 0.079	0.658AlaCys: 0.658 ± 0.018	2.858AlaAsp: 2.858 ± 0.033	3.421AlaGlu: 3.421 ± 0.043	2.353AlaPhe: 2.353 ± 0.03	3.495AlaGly: 3.495 ± 0.057	1.299AlaHis: 1.299 ± 0.024	3.852AlaIle: 3.852 ± 0.04	4.285AlaLys: 4.285 ± 0.052	5.818AlaLeu: 5.818 ± 0.06	1.135AlaMet: 1.135 ± 0.022	3.239AlaAsn: 3.239 ± 0.039	3.151AlaPro: 3.151 ± 0.049	2.482AlaGln: 2.482 ± 0.039	2.746AlaArg: 2.746 ± 0.037	5.692AlaSer: 5.692 ± 0.05	3.714AlaThr: 3.714 ± 0.045	3.621AlaVal: 3.621 ± 0.044	0.559AlaTrp: 0.559 ± 0.015	1.92AlaTyr: 1.92 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.594CysAla: 0.594 ± 0.015	0.21CysCys: 0.21 ± 0.009	0.581CysAsp: 0.581 ± 0.016	0.513CysGlu: 0.513 ± 0.015	0.562CysPhe: 0.562 ± 0.015	0.775CysGly: 0.775 ± 0.02	0.276CysHis: 0.276 ± 0.01	0.732CysIle: 0.732 ± 0.018	0.57CysLys: 0.57 ± 0.016	1.165CysLeu: 1.165 ± 0.024	0.219CysMet: 0.219 ± 0.01	0.476CysAsn: 0.476 ± 0.015	0.474CysPro: 0.474 ± 0.014	0.354CysGln: 0.354 ± 0.012	0.423CysArg: 0.423 ± 0.013	0.823CysSer: 0.823 ± 0.022	0.538CysThr: 0.538 ± 0.013	0.654CysVal: 0.654 ± 0.016	0.145CysTrp: 0.145 ± 0.008	0.4CysTyr: 0.4 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.235AspAla: 3.235 ± 0.04	0.524AspCys: 0.524 ± 0.014	4.667AspAsp: 4.667 ± 0.063	5.147AspGlu: 5.147 ± 0.063	2.771AspPhe: 2.771 ± 0.035	2.936AspGly: 2.936 ± 0.038	1.276AspHis: 1.276 ± 0.024	3.86AspIle: 3.86 ± 0.042	3.48AspLys: 3.48 ± 0.038	6.068AspLeu: 6.068 ± 0.055	0.975AspMet: 0.975 ± 0.019	2.738AspAsn: 2.738 ± 0.038	2.689AspPro: 2.689 ± 0.03	2.102AspGln: 2.102 ± 0.028	2.003AspArg: 2.003 ± 0.03	4.908AspSer: 4.908 ± 0.054	2.869AspThr: 2.869 ± 0.034	3.279AspVal: 3.279 ± 0.035	0.635AspTrp: 0.635 ± 0.017	2.279AspTyr: 2.279 ± 0.033	0.001AspXaa: 0.001 ± 0.001
Glu	3.94GluAla: 3.94 ± 0.039	0.543GluCys: 0.543 ± 0.016	4.573GluAsp: 4.573 ± 0.053	6.025GluGlu: 6.025 ± 0.092	2.811GluPhe: 2.811 ± 0.03	2.895GluGly: 2.895 ± 0.039	1.293GluHis: 1.293 ± 0.025	4.289GluIle: 4.289 ± 0.048	4.696GluLys: 4.696 ± 0.054	6.964GluLeu: 6.964 ± 0.062	1.236GluMet: 1.236 ± 0.019	3.515GluAsn: 3.515 ± 0.039	2.248GluPro: 2.248 ± 0.034	2.559GluGln: 2.559 ± 0.04	2.678GluArg: 2.678 ± 0.038	4.972GluSer: 4.972 ± 0.054	3.29GluThr: 3.29 ± 0.037	3.926GluVal: 3.926 ± 0.045	0.67GluTrp: 0.67 ± 0.016	2.282GluTyr: 2.282 ± 0.031	0.001GluXaa: 0.001 ± 0.001
Phe	2.509PheAla: 2.509 ± 0.032	0.478PheCys: 0.478 ± 0.015	2.811PheAsp: 2.811 ± 0.039	2.915PheGlu: 2.915 ± 0.039	1.981PhePhe: 1.981 ± 0.031	2.865PheGly: 2.865 ± 0.046	1.027PheHis: 1.027 ± 0.019	2.783PheIle: 2.783 ± 0.037	3.062PheLys: 3.062 ± 0.04	4.183PheLeu: 4.183 ± 0.051	0.843PheMet: 0.843 ± 0.018	2.725PheAsn: 2.725 ± 0.039	1.779PhePro: 1.779 ± 0.027	1.781PheGln: 1.781 ± 0.027	1.668PheArg: 1.668 ± 0.025	3.389PheSer: 3.389 ± 0.042	2.427PheThr: 2.427 ± 0.034	2.742PheVal: 2.742 ± 0.033	0.506PheTrp: 0.506 ± 0.019	1.516PheTyr: 1.516 ± 0.029	0.001PheXaa: 0.001 ± 0.001
Gly	3.517GlyAla: 3.517 ± 0.051	0.666GlyCys: 0.666 ± 0.016	2.971GlyAsp: 2.971 ± 0.035	3.059GlyGlu: 3.059 ± 0.038	2.626GlyPhe: 2.626 ± 0.035	3.791GlyGly: 3.791 ± 0.066	1.266GlyHis: 1.266 ± 0.021	3.493GlyIle: 3.493 ± 0.039	3.568GlyLys: 3.568 ± 0.044	5.348GlyLeu: 5.348 ± 0.06	0.979GlyMet: 0.979 ± 0.022	2.673GlyAsn: 2.673 ± 0.031	2.02GlyPro: 2.02 ± 0.032	1.824GlyGln: 1.824 ± 0.03	2.181GlyArg: 2.181 ± 0.037	4.941GlySer: 4.941 ± 0.052	3.079GlyThr: 3.079 ± 0.035	3.547GlyVal: 3.547 ± 0.043	0.652GlyTrp: 0.652 ± 0.017	2.051GlyTyr: 2.051 ± 0.036	0.001GlyXaa: 0.001 ± 0.001
His	1.184HisAla: 1.184 ± 0.021	0.266HisCys: 0.266 ± 0.011	1.241HisAsp: 1.241 ± 0.022	1.419HisGlu: 1.419 ± 0.024	1.02HisPhe: 1.02 ± 0.022	1.26HisGly: 1.26 ± 0.025	0.879HisHis: 0.879 ± 0.03	1.393HisIle: 1.393 ± 0.023	1.425HisLys: 1.425 ± 0.022	2.341HisLeu: 2.341 ± 0.031	0.379HisMet: 0.379 ± 0.012	1.255HisAsn: 1.255 ± 0.024	1.278HisPro: 1.278 ± 0.025	1.21HisGln: 1.21 ± 0.025	1.041HisArg: 1.041 ± 0.024	1.84HisSer: 1.84 ± 0.028	1.235HisThr: 1.235 ± 0.024	1.163HisVal: 1.163 ± 0.02	0.237HisTrp: 0.237 ± 0.01	0.895HisTyr: 0.895 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.737IleAla: 3.737 ± 0.038	0.721IleCys: 0.721 ± 0.017	4.187IleAsp: 4.187 ± 0.041	4.141IleGlu: 4.141 ± 0.043	2.63IlePhe: 2.63 ± 0.036	3.304IleGly: 3.304 ± 0.041	1.506IleHis: 1.506 ± 0.024	4.023IleIle: 4.023 ± 0.048	4.469IleLys: 4.469 ± 0.044	6.204IleLeu: 6.204 ± 0.065	1.167IleMet: 1.167 ± 0.023	3.842IleAsn: 3.842 ± 0.049	3.216IlePro: 3.216 ± 0.032	2.471IleGln: 2.471 ± 0.032	2.725IleArg: 2.725 ± 0.032	5.283IleSer: 5.283 ± 0.052	3.653IleThr: 3.653 ± 0.042	3.763IleVal: 3.763 ± 0.044	0.653IleTrp: 0.653 ± 0.016	2.063IleTyr: 2.063 ± 0.031	0.002IleXaa: 0.002 ± 0.001
Lys	3.983LysAla: 3.983 ± 0.047	0.645LysCys: 0.645 ± 0.018	3.907LysAsp: 3.907 ± 0.044	4.757LysGlu: 4.757 ± 0.06	3.097LysPhe: 3.097 ± 0.039	2.96LysGly: 2.96 ± 0.035	1.578LysHis: 1.578 ± 0.025	4.369LysIle: 4.369 ± 0.049	5.813LysLys: 5.813 ± 0.072	7.388LysLeu: 7.388 ± 0.064	1.193LysMet: 1.193 ± 0.021	3.733LysAsn: 3.733 ± 0.045	3.079LysPro: 3.079 ± 0.036	2.771LysGln: 2.771 ± 0.038	3.374LysArg: 3.374 ± 0.039	5.513LysSer: 5.513 ± 0.053	3.568LysThr: 3.568 ± 0.034	4.141LysVal: 4.141 ± 0.042	0.749LysTrp: 0.749 ± 0.018	2.632LysTyr: 2.632 ± 0.033	0.001LysXaa: 0.001 ± 0.001
Leu	6.53LeuAla: 6.53 ± 0.065	1.071LeuCys: 1.071 ± 0.025	5.699LeuAsp: 5.699 ± 0.05	6.276LeuGlu: 6.276 ± 0.051	4.109LeuPhe: 4.109 ± 0.052	5.268LeuGly: 5.268 ± 0.049	2.212LeuHis: 2.212 ± 0.036	6.344LeuIle: 6.344 ± 0.07	7.202LeuLys: 7.202 ± 0.062	9.565LeuLeu: 9.565 ± 0.091	1.825LeuMet: 1.825 ± 0.031	5.781LeuAsn: 5.781 ± 0.056	4.77LeuPro: 4.77 ± 0.044	4.047LeuGln: 4.047 ± 0.042	4.382LeuArg: 4.382 ± 0.042	8.435LeuSer: 8.435 ± 0.066	5.536LeuThr: 5.536 ± 0.054	6.347LeuVal: 6.347 ± 0.062	0.899LeuTrp: 0.899 ± 0.023	3.086LeuTyr: 3.086 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	1.323MetAla: 1.323 ± 0.023	0.215MetCys: 0.215 ± 0.009	1.101MetAsp: 1.101 ± 0.018	1.05MetGlu: 1.05 ± 0.018	0.77MetPhe: 0.77 ± 0.017	1.102MetGly: 1.102 ± 0.019	0.292MetHis: 0.292 ± 0.01	1.163MetIle: 1.163 ± 0.019	1.264MetLys: 1.264 ± 0.022	1.588MetLeu: 1.588 ± 0.026	0.424MetMet: 0.424 ± 0.013	1.081MetAsn: 1.081 ± 0.022	0.748MetPro: 0.748 ± 0.019	0.509MetGln: 0.509 ± 0.015	0.717MetArg: 0.717 ± 0.016	1.789MetSer: 1.789 ± 0.026	0.985MetThr: 0.985 ± 0.019	1.177MetVal: 1.177 ± 0.021	0.164MetTrp: 0.164 ± 0.008	0.568MetTyr: 0.568 ± 0.015	0.001MetXaa: 0.001 ± 0.0
Asn	2.947AsnAla: 2.947 ± 0.033	0.571AsnCys: 0.571 ± 0.015	3.441AsnAsp: 3.441 ± 0.04	3.663AsnGlu: 3.663 ± 0.04	2.523AsnPhe: 2.523 ± 0.038	3.257AsnGly: 3.257 ± 0.041	1.38AsnHis: 1.38 ± 0.026	3.313AsnIle: 3.313 ± 0.042	3.484AsnLys: 3.484 ± 0.04	5.488AsnLeu: 5.488 ± 0.065	0.939AsnMet: 0.939 ± 0.017	3.311AsnAsn: 3.311 ± 0.047	2.708AsnPro: 2.708 ± 0.031	2.328AsnGln: 2.328 ± 0.035	2.064AsnArg: 2.064 ± 0.029	4.887AsnSer: 4.887 ± 0.056	2.856AsnThr: 2.856 ± 0.035	2.944AsnVal: 2.944 ± 0.036	0.632AsnTrp: 0.632 ± 0.015	2.202AsnTyr: 2.202 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.07ProAla: 3.07 ± 0.044	0.336ProCys: 0.336 ± 0.012	2.278ProAsp: 2.278 ± 0.031	3.393ProGlu: 3.393 ± 0.039	1.895ProPhe: 1.895 ± 0.029	2.384ProGly: 2.384 ± 0.03	1.085ProHis: 1.085 ± 0.025	2.874ProIle: 2.874 ± 0.033	3.201ProLys: 3.201 ± 0.04	4.11ProLeu: 4.11 ± 0.04	0.747ProMet: 0.747 ± 0.017	2.489ProAsn: 2.489 ± 0.035	2.933ProPro: 2.933 ± 0.082	2.186ProGln: 2.186 ± 0.043	1.898ProArg: 1.898 ± 0.032	4.507ProSer: 4.507 ± 0.051	2.92ProThr: 2.92 ± 0.037	3.074ProVal: 3.074 ± 0.037	0.423ProTrp: 0.423 ± 0.015	1.424ProTyr: 1.424 ± 0.024	0.001ProXaa: 0.001 ± 0.0
Gln	2.594GlnAla: 2.594 ± 0.038	0.381GlnCys: 0.381 ± 0.013	2.067GlnAsp: 2.067 ± 0.031	2.708GlnGlu: 2.708 ± 0.039	1.855GlnPhe: 1.855 ± 0.028	1.875GlnGly: 1.875 ± 0.029	1.005GlnHis: 1.005 ± 0.024	2.48GlnIle: 2.48 ± 0.031	2.536GlnLys: 2.536 ± 0.034	4.413GlnLeu: 4.413 ± 0.043	0.77GlnMet: 0.77 ± 0.016	1.977GlnAsn: 1.977 ± 0.03	1.94GlnPro: 1.94 ± 0.044	2.668GlnGln: 2.668 ± 0.096	1.76GlnArg: 1.76 ± 0.025	3.085GlnSer: 3.085 ± 0.043	1.985GlnThr: 1.985 ± 0.03	2.354GlnVal: 2.354 ± 0.033	0.412GlnTrp: 0.412 ± 0.013	1.45GlnTyr: 1.45 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.555ArgAla: 2.555 ± 0.037	0.468ArgCys: 0.468 ± 0.014	2.314ArgAsp: 2.314 ± 0.029	2.576ArgGlu: 2.576 ± 0.029	1.977ArgPhe: 1.977 ± 0.03	2.167ArgGly: 2.167 ± 0.041	0.983ArgHis: 0.983 ± 0.018	2.813ArgIle: 2.813 ± 0.037	3.225ArgLys: 3.225 ± 0.038	4.328ArgLeu: 4.328 ± 0.044	0.855ArgMet: 0.855 ± 0.016	2.28ArgAsn: 2.28 ± 0.031	1.789ArgPro: 1.789 ± 0.027	1.642ArgGln: 1.642 ± 0.027	2.555ArgArg: 2.555 ± 0.043	3.458ArgSer: 3.458 ± 0.043	2.257ArgThr: 2.257 ± 0.028	2.432ArgVal: 2.432 ± 0.031	0.465ArgTrp: 0.465 ± 0.013	1.46ArgTyr: 1.46 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	4.835SerAla: 4.835 ± 0.047	0.783SerCys: 0.783 ± 0.018	4.511SerAsp: 4.511 ± 0.05	4.681SerGlu: 4.681 ± 0.043	3.739SerPhe: 3.739 ± 0.043	4.715SerGly: 4.715 ± 0.056	1.956SerHis: 1.956 ± 0.033	5.791SerIle: 5.791 ± 0.058	6.152SerLys: 6.152 ± 0.06	8.411SerLeu: 8.411 ± 0.066	1.564SerMet: 1.564 ± 0.023	5.007SerAsn: 5.007 ± 0.061	4.202SerPro: 4.202 ± 0.053	3.362SerGln: 3.362 ± 0.042	3.694SerArg: 3.694 ± 0.038	9.702SerSer: 9.702 ± 0.114	5.628SerThr: 5.628 ± 0.065	4.787SerVal: 4.787 ± 0.044	0.819SerTrp: 0.819 ± 0.018	2.7SerTyr: 2.7 ± 0.028	0.001SerXaa: 0.001 ± 0.001
Thr	3.351ThrAla: 3.351 ± 0.047	0.586ThrCys: 0.586 ± 0.017	2.649ThrAsp: 2.649 ± 0.036	3.003ThrGlu: 3.003 ± 0.034	2.396ThrPhe: 2.396 ± 0.029	3.258ThrGly: 3.258 ± 0.041	1.239ThrHis: 1.239 ± 0.026	3.755ThrIle: 3.755 ± 0.039	3.897ThrLys: 3.897 ± 0.04	5.22ThrLeu: 5.22 ± 0.04	0.895ThrMet: 0.895 ± 0.019	3.161ThrAsn: 3.161 ± 0.035	3.398ThrPro: 3.398 ± 0.046	1.932ThrGln: 1.932 ± 0.028	2.365ThrArg: 2.365 ± 0.029	5.365ThrSer: 5.365 ± 0.049	3.85ThrThr: 3.85 ± 0.054	3.327ThrVal: 3.327 ± 0.037	0.54ThrTrp: 0.54 ± 0.018	1.762ThrTyr: 1.762 ± 0.027	0.002ThrXaa: 0.002 ± 0.001
Val	4.014ValAla: 4.014 ± 0.045	0.694ValCys: 0.694 ± 0.019	3.704ValAsp: 3.704 ± 0.036	3.951ValGlu: 3.951 ± 0.049	2.662ValPhe: 2.662 ± 0.034	3.337ValGly: 3.337 ± 0.044	1.296ValHis: 1.296 ± 0.025	3.703ValIle: 3.703 ± 0.045	3.947ValLys: 3.947 ± 0.034	6.033ValLeu: 6.033 ± 0.056	1.091ValMet: 1.091 ± 0.021	3.037ValAsn: 3.037 ± 0.032	3.058ValPro: 3.058 ± 0.036	2.236ValGln: 2.236 ± 0.028	2.407ValArg: 2.407 ± 0.029	4.908ValSer: 4.908 ± 0.047	3.174ValThr: 3.174 ± 0.034	4.107ValVal: 4.107 ± 0.058	0.662ValTrp: 0.662 ± 0.018	1.976ValTyr: 1.976 ± 0.031	0.001ValXaa: 0.001 ± 0.001
Trp	0.591TrpAla: 0.591 ± 0.015	0.211TrpCys: 0.211 ± 0.009	0.644TrpAsp: 0.644 ± 0.017	0.591TrpGlu: 0.591 ± 0.015	0.544TrpPhe: 0.544 ± 0.015	0.589TrpGly: 0.589 ± 0.018	0.211TrpHis: 0.211 ± 0.01	0.663TrpIle: 0.663 ± 0.016	0.759TrpLys: 0.759 ± 0.018	1.057TrpLeu: 1.057 ± 0.024	0.219TrpMet: 0.219 ± 0.011	0.617TrpAsn: 0.617 ± 0.016	0.313TrpPro: 0.313 ± 0.012	0.323TrpGln: 0.323 ± 0.012	0.502TrpArg: 0.502 ± 0.015	0.809TrpSer: 0.809 ± 0.017	0.574TrpThr: 0.574 ± 0.015	0.617TrpVal: 0.617 ± 0.016	0.17TrpTrp: 0.17 ± 0.008	0.402TrpTyr: 0.402 ± 0.013	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.79TyrAla: 1.79 ± 0.025	0.456TyrCys: 0.456 ± 0.013	2.235TyrAsp: 2.235 ± 0.03	2.119TyrGlu: 2.119 ± 0.029	1.672TyrPhe: 1.672 ± 0.027	2.02TyrGly: 2.02 ± 0.029	0.902TyrHis: 0.902 ± 0.019	2.065TyrIle: 2.065 ± 0.028	2.211TyrLys: 2.211 ± 0.027	3.693TyrLeu: 3.693 ± 0.042	0.576TyrMet: 0.576 ± 0.014	2.001TyrAsn: 2.001 ± 0.028	1.437TyrPro: 1.437 ± 0.025	1.524TyrGln: 1.524 ± 0.027	1.416TyrArg: 1.416 ± 0.022	2.73TyrSer: 2.73 ± 0.035	1.812TyrThr: 1.812 ± 0.03	1.994TyrVal: 1.994 ± 0.029	0.414TyrTrp: 0.414 ± 0.013	1.473TyrTyr: 1.473 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.041XaaXaa: 0.041 ± 0.023

Statistics based on 5882 proteins (2688497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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