Amino acid dipepetide frequency for Halopelagius longus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.034AlaAla: 14.034 ± 0.183	0.709AlaCys: 0.709 ± 0.025	9.366AlaAsp: 9.366 ± 0.124	9.467AlaGlu: 9.467 ± 0.107	4.226AlaPhe: 4.226 ± 0.081	9.396AlaGly: 9.396 ± 0.124	1.722AlaHis: 1.722 ± 0.041	3.768AlaIle: 3.768 ± 0.067	2.015AlaLys: 2.015 ± 0.049	9.668AlaLeu: 9.668 ± 0.122	2.024AlaMet: 2.024 ± 0.045	2.448AlaAsn: 2.448 ± 0.045	4.041AlaPro: 4.041 ± 0.066	2.018AlaGln: 2.018 ± 0.038	6.29AlaArg: 6.29 ± 0.091	5.795AlaSer: 5.795 ± 0.086	6.561AlaThr: 6.561 ± 0.089	11.182AlaVal: 11.182 ± 0.143	1.101AlaTrp: 1.101 ± 0.033	2.816AlaTyr: 2.816 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.614CysAla: 0.614 ± 0.03	0.077CysCys: 0.077 ± 0.008	0.551CysAsp: 0.551 ± 0.028	0.58CysGlu: 0.58 ± 0.023	0.185CysPhe: 0.185 ± 0.012	0.792CysGly: 0.792 ± 0.031	0.173CysHis: 0.173 ± 0.014	0.236CysIle: 0.236 ± 0.014	0.101CysLys: 0.101 ± 0.009	0.511CysLeu: 0.511 ± 0.022	0.106CysMet: 0.106 ± 0.009	0.159CysAsn: 0.159 ± 0.011	0.465CysPro: 0.465 ± 0.024	0.125CysGln: 0.125 ± 0.01	0.46CysArg: 0.46 ± 0.022	0.425CysSer: 0.425 ± 0.019	0.383CysThr: 0.383 ± 0.022	0.505CysVal: 0.505 ± 0.021	0.07CysTrp: 0.07 ± 0.008	0.175CysTyr: 0.175 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	10.746AspAla: 10.746 ± 0.15	0.583AspCys: 0.583 ± 0.025	7.252AspAsp: 7.252 ± 0.101	8.243AspGlu: 8.243 ± 0.112	2.027AspPhe: 2.027 ± 0.044	8.08AspGly: 8.08 ± 0.115	1.606AspHis: 1.606 ± 0.042	2.977AspIle: 2.977 ± 0.057	0.982AspLys: 0.982 ± 0.03	5.63AspLeu: 5.63 ± 0.08	1.182AspMet: 1.182 ± 0.029	1.166AspAsn: 1.166 ± 0.039	4.434AspPro: 4.434 ± 0.072	1.23AspGln: 1.23 ± 0.029	5.94AspArg: 5.94 ± 0.084	3.9AspSer: 3.9 ± 0.064	3.331AspThr: 3.331 ± 0.061	7.922AspVal: 7.922 ± 0.101	0.866AspTrp: 0.866 ± 0.029	1.878AspTyr: 1.878 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.887GluAla: 8.887 ± 0.117	0.49GluCys: 0.49 ± 0.026	5.779GluAsp: 5.779 ± 0.082	8.643GluGlu: 8.643 ± 0.124	3.18GluPhe: 3.18 ± 0.051	6.281GluGly: 6.281 ± 0.08	1.697GluHis: 1.697 ± 0.039	3.353GluIle: 3.353 ± 0.062	2.167GluLys: 2.167 ± 0.049	7.884GluLeu: 7.884 ± 0.102	2.125GluMet: 2.125 ± 0.046	2.687GluAsn: 2.687 ± 0.054	3.508GluPro: 3.508 ± 0.061	2.36GluGln: 2.36 ± 0.046	7.917GluArg: 7.917 ± 0.097	6.01GluSer: 6.01 ± 0.08	6.736GluThr: 6.736 ± 0.098	6.038GluVal: 6.038 ± 0.085	1.344GluTrp: 1.344 ± 0.039	2.892GluTyr: 2.892 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	3.835PheAla: 3.835 ± 0.067	0.257PheCys: 0.257 ± 0.018	3.34PheAsp: 3.34 ± 0.054	3.453PheGlu: 3.453 ± 0.062	1.163PhePhe: 1.163 ± 0.038	3.483PheGly: 3.483 ± 0.068	0.592PheHis: 0.592 ± 0.024	0.982PheIle: 0.982 ± 0.036	0.485PheLys: 0.485 ± 0.024	3.068PheLeu: 3.068 ± 0.067	0.513PheMet: 0.513 ± 0.023	0.699PheAsn: 0.699 ± 0.026	1.41PhePro: 1.41 ± 0.035	0.715PheGln: 0.715 ± 0.028	1.945PheArg: 1.945 ± 0.044	1.905PheSer: 1.905 ± 0.047	1.779PheThr: 1.779 ± 0.039	3.737PheVal: 3.737 ± 0.07	0.426PheTrp: 0.426 ± 0.021	0.889PheTyr: 0.889 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.209GlyAla: 8.209 ± 0.098	0.677GlyCys: 0.677 ± 0.027	6.887GlyAsp: 6.887 ± 0.081	7.538GlyGlu: 7.538 ± 0.091	3.138GlyPhe: 3.138 ± 0.052	8.118GlyGly: 8.118 ± 0.103	1.639GlyHis: 1.639 ± 0.043	3.769GlyIle: 3.769 ± 0.067	1.946GlyLys: 1.946 ± 0.052	7.136GlyLeu: 7.136 ± 0.089	1.681GlyMet: 1.681 ± 0.042	2.022GlyAsn: 2.022 ± 0.05	3.444GlyPro: 3.444 ± 0.06	1.776GlyGln: 1.776 ± 0.052	5.562GlyArg: 5.562 ± 0.095	5.022GlySer: 5.022 ± 0.074	5.769GlyThr: 5.769 ± 0.071	8.326GlyVal: 8.326 ± 0.109	1.099GlyTrp: 1.099 ± 0.032	2.692GlyTyr: 2.692 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.859HisAla: 1.859 ± 0.04	0.167HisCys: 0.167 ± 0.01	1.595HisAsp: 1.595 ± 0.039	1.607HisGlu: 1.607 ± 0.047	0.549HisPhe: 0.549 ± 0.022	1.817HisGly: 1.817 ± 0.041	0.509HisHis: 0.509 ± 0.022	0.594HisIle: 0.594 ± 0.023	0.27HisLys: 0.27 ± 0.019	1.747HisLeu: 1.747 ± 0.043	0.264HisMet: 0.264 ± 0.015	0.421HisAsn: 0.421 ± 0.02	1.193HisPro: 1.193 ± 0.035	0.387HisGln: 0.387 ± 0.021	1.295HisArg: 1.295 ± 0.036	0.799HisSer: 0.799 ± 0.026	0.905HisThr: 0.905 ± 0.03	1.822HisVal: 1.822 ± 0.044	0.199HisTrp: 0.199 ± 0.013	0.54HisTyr: 0.54 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.028IleAla: 4.028 ± 0.071	0.196IleCys: 0.196 ± 0.014	3.24IleAsp: 3.24 ± 0.064	3.52IleGlu: 3.52 ± 0.063	0.941IlePhe: 0.941 ± 0.033	3.236IleGly: 3.236 ± 0.067	0.659IleHis: 0.659 ± 0.025	1.226IleIle: 1.226 ± 0.038	0.65IleLys: 0.65 ± 0.028	2.917IleLeu: 2.917 ± 0.066	0.405IleMet: 0.405 ± 0.021	0.831IleAsn: 0.831 ± 0.031	1.979IlePro: 1.979 ± 0.044	0.886IleGln: 0.886 ± 0.033	2.378IleArg: 2.378 ± 0.056	1.969IleSer: 1.969 ± 0.047	1.928IleThr: 1.928 ± 0.042	3.307IleVal: 3.307 ± 0.057	0.293IleTrp: 0.293 ± 0.015	0.804IleTyr: 0.804 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.798LysAla: 1.798 ± 0.05	0.107LysCys: 0.107 ± 0.011	1.093LysAsp: 1.093 ± 0.033	1.57LysGlu: 1.57 ± 0.044	0.6LysPhe: 0.6 ± 0.025	1.469LysGly: 1.469 ± 0.039	0.45LysHis: 0.45 ± 0.021	0.76LysIle: 0.76 ± 0.023	0.583LysLys: 0.583 ± 0.029	1.723LysLeu: 1.723 ± 0.04	0.431LysMet: 0.431 ± 0.022	0.6LysAsn: 0.6 ± 0.025	0.984LysPro: 0.984 ± 0.03	0.745LysGln: 0.745 ± 0.027	1.79LysArg: 1.79 ± 0.041	1.236LysSer: 1.236 ± 0.039	1.419LysThr: 1.419 ± 0.037	1.379LysVal: 1.379 ± 0.034	0.258LysTrp: 0.258 ± 0.015	0.665LysTyr: 0.665 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	9.908LeuAla: 9.908 ± 0.132	0.589LeuCys: 0.589 ± 0.027	7.291LeuAsp: 7.291 ± 0.089	6.263LeuGlu: 6.263 ± 0.097	3.258LeuPhe: 3.258 ± 0.066	7.464LeuGly: 7.464 ± 0.102	1.462LeuHis: 1.462 ± 0.036	2.444LeuIle: 2.444 ± 0.056	1.706LeuLys: 1.706 ± 0.046	8.279LeuLeu: 8.279 ± 0.137	1.383LeuMet: 1.383 ± 0.038	1.93LeuAsn: 1.93 ± 0.039	4.232LeuPro: 4.232 ± 0.063	1.893LeuGln: 1.893 ± 0.041	5.976LeuArg: 5.976 ± 0.085	6.203LeuSer: 6.203 ± 0.068	5.116LeuThr: 5.116 ± 0.072	8.581LeuVal: 8.581 ± 0.125	0.837LeuTrp: 0.837 ± 0.031	2.21LeuTyr: 2.21 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.781MetAla: 1.781 ± 0.043	0.115MetCys: 0.115 ± 0.011	1.261MetAsp: 1.261 ± 0.038	1.116MetGlu: 1.116 ± 0.032	0.574MetPhe: 0.574 ± 0.024	1.39MetGly: 1.39 ± 0.034	0.324MetHis: 0.324 ± 0.016	0.576MetIle: 0.576 ± 0.022	0.484MetLys: 0.484 ± 0.019	1.581MetLeu: 1.581 ± 0.038	0.308MetMet: 0.308 ± 0.014	0.619MetAsn: 0.619 ± 0.025	0.842MetPro: 0.842 ± 0.025	0.478MetGln: 0.478 ± 0.019	1.274MetArg: 1.274 ± 0.03	1.602MetSer: 1.602 ± 0.035	1.457MetThr: 1.457 ± 0.036	1.397MetVal: 1.397 ± 0.034	0.172MetTrp: 0.172 ± 0.012	0.396MetTyr: 0.396 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.746AsnAla: 2.746 ± 0.054	0.223AsnCys: 0.223 ± 0.014	1.696AsnAsp: 1.696 ± 0.042	1.885AsnGlu: 1.885 ± 0.044	0.77AsnPhe: 0.77 ± 0.03	2.181AsnGly: 2.181 ± 0.049	0.499AsnHis: 0.499 ± 0.02	0.902AsnIle: 0.902 ± 0.034	0.425AsnLys: 0.425 ± 0.022	2.121AsnLeu: 2.121 ± 0.042	0.424AsnMet: 0.424 ± 0.019	0.569AsnAsn: 0.569 ± 0.026	1.628AsnPro: 1.628 ± 0.04	0.586AsnGln: 0.586 ± 0.026	1.755AsnArg: 1.755 ± 0.038	1.105AsnSer: 1.105 ± 0.039	1.256AsnThr: 1.256 ± 0.034	2.587AsnVal: 2.587 ± 0.05	0.311AsnTrp: 0.311 ± 0.018	0.752AsnTyr: 0.752 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.379ProAla: 4.379 ± 0.059	0.232ProCys: 0.232 ± 0.014	4.549ProAsp: 4.549 ± 0.074	4.88ProGlu: 4.88 ± 0.067	1.758ProPhe: 1.758 ± 0.041	3.706ProGly: 3.706 ± 0.066	0.873ProHis: 0.873 ± 0.028	1.592ProIle: 1.592 ± 0.036	0.959ProLys: 0.959 ± 0.03	3.676ProLeu: 3.676 ± 0.054	0.86ProMet: 0.86 ± 0.024	1.34ProAsn: 1.34 ± 0.034	2.154ProPro: 2.154 ± 0.044	0.91ProGln: 0.91 ± 0.025	2.41ProArg: 2.41 ± 0.046	2.919ProSer: 2.919 ± 0.056	3.172ProThr: 3.172 ± 0.063	4.286ProVal: 4.286 ± 0.054	0.572ProTrp: 0.572 ± 0.02	1.195ProTyr: 1.195 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	1.954GlnAla: 1.954 ± 0.048	0.138GlnCys: 0.138 ± 0.01	1.05GlnAsp: 1.05 ± 0.028	1.546GlnGlu: 1.546 ± 0.04	1.064GlnPhe: 1.064 ± 0.035	1.361GlnGly: 1.361 ± 0.038	0.442GlnHis: 0.442 ± 0.02	1.014GlnIle: 1.014 ± 0.033	0.624GlnLys: 0.624 ± 0.023	1.979GlnLeu: 1.979 ± 0.05	0.556GlnMet: 0.556 ± 0.024	0.796GlnAsn: 0.796 ± 0.028	0.89GlnPro: 0.89 ± 0.026	0.869GlnGln: 0.869 ± 0.038	1.659GlnArg: 1.659 ± 0.044	1.646GlnSer: 1.646 ± 0.042	1.612GlnThr: 1.612 ± 0.037	1.623GlnVal: 1.623 ± 0.039	0.331GlnTrp: 0.331 ± 0.017	0.786GlnTyr: 0.786 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.647ArgAla: 6.647 ± 0.106	0.412ArgCys: 0.412 ± 0.023	5.169ArgAsp: 5.169 ± 0.066	7.093ArgGlu: 7.093 ± 0.095	2.494ArgPhe: 2.494 ± 0.05	4.882ArgGly: 4.882 ± 0.075	1.231ArgHis: 1.231 ± 0.035	2.96ArgIle: 2.96 ± 0.057	1.503ArgLys: 1.503 ± 0.042	6.093ArgLeu: 6.093 ± 0.084	1.429ArgMet: 1.429 ± 0.032	1.8ArgAsn: 1.8 ± 0.041	2.798ArgPro: 2.798 ± 0.052	1.626ArgGln: 1.626 ± 0.043	6.073ArgArg: 6.073 ± 0.095	3.824ArgSer: 3.824 ± 0.064	4.509ArgThr: 4.509 ± 0.07	5.719ArgVal: 5.719 ± 0.076	0.826ArgTrp: 0.826 ± 0.03	2.039ArgTyr: 2.039 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.827SerAla: 5.827 ± 0.078	0.324SerCys: 0.324 ± 0.018	4.903SerAsp: 4.903 ± 0.073	4.914SerGlu: 4.914 ± 0.083	2.096SerPhe: 2.096 ± 0.042	5.502SerGly: 5.502 ± 0.076	1.001SerHis: 1.001 ± 0.03	2.163SerIle: 2.163 ± 0.044	1.357SerLys: 1.357 ± 0.041	5.41SerLeu: 5.41 ± 0.086	1.084SerMet: 1.084 ± 0.028	1.58SerAsn: 1.58 ± 0.039	2.872SerPro: 2.872 ± 0.06	1.281SerGln: 1.281 ± 0.039	3.407SerArg: 3.407 ± 0.059	3.387SerSer: 3.387 ± 0.079	3.351SerThr: 3.351 ± 0.064	5.612SerVal: 5.612 ± 0.083	0.682SerTrp: 0.682 ± 0.028	1.387SerTyr: 1.387 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.662ThrAla: 6.662 ± 0.08	0.368ThrCys: 0.368 ± 0.019	5.187ThrAsp: 5.187 ± 0.072	4.919ThrGlu: 4.919 ± 0.087	2.213ThrPhe: 2.213 ± 0.053	5.411ThrGly: 5.411 ± 0.069	1.146ThrHis: 1.146 ± 0.032	2.227ThrIle: 2.227 ± 0.05	1.136ThrLys: 1.136 ± 0.034	5.785ThrLeu: 5.785 ± 0.068	1.058ThrMet: 1.058 ± 0.034	1.529ThrAsn: 1.529 ± 0.04	3.276ThrPro: 3.276 ± 0.066	1.225ThrGln: 1.225 ± 0.038	3.399ThrArg: 3.399 ± 0.057	2.762ThrSer: 2.762 ± 0.045	4.012ThrThr: 4.012 ± 0.077	6.938ThrVal: 6.938 ± 0.091	0.663ThrTrp: 0.663 ± 0.027	1.767ThrTyr: 1.767 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	10.944ValAla: 10.944 ± 0.129	0.696ValCys: 0.696 ± 0.026	6.351ValAsp: 6.351 ± 0.081	9.203ValGlu: 9.203 ± 0.102	3.065ValPhe: 3.065 ± 0.065	8.583ValGly: 8.583 ± 0.103	1.674ValHis: 1.674 ± 0.04	2.69ValIle: 2.69 ± 0.051	1.56ValLys: 1.56 ± 0.043	8.175ValLeu: 8.175 ± 0.108	1.309ValMet: 1.309 ± 0.035	2.206ValAsn: 2.206 ± 0.048	4.548ValPro: 4.548 ± 0.066	1.817ValGln: 1.817 ± 0.041	6.6ValArg: 6.6 ± 0.091	5.696ValSer: 5.696 ± 0.079	6.206ValThr: 6.206 ± 0.077	10.178ValVal: 10.178 ± 0.127	0.859ValTrp: 0.859 ± 0.03	2.26ValTyr: 2.26 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.986TrpAla: 0.986 ± 0.032	0.087TrpCys: 0.087 ± 0.01	0.799TrpAsp: 0.799 ± 0.031	0.888TrpGlu: 0.888 ± 0.028	0.479TrpPhe: 0.479 ± 0.02	0.847TrpGly: 0.847 ± 0.028	0.219TrpHis: 0.219 ± 0.013	0.449TrpIle: 0.449 ± 0.021	0.293TrpLys: 0.293 ± 0.016	1.051TrpLeu: 1.051 ± 0.032	0.249TrpMet: 0.249 ± 0.014	0.408TrpAsn: 0.408 ± 0.021	0.45TrpPro: 0.45 ± 0.02	0.323TrpGln: 0.323 ± 0.02	0.897TrpArg: 0.897 ± 0.031	0.668TrpSer: 0.668 ± 0.028	0.826TrpThr: 0.826 ± 0.028	0.966TrpVal: 0.966 ± 0.033	0.21TrpTrp: 0.21 ± 0.016	0.391TrpTyr: 0.391 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.807TyrAla: 2.807 ± 0.05	0.246TyrCys: 0.246 ± 0.016	2.614TyrAsp: 2.614 ± 0.046	2.649TyrGlu: 2.649 ± 0.054	0.896TyrPhe: 0.896 ± 0.027	2.448TyrGly: 2.448 ± 0.048	0.621TyrHis: 0.621 ± 0.025	0.713TyrIle: 0.713 ± 0.03	0.413TyrLys: 0.413 ± 0.018	2.591TyrLeu: 2.591 ± 0.053	0.356TyrMet: 0.356 ± 0.017	0.609TyrAsn: 0.609 ± 0.024	1.276TyrPro: 1.276 ± 0.036	0.689TyrGln: 0.689 ± 0.026	2.103TyrArg: 2.103 ± 0.054	1.266TyrSer: 1.266 ± 0.03	1.357TyrThr: 1.357 ± 0.033	2.514TyrVal: 2.514 ± 0.049	0.365TyrTrp: 0.365 ± 0.018	0.845TyrTyr: 0.845 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3802 proteins (1114234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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