Amino acid dipepetide frequency for Botryotinia calthae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.079AlaAla: 7.079 ± 0.053
0.934AlaCys: 0.934 ± 0.014
3.595AlaAsp: 3.595 ± 0.028
4.678AlaGlu: 4.678 ± 0.04
2.87AlaPhe: 2.87 ± 0.025
5.073AlaGly: 5.073 ± 0.038
1.54AlaHis: 1.54 ± 0.015
4.374AlaIle: 4.374 ± 0.029
4.118AlaLys: 4.118 ± 0.031
6.746AlaLeu: 6.746 ± 0.043
1.832AlaMet: 1.832 ± 0.02
3.043AlaAsn: 3.043 ± 0.024
4.194AlaPro: 4.194 ± 0.036
3.026AlaGln: 3.026 ± 0.028
4.061AlaArg: 4.061 ± 0.033
6.79AlaSer: 6.79 ± 0.045
4.927AlaThr: 4.927 ± 0.037
4.457AlaVal: 4.457 ± 0.032
0.988AlaTrp: 0.988 ± 0.016
2.02AlaTyr: 2.02 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.013
0.236CysCys: 0.236 ± 0.008
0.641CysAsp: 0.641 ± 0.011
0.634CysGlu: 0.634 ± 0.013
0.538CysPhe: 0.538 ± 0.01
0.932CysGly: 0.932 ± 0.015
0.294CysHis: 0.294 ± 0.007
0.721CysIle: 0.721 ± 0.012
0.581CysLys: 0.581 ± 0.013
1.16CysLeu: 1.16 ± 0.016
0.284CysMet: 0.284 ± 0.008
0.472CysAsn: 0.472 ± 0.009
0.63CysPro: 0.63 ± 0.013
0.419CysGln: 0.419 ± 0.009
0.645CysArg: 0.645 ± 0.011
0.926CysSer: 0.926 ± 0.015
0.7CysThr: 0.7 ± 0.012
0.737CysVal: 0.737 ± 0.011
0.188CysTrp: 0.188 ± 0.006
0.354CysTyr: 0.354 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.063AspAla: 4.063 ± 0.028
0.632AspCys: 0.632 ± 0.013
4.104AspAsp: 4.104 ± 0.041
4.627AspGlu: 4.627 ± 0.04
2.25AspPhe: 2.25 ± 0.021
3.873AspGly: 3.873 ± 0.03
1.164AspHis: 1.164 ± 0.014
3.386AspIle: 3.386 ± 0.028
2.451AspLys: 2.451 ± 0.026
4.916AspLeu: 4.916 ± 0.034
1.26AspMet: 1.26 ± 0.015
2.138AspAsn: 2.138 ± 0.02
2.929AspPro: 2.929 ± 0.026
1.771AspGln: 1.771 ± 0.019
2.746AspArg: 2.746 ± 0.032
4.337AspSer: 4.337 ± 0.031
3.02AspThr: 3.02 ± 0.025
3.431AspVal: 3.431 ± 0.027
0.863AspTrp: 0.863 ± 0.013
1.63AspTyr: 1.63 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
4.914GluAla: 4.914 ± 0.036
0.645GluCys: 0.645 ± 0.014
4.428GluAsp: 4.428 ± 0.037
6.237GluGlu: 6.237 ± 0.06
2.106GluPhe: 2.106 ± 0.021
4.0GluGly: 4.0 ± 0.033
1.328GluHis: 1.328 ± 0.014
3.799GluIle: 3.799 ± 0.028
4.519GluLys: 4.519 ± 0.039
5.202GluLeu: 5.202 ± 0.038
1.664GluMet: 1.664 ± 0.018
2.971GluAsn: 2.971 ± 0.024
2.581GluPro: 2.581 ± 0.029
2.359GluGln: 2.359 ± 0.028
4.019GluArg: 4.019 ± 0.044
4.8GluSer: 4.8 ± 0.039
3.554GluThr: 3.554 ± 0.028
3.751GluVal: 3.751 ± 0.027
0.918GluTrp: 0.918 ± 0.014
1.788GluTyr: 1.788 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
2.814PheAla: 2.814 ± 0.027
0.557PheCys: 0.557 ± 0.01
2.299PheAsp: 2.299 ± 0.021
2.342PheGlu: 2.342 ± 0.021
1.57PhePhe: 1.57 ± 0.019
2.887PheGly: 2.887 ± 0.027
0.893PheHis: 0.893 ± 0.013
1.945PheIle: 1.945 ± 0.019
1.726PheLys: 1.726 ± 0.02
3.423PheLeu: 3.423 ± 0.029
0.831PheMet: 0.831 ± 0.012
1.613PheAsn: 1.613 ± 0.018
1.964PhePro: 1.964 ± 0.018
1.428PheGln: 1.428 ± 0.018
1.826PheArg: 1.826 ± 0.017
3.163PheSer: 3.163 ± 0.027
2.277PheThr: 2.277 ± 0.025
2.274PheVal: 2.274 ± 0.023
0.633PheTrp: 0.633 ± 0.011
1.115PheTyr: 1.115 ± 0.016
0.0PheXaa: 0.0 ± 0.0
Gly
4.651GlyAla: 4.651 ± 0.038
0.835GlyCys: 0.835 ± 0.014
3.479GlyAsp: 3.479 ± 0.026
3.92GlyGlu: 3.92 ± 0.031
2.773GlyPhe: 2.773 ± 0.027
5.733GlyGly: 5.733 ± 0.054
1.543GlyHis: 1.543 ± 0.02
3.782GlyIle: 3.782 ± 0.028
3.93GlyLys: 3.93 ± 0.035
5.685GlyLeu: 5.685 ± 0.037
1.708GlyMet: 1.708 ± 0.02
2.961GlyAsn: 2.961 ± 0.031
2.901GlyPro: 2.901 ± 0.03
2.268GlyGln: 2.268 ± 0.024
3.769GlyArg: 3.769 ± 0.029
5.763GlySer: 5.763 ± 0.043
3.987GlyThr: 3.987 ± 0.033
4.16GlyVal: 4.16 ± 0.03
1.127GlyTrp: 1.127 ± 0.016
2.177GlyTyr: 2.177 ± 0.021
0.0GlyXaa: 0.0 ± 0.0
His
1.555HisAla: 1.555 ± 0.02
0.311HisCys: 0.311 ± 0.008
1.244HisAsp: 1.244 ± 0.016
1.336HisGlu: 1.336 ± 0.016
0.908HisPhe: 0.908 ± 0.013
1.554HisGly: 1.554 ± 0.018
0.762HisHis: 0.762 ± 0.014
1.261HisIle: 1.261 ± 0.015
1.023HisLys: 1.023 ± 0.014
2.045HisLeu: 2.045 ± 0.022
0.485HisMet: 0.485 ± 0.009
0.969HisAsn: 0.969 ± 0.015
1.488HisPro: 1.488 ± 0.016
0.974HisGln: 0.974 ± 0.015
1.336HisArg: 1.336 ± 0.017
1.916HisSer: 1.916 ± 0.02
1.323HisThr: 1.323 ± 0.017
1.252HisVal: 1.252 ± 0.015
0.302HisTrp: 0.302 ± 0.008
0.692HisTyr: 0.692 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
4.304IleAla: 4.304 ± 0.032
0.804IleCys: 0.804 ± 0.013
3.22IleAsp: 3.22 ± 0.027
3.497IleGlu: 3.497 ± 0.028
2.273IlePhe: 2.273 ± 0.022
3.473IleGly: 3.473 ± 0.028
1.297IleHis: 1.297 ± 0.015
3.126IleIle: 3.126 ± 0.029
2.74IleLys: 2.74 ± 0.022
5.052IleLeu: 5.052 ± 0.035
1.159IleMet: 1.159 ± 0.014
2.278IleAsn: 2.278 ± 0.021
3.498IlePro: 3.498 ± 0.025
2.116IleGln: 2.116 ± 0.022
2.817IleArg: 2.817 ± 0.025
4.836IleSer: 4.836 ± 0.033
3.35IleThr: 3.35 ± 0.031
3.375IleVal: 3.375 ± 0.028
0.79IleTrp: 0.79 ± 0.015
1.612IleTyr: 1.612 ± 0.018
0.0IleXaa: 0.0 ± 0.0
Lys
4.283LysAla: 4.283 ± 0.032
0.586LysCys: 0.586 ± 0.011
3.148LysAsp: 3.148 ± 0.028
4.142LysGlu: 4.142 ± 0.041
1.774LysPhe: 1.774 ± 0.019
3.288LysGly: 3.288 ± 0.03
1.185LysHis: 1.185 ± 0.016
2.993LysIle: 2.993 ± 0.023
4.131LysLys: 4.131 ± 0.044
4.451LysLeu: 4.451 ± 0.029
1.196LysMet: 1.196 ± 0.016
2.32LysAsn: 2.32 ± 0.021
2.788LysPro: 2.788 ± 0.028
1.895LysGln: 1.895 ± 0.021
3.585LysArg: 3.585 ± 0.034
4.44LysSer: 4.44 ± 0.034
3.181LysThr: 3.181 ± 0.029
3.128LysVal: 3.128 ± 0.026
0.746LysTrp: 0.746 ± 0.012
1.552LysTyr: 1.552 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
6.789LeuAla: 6.789 ± 0.041
1.133LeuCys: 1.133 ± 0.016
4.823LeuAsp: 4.823 ± 0.029
5.65LeuGlu: 5.65 ± 0.045
3.203LeuPhe: 3.203 ± 0.029
5.552LeuGly: 5.552 ± 0.039
2.045LeuHis: 2.045 ± 0.024
4.24LeuIle: 4.24 ± 0.033
4.682LeuLys: 4.682 ± 0.041
7.772LeuLeu: 7.772 ± 0.056
1.792LeuMet: 1.792 ± 0.02
3.508LeuAsn: 3.508 ± 0.026
5.228LeuPro: 5.228 ± 0.035
3.701LeuGln: 3.701 ± 0.033
5.083LeuArg: 5.083 ± 0.039
7.343LeuSer: 7.343 ± 0.042
4.76LeuThr: 4.76 ± 0.029
4.851LeuVal: 4.851 ± 0.037
1.125LeuTrp: 1.125 ± 0.016
2.297LeuTyr: 2.297 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
2.052MetAla: 2.052 ± 0.018
0.244MetCys: 0.244 ± 0.007
1.305MetAsp: 1.305 ± 0.018
1.498MetGlu: 1.498 ± 0.02
0.768MetPhe: 0.768 ± 0.014
1.575MetGly: 1.575 ± 0.018
0.471MetHis: 0.471 ± 0.01
1.179MetIle: 1.179 ± 0.015
1.229MetLys: 1.229 ± 0.016
1.748MetLeu: 1.748 ± 0.019
0.618MetMet: 0.618 ± 0.012
0.998MetAsn: 0.998 ± 0.015
1.192MetPro: 1.192 ± 0.014
0.856MetGln: 0.856 ± 0.015
1.235MetArg: 1.235 ± 0.016
2.016MetSer: 2.016 ± 0.017
1.307MetThr: 1.307 ± 0.017
1.305MetVal: 1.305 ± 0.017
0.258MetTrp: 0.258 ± 0.007
0.545MetTyr: 0.545 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.236AsnAla: 3.236 ± 0.022
0.503AsnCys: 0.503 ± 0.009
2.311AsnAsp: 2.311 ± 0.024
2.504AsnGlu: 2.504 ± 0.026
1.674AsnPhe: 1.674 ± 0.017
3.414AsnGly: 3.414 ± 0.035
1.049AsnHis: 1.049 ± 0.014
2.565AsnIle: 2.565 ± 0.022
1.929AsnLys: 1.929 ± 0.018
3.711AsnLeu: 3.711 ± 0.028
0.967AsnMet: 0.967 ± 0.014
2.009AsnAsn: 2.009 ± 0.024
2.642AsnPro: 2.642 ± 0.027
1.596AsnGln: 1.596 ± 0.019
2.091AsnArg: 2.091 ± 0.022
3.691AsnSer: 3.691 ± 0.03
2.754AsnThr: 2.754 ± 0.025
2.456AsnVal: 2.456 ± 0.022
0.598AsnTrp: 0.598 ± 0.011
1.261AsnTyr: 1.261 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
4.285ProAla: 4.285 ± 0.029
0.456ProCys: 0.456 ± 0.01
2.763ProAsp: 2.763 ± 0.023
3.588ProGlu: 3.588 ± 0.028
1.964ProPhe: 1.964 ± 0.021
3.41ProGly: 3.41 ± 0.031
1.24ProHis: 1.24 ± 0.016
3.013ProIle: 3.013 ± 0.026
2.918ProLys: 2.918 ± 0.025
4.517ProLeu: 4.517 ± 0.03
1.048ProMet: 1.048 ± 0.015
2.44ProAsn: 2.44 ± 0.024
4.555ProPro: 4.555 ± 0.058
2.423ProGln: 2.423 ± 0.031
3.1ProArg: 3.1 ± 0.029
6.015ProSer: 6.015 ± 0.049
4.045ProThr: 4.045 ± 0.032
3.197ProVal: 3.197 ± 0.031
0.642ProTrp: 0.642 ± 0.012
1.519ProTyr: 1.519 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.044GlnAla: 3.044 ± 0.029
0.414GlnCys: 0.414 ± 0.007
1.972GlnAsp: 1.972 ± 0.02
2.443GlnGlu: 2.443 ± 0.026
1.332GlnPhe: 1.332 ± 0.016
2.189GlnGly: 2.189 ± 0.024
0.977GlnHis: 0.977 ± 0.016
2.135GlnIle: 2.135 ± 0.018
2.259GlnLys: 2.259 ± 0.023
3.139GlnLeu: 3.139 ± 0.027
0.897GlnMet: 0.897 ± 0.014
1.901GlnAsn: 1.901 ± 0.02
2.17GlnPro: 2.17 ± 0.027
2.178GlnGln: 2.178 ± 0.041
2.345GlnArg: 2.345 ± 0.023
3.308GlnSer: 3.308 ± 0.031
2.317GlnThr: 2.317 ± 0.022
2.02GlnVal: 2.02 ± 0.022
0.535GlnTrp: 0.535 ± 0.009
1.211GlnTyr: 1.211 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
3.896ArgAla: 3.896 ± 0.029
0.63ArgCys: 0.63 ± 0.011
3.08ArgAsp: 3.08 ± 0.034
3.926ArgGlu: 3.926 ± 0.041
1.949ArgPhe: 1.949 ± 0.02
3.6ArgGly: 3.6 ± 0.032
1.311ArgHis: 1.311 ± 0.018
2.983ArgIle: 2.983 ± 0.024
3.723ArgLys: 3.723 ± 0.032
4.665ArgLeu: 4.665 ± 0.033
1.274ArgMet: 1.274 ± 0.015
2.527ArgAsn: 2.527 ± 0.024
2.972ArgPro: 2.972 ± 0.027
2.27ArgGln: 2.27 ± 0.022
4.383ArgArg: 4.383 ± 0.044
4.649ArgSer: 4.649 ± 0.038
3.022ArgThr: 3.022 ± 0.026
2.947ArgVal: 2.947 ± 0.023
0.793ArgTrp: 0.793 ± 0.013
1.568ArgTyr: 1.568 ± 0.017
0.0ArgXaa: 0.0 ± 0.0
Ser
6.287SerAla: 6.287 ± 0.048
0.9SerCys: 0.9 ± 0.013
4.369SerAsp: 4.369 ± 0.033
4.668SerGlu: 4.668 ± 0.03
3.217SerPhe: 3.217 ± 0.028
5.652SerGly: 5.652 ± 0.045
2.055SerHis: 2.055 ± 0.023
4.974SerIle: 4.974 ± 0.038
4.513SerLys: 4.513 ± 0.037
7.279SerLeu: 7.279 ± 0.046
1.836SerMet: 1.836 ± 0.02
3.899SerAsn: 3.899 ± 0.028
5.661SerPro: 5.661 ± 0.053
3.493SerGln: 3.493 ± 0.028
4.868SerArg: 4.868 ± 0.037
10.138SerSer: 10.138 ± 0.095
6.463SerThr: 6.463 ± 0.053
4.478SerVal: 4.478 ± 0.032
1.08SerTrp: 1.08 ± 0.012
2.308SerTyr: 2.308 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
4.72ThrAla: 4.72 ± 0.037
0.754ThrCys: 0.754 ± 0.014
2.771ThrAsp: 2.771 ± 0.025
3.279ThrGlu: 3.279 ± 0.023
2.373ThrPhe: 2.373 ± 0.023
4.09ThrGly: 4.09 ± 0.031
1.312ThrHis: 1.312 ± 0.016
3.705ThrIle: 3.705 ± 0.029
3.046ThrLys: 3.046 ± 0.027
5.227ThrLeu: 5.227 ± 0.036
1.244ThrMet: 1.244 ± 0.015
2.59ThrAsn: 2.59 ± 0.022
4.487ThrPro: 4.487 ± 0.036
2.197ThrGln: 2.197 ± 0.023
2.967ThrArg: 2.967 ± 0.027
6.241ThrSer: 6.241 ± 0.051
4.72ThrThr: 4.72 ± 0.053
3.455ThrVal: 3.455 ± 0.029
0.796ThrTrp: 0.796 ± 0.013
1.716ThrTyr: 1.716 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
4.572ValAla: 4.572 ± 0.03
0.738ValCys: 0.738 ± 0.012
3.476ValAsp: 3.476 ± 0.028
4.041ValGlu: 4.041 ± 0.032
2.295ValPhe: 2.295 ± 0.026
3.844ValGly: 3.844 ± 0.034
1.231ValHis: 1.231 ± 0.014
3.074ValIle: 3.074 ± 0.027
3.121ValLys: 3.121 ± 0.03
5.04ValLeu: 5.04 ± 0.034
1.302ValMet: 1.302 ± 0.016
2.302ValAsn: 2.302 ± 0.021
3.21ValPro: 3.21 ± 0.027
2.146ValGln: 2.146 ± 0.022
2.952ValArg: 2.952 ± 0.026
4.515ValSer: 4.515 ± 0.031
3.339ValThr: 3.339 ± 0.025
3.915ValVal: 3.915 ± 0.032
0.8ValTrp: 0.8 ± 0.013
1.621ValTyr: 1.621 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
0.953TrpAla: 0.953 ± 0.014
0.196TrpCys: 0.196 ± 0.006
0.853TrpAsp: 0.853 ± 0.014
0.903TrpGlu: 0.903 ± 0.013
0.513TrpPhe: 0.513 ± 0.01
0.94TrpGly: 0.94 ± 0.014
0.315TrpHis: 0.315 ± 0.007
0.807TrpIle: 0.807 ± 0.012
0.884TrpLys: 0.884 ± 0.012
1.21TrpLeu: 1.21 ± 0.016
0.377TrpMet: 0.377 ± 0.008
0.695TrpAsn: 0.695 ± 0.011
0.534TrpPro: 0.534 ± 0.012
0.512TrpGln: 0.512 ± 0.009
0.821TrpArg: 0.821 ± 0.012
1.022TrpSer: 1.022 ± 0.014
0.864TrpThr: 0.864 ± 0.012
0.81TrpVal: 0.81 ± 0.013
0.259TrpTrp: 0.259 ± 0.007
0.414TrpTyr: 0.414 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.999TyrAla: 1.999 ± 0.019
0.431TyrCys: 0.431 ± 0.01
1.707TyrAsp: 1.707 ± 0.021
1.672TyrGlu: 1.672 ± 0.02
1.23TyrPhe: 1.23 ± 0.016
2.074TyrGly: 2.074 ± 0.022
0.725TyrHis: 0.725 ± 0.012
1.557TyrIle: 1.557 ± 0.017
1.29TyrLys: 1.29 ± 0.014
2.591TyrLeu: 2.591 ± 0.026
0.627TyrMet: 0.627 ± 0.011
1.325TyrAsn: 1.325 ± 0.017
1.517TyrPro: 1.517 ± 0.018
1.156TyrGln: 1.156 ± 0.017
1.518TyrArg: 1.518 ± 0.017
2.227TyrSer: 2.227 ± 0.018
1.779TyrThr: 1.779 ± 0.019
1.537TyrVal: 1.537 ± 0.019
0.437TyrTrp: 0.437 ± 0.01
0.982TyrTyr: 0.982 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12263 proteins (5604297 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski