Human papillomavirus 170

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 7

Average proteome isoelectric point is 6.48

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|K4MNB7|K4MNB7_9PAPI Protein E7 OS=Human papillomavirus 170 OX=1315265 GN=E7 PE=3 SV=1
MM1 pKa = 7.33EE2 pKa = 4.62SEE4 pKa = 4.43RR5 pKa = 11.84PRR7 pKa = 11.84KK8 pKa = 8.06RR9 pKa = 11.84TKK11 pKa = 10.21RR12 pKa = 11.84DD13 pKa = 3.08SATNLYY19 pKa = 9.71NRR21 pKa = 11.84CQISGNCPEE30 pKa = 4.35DD31 pKa = 3.3VKK33 pKa = 11.62NKK35 pKa = 10.16IEE37 pKa = 4.32GNTLADD43 pKa = 3.78KK44 pKa = 10.6LLKK47 pKa = 9.94ILSSIVYY54 pKa = 9.98FGGLGIGTGRR64 pKa = 11.84GTGGATGYY72 pKa = 10.46RR73 pKa = 11.84PLGSGGGGGGRR84 pKa = 11.84VTPDD88 pKa = 2.82GTVIRR93 pKa = 11.84PNIVVEE99 pKa = 4.05PVGPPEE105 pKa = 4.27IVPIDD110 pKa = 3.79ALSPGSSSIIPMVEE124 pKa = 3.84AGPEE128 pKa = 4.19LIIPEE133 pKa = 4.99TIPDD137 pKa = 3.62LTIGEE142 pKa = 4.54TEE144 pKa = 4.65VITEE148 pKa = 4.69ADD150 pKa = 4.0TIDD153 pKa = 3.12ITGPGGAPAVSTIDD167 pKa = 3.45DD168 pKa = 3.61TSAVIEE174 pKa = 4.3VTPSGPPPRR183 pKa = 11.84RR184 pKa = 11.84VATSTSRR191 pKa = 11.84FSNPTFVSVSTGPTVPQQGATNISVFIDD219 pKa = 3.7GLAGSEE225 pKa = 4.23FVGEE229 pKa = 4.8EE230 pKa = 3.83IPLDD234 pKa = 3.78TFNEE238 pKa = 4.04PQEE241 pKa = 4.4FEE243 pKa = 4.65IEE245 pKa = 5.02DD246 pKa = 3.58IPQPRR251 pKa = 11.84SSTPQAFSRR260 pKa = 11.84AFGRR264 pKa = 11.84ARR266 pKa = 11.84EE267 pKa = 4.14LYY269 pKa = 9.25NRR271 pKa = 11.84RR272 pKa = 11.84VRR274 pKa = 11.84QIRR277 pKa = 11.84TQNINFLTRR286 pKa = 11.84APEE289 pKa = 3.87AVQFTFEE296 pKa = 5.02NPAFDD301 pKa = 4.4NDD303 pKa = 3.25ITLGFQQDD311 pKa = 3.98LDD313 pKa = 3.9QLAAAAPDD321 pKa = 4.13PDD323 pKa = 3.69FADD326 pKa = 2.88IVKK329 pKa = 9.96LHH331 pKa = 6.53RR332 pKa = 11.84PKK334 pKa = 10.62FSEE337 pKa = 4.31TIEE340 pKa = 3.94GRR342 pKa = 11.84VRR344 pKa = 11.84LSRR347 pKa = 11.84LGTKK351 pKa = 8.59GTIRR355 pKa = 11.84LRR357 pKa = 11.84SGTQIGEE364 pKa = 4.53TVHH367 pKa = 7.14LYY369 pKa = 10.96YY370 pKa = 10.71DD371 pKa = 3.42ISSIEE376 pKa = 3.94NADD379 pKa = 4.04AIEE382 pKa = 4.13LSVLGEE388 pKa = 4.03HH389 pKa = 6.72SGDD392 pKa = 3.12ATVINPLAEE401 pKa = 4.28STFVDD406 pKa = 4.02AEE408 pKa = 4.07NSEE411 pKa = 4.29APLLFPEE418 pKa = 4.93QDD420 pKa = 3.67LLDD423 pKa = 5.91DD424 pKa = 3.56ITEE427 pKa = 4.53DD428 pKa = 3.76FSNSHH433 pKa = 6.22IVLSAGGSRR442 pKa = 11.84RR443 pKa = 11.84STLAIPTLPPGVALKK458 pKa = 10.94VFVDD462 pKa = 3.99DD463 pKa = 4.51FGGGLFVSHH472 pKa = 7.73AITTEE477 pKa = 4.44PISNITVPISDD488 pKa = 5.24LGPSILIDD496 pKa = 3.49EE497 pKa = 5.11FSSEE501 pKa = 4.68DD502 pKa = 3.84FVLHH506 pKa = 6.53PSLSKK511 pKa = 9.8KK512 pKa = 9.93RR513 pKa = 11.84KK514 pKa = 8.74RR515 pKa = 11.84KK516 pKa = 9.53RR517 pKa = 11.84LYY519 pKa = 10.76SDD521 pKa = 4.05FF522 pKa = 4.57

Molecular weight: 55.96 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|K4MZ00|K4MZ00_9PAPI Protein E6 OS=Human papillomavirus 170 OX=1315265 GN=E6 PE=3 SV=1
MM1 pKa = 7.71EE2 pKa = 4.81SLEE5 pKa = 4.36DD6 pKa = 4.54RR7 pKa = 11.84FDD9 pKa = 3.98ALQEE13 pKa = 4.05NLLQLYY19 pKa = 8.06EE20 pKa = 4.59AGSDD24 pKa = 3.77NIKK27 pKa = 10.77DD28 pKa = 3.64QILYY32 pKa = 9.31WDD34 pKa = 3.85IVRR37 pKa = 11.84QEE39 pKa = 3.94NVLLHH44 pKa = 5.07YY45 pKa = 10.37ARR47 pKa = 11.84KK48 pKa = 9.91KK49 pKa = 8.74GLNRR53 pKa = 11.84IGLQVIPTLIVSEE66 pKa = 4.49NKK68 pKa = 9.97AKK70 pKa = 10.38QAILMTLQLRR80 pKa = 11.84SLQKK84 pKa = 10.33SAFGSEE90 pKa = 3.77SWTLQDD96 pKa = 3.47TSYY99 pKa = 10.99EE100 pKa = 4.39AYY102 pKa = 9.61TSAPEE107 pKa = 3.89NTFKK111 pKa = 11.04KK112 pKa = 10.57GGFTVDD118 pKa = 2.68VFYY121 pKa = 11.25DD122 pKa = 3.65NDD124 pKa = 3.32EE125 pKa = 4.5DD126 pKa = 4.19NYY128 pKa = 11.19YY129 pKa = 10.18PYY131 pKa = 9.97TAWSYY136 pKa = 11.25IYY138 pKa = 9.65YY139 pKa = 10.53QNGDD143 pKa = 4.31DD144 pKa = 3.39IWYY147 pKa = 9.04KK148 pKa = 10.81VPGQVDD154 pKa = 3.86YY155 pKa = 11.54EE156 pKa = 4.34GLFYY160 pKa = 9.27EE161 pKa = 4.45THH163 pKa = 7.04DD164 pKa = 4.17GEE166 pKa = 4.14KK167 pKa = 10.16QYY169 pKa = 11.63YY170 pKa = 7.34VTFDD174 pKa = 3.0KK175 pKa = 11.17DD176 pKa = 2.86AARR179 pKa = 11.84FSRR182 pKa = 11.84TGMWTVKK189 pKa = 10.32YY190 pKa = 9.68KK191 pKa = 10.88NHH193 pKa = 6.97TISSTSITSTSGHH206 pKa = 7.11PGHH209 pKa = 6.45SPPRR213 pKa = 11.84EE214 pKa = 3.63QSTNSLARR222 pKa = 11.84EE223 pKa = 4.31TEE225 pKa = 3.63ASEE228 pKa = 3.69AGRR231 pKa = 11.84RR232 pKa = 11.84QRR234 pKa = 11.84SSEE237 pKa = 3.84SDD239 pKa = 3.22PRR241 pKa = 11.84RR242 pKa = 11.84SGPLATQSDD251 pKa = 4.66RR252 pKa = 11.84ATSPEE257 pKa = 3.63TSRR260 pKa = 11.84RR261 pKa = 11.84RR262 pKa = 11.84VQRR265 pKa = 11.84RR266 pKa = 11.84RR267 pKa = 11.84RR268 pKa = 11.84RR269 pKa = 11.84GEE271 pKa = 3.69RR272 pKa = 11.84EE273 pKa = 3.33PAAKK277 pKa = 9.87RR278 pKa = 11.84RR279 pKa = 11.84EE280 pKa = 3.76QRR282 pKa = 11.84AARR285 pKa = 11.84GGLSSAPSPEE295 pKa = 4.23EE296 pKa = 3.28VGKK299 pKa = 9.86RR300 pKa = 11.84HH301 pKa = 6.33RR302 pKa = 11.84LVEE305 pKa = 4.4GKK307 pKa = 10.1GLPRR311 pKa = 11.84LRR313 pKa = 11.84RR314 pKa = 11.84LQEE317 pKa = 3.78EE318 pKa = 4.19ARR320 pKa = 11.84DD321 pKa = 3.88PPLVLLKK328 pKa = 11.12GPGNTLKK335 pKa = 10.6CWRR338 pKa = 11.84FKK340 pKa = 10.89CKK342 pKa = 9.83QKK344 pKa = 11.1YY345 pKa = 8.74CGLYY349 pKa = 10.32HH350 pKa = 7.54RR351 pKa = 11.84ISTNFSWVGEE361 pKa = 4.12GSARR365 pKa = 11.84LGTPRR370 pKa = 11.84MLIAFTSPTQRR381 pKa = 11.84QAFLRR386 pKa = 11.84SVVFPKK392 pKa = 10.03GTEE395 pKa = 3.81FSLGNLYY402 pKa = 10.83SLL404 pKa = 4.87

Molecular weight: 46.33 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2300

94

617

383.3

42.83

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.957 ± 0.333

2.348 ± 0.942

6.0 ± 0.523

6.043 ± 0.775

4.435 ± 0.275

6.522 ± 0.841

1.913 ± 0.215

5.652 ± 0.801

5.13 ± 0.72

9.304 ± 0.843

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.304 ± 0.293

4.565 ± 0.511

5.348 ± 1.003

4.217 ± 0.504

5.696 ± 1.009

8.826 ± 0.23

6.435 ± 0.641

5.826 ± 0.583

1.087 ± 0.315

3.391 ± 0.58
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski