Amino acid dipepetide frequency for Aspergillus glaucus CBS 516.65

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.029AlaAla: 8.029 ± 0.062	1.042AlaCys: 1.042 ± 0.017	3.961AlaAsp: 3.961 ± 0.031	4.796AlaGlu: 4.796 ± 0.041	3.065AlaPhe: 3.065 ± 0.027	5.46AlaGly: 5.46 ± 0.038	1.76AlaHis: 1.76 ± 0.018	4.115AlaIle: 4.115 ± 0.034	3.727AlaLys: 3.727 ± 0.034	7.298AlaLeu: 7.298 ± 0.046	1.929AlaMet: 1.929 ± 0.02	2.981AlaAsn: 2.981 ± 0.025	4.614AlaPro: 4.614 ± 0.048	3.319AlaGln: 3.319 ± 0.031	4.674AlaArg: 4.674 ± 0.034	6.904AlaSer: 6.904 ± 0.049	4.886AlaThr: 4.886 ± 0.034	5.156AlaVal: 5.156 ± 0.04	1.08AlaTrp: 1.08 ± 0.017	2.142AlaTyr: 2.142 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.942CysAla: 0.942 ± 0.016	0.268CysCys: 0.268 ± 0.009	0.7CysAsp: 0.7 ± 0.014	0.613CysGlu: 0.613 ± 0.011	0.563CysPhe: 0.563 ± 0.011	0.937CysGly: 0.937 ± 0.018	0.37CysHis: 0.37 ± 0.009	0.718CysIle: 0.718 ± 0.013	0.496CysLys: 0.496 ± 0.01	1.326CysLeu: 1.326 ± 0.021	0.304CysMet: 0.304 ± 0.008	0.448CysAsn: 0.448 ± 0.011	0.667CysPro: 0.667 ± 0.013	0.483CysGln: 0.483 ± 0.011	0.819CysArg: 0.819 ± 0.014	0.978CysSer: 0.978 ± 0.016	0.704CysThr: 0.704 ± 0.015	0.838CysVal: 0.838 ± 0.013	0.214CysTrp: 0.214 ± 0.007	0.388CysTyr: 0.388 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.485AspAla: 4.485 ± 0.031	0.649AspCys: 0.649 ± 0.013	4.208AspAsp: 4.208 ± 0.044	4.552AspGlu: 4.552 ± 0.041	2.195AspPhe: 2.195 ± 0.023	3.944AspGly: 3.944 ± 0.031	1.283AspHis: 1.283 ± 0.016	3.2AspIle: 3.2 ± 0.028	2.341AspLys: 2.341 ± 0.02	5.097AspLeu: 5.097 ± 0.036	1.275AspMet: 1.275 ± 0.02	2.093AspAsn: 2.093 ± 0.023	3.352AspPro: 3.352 ± 0.029	1.988AspGln: 1.988 ± 0.02	3.029AspArg: 3.029 ± 0.029	4.14AspSer: 4.14 ± 0.04	3.049AspThr: 3.049 ± 0.025	3.688AspVal: 3.688 ± 0.027	0.891AspTrp: 0.891 ± 0.015	1.726AspTyr: 1.726 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	4.985GluAla: 4.985 ± 0.04	0.661GluCys: 0.661 ± 0.013	4.302GluAsp: 4.302 ± 0.04	5.766GluGlu: 5.766 ± 0.063	2.014GluPhe: 2.014 ± 0.018	3.896GluGly: 3.896 ± 0.034	1.433GluHis: 1.433 ± 0.016	3.077GluIle: 3.077 ± 0.024	3.827GluLys: 3.827 ± 0.039	5.085GluLeu: 5.085 ± 0.035	1.512GluMet: 1.512 ± 0.021	2.515GluAsn: 2.515 ± 0.025	2.974GluPro: 2.974 ± 0.058	2.765GluGln: 2.765 ± 0.029	3.99GluArg: 3.99 ± 0.038	4.501GluSer: 4.501 ± 0.034	3.563GluThr: 3.563 ± 0.028	3.542GluVal: 3.542 ± 0.028	0.924GluTrp: 0.924 ± 0.013	1.787GluTyr: 1.787 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.957PheAla: 2.957 ± 0.026	0.601PheCys: 0.601 ± 0.013	2.32PheAsp: 2.32 ± 0.022	2.163PheGlu: 2.163 ± 0.02	1.728PhePhe: 1.728 ± 0.024	2.849PheGly: 2.849 ± 0.034	0.962PheHis: 0.962 ± 0.016	1.869PheIle: 1.869 ± 0.02	1.451PheLys: 1.451 ± 0.017	3.695PheLeu: 3.695 ± 0.036	0.826PheMet: 0.826 ± 0.014	1.493PheAsn: 1.493 ± 0.018	2.081PhePro: 2.081 ± 0.02	1.466PheGln: 1.466 ± 0.017	2.022PheArg: 2.022 ± 0.02	3.123PheSer: 3.123 ± 0.028	2.11PheThr: 2.11 ± 0.021	2.392PheVal: 2.392 ± 0.023	0.641PheTrp: 0.641 ± 0.013	1.158PheTyr: 1.158 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.013GlyAla: 5.013 ± 0.04	0.918GlyCys: 0.918 ± 0.015	3.673GlyAsp: 3.673 ± 0.03	3.769GlyGlu: 3.769 ± 0.028	2.859GlyPhe: 2.859 ± 0.028	5.509GlyGly: 5.509 ± 0.07	1.696GlyHis: 1.696 ± 0.023	3.601GlyIle: 3.601 ± 0.029	3.43GlyLys: 3.43 ± 0.033	6.116GlyLeu: 6.116 ± 0.042	1.612GlyMet: 1.612 ± 0.021	2.588GlyAsn: 2.588 ± 0.027	3.264GlyPro: 3.264 ± 0.026	2.628GlyGln: 2.628 ± 0.025	4.001GlyArg: 4.001 ± 0.034	5.594GlySer: 5.594 ± 0.041	3.831GlyThr: 3.831 ± 0.035	4.44GlyVal: 4.44 ± 0.036	1.13GlyTrp: 1.13 ± 0.017	2.187GlyTyr: 2.187 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.83HisAla: 1.83 ± 0.021	0.351HisCys: 0.351 ± 0.009	1.396HisAsp: 1.396 ± 0.016	1.403HisGlu: 1.403 ± 0.018	0.945HisPhe: 0.945 ± 0.014	1.742HisGly: 1.742 ± 0.018	0.903HisHis: 0.903 ± 0.017	1.266HisIle: 1.266 ± 0.017	0.889HisLys: 0.889 ± 0.014	2.355HisLeu: 2.355 ± 0.026	0.499HisMet: 0.499 ± 0.01	0.909HisAsn: 0.909 ± 0.013	1.748HisPro: 1.748 ± 0.02	1.021HisGln: 1.021 ± 0.017	1.572HisArg: 1.572 ± 0.021	1.845HisSer: 1.845 ± 0.023	1.281HisThr: 1.281 ± 0.016	1.45HisVal: 1.45 ± 0.018	0.37HisTrp: 0.37 ± 0.01	0.743HisTyr: 0.743 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.005IleAla: 4.005 ± 0.034	0.792IleCys: 0.792 ± 0.013	2.858IleAsp: 2.858 ± 0.024	2.878IleGlu: 2.878 ± 0.025	2.057IlePhe: 2.057 ± 0.025	3.146IleGly: 3.146 ± 0.034	1.295IleHis: 1.295 ± 0.018	2.497IleIle: 2.497 ± 0.03	2.1IleLys: 2.1 ± 0.02	4.686IleLeu: 4.686 ± 0.034	1.034IleMet: 1.034 ± 0.015	1.848IleAsn: 1.848 ± 0.021	3.2IlePro: 3.2 ± 0.024	1.971IleGln: 1.971 ± 0.021	2.853IleArg: 2.853 ± 0.027	3.899IleSer: 3.899 ± 0.032	2.783IleThr: 2.783 ± 0.025	3.131IleVal: 3.131 ± 0.027	0.731IleTrp: 0.731 ± 0.013	1.487IleTyr: 1.487 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.861LysAla: 3.861 ± 0.038	0.509LysCys: 0.509 ± 0.011	2.766LysAsp: 2.766 ± 0.029	3.438LysGlu: 3.438 ± 0.035	1.392LysPhe: 1.392 ± 0.017	2.929LysGly: 2.929 ± 0.026	1.119LysHis: 1.119 ± 0.014	2.193LysIle: 2.193 ± 0.022	3.265LysLys: 3.265 ± 0.043	3.897LysLeu: 3.897 ± 0.03	0.985LysMet: 0.985 ± 0.016	1.815LysAsn: 1.815 ± 0.022	2.79LysPro: 2.79 ± 0.031	1.957LysGln: 1.957 ± 0.022	3.359LysArg: 3.359 ± 0.03	3.439LysSer: 3.439 ± 0.033	2.791LysThr: 2.791 ± 0.025	2.733LysVal: 2.733 ± 0.026	0.664LysTrp: 0.664 ± 0.011	1.375LysTyr: 1.375 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.308LeuAla: 7.308 ± 0.044	1.286LeuCys: 1.286 ± 0.019	5.175LeuAsp: 5.175 ± 0.038	5.603LeuGlu: 5.603 ± 0.039	3.48LeuPhe: 3.48 ± 0.034	5.93LeuGly: 5.93 ± 0.043	2.312LeuHis: 2.312 ± 0.023	3.921LeuIle: 3.921 ± 0.035	3.994LeuLys: 3.994 ± 0.035	8.448LeuLeu: 8.448 ± 0.066	1.837LeuMet: 1.837 ± 0.018	3.284LeuAsn: 3.284 ± 0.027	5.42LeuPro: 5.42 ± 0.035	3.931LeuGln: 3.931 ± 0.034	5.77LeuArg: 5.77 ± 0.036	7.581LeuSer: 7.581 ± 0.041	4.717LeuThr: 4.717 ± 0.035	5.491LeuVal: 5.491 ± 0.043	1.217LeuTrp: 1.217 ± 0.02	2.473LeuTyr: 2.473 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.168MetAla: 2.168 ± 0.02	0.262MetCys: 0.262 ± 0.007	1.314MetAsp: 1.314 ± 0.016	1.352MetGlu: 1.352 ± 0.019	0.759MetPhe: 0.759 ± 0.013	1.552MetGly: 1.552 ± 0.019	0.488MetHis: 0.488 ± 0.01	1.017MetIle: 1.017 ± 0.014	1.031MetLys: 1.031 ± 0.017	1.897MetLeu: 1.897 ± 0.021	0.572MetMet: 0.572 ± 0.012	0.853MetAsn: 0.853 ± 0.013	1.267MetPro: 1.267 ± 0.017	0.892MetGln: 0.892 ± 0.014	1.257MetArg: 1.257 ± 0.014	1.88MetSer: 1.88 ± 0.021	1.311MetThr: 1.311 ± 0.016	1.397MetVal: 1.397 ± 0.017	0.256MetTrp: 0.256 ± 0.007	0.545MetTyr: 0.545 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.178AsnAla: 3.178 ± 0.024	0.476AsnCys: 0.476 ± 0.01	2.121AsnAsp: 2.121 ± 0.023	2.234AsnGlu: 2.234 ± 0.021	1.383AsnPhe: 1.383 ± 0.017	3.038AsnGly: 3.038 ± 0.028	0.934AsnHis: 0.934 ± 0.014	2.082AsnIle: 2.082 ± 0.026	1.621AsnLys: 1.621 ± 0.019	3.335AsnLeu: 3.335 ± 0.024	0.87AsnMet: 0.87 ± 0.013	1.747AsnAsn: 1.747 ± 0.028	2.625AsnPro: 2.625 ± 0.023	1.468AsnGln: 1.468 ± 0.019	2.11AsnArg: 2.11 ± 0.017	2.759AsnSer: 2.759 ± 0.028	2.346AsnThr: 2.346 ± 0.022	2.424AsnVal: 2.424 ± 0.025	0.586AsnTrp: 0.586 ± 0.012	1.1AsnTyr: 1.1 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.021ProAla: 5.021 ± 0.043	0.551ProCys: 0.551 ± 0.013	3.318ProAsp: 3.318 ± 0.025	4.206ProGlu: 4.206 ± 0.053	2.174ProPhe: 2.174 ± 0.027	3.953ProGly: 3.953 ± 0.034	1.3ProHis: 1.3 ± 0.016	2.559ProIle: 2.559 ± 0.026	2.62ProLys: 2.62 ± 0.029	4.679ProLeu: 4.679 ± 0.035	1.123ProMet: 1.123 ± 0.016	2.272ProAsn: 2.272 ± 0.024	5.014ProPro: 5.014 ± 0.073	2.611ProGln: 2.611 ± 0.036	3.425ProArg: 3.425 ± 0.035	6.229ProSer: 6.229 ± 0.059	3.889ProThr: 3.889 ± 0.037	3.692ProVal: 3.692 ± 0.029	0.741ProTrp: 0.741 ± 0.013	1.559ProTyr: 1.559 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.302GlnAla: 3.302 ± 0.033	0.466GlnCys: 0.466 ± 0.011	2.15GlnAsp: 2.15 ± 0.022	2.631GlnGlu: 2.631 ± 0.029	1.354GlnPhe: 1.354 ± 0.017	2.497GlnGly: 2.497 ± 0.025	1.108GlnHis: 1.108 ± 0.015	1.909GlnIle: 1.909 ± 0.022	2.137GlnLys: 2.137 ± 0.025	3.47GlnLeu: 3.47 ± 0.033	0.915GlnMet: 0.915 ± 0.013	1.713GlnAsn: 1.713 ± 0.019	2.775GlnPro: 2.775 ± 0.036	2.725GlnGln: 2.725 ± 0.045	2.735GlnArg: 2.735 ± 0.027	3.37GlnSer: 3.37 ± 0.027	2.435GlnThr: 2.435 ± 0.024	2.233GlnVal: 2.233 ± 0.022	0.57GlnTrp: 0.57 ± 0.011	1.218GlnTyr: 1.218 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.453ArgAla: 4.453 ± 0.032	0.767ArgCys: 0.767 ± 0.016	3.392ArgAsp: 3.392 ± 0.036	3.958ArgGlu: 3.958 ± 0.039	2.255ArgPhe: 2.255 ± 0.023	3.712ArgGly: 3.712 ± 0.034	1.571ArgHis: 1.571 ± 0.02	2.924ArgIle: 2.924 ± 0.026	3.411ArgLys: 3.411 ± 0.03	5.478ArgLeu: 5.478 ± 0.037	1.378ArgMet: 1.378 ± 0.017	2.354ArgAsn: 2.354 ± 0.022	3.494ArgPro: 3.494 ± 0.034	2.648ArgGln: 2.648 ± 0.022	5.018ArgArg: 5.018 ± 0.048	4.711ArgSer: 4.711 ± 0.042	3.266ArgThr: 3.266 ± 0.028	3.49ArgVal: 3.49 ± 0.025	0.935ArgTrp: 0.935 ± 0.014	1.699ArgTyr: 1.699 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.305SerAla: 6.305 ± 0.048	0.931SerCys: 0.931 ± 0.015	4.246SerAsp: 4.246 ± 0.035	4.27SerGlu: 4.27 ± 0.031	3.177SerPhe: 3.177 ± 0.03	5.52SerGly: 5.52 ± 0.039	2.045SerHis: 2.045 ± 0.024	4.013SerIle: 4.013 ± 0.031	3.664SerLys: 3.664 ± 0.034	7.449SerLeu: 7.449 ± 0.047	1.794SerMet: 1.794 ± 0.023	3.148SerAsn: 3.148 ± 0.025	5.517SerPro: 5.517 ± 0.059	3.458SerGln: 3.458 ± 0.031	5.079SerArg: 5.079 ± 0.042	8.797SerSer: 8.797 ± 0.078	5.547SerThr: 5.547 ± 0.043	4.653SerVal: 4.653 ± 0.038	1.131SerTrp: 1.131 ± 0.016	2.124SerTyr: 2.124 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.006ThrAla: 5.006 ± 0.034	0.745ThrCys: 0.745 ± 0.014	2.902ThrAsp: 2.902 ± 0.025	3.196ThrGlu: 3.196 ± 0.024	2.164ThrPhe: 2.164 ± 0.021	4.217ThrGly: 4.217 ± 0.033	1.31ThrHis: 1.31 ± 0.015	3.022ThrIle: 3.022 ± 0.025	2.544ThrLys: 2.544 ± 0.022	5.142ThrLeu: 5.142 ± 0.033	1.205ThrMet: 1.205 ± 0.017	2.195ThrAsn: 2.195 ± 0.023	4.345ThrPro: 4.345 ± 0.045	2.136ThrGln: 2.136 ± 0.023	3.09ThrArg: 3.09 ± 0.024	5.17ThrSer: 5.17 ± 0.043	4.322ThrThr: 4.322 ± 0.042	3.725ThrVal: 3.725 ± 0.03	0.811ThrTrp: 0.811 ± 0.013	1.574ThrTyr: 1.574 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.856ValAla: 4.856 ± 0.036	0.865ValCys: 0.865 ± 0.013	3.82ValAsp: 3.82 ± 0.032	3.827ValGlu: 3.827 ± 0.032	2.54ValPhe: 2.54 ± 0.025	3.986ValGly: 3.986 ± 0.037	1.459ValHis: 1.459 ± 0.016	3.023ValIle: 3.023 ± 0.03	2.819ValLys: 2.819 ± 0.029	5.662ValLeu: 5.662 ± 0.041	1.355ValMet: 1.355 ± 0.017	2.357ValAsn: 2.357 ± 0.024	3.594ValPro: 3.594 ± 0.03	2.491ValGln: 2.491 ± 0.022	3.465ValArg: 3.465 ± 0.029	4.798ValSer: 4.798 ± 0.035	3.428ValThr: 3.428 ± 0.03	4.276ValVal: 4.276 ± 0.035	0.851ValTrp: 0.851 ± 0.013	1.789ValTyr: 1.789 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.061TrpAla: 1.061 ± 0.016	0.195TrpCys: 0.195 ± 0.007	0.898TrpAsp: 0.898 ± 0.014	0.883TrpGlu: 0.883 ± 0.014	0.547TrpPhe: 0.547 ± 0.011	0.925TrpGly: 0.925 ± 0.015	0.356TrpHis: 0.356 ± 0.009	0.763TrpIle: 0.763 ± 0.013	0.82TrpLys: 0.82 ± 0.013	1.338TrpLeu: 1.338 ± 0.02	0.397TrpMet: 0.397 ± 0.009	0.646TrpAsn: 0.646 ± 0.011	0.596TrpPro: 0.596 ± 0.012	0.579TrpGln: 0.579 ± 0.011	0.961TrpArg: 0.961 ± 0.015	1.035TrpSer: 1.035 ± 0.016	0.886TrpThr: 0.886 ± 0.012	0.875TrpVal: 0.875 ± 0.014	0.276TrpTrp: 0.276 ± 0.008	0.433TrpTyr: 0.433 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.168TyrAla: 2.168 ± 0.023	0.441TyrCys: 0.441 ± 0.01	1.665TyrAsp: 1.665 ± 0.02	1.581TyrGlu: 1.581 ± 0.02	1.256TyrPhe: 1.256 ± 0.019	2.117TyrGly: 2.117 ± 0.027	0.81TyrHis: 0.81 ± 0.013	1.48TyrIle: 1.48 ± 0.018	1.093TyrLys: 1.093 ± 0.015	2.727TyrLeu: 2.727 ± 0.025	0.652TyrMet: 0.652 ± 0.013	1.176TyrAsn: 1.176 ± 0.015	1.6TyrPro: 1.6 ± 0.021	1.175TyrGln: 1.175 ± 0.017	1.686TyrArg: 1.686 ± 0.018	2.116TyrSer: 2.116 ± 0.023	1.678TyrThr: 1.678 ± 0.02	1.636TyrVal: 1.636 ± 0.019	0.452TyrTrp: 0.452 ± 0.01	0.988TyrTyr: 0.988 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11245 proteins (4932616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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