Amino acid dipepetide frequency for TM7 phylum sp. oral taxon 349

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.748AlaAla: 10.748 ± 0.288
0.749AlaCys: 0.749 ± 0.045
4.963AlaAsp: 4.963 ± 0.147
5.347AlaGlu: 5.347 ± 0.153
2.911AlaPhe: 2.911 ± 0.103
6.462AlaGly: 6.462 ± 0.173
2.125AlaHis: 2.125 ± 0.085
6.397AlaIle: 6.397 ± 0.153
5.796AlaLys: 5.796 ± 0.164
8.905AlaLeu: 8.905 ± 0.209
2.063AlaMet: 2.063 ± 0.101
3.7AlaAsn: 3.7 ± 0.125
3.396AlaPro: 3.396 ± 0.154
3.797AlaGln: 3.797 ± 0.126
5.723AlaArg: 5.723 ± 0.159
5.437AlaSer: 5.437 ± 0.166
5.369AlaThr: 5.369 ± 0.163
6.987AlaVal: 6.987 ± 0.189
1.006AlaTrp: 1.006 ± 0.06
2.831AlaTyr: 2.831 ± 0.116
0.0AlaXaa: 0.0 ± 0.0
Cys
0.681CysAla: 0.681 ± 0.047
0.119CysCys: 0.119 ± 0.022
0.557CysAsp: 0.557 ± 0.045
0.413CysGlu: 0.413 ± 0.043
0.224CysPhe: 0.224 ± 0.028
0.608CysGly: 0.608 ± 0.051
0.195CysHis: 0.195 ± 0.027
0.492CysIle: 0.492 ± 0.04
0.38CysLys: 0.38 ± 0.039
0.717CysLeu: 0.717 ± 0.051
0.203CysMet: 0.203 ± 0.026
0.351CysAsn: 0.351 ± 0.034
0.387CysPro: 0.387 ± 0.039
0.253CysGln: 0.253 ± 0.032
0.514CysArg: 0.514 ± 0.053
0.525CysSer: 0.525 ± 0.041
0.38CysThr: 0.38 ± 0.042
0.561CysVal: 0.561 ± 0.05
0.101CysTrp: 0.101 ± 0.032
0.308CysTyr: 0.308 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
5.137AspAla: 5.137 ± 0.142
0.398AspCys: 0.398 ± 0.043
3.978AspAsp: 3.978 ± 0.145
4.637AspGlu: 4.637 ± 0.133
2.27AspPhe: 2.27 ± 0.088
4.532AspGly: 4.532 ± 0.153
0.988AspHis: 0.988 ± 0.064
4.094AspIle: 4.094 ± 0.142
3.472AspLys: 3.472 ± 0.12
4.471AspLeu: 4.471 ± 0.132
1.47AspMet: 1.47 ± 0.075
2.349AspAsn: 2.349 ± 0.087
1.984AspPro: 1.984 ± 0.08
1.882AspGln: 1.882 ± 0.088
2.806AspArg: 2.806 ± 0.102
3.312AspSer: 3.312 ± 0.116
3.551AspThr: 3.551 ± 0.118
4.221AspVal: 4.221 ± 0.132
0.659AspTrp: 0.659 ± 0.047
2.078AspTyr: 2.078 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
4.898GluAla: 4.898 ± 0.156
0.478GluCys: 0.478 ± 0.045
2.704GluAsp: 2.704 ± 0.129
3.2GluGlu: 3.2 ± 0.121
2.353GluPhe: 2.353 ± 0.087
2.69GluGly: 2.69 ± 0.126
1.39GluHis: 1.39 ± 0.078
4.188GluIle: 4.188 ± 0.136
3.986GluLys: 3.986 ± 0.147
6.332GluLeu: 6.332 ± 0.177
1.386GluMet: 1.386 ± 0.075
2.317GluAsn: 2.317 ± 0.099
1.89GluPro: 1.89 ± 0.078
2.802GluGln: 2.802 ± 0.102
4.17GluArg: 4.17 ± 0.146
3.178GluSer: 3.178 ± 0.121
3.244GluThr: 3.244 ± 0.128
3.884GluVal: 3.884 ± 0.153
0.583GluTrp: 0.583 ± 0.049
2.002GluTyr: 2.002 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
3.562PheAla: 3.562 ± 0.116
0.344PheCys: 0.344 ± 0.037
2.411PheAsp: 2.411 ± 0.086
1.901PheGlu: 1.901 ± 0.09
1.441PhePhe: 1.441 ± 0.092
2.722PheGly: 2.722 ± 0.101
0.699PheHis: 0.699 ± 0.054
2.516PheIle: 2.516 ± 0.098
1.481PheLys: 1.481 ± 0.079
2.744PheLeu: 2.744 ± 0.105
0.851PheMet: 0.851 ± 0.053
1.607PheAsn: 1.607 ± 0.085
1.14PhePro: 1.14 ± 0.056
0.912PheGln: 0.912 ± 0.05
1.846PheArg: 1.846 ± 0.083
2.773PheSer: 2.773 ± 0.107
2.462PheThr: 2.462 ± 0.093
2.885PheVal: 2.885 ± 0.105
0.434PheTrp: 0.434 ± 0.036
1.365PheTyr: 1.365 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
5.825GlyAla: 5.825 ± 0.165
0.539GlyCys: 0.539 ± 0.052
3.975GlyAsp: 3.975 ± 0.124
4.094GlyGlu: 4.094 ± 0.136
2.53GlyPhe: 2.53 ± 0.091
5.256GlyGly: 5.256 ± 0.208
1.198GlyHis: 1.198 ± 0.071
4.312GlyIle: 4.312 ± 0.129
4.293GlyLys: 4.293 ± 0.147
5.76GlyLeu: 5.76 ± 0.174
1.495GlyMet: 1.495 ± 0.066
2.672GlyAsn: 2.672 ± 0.119
1.329GlyPro: 1.329 ± 0.069
2.241GlyGln: 2.241 ± 0.092
3.649GlyArg: 3.649 ± 0.127
4.598GlySer: 4.598 ± 0.159
3.801GlyThr: 3.801 ± 0.13
5.817GlyVal: 5.817 ± 0.151
0.967GlyTrp: 0.967 ± 0.066
2.556GlyTyr: 2.556 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
1.886HisAla: 1.886 ± 0.091
0.174HisCys: 0.174 ± 0.026
1.401HisAsp: 1.401 ± 0.082
1.401HisGlu: 1.401 ± 0.074
0.735HisPhe: 0.735 ± 0.052
1.434HisGly: 1.434 ± 0.074
0.467HisHis: 0.467 ± 0.042
1.647HisIle: 1.647 ± 0.081
0.977HisLys: 0.977 ± 0.065
1.499HisLeu: 1.499 ± 0.084
0.496HisMet: 0.496 ± 0.044
0.84HisAsn: 0.84 ± 0.055
1.014HisPro: 1.014 ± 0.057
0.749HisGln: 0.749 ± 0.059
1.18HisArg: 1.18 ± 0.074
1.205HisSer: 1.205 ± 0.058
1.318HisThr: 1.318 ± 0.07
1.524HisVal: 1.524 ± 0.076
0.21HisTrp: 0.21 ± 0.028
0.688HisTyr: 0.688 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
7.425IleAla: 7.425 ± 0.181
0.55IleCys: 0.55 ± 0.045
4.489IleAsp: 4.489 ± 0.141
3.91IleGlu: 3.91 ± 0.126
2.067IlePhe: 2.067 ± 0.096
4.637IleGly: 4.637 ± 0.147
1.213IleHis: 1.213 ± 0.076
4.883IleIle: 4.883 ± 0.17
3.425IleLys: 3.425 ± 0.126
5.401IleLeu: 5.401 ± 0.157
1.488IleMet: 1.488 ± 0.077
2.798IleAsn: 2.798 ± 0.1
2.418IlePro: 2.418 ± 0.11
2.024IleGln: 2.024 ± 0.096
3.28IleArg: 3.28 ± 0.114
4.188IleSer: 4.188 ± 0.129
4.214IleThr: 4.214 ± 0.125
5.836IleVal: 5.836 ± 0.142
0.478IleTrp: 0.478 ± 0.041
1.948IleTyr: 1.948 ± 0.091
0.0IleXaa: 0.0 ± 0.0
Lys
4.38LysAla: 4.38 ± 0.153
0.319LysCys: 0.319 ± 0.034
3.142LysAsp: 3.142 ± 0.118
3.171LysGlu: 3.171 ± 0.109
1.799LysPhe: 1.799 ± 0.08
3.026LysGly: 3.026 ± 0.106
1.271LysHis: 1.271 ± 0.068
3.953LysIle: 3.953 ± 0.125
4.268LysLys: 4.268 ± 0.167
5.495LysLeu: 5.495 ± 0.147
1.253LysMet: 1.253 ± 0.076
2.882LysAsn: 2.882 ± 0.092
2.179LysPro: 2.179 ± 0.099
2.795LysGln: 2.795 ± 0.1
3.624LysArg: 3.624 ± 0.101
3.483LysSer: 3.483 ± 0.123
3.664LysThr: 3.664 ± 0.122
3.443LysVal: 3.443 ± 0.113
0.51LysTrp: 0.51 ± 0.044
1.984LysTyr: 1.984 ± 0.085
0.0LysXaa: 0.0 ± 0.0
Leu
9.329LeuAla: 9.329 ± 0.204
0.681LeuCys: 0.681 ± 0.053
5.01LeuAsp: 5.01 ± 0.155
4.865LeuGlu: 4.865 ± 0.15
3.298LeuPhe: 3.298 ± 0.137
5.644LeuGly: 5.644 ± 0.147
1.951LeuHis: 1.951 ± 0.078
5.274LeuIle: 5.274 ± 0.152
4.525LeuLys: 4.525 ± 0.134
8.438LeuLeu: 8.438 ± 0.244
2.266LeuMet: 2.266 ± 0.106
3.457LeuAsn: 3.457 ± 0.122
4.094LeuPro: 4.094 ± 0.114
3.41LeuGln: 3.41 ± 0.122
5.749LeuArg: 5.749 ± 0.171
6.607LeuSer: 6.607 ± 0.184
5.426LeuThr: 5.426 ± 0.143
6.458LeuVal: 6.458 ± 0.173
0.927LeuTrp: 0.927 ± 0.057
2.806LeuTyr: 2.806 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
2.205MetAla: 2.205 ± 0.094
0.156MetCys: 0.156 ± 0.025
1.035MetAsp: 1.035 ± 0.06
0.992MetGlu: 0.992 ± 0.054
0.88MetPhe: 0.88 ± 0.061
1.321MetGly: 1.321 ± 0.06
0.431MetHis: 0.431 ± 0.039
1.459MetIle: 1.459 ± 0.077
1.593MetLys: 1.593 ± 0.072
2.176MetLeu: 2.176 ± 0.084
0.652MetMet: 0.652 ± 0.054
1.101MetAsn: 1.101 ± 0.063
1.09MetPro: 1.09 ± 0.069
0.909MetGln: 0.909 ± 0.058
1.611MetArg: 1.611 ± 0.064
1.712MetSer: 1.712 ± 0.088
1.539MetThr: 1.539 ± 0.073
1.405MetVal: 1.405 ± 0.073
0.203MetTrp: 0.203 ± 0.028
0.735MetTyr: 0.735 ± 0.061
0.0MetXaa: 0.0 ± 0.0
Asn
3.417AsnAla: 3.417 ± 0.127
0.3AsnCys: 0.3 ± 0.033
2.755AsnAsp: 2.755 ± 0.092
2.353AsnGlu: 2.353 ± 0.101
1.415AsnPhe: 1.415 ± 0.066
3.124AsnGly: 3.124 ± 0.135
0.757AsnHis: 0.757 ± 0.05
2.787AsnIle: 2.787 ± 0.094
2.147AsnLys: 2.147 ± 0.093
3.428AsnLeu: 3.428 ± 0.112
1.068AsnMet: 1.068 ± 0.064
2.118AsnAsn: 2.118 ± 0.105
2.255AsnPro: 2.255 ± 0.083
1.611AsnGln: 1.611 ± 0.073
2.237AsnArg: 2.237 ± 0.092
2.588AsnSer: 2.588 ± 0.116
2.57AsnThr: 2.57 ± 0.112
2.766AsnVal: 2.766 ± 0.099
0.463AsnTrp: 0.463 ± 0.045
1.495AsnTyr: 1.495 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
3.74ProAla: 3.74 ± 0.163
0.29ProCys: 0.29 ± 0.036
2.407ProAsp: 2.407 ± 0.105
2.538ProGlu: 2.538 ± 0.095
1.379ProPhe: 1.379 ± 0.076
2.541ProGly: 2.541 ± 0.107
1.024ProHis: 1.024 ± 0.059
2.284ProIle: 2.284 ± 0.1
2.016ProLys: 2.016 ± 0.08
3.121ProLeu: 3.121 ± 0.1
0.72ProMet: 0.72 ± 0.05
1.683ProAsn: 1.683 ± 0.086
1.557ProPro: 1.557 ± 0.103
1.636ProGln: 1.636 ± 0.099
2.103ProArg: 2.103 ± 0.09
2.588ProSer: 2.588 ± 0.091
2.407ProThr: 2.407 ± 0.095
2.943ProVal: 2.943 ± 0.122
0.373ProTrp: 0.373 ± 0.036
1.318ProTyr: 1.318 ± 0.073
0.0ProXaa: 0.0 ± 0.0
Gln
3.964GlnAla: 3.964 ± 0.14
0.235GlnCys: 0.235 ± 0.027
1.513GlnAsp: 1.513 ± 0.079
2.1GlnGlu: 2.1 ± 0.085
1.463GlnPhe: 1.463 ± 0.07
1.777GlnGly: 1.777 ± 0.083
0.858GlnHis: 0.858 ± 0.056
2.541GlnIle: 2.541 ± 0.089
2.23GlnLys: 2.23 ± 0.073
4.12GlnLeu: 4.12 ± 0.132
0.843GlnMet: 0.843 ± 0.049
1.455GlnAsn: 1.455 ± 0.076
2.006GlnPro: 2.006 ± 0.119
2.179GlnGln: 2.179 ± 0.101
2.52GlnArg: 2.52 ± 0.1
2.306GlnSer: 2.306 ± 0.098
2.574GlnThr: 2.574 ± 0.1
2.168GlnVal: 2.168 ± 0.088
0.358GlnTrp: 0.358 ± 0.035
1.434GlnTyr: 1.434 ± 0.079
0.0GlnXaa: 0.0 ± 0.0
Arg
5.26ArgAla: 5.26 ± 0.145
0.42ArgCys: 0.42 ± 0.043
3.674ArgAsp: 3.674 ± 0.114
3.721ArgGlu: 3.721 ± 0.126
2.092ArgPhe: 2.092 ± 0.091
3.653ArgGly: 3.653 ± 0.127
1.437ArgHis: 1.437 ± 0.078
3.457ArgIle: 3.457 ± 0.121
3.457ArgLys: 3.457 ± 0.123
5.734ArgLeu: 5.734 ± 0.143
1.473ArgMet: 1.473 ± 0.075
2.208ArgAsn: 2.208 ± 0.107
1.919ArgPro: 1.919 ± 0.085
3.03ArgGln: 3.03 ± 0.118
4.616ArgArg: 4.616 ± 0.142
3.45ArgSer: 3.45 ± 0.111
3.312ArgThr: 3.312 ± 0.128
4.004ArgVal: 4.004 ± 0.133
0.601ArgTrp: 0.601 ± 0.048
2.324ArgTyr: 2.324 ± 0.092
0.0ArgXaa: 0.0 ± 0.0
Ser
5.412SerAla: 5.412 ± 0.186
0.521SerCys: 0.521 ± 0.048
3.971SerAsp: 3.971 ± 0.138
3.602SerGlu: 3.602 ± 0.114
2.512SerPhe: 2.512 ± 0.094
5.137SerGly: 5.137 ± 0.171
1.339SerHis: 1.339 ± 0.067
3.935SerIle: 3.935 ± 0.133
3.287SerLys: 3.287 ± 0.113
5.669SerLeu: 5.669 ± 0.14
1.463SerMet: 1.463 ± 0.078
2.599SerAsn: 2.599 ± 0.117
2.436SerPro: 2.436 ± 0.101
2.306SerGln: 2.306 ± 0.092
3.761SerArg: 3.761 ± 0.12
4.681SerSer: 4.681 ± 0.183
3.613SerThr: 3.613 ± 0.117
4.572SerVal: 4.572 ± 0.141
0.764SerTrp: 0.764 ± 0.064
2.15SerTyr: 2.15 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
5.55ThrAla: 5.55 ± 0.167
0.471ThrCys: 0.471 ± 0.043
3.095ThrAsp: 3.095 ± 0.109
2.766ThrGlu: 2.766 ± 0.109
2.049ThrPhe: 2.049 ± 0.091
4.485ThrGly: 4.485 ± 0.134
1.267ThrHis: 1.267 ± 0.065
4.768ThrIle: 4.768 ± 0.125
3.142ThrLys: 3.142 ± 0.115
5.542ThrLeu: 5.542 ± 0.135
1.386ThrMet: 1.386 ± 0.06
2.577ThrAsn: 2.577 ± 0.095
3.309ThrPro: 3.309 ± 0.115
1.843ThrGln: 1.843 ± 0.091
2.99ThrArg: 2.99 ± 0.103
3.613ThrSer: 3.613 ± 0.141
3.863ThrThr: 3.863 ± 0.145
4.865ThrVal: 4.865 ± 0.148
0.583ThrTrp: 0.583 ± 0.051
2.031ThrTyr: 2.031 ± 0.088
0.0ThrXaa: 0.0 ± 0.0
Val
7.515ValAla: 7.515 ± 0.163
0.742ValCys: 0.742 ± 0.063
4.449ValAsp: 4.449 ± 0.135
4.355ValGlu: 4.355 ± 0.151
2.693ValPhe: 2.693 ± 0.092
4.789ValGly: 4.789 ± 0.134
1.187ValHis: 1.187 ± 0.064
4.909ValIle: 4.909 ± 0.15
3.917ValLys: 3.917 ± 0.12
6.563ValLeu: 6.563 ± 0.185
1.687ValMet: 1.687 ± 0.077
2.885ValAsn: 2.885 ± 0.115
2.701ValPro: 2.701 ± 0.099
2.357ValGln: 2.357 ± 0.098
4.391ValArg: 4.391 ± 0.132
4.728ValSer: 4.728 ± 0.159
4.272ValThr: 4.272 ± 0.139
6.125ValVal: 6.125 ± 0.174
0.818ValTrp: 0.818 ± 0.063
2.299ValTyr: 2.299 ± 0.092
0.0ValXaa: 0.0 ± 0.0
Trp
0.829TrpAla: 0.829 ± 0.058
0.163TrpCys: 0.163 ± 0.024
0.507TrpAsp: 0.507 ± 0.044
0.46TrpGlu: 0.46 ± 0.041
0.489TrpPhe: 0.489 ± 0.048
0.731TrpGly: 0.731 ± 0.063
0.315TrpHis: 0.315 ± 0.029
0.605TrpIle: 0.605 ± 0.045
0.384TrpLys: 0.384 ± 0.038
1.314TrpLeu: 1.314 ± 0.084
0.243TrpMet: 0.243 ± 0.031
0.445TrpAsn: 0.445 ± 0.052
0.304TrpPro: 0.304 ± 0.034
0.619TrpGln: 0.619 ± 0.05
0.948TrpArg: 0.948 ± 0.068
0.586TrpSer: 0.586 ± 0.053
0.543TrpThr: 0.543 ± 0.046
0.518TrpVal: 0.518 ± 0.037
0.232TrpTrp: 0.232 ± 0.033
0.398TrpTyr: 0.398 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.95TyrAla: 2.95 ± 0.094
0.322TyrCys: 0.322 ± 0.042
2.252TyrAsp: 2.252 ± 0.109
1.85TyrGlu: 1.85 ± 0.083
1.495TyrPhe: 1.495 ± 0.068
2.335TyrGly: 2.335 ± 0.085
0.731TyrHis: 0.731 ± 0.055
2.168TyrIle: 2.168 ± 0.094
1.864TyrLys: 1.864 ± 0.082
2.791TyrLeu: 2.791 ± 0.115
0.691TyrMet: 0.691 ± 0.045
1.611TyrAsn: 1.611 ± 0.076
1.263TyrPro: 1.263 ± 0.07
1.289TyrGln: 1.289 ± 0.065
2.125TyrArg: 2.125 ± 0.085
2.172TyrSer: 2.172 ± 0.089
2.074TyrThr: 2.074 ± 0.101
2.4TyrVal: 2.4 ± 0.096
0.362TyrTrp: 0.362 ± 0.041
1.274TyrTyr: 1.274 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 963 proteins (276238 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski