Amino acid dipepetide frequency for Nitrincola tapanii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.173AlaAla: 10.173 ± 0.141
1.222AlaCys: 1.222 ± 0.041
5.099AlaAsp: 5.099 ± 0.083
7.409AlaGlu: 7.409 ± 0.105
3.581AlaPhe: 3.581 ± 0.074
7.049AlaGly: 7.049 ± 0.112
2.132AlaHis: 2.132 ± 0.051
5.095AlaIle: 5.095 ± 0.088
3.167AlaLys: 3.167 ± 0.062
13.443AlaLeu: 13.443 ± 0.143
2.554AlaMet: 2.554 ± 0.053
2.56AlaAsn: 2.56 ± 0.059
3.632AlaPro: 3.632 ± 0.077
6.246AlaGln: 6.246 ± 0.111
5.911AlaArg: 5.911 ± 0.078
5.588AlaSer: 5.588 ± 0.09
4.11AlaThr: 4.11 ± 0.073
6.224AlaVal: 6.224 ± 0.096
1.46AlaTrp: 1.46 ± 0.049
2.478AlaTyr: 2.478 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.979CysAla: 0.979 ± 0.034
0.149CysCys: 0.149 ± 0.013
0.535CysAsp: 0.535 ± 0.024
0.608CysGlu: 0.608 ± 0.028
0.414CysPhe: 0.414 ± 0.021
0.89CysGly: 0.89 ± 0.034
0.346CysHis: 0.346 ± 0.021
0.505CysIle: 0.505 ± 0.025
0.289CysLys: 0.289 ± 0.02
1.281CysLeu: 1.281 ± 0.046
0.207CysMet: 0.207 ± 0.016
0.294CysAsn: 0.294 ± 0.02
0.535CysPro: 0.535 ± 0.025
0.614CysGln: 0.614 ± 0.026
0.624CysArg: 0.624 ± 0.03
0.57CysSer: 0.57 ± 0.028
0.454CysThr: 0.454 ± 0.023
0.71CysVal: 0.71 ± 0.024
0.125CysTrp: 0.125 ± 0.012
0.272CysTyr: 0.272 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.186AspAla: 5.186 ± 0.075
0.497AspCys: 0.497 ± 0.026
2.237AspAsp: 2.237 ± 0.063
3.733AspGlu: 3.733 ± 0.064
2.169AspPhe: 2.169 ± 0.052
2.866AspGly: 2.866 ± 0.06
1.174AspHis: 1.174 ± 0.056
2.741AspIle: 2.741 ± 0.057
1.912AspLys: 1.912 ± 0.05
6.987AspLeu: 6.987 ± 0.095
1.144AspMet: 1.144 ± 0.04
1.392AspAsn: 1.392 ± 0.046
2.693AspPro: 2.693 ± 0.062
2.859AspGln: 2.859 ± 0.064
2.93AspArg: 2.93 ± 0.06
2.626AspSer: 2.626 ± 0.058
2.398AspThr: 2.398 ± 0.049
3.075AspVal: 3.075 ± 0.064
0.973AspTrp: 0.973 ± 0.037
1.703AspTyr: 1.703 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
7.087GluAla: 7.087 ± 0.1
0.496GluCys: 0.496 ± 0.025
3.031GluAsp: 3.031 ± 0.06
4.082GluGlu: 4.082 ± 0.078
2.321GluPhe: 2.321 ± 0.058
4.197GluGly: 4.197 ± 0.078
1.651GluHis: 1.651 ± 0.047
3.949GluIle: 3.949 ± 0.073
2.769GluLys: 2.769 ± 0.071
7.467GluLeu: 7.467 ± 0.093
1.797GluMet: 1.797 ± 0.045
1.816GluAsn: 1.816 ± 0.049
2.341GluPro: 2.341 ± 0.054
4.284GluGln: 4.284 ± 0.081
4.669GluArg: 4.669 ± 0.088
3.383GluSer: 3.383 ± 0.067
3.203GluThr: 3.203 ± 0.058
4.843GluVal: 4.843 ± 0.086
0.823GluTrp: 0.823 ± 0.034
1.535GluTyr: 1.535 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.688PheAla: 3.688 ± 0.074
0.49PheCys: 0.49 ± 0.023
2.346PheAsp: 2.346 ± 0.054
2.258PheGlu: 2.258 ± 0.052
1.586PhePhe: 1.586 ± 0.051
2.588PheGly: 2.588 ± 0.057
0.778PheHis: 0.778 ± 0.026
2.209PheIle: 2.209 ± 0.061
1.255PheLys: 1.255 ± 0.032
3.744PheLeu: 3.744 ± 0.082
0.951PheMet: 0.951 ± 0.036
1.45PheAsn: 1.45 ± 0.042
1.522PhePro: 1.522 ± 0.048
1.569PheGln: 1.569 ± 0.047
2.066PheArg: 2.066 ± 0.048
2.906PheSer: 2.906 ± 0.059
1.921PheThr: 1.921 ± 0.043
2.381PheVal: 2.381 ± 0.061
0.565PheTrp: 0.565 ± 0.031
1.222PheTyr: 1.222 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
5.736GlyAla: 5.736 ± 0.107
0.929GlyCys: 0.929 ± 0.035
3.425GlyAsp: 3.425 ± 0.073
4.389GlyGlu: 4.389 ± 0.085
3.141GlyPhe: 3.141 ± 0.064
4.705GlyGly: 4.705 ± 0.108
1.714GlyHis: 1.714 ± 0.05
4.242GlyIle: 4.242 ± 0.08
2.8GlyLys: 2.8 ± 0.075
8.102GlyLeu: 8.102 ± 0.115
2.058GlyMet: 2.058 ± 0.054
1.87GlyAsn: 1.87 ± 0.055
1.931GlyPro: 1.931 ± 0.054
3.774GlyGln: 3.774 ± 0.072
4.377GlyArg: 4.377 ± 0.08
3.819GlySer: 3.819 ± 0.067
2.988GlyThr: 2.988 ± 0.066
5.376GlyVal: 5.376 ± 0.104
1.13GlyTrp: 1.13 ± 0.037
2.293GlyTyr: 2.293 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.156HisAla: 2.156 ± 0.052
0.306HisCys: 0.306 ± 0.02
1.016HisAsp: 1.016 ± 0.041
1.281HisGlu: 1.281 ± 0.039
1.141HisPhe: 1.141 ± 0.039
1.43HisGly: 1.43 ± 0.045
0.73HisHis: 0.73 ± 0.036
1.05HisIle: 1.05 ± 0.035
0.769HisLys: 0.769 ± 0.034
3.455HisLeu: 3.455 ± 0.076
0.453HisMet: 0.453 ± 0.023
0.684HisAsn: 0.684 ± 0.034
1.675HisPro: 1.675 ± 0.05
1.439HisGln: 1.439 ± 0.043
1.34HisArg: 1.34 ± 0.044
1.407HisSer: 1.407 ± 0.051
1.119HisThr: 1.119 ± 0.04
1.052HisVal: 1.052 ± 0.033
0.487HisTrp: 0.487 ± 0.024
0.826HisTyr: 0.826 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.51IleAla: 5.51 ± 0.1
0.656IleCys: 0.656 ± 0.03
3.278IleAsp: 3.278 ± 0.064
4.16IleGlu: 4.16 ± 0.085
1.825IlePhe: 1.825 ± 0.058
3.862IleGly: 3.862 ± 0.073
1.3IleHis: 1.3 ± 0.04
2.613IleIle: 2.613 ± 0.076
1.914IleLys: 1.914 ± 0.058
5.695IleLeu: 5.695 ± 0.089
1.028IleMet: 1.028 ± 0.033
1.894IleAsn: 1.894 ± 0.05
2.554IlePro: 2.554 ± 0.055
2.705IleGln: 2.705 ± 0.051
3.48IleArg: 3.48 ± 0.071
3.679IleSer: 3.679 ± 0.067
2.962IleThr: 2.962 ± 0.065
2.929IleVal: 2.929 ± 0.066
0.665IleTrp: 0.665 ± 0.033
1.423IleTyr: 1.423 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.659LysAla: 3.659 ± 0.074
0.223LysCys: 0.223 ± 0.019
1.79LysAsp: 1.79 ± 0.048
2.138LysGlu: 2.138 ± 0.064
0.93LysPhe: 0.93 ± 0.035
2.5LysGly: 2.5 ± 0.066
0.845LysHis: 0.845 ± 0.034
2.049LysIle: 2.049 ± 0.05
1.661LysLys: 1.661 ± 0.057
3.734LysLeu: 3.734 ± 0.077
0.985LysMet: 0.985 ± 0.039
1.133LysAsn: 1.133 ± 0.045
1.859LysPro: 1.859 ± 0.048
1.945LysGln: 1.945 ± 0.046
2.471LysArg: 2.471 ± 0.058
2.158LysSer: 2.158 ± 0.06
2.108LysThr: 2.108 ± 0.049
2.538LysVal: 2.538 ± 0.054
0.296LysTrp: 0.296 ± 0.019
0.749LysTyr: 0.749 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
12.734LeuAla: 12.734 ± 0.167
1.292LeuCys: 1.292 ± 0.038
6.518LeuAsp: 6.518 ± 0.092
7.767LeuGlu: 7.767 ± 0.117
4.229LeuPhe: 4.229 ± 0.087
8.297LeuGly: 8.297 ± 0.132
2.702LeuHis: 2.702 ± 0.062
6.707LeuIle: 6.707 ± 0.104
4.867LeuLys: 4.867 ± 0.076
14.123LeuLeu: 14.123 ± 0.212
3.011LeuMet: 3.011 ± 0.062
4.248LeuAsn: 4.248 ± 0.068
6.327LeuPro: 6.327 ± 0.102
6.367LeuGln: 6.367 ± 0.112
7.13LeuArg: 7.13 ± 0.089
8.399LeuSer: 8.399 ± 0.106
5.882LeuThr: 5.882 ± 0.097
7.476LeuVal: 7.476 ± 0.093
1.463LeuTrp: 1.463 ± 0.049
2.734LeuTyr: 2.734 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.546MetAla: 2.546 ± 0.055
0.17MetCys: 0.17 ± 0.013
1.229MetAsp: 1.229 ± 0.04
1.212MetGlu: 1.212 ± 0.038
0.76MetPhe: 0.76 ± 0.031
1.662MetGly: 1.662 ± 0.05
0.522MetHis: 0.522 ± 0.024
1.359MetIle: 1.359 ± 0.04
1.103MetLys: 1.103 ± 0.036
2.806MetLeu: 2.806 ± 0.061
0.675MetMet: 0.675 ± 0.036
0.887MetAsn: 0.887 ± 0.031
1.309MetPro: 1.309 ± 0.038
1.5MetGln: 1.5 ± 0.044
1.59MetArg: 1.59 ± 0.038
1.861MetSer: 1.861 ± 0.048
1.436MetThr: 1.436 ± 0.042
1.409MetVal: 1.409 ± 0.046
0.155MetTrp: 0.155 ± 0.013
0.386MetTyr: 0.386 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.911AsnAla: 2.911 ± 0.056
0.322AsnCys: 0.322 ± 0.02
1.416AsnAsp: 1.416 ± 0.044
1.623AsnGlu: 1.623 ± 0.047
1.167AsnPhe: 1.167 ± 0.04
1.958AsnGly: 1.958 ± 0.051
0.721AsnHis: 0.721 ± 0.033
1.721AsnIle: 1.721 ± 0.046
1.04AsnLys: 1.04 ± 0.041
3.759AsnLeu: 3.759 ± 0.07
0.729AsnMet: 0.729 ± 0.03
0.983AsnAsn: 0.983 ± 0.045
2.058AsnPro: 2.058 ± 0.052
1.641AsnGln: 1.641 ± 0.043
1.962AsnArg: 1.962 ± 0.05
1.682AsnSer: 1.682 ± 0.049
1.693AsnThr: 1.693 ± 0.047
1.597AsnVal: 1.597 ± 0.05
0.481AsnTrp: 0.481 ± 0.023
0.825AsnTyr: 0.825 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.331ProAla: 4.331 ± 0.076
0.408ProCys: 0.408 ± 0.019
2.854ProAsp: 2.854 ± 0.054
4.251ProGlu: 4.251 ± 0.081
1.662ProPhe: 1.662 ± 0.046
3.464ProGly: 3.464 ± 0.067
0.966ProHis: 0.966 ± 0.038
2.261ProIle: 2.261 ± 0.052
1.609ProLys: 1.609 ± 0.041
5.198ProLeu: 5.198 ± 0.095
1.098ProMet: 1.098 ± 0.035
1.469ProAsn: 1.469 ± 0.042
1.637ProPro: 1.637 ± 0.046
2.19ProGln: 2.19 ± 0.056
1.964ProArg: 1.964 ± 0.049
2.732ProSer: 2.732 ± 0.055
1.954ProThr: 1.954 ± 0.054
3.482ProVal: 3.482 ± 0.064
0.725ProTrp: 0.725 ± 0.032
1.172ProTyr: 1.172 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
7.114GlnAla: 7.114 ± 0.12
0.36GlnCys: 0.36 ± 0.021
2.466GlnAsp: 2.466 ± 0.059
3.305GlnGlu: 3.305 ± 0.065
1.412GlnPhe: 1.412 ± 0.04
4.281GlnGly: 4.281 ± 0.086
1.454GlnHis: 1.454 ± 0.045
2.862GlnIle: 2.862 ± 0.06
1.755GlnLys: 1.755 ± 0.047
6.646GlnLeu: 6.646 ± 0.113
1.314GlnMet: 1.314 ± 0.04
1.343GlnAsn: 1.343 ± 0.044
2.632GlnPro: 2.632 ± 0.066
3.805GlnGln: 3.805 ± 0.077
4.085GlnArg: 4.085 ± 0.07
2.934GlnSer: 2.934 ± 0.065
2.716GlnThr: 2.716 ± 0.064
4.053GlnVal: 4.053 ± 0.075
0.598GlnTrp: 0.598 ± 0.026
0.991GlnTyr: 0.991 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.102ArgAla: 5.102 ± 0.082
0.592ArgCys: 0.592 ± 0.03
3.037ArgAsp: 3.037 ± 0.069
4.119ArgGlu: 4.119 ± 0.067
2.854ArgPhe: 2.854 ± 0.062
3.423ArgGly: 3.423 ± 0.07
1.718ArgHis: 1.718 ± 0.053
3.786ArgIle: 3.786 ± 0.066
2.136ArgLys: 2.136 ± 0.051
8.281ArgLeu: 8.281 ± 0.117
1.613ArgMet: 1.613 ± 0.044
1.889ArgAsn: 1.889 ± 0.053
2.532ArgPro: 2.532 ± 0.052
3.684ArgGln: 3.684 ± 0.073
3.799ArgArg: 3.799 ± 0.086
3.498ArgSer: 3.498 ± 0.067
2.393ArgThr: 2.393 ± 0.06
4.356ArgVal: 4.356 ± 0.068
1.009ArgTrp: 1.009 ± 0.036
1.972ArgTyr: 1.972 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.177SerAla: 6.177 ± 0.087
0.592SerCys: 0.592 ± 0.029
3.049SerAsp: 3.049 ± 0.063
3.821SerGlu: 3.821 ± 0.068
2.348SerPhe: 2.348 ± 0.05
5.015SerGly: 5.015 ± 0.09
1.429SerHis: 1.429 ± 0.043
3.083SerIle: 3.083 ± 0.066
1.878SerLys: 1.878 ± 0.054
7.746SerLeu: 7.746 ± 0.111
1.442SerMet: 1.442 ± 0.042
1.78SerAsn: 1.78 ± 0.045
2.588SerPro: 2.588 ± 0.059
2.963SerGln: 2.963 ± 0.058
3.67SerArg: 3.67 ± 0.068
3.771SerSer: 3.771 ± 0.072
2.627SerThr: 2.627 ± 0.051
4.093SerVal: 4.093 ± 0.07
0.829SerTrp: 0.829 ± 0.035
1.416SerTyr: 1.416 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.317ThrAla: 4.317 ± 0.072
0.502ThrCys: 0.502 ± 0.027
2.569ThrAsp: 2.569 ± 0.056
2.994ThrGlu: 2.994 ± 0.065
1.668ThrPhe: 1.668 ± 0.043
3.924ThrGly: 3.924 ± 0.078
1.199ThrHis: 1.199 ± 0.038
1.805ThrIle: 1.805 ± 0.046
1.086ThrLys: 1.086 ± 0.037
7.223ThrLeu: 7.223 ± 0.096
0.722ThrMet: 0.722 ± 0.029
1.135ThrAsn: 1.135 ± 0.036
3.064ThrPro: 3.064 ± 0.063
2.852ThrGln: 2.852 ± 0.059
2.966ThrArg: 2.966 ± 0.067
2.714ThrSer: 2.714 ± 0.064
2.253ThrThr: 2.253 ± 0.059
2.509ThrVal: 2.509 ± 0.06
0.679ThrTrp: 0.679 ± 0.036
1.255ThrTyr: 1.255 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
6.303ValAla: 6.303 ± 0.092
0.751ValCys: 0.751 ± 0.033
3.561ValAsp: 3.561 ± 0.074
4.581ValGlu: 4.581 ± 0.083
2.675ValPhe: 2.675 ± 0.063
4.164ValGly: 4.164 ± 0.08
1.372ValHis: 1.372 ± 0.043
3.998ValIle: 3.998 ± 0.076
2.612ValLys: 2.612 ± 0.07
7.239ValLeu: 7.239 ± 0.106
1.868ValMet: 1.868 ± 0.044
2.29ValAsn: 2.29 ± 0.052
2.484ValPro: 2.484 ± 0.055
2.794ValGln: 2.794 ± 0.06
3.889ValArg: 3.889 ± 0.069
4.211ValSer: 4.211 ± 0.081
3.396ValThr: 3.396 ± 0.065
4.657ValVal: 4.657 ± 0.105
0.818ValTrp: 0.818 ± 0.035
1.63ValTyr: 1.63 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.974TrpAla: 0.974 ± 0.037
0.173TrpCys: 0.173 ± 0.015
0.523TrpAsp: 0.523 ± 0.024
0.587TrpGlu: 0.587 ± 0.028
0.532TrpPhe: 0.532 ± 0.026
0.777TrpGly: 0.777 ± 0.033
0.396TrpHis: 0.396 ± 0.024
0.899TrpIle: 0.899 ± 0.033
0.418TrpLys: 0.418 ± 0.025
2.068TrpLeu: 2.068 ± 0.063
0.43TrpMet: 0.43 ± 0.024
0.421TrpAsn: 0.421 ± 0.022
0.67TrpPro: 0.67 ± 0.032
1.213TrpGln: 1.213 ± 0.041
0.889TrpArg: 0.889 ± 0.035
0.877TrpSer: 0.877 ± 0.034
0.548TrpThr: 0.548 ± 0.025
0.987TrpVal: 0.987 ± 0.037
0.199TrpTrp: 0.199 ± 0.016
0.331TrpTyr: 0.331 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.45TyrAla: 2.45 ± 0.058
0.268TyrCys: 0.268 ± 0.019
1.313TyrAsp: 1.313 ± 0.044
1.429TyrGlu: 1.429 ± 0.047
1.08TyrPhe: 1.08 ± 0.033
1.745TyrGly: 1.745 ± 0.056
0.664TyrHis: 0.664 ± 0.028
1.199TyrIle: 1.199 ± 0.041
0.731TyrLys: 0.731 ± 0.031
3.279TyrLeu: 3.279 ± 0.061
0.498TyrMet: 0.498 ± 0.027
0.751TyrAsn: 0.751 ± 0.029
1.382TyrPro: 1.382 ± 0.035
1.683TyrGln: 1.683 ± 0.044
1.981TyrArg: 1.981 ± 0.049
1.505TyrSer: 1.505 ± 0.038
1.278TyrThr: 1.278 ± 0.04
1.546TyrVal: 1.546 ± 0.037
0.433TyrTrp: 0.433 ± 0.021
0.752TyrTyr: 0.752 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2528 proteins (850769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski