Human papillomavirus 35

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9

Average proteome isoelectric point is 6.65

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 9 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P27232|VL1_HPV35 Major capsid protein L1 OS=Human papillomavirus 35 OX=10587 GN=L1 PE=1 SV=2
MM1 pKa = 7.5HH2 pKa = 7.43GEE4 pKa = 3.67ITTLQDD10 pKa = 3.25YY11 pKa = 11.13VLDD14 pKa = 4.56LEE16 pKa = 4.98PEE18 pKa = 4.11ATDD21 pKa = 4.13LYY23 pKa = 10.84CYY25 pKa = 9.68EE26 pKa = 4.13QLCDD30 pKa = 3.61SSEE33 pKa = 4.18EE34 pKa = 4.14EE35 pKa = 4.56EE36 pKa = 4.31DD37 pKa = 4.46TIDD40 pKa = 4.93GPAGQAKK47 pKa = 10.0PDD49 pKa = 3.53TSNYY53 pKa = 10.45NIVTSCCKK61 pKa = 10.55CEE63 pKa = 3.68ATLRR67 pKa = 11.84LCVQSTHH74 pKa = 6.37IDD76 pKa = 3.01IRR78 pKa = 11.84KK79 pKa = 9.86LEE81 pKa = 4.51DD82 pKa = 3.47LLMGTFGIVCPGCSQRR98 pKa = 11.84AA99 pKa = 3.31

Molecular weight: 10.95 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P27220|VE1_HPV35 Replication protein E1 OS=Human papillomavirus 35 OX=10587 GN=E1 PE=3 SV=2
MM1 pKa = 7.97AILKK5 pKa = 8.8WKK7 pKa = 8.72YY8 pKa = 10.4SRR10 pKa = 11.84YY11 pKa = 9.75NSSTEE16 pKa = 3.64LSTAEE21 pKa = 4.7IATQLHH27 pKa = 7.13AYY29 pKa = 7.39NTTEE33 pKa = 4.03THH35 pKa = 6.0TKK37 pKa = 8.9ACSVGTTEE45 pKa = 4.43TQKK48 pKa = 9.9TNHH51 pKa = 5.54KK52 pKa = 9.06RR53 pKa = 11.84LRR55 pKa = 11.84GGTEE59 pKa = 3.74LPYY62 pKa = 11.14NPTKK66 pKa = 10.41RR67 pKa = 11.84VRR69 pKa = 11.84LSAVDD74 pKa = 3.57SVDD77 pKa = 3.1RR78 pKa = 11.84GVYY81 pKa = 8.61STSDD85 pKa = 3.34CTNKK89 pKa = 9.92DD90 pKa = 3.12RR91 pKa = 11.84CGSCSTTTPIVHH103 pKa = 7.03LKK105 pKa = 10.65GDD107 pKa = 4.07ANTLKK112 pKa = 10.58CLRR115 pKa = 11.84YY116 pKa = 9.7RR117 pKa = 11.84LGKK120 pKa = 10.51YY121 pKa = 8.76KK122 pKa = 10.69ALYY125 pKa = 9.73QDD127 pKa = 5.29ASSTWRR133 pKa = 11.84WTCTNDD139 pKa = 2.94KK140 pKa = 10.32KK141 pKa = 11.02QIAIVTLTYY150 pKa = 7.52TTEE153 pKa = 3.88YY154 pKa = 10.77QRR156 pKa = 11.84DD157 pKa = 3.6KK158 pKa = 11.26FLTTVKK164 pKa = 10.15IPNTVTVSKK173 pKa = 10.98GYY175 pKa = 10.05MSII178 pKa = 3.76

Molecular weight: 20.12 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

0

9

2575

81

637

286.1

32.1

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.748 ± 0.64

3.301 ± 0.81

5.67 ± 0.599

5.01 ± 0.74

3.34 ± 0.471

5.204 ± 0.557

2.369 ± 0.218

5.398 ± 0.693

5.981 ± 0.798

8.466 ± 0.83

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.903 ± 0.141

4.194 ± 0.417

5.476 ± 1.449

3.806 ± 0.498

4.544 ± 0.313

7.961 ± 0.648

9.359 ± 1.451

6.485 ± 0.489

1.398 ± 0.363

4.388 ± 0.484
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski