Human papillomavirus type 50

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 3

Average proteome isoelectric point is 5.95

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|Q80932|VL2_HPV50 Minor capsid protein L2 OS=Human papillomavirus type 50 OX=40539 GN=L2 PE=3 SV=1
MM1 pKa = 7.5LRR3 pKa = 11.84RR4 pKa = 11.84RR5 pKa = 11.84KK6 pKa = 9.54RR7 pKa = 11.84ASPTDD12 pKa = 4.02LYY14 pKa = 10.94RR15 pKa = 11.84SCLQGGDD22 pKa = 4.9CIPDD26 pKa = 3.37VQNKK30 pKa = 9.65FEE32 pKa = 4.96GNTIADD38 pKa = 3.83WLLKK42 pKa = 10.38IFGGLVYY49 pKa = 10.47FGNLGIGTGRR59 pKa = 11.84GTGGTFGYY67 pKa = 10.22RR68 pKa = 11.84PFGAPGSGRR77 pKa = 11.84PTQEE81 pKa = 4.06LPIARR86 pKa = 11.84PNVVIDD92 pKa = 4.1PLGPAPIVPVDD103 pKa = 3.96PSAASIVPLVEE114 pKa = 4.01GAPDD118 pKa = 3.39VGFAAPDD125 pKa = 3.7AGPAAGGTDD134 pKa = 2.95IEE136 pKa = 5.77LYY138 pKa = 10.36TITNSTTDD146 pKa = 3.08VGAVGGGPTVTSNEE160 pKa = 4.03EE161 pKa = 3.81FEE163 pKa = 4.65VAVIDD168 pKa = 4.12AQPIAPYY175 pKa = 9.75PKK177 pKa = 9.61QLLYY181 pKa = 11.04DD182 pKa = 3.6STIAATFEE190 pKa = 4.2TQINPFINPDD200 pKa = 3.17INNVNVLVDD209 pKa = 3.59PSFAGDD215 pKa = 3.44TVGDD219 pKa = 3.75YY220 pKa = 10.51FYY222 pKa = 11.5EE223 pKa = 4.62EE224 pKa = 4.36IPLEE228 pKa = 4.14RR229 pKa = 11.84LDD231 pKa = 3.68IQTFDD236 pKa = 3.1ILEE239 pKa = 4.72PPTEE243 pKa = 4.22STPTQLGNRR252 pKa = 11.84FVSRR256 pKa = 11.84ARR258 pKa = 11.84DD259 pKa = 3.38LYY261 pKa = 11.34SRR263 pKa = 11.84FVAQQPISEE272 pKa = 4.88PDD274 pKa = 3.66FLSQPSRR281 pKa = 11.84LVQFEE286 pKa = 4.09YY287 pKa = 10.7RR288 pKa = 11.84NPAFDD293 pKa = 5.21PDD295 pKa = 3.26VSLYY299 pKa = 10.11FEE301 pKa = 5.6RR302 pKa = 11.84DD303 pKa = 3.35LEE305 pKa = 4.3GLRR308 pKa = 11.84AAPLQEE314 pKa = 4.25FADD317 pKa = 3.91VVYY320 pKa = 10.67LGRR323 pKa = 11.84PRR325 pKa = 11.84VSSTSEE331 pKa = 3.36GTIRR335 pKa = 11.84VSRR338 pKa = 11.84LGTRR342 pKa = 11.84AALTTRR348 pKa = 11.84SGLSVGPQVHH358 pKa = 6.93FYY360 pKa = 10.1MDD362 pKa = 4.23LSDD365 pKa = 5.09IPPEE369 pKa = 4.17DD370 pKa = 4.13SIEE373 pKa = 4.11LHH375 pKa = 5.85TLNVTPQTSTIVDD388 pKa = 4.75DD389 pKa = 4.3ILATTTFDD397 pKa = 4.7DD398 pKa = 4.35PANSLFTQFNEE409 pKa = 4.93DD410 pKa = 3.56VLTDD414 pKa = 3.82DD415 pKa = 4.17VEE417 pKa = 5.22HH418 pKa = 6.78NFTEE422 pKa = 4.15SHH424 pKa = 6.0LVIPATDD431 pKa = 3.86EE432 pKa = 4.22EE433 pKa = 5.02NDD435 pKa = 3.6TAINIINLRR444 pKa = 11.84NIPLTVGMNSGDD456 pKa = 3.17ISTTLSDD463 pKa = 4.17YY464 pKa = 11.3NILDD468 pKa = 3.31ASLIVKK474 pKa = 10.29SNVSEE479 pKa = 4.08QPLFVLDD486 pKa = 3.7YY487 pKa = 11.05SDD489 pKa = 5.27YY490 pKa = 11.15DD491 pKa = 3.52LHH493 pKa = 7.29PGLLPKK499 pKa = 10.12RR500 pKa = 11.84RR501 pKa = 11.84RR502 pKa = 11.84IDD504 pKa = 3.38YY505 pKa = 9.4FF506 pKa = 3.72

Molecular weight: 55.2 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q80931|Q80931_HPV50 E4 protein (Fragment) OS=Human papillomavirus type 50 OX=40539 GN=E4 PE=4 SV=1
MM1 pKa = 7.08TQMEE5 pKa = 4.44TQEE8 pKa = 4.16TLSARR13 pKa = 11.84FLAQQDD19 pKa = 3.2IQLNLIEE26 pKa = 5.45KK27 pKa = 10.09DD28 pKa = 3.64SKK30 pKa = 11.03NLKK33 pKa = 10.05DD34 pKa = 5.23HH35 pKa = 6.45IDD37 pKa = 3.31YY38 pKa = 9.76WEE40 pKa = 4.21SMRR43 pKa = 11.84KK44 pKa = 8.0EE45 pKa = 3.87QVLAFYY51 pKa = 10.55AKK53 pKa = 9.87KK54 pKa = 10.77EE55 pKa = 3.96NMSRR59 pKa = 11.84LGLQPLPPAKK69 pKa = 10.43VSEE72 pKa = 4.34QKK74 pKa = 11.03AKK76 pKa = 10.72DD77 pKa = 3.62AIRR80 pKa = 11.84IQLLLQSLYY89 pKa = 10.89KK90 pKa = 10.18SDD92 pKa = 4.33FGSEE96 pKa = 3.58PWTLSEE102 pKa = 5.6CSLEE106 pKa = 4.18MLNAPPRR113 pKa = 11.84NCFKK117 pKa = 10.61KK118 pKa = 10.32QPFTVTVQFDD128 pKa = 3.84NDD130 pKa = 3.74PKK132 pKa = 11.0NVYY135 pKa = 9.96PYY137 pKa = 9.92ICYY140 pKa = 10.19EE141 pKa = 3.92YY142 pKa = 10.03IYY144 pKa = 10.61YY145 pKa = 10.07QDD147 pKa = 6.16DD148 pKa = 3.18RR149 pKa = 11.84DD150 pKa = 3.42KK151 pKa = 8.74WHH153 pKa = 6.57KK154 pKa = 10.77VKK156 pKa = 10.88GLVDD160 pKa = 3.59HH161 pKa = 6.88NGLYY165 pKa = 10.41FKK167 pKa = 10.47EE168 pKa = 4.27VTGDD172 pKa = 3.27SVYY175 pKa = 10.94FKK177 pKa = 10.78LFQPDD182 pKa = 2.79ATVYY186 pKa = 10.3GKK188 pKa = 10.21SGQWTVIFKK197 pKa = 10.89NKK199 pKa = 8.9TIHH202 pKa = 6.79SSVTSSSRR210 pKa = 11.84SAFGPADD217 pKa = 3.93EE218 pKa = 4.78QPGPSTSYY226 pKa = 11.11DD227 pKa = 2.92KK228 pKa = 11.24SQQEE232 pKa = 4.35RR233 pKa = 11.84SGSGQPKK240 pKa = 9.85ALQDD244 pKa = 3.84TEE246 pKa = 4.83PPTSTSTVRR255 pKa = 11.84LRR257 pKa = 11.84RR258 pKa = 11.84GRR260 pKa = 11.84RR261 pKa = 11.84EE262 pKa = 4.1RR263 pKa = 11.84EE264 pKa = 3.67HH265 pKa = 6.93HH266 pKa = 6.34SYY268 pKa = 10.57RR269 pKa = 11.84HH270 pKa = 5.94RR271 pKa = 11.84KK272 pKa = 7.92SQSEE276 pKa = 4.24LGADD280 pKa = 3.54SAPTPEE286 pKa = 4.02EE287 pKa = 3.82VGRR290 pKa = 11.84RR291 pKa = 11.84SHH293 pKa = 5.88TVAAHH298 pKa = 5.29GLSRR302 pKa = 11.84LRR304 pKa = 11.84RR305 pKa = 11.84LQEE308 pKa = 3.72EE309 pKa = 4.14ARR311 pKa = 11.84DD312 pKa = 3.92PPVLIITGQQNNLKK326 pKa = 8.62CWRR329 pKa = 11.84YY330 pKa = 9.96RR331 pKa = 11.84FSQKK335 pKa = 10.54YY336 pKa = 9.1ADD338 pKa = 4.93LYY340 pKa = 9.51EE341 pKa = 4.74CCSSAWKK348 pKa = 9.36WLGPKK353 pKa = 9.87SEE355 pKa = 4.6GYY357 pKa = 10.35RR358 pKa = 11.84GDD360 pKa = 3.68AKK362 pKa = 11.16LLIAFKK368 pKa = 10.83NPEE371 pKa = 3.74QRR373 pKa = 11.84LSFLNTVGLPKK384 pKa = 9.9NTTYY388 pKa = 11.71SMGHH392 pKa = 6.95LDD394 pKa = 3.82SLL396 pKa = 4.39

Molecular weight: 45.56 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2396

93

599

342.3

38.87

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.676 ± 0.512

2.546 ± 0.814

7.137 ± 0.446

5.801 ± 0.356

4.633 ± 0.436

5.134 ± 0.89

1.92 ± 0.295

5.008 ± 0.606

5.593 ± 1.158

9.683 ± 0.687

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.586 ± 0.43

5.634 ± 0.642

5.843 ± 0.882

4.215 ± 0.596

5.217 ± 0.548

7.095 ± 0.52

6.01 ± 0.549

5.718 ± 0.675

1.169 ± 0.276

4.382 ± 0.483
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski