Amino acid dipepetide frequency for Torilis crimson leaf virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.484AlaAla: 4.484 ± 1.36
1.602AlaCys: 1.602 ± 0.587
0.961AlaAsp: 0.961 ± 0.416
2.883AlaGlu: 2.883 ± 0.581
2.562AlaPhe: 2.562 ± 0.898
3.844AlaGly: 3.844 ± 0.768
1.602AlaHis: 1.602 ± 0.826
3.844AlaIle: 3.844 ± 0.597
4.805AlaLys: 4.805 ± 1.114
2.883AlaLeu: 2.883 ± 0.828
1.602AlaMet: 1.602 ± 0.709
2.883AlaAsn: 2.883 ± 0.498
3.523AlaPro: 3.523 ± 1.139
1.602AlaGln: 1.602 ± 0.661
5.125AlaArg: 5.125 ± 0.819
4.484AlaSer: 4.484 ± 1.719
6.086AlaThr: 6.086 ± 0.711
2.562AlaVal: 2.562 ± 1.122
0.0AlaTrp: 0.0 ± 0.0
3.844AlaTyr: 3.844 ± 0.75
0.0AlaXaa: 0.0 ± 0.0
Cys
0.961CysAla: 0.961 ± 0.569
0.0CysCys: 0.0 ± 0.0
0.641CysAsp: 0.641 ± 0.265
3.203CysGlu: 3.203 ± 0.5
1.281CysPhe: 1.281 ± 0.658
1.281CysGly: 1.281 ± 0.939
0.0CysHis: 0.0 ± 0.0
0.641CysIle: 0.641 ± 0.446
0.32CysLys: 0.32 ± 0.487
1.922CysLeu: 1.922 ± 0.945
0.0CysMet: 0.0 ± 0.0
0.641CysAsn: 0.641 ± 0.265
0.32CysPro: 0.32 ± 0.486
0.641CysGln: 0.641 ± 0.318
0.32CysArg: 0.32 ± 0.486
1.922CysSer: 1.922 ± 0.945
0.32CysThr: 0.32 ± 0.234
1.281CysVal: 1.281 ± 0.547
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.164AspAla: 4.164 ± 1.542
0.961AspCys: 0.961 ± 0.472
2.883AspAsp: 2.883 ± 0.569
3.523AspGlu: 3.523 ± 1.173
0.0AspPhe: 0.0 ± 0.0
3.203AspGly: 3.203 ± 0.739
1.281AspHis: 1.281 ± 1.14
1.602AspIle: 1.602 ± 0.882
0.961AspLys: 0.961 ± 0.419
4.805AspLeu: 4.805 ± 1.56
2.562AspMet: 2.562 ± 0.68
2.242AspAsn: 2.242 ± 1.047
2.562AspPro: 2.562 ± 0.759
1.922AspGln: 1.922 ± 0.665
0.961AspArg: 0.961 ± 0.484
2.883AspSer: 2.883 ± 1.198
1.602AspThr: 1.602 ± 0.32
1.281AspVal: 1.281 ± 0.466
1.281AspTrp: 1.281 ± 0.674
0.641AspTyr: 0.641 ± 0.436
0.0AspXaa: 0.0 ± 0.0
Glu
3.523GluAla: 3.523 ± 1.27
1.281GluCys: 1.281 ± 0.468
2.242GluAsp: 2.242 ± 1.298
3.844GluGlu: 3.844 ± 1.132
2.562GluPhe: 2.562 ± 0.496
4.164GluGly: 4.164 ± 1.214
0.641GluHis: 0.641 ± 0.265
2.562GluIle: 2.562 ± 1.309
2.562GluLys: 2.562 ± 0.824
6.726GluLeu: 6.726 ± 0.722
0.641GluMet: 0.641 ± 0.515
6.406GluAsn: 6.406 ± 0.864
2.242GluPro: 2.242 ± 0.907
4.164GluGln: 4.164 ± 1.687
2.883GluArg: 2.883 ± 0.74
2.883GluSer: 2.883 ± 0.814
4.805GluThr: 4.805 ± 1.228
3.844GluVal: 3.844 ± 1.769
1.922GluTrp: 1.922 ± 0.734
0.961GluTyr: 0.961 ± 0.722
0.0GluXaa: 0.0 ± 0.0
Phe
1.922PheAla: 1.922 ± 0.68
0.641PheCys: 0.641 ± 0.469
1.281PheAsp: 1.281 ± 0.675
3.844PheGlu: 3.844 ± 0.83
1.602PhePhe: 1.602 ± 0.806
3.844PheGly: 3.844 ± 0.854
2.242PheHis: 2.242 ± 0.452
3.523PheIle: 3.523 ± 0.609
3.844PheLys: 3.844 ± 0.929
3.523PheLeu: 3.523 ± 1.003
0.0PheMet: 0.0 ± 0.0
2.242PheAsn: 2.242 ± 0.843
1.922PhePro: 1.922 ± 0.796
1.602PheGln: 1.602 ± 1.018
2.242PheArg: 2.242 ± 0.778
6.406PheSer: 6.406 ± 1.571
1.281PheThr: 1.281 ± 0.865
1.281PheVal: 1.281 ± 0.891
0.32PheTrp: 0.32 ± 0.273
0.32PheTyr: 0.32 ± 0.273
0.0PheXaa: 0.0 ± 0.0
Gly
4.805GlyAla: 4.805 ± 1.29
0.32GlyCys: 0.32 ± 0.273
3.844GlyAsp: 3.844 ± 0.81
4.805GlyGlu: 4.805 ± 0.881
3.844GlyPhe: 3.844 ± 1.553
4.164GlyGly: 4.164 ± 1.848
1.602GlyHis: 1.602 ± 0.47
1.281GlyIle: 1.281 ± 0.875
5.125GlyLys: 5.125 ± 2.003
6.406GlyLeu: 6.406 ± 0.811
0.641GlyMet: 0.641 ± 0.422
3.523GlyAsn: 3.523 ± 1.552
2.883GlyPro: 2.883 ± 0.879
2.562GlyGln: 2.562 ± 1.309
5.125GlyArg: 5.125 ± 1.966
6.726GlySer: 6.726 ± 1.573
4.164GlyThr: 4.164 ± 0.558
2.242GlyVal: 2.242 ± 0.998
0.961GlyTrp: 0.961 ± 0.571
4.164GlyTyr: 4.164 ± 1.45
0.0GlyXaa: 0.0 ± 0.0
His
0.961HisAla: 0.961 ± 0.435
0.641HisCys: 0.641 ± 0.52
0.961HisAsp: 0.961 ± 0.521
1.281HisGlu: 1.281 ± 0.788
0.961HisPhe: 0.961 ± 0.291
0.641HisGly: 0.641 ± 0.318
1.281HisHis: 1.281 ± 0.865
0.32HisIle: 0.32 ± 0.234
0.641HisLys: 0.641 ± 0.446
1.281HisLeu: 1.281 ± 1.182
0.0HisMet: 0.0 ± 0.0
1.922HisAsn: 1.922 ± 0.665
1.281HisPro: 1.281 ± 0.58
0.641HisGln: 0.641 ± 0.515
1.281HisArg: 1.281 ± 0.8
1.922HisSer: 1.922 ± 0.51
0.641HisThr: 0.641 ± 0.318
1.602HisVal: 1.602 ± 0.423
0.32HisTrp: 0.32 ± 0.486
0.641HisTyr: 0.641 ± 0.52
0.0HisXaa: 0.0 ± 0.0
Ile
2.562IleAla: 2.562 ± 0.72
1.922IleCys: 1.922 ± 0.596
0.961IleAsp: 0.961 ± 0.703
0.641IleGlu: 0.641 ± 0.318
3.844IlePhe: 3.844 ± 0.581
1.922IleGly: 1.922 ± 0.672
1.602IleHis: 1.602 ± 0.543
2.242IleIle: 2.242 ± 0.472
3.523IleLys: 3.523 ± 0.758
4.164IleLeu: 4.164 ± 1.1
0.961IleMet: 0.961 ± 0.472
2.242IleAsn: 2.242 ± 0.493
3.844IlePro: 3.844 ± 1.89
2.242IleGln: 2.242 ± 0.615
1.602IleArg: 1.602 ± 0.818
2.562IleSer: 2.562 ± 0.999
3.844IleThr: 3.844 ± 0.874
3.844IleVal: 3.844 ± 1.249
2.242IleTrp: 2.242 ± 0.838
3.523IleTyr: 3.523 ± 0.803
0.0IleXaa: 0.0 ± 0.0
Lys
3.203LysAla: 3.203 ± 0.754
0.32LysCys: 0.32 ± 0.234
2.883LysAsp: 2.883 ± 1.067
2.883LysGlu: 2.883 ± 0.549
2.242LysPhe: 2.242 ± 0.626
3.203LysGly: 3.203 ± 1.263
0.32LysHis: 0.32 ± 0.234
5.766LysIle: 5.766 ± 1.189
4.164LysLys: 4.164 ± 1.945
6.726LysLeu: 6.726 ± 2.056
1.602LysMet: 1.602 ± 0.619
2.883LysAsn: 2.883 ± 1.152
4.164LysPro: 4.164 ± 1.986
3.523LysGln: 3.523 ± 1.028
4.805LysArg: 4.805 ± 0.752
2.883LysSer: 2.883 ± 1.346
2.562LysThr: 2.562 ± 0.655
2.562LysVal: 2.562 ± 0.829
0.32LysTrp: 0.32 ± 0.234
0.961LysTyr: 0.961 ± 0.568
0.32LysXaa: 0.32 ± 0.273
Leu
7.047LeuAla: 7.047 ± 1.581
1.922LeuCys: 1.922 ± 0.945
5.125LeuAsp: 5.125 ± 0.879
6.086LeuGlu: 6.086 ± 1.376
5.766LeuPhe: 5.766 ± 1.932
2.562LeuGly: 2.562 ± 0.618
0.961LeuHis: 0.961 ± 0.435
5.125LeuIle: 5.125 ± 0.81
4.805LeuLys: 4.805 ± 0.897
6.726LeuLeu: 6.726 ± 1.375
1.602LeuMet: 1.602 ± 0.501
2.242LeuAsn: 2.242 ± 1.576
3.844LeuPro: 3.844 ± 1.733
3.844LeuGln: 3.844 ± 1.082
4.805LeuArg: 4.805 ± 0.712
9.289LeuSer: 9.289 ± 1.144
8.008LeuThr: 8.008 ± 0.624
5.766LeuVal: 5.766 ± 1.46
2.883LeuTrp: 2.883 ± 0.625
1.922LeuTyr: 1.922 ± 0.937
0.0LeuXaa: 0.0 ± 0.0
Met
2.242MetAla: 2.242 ± 0.901
0.0MetCys: 0.0 ± 0.0
0.961MetAsp: 0.961 ± 1.205
0.961MetGlu: 0.961 ± 0.484
0.641MetPhe: 0.641 ± 0.519
2.562MetGly: 2.562 ± 0.473
0.641MetHis: 0.641 ± 0.318
0.641MetIle: 0.641 ± 0.318
0.961MetLys: 0.961 ± 0.569
1.922MetLeu: 1.922 ± 0.665
0.32MetMet: 0.32 ± 0.298
0.641MetAsn: 0.641 ± 0.318
0.961MetPro: 0.961 ± 0.688
0.32MetGln: 0.32 ± 0.486
0.961MetArg: 0.961 ± 0.291
1.602MetSer: 1.602 ± 0.423
1.281MetThr: 1.281 ± 0.546
2.242MetVal: 2.242 ± 0.443
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.922AsnAla: 1.922 ± 0.366
0.32AsnCys: 0.32 ± 0.234
2.242AsnAsp: 2.242 ± 1.227
3.844AsnGlu: 3.844 ± 1.1
3.203AsnPhe: 3.203 ± 1.063
7.047AsnGly: 7.047 ± 1.508
0.0AsnHis: 0.0 ± 0.0
0.641AsnIle: 0.641 ± 0.472
3.523AsnLys: 3.523 ± 0.505
5.766AsnLeu: 5.766 ± 0.885
0.641AsnMet: 0.641 ± 0.446
3.203AsnAsn: 3.203 ± 2.396
1.602AsnPro: 1.602 ± 0.996
1.602AsnGln: 1.602 ± 0.56
4.164AsnArg: 4.164 ± 0.647
5.766AsnSer: 5.766 ± 1.079
2.242AsnThr: 2.242 ± 0.727
2.562AsnVal: 2.562 ± 0.418
0.961AsnTrp: 0.961 ± 0.472
2.562AsnTyr: 2.562 ± 0.481
0.0AsnXaa: 0.0 ± 0.0
Pro
2.562ProAla: 2.562 ± 0.414
0.641ProCys: 0.641 ± 0.971
0.641ProAsp: 0.641 ± 0.446
2.562ProGlu: 2.562 ± 0.693
0.961ProPhe: 0.961 ± 0.416
4.805ProGly: 4.805 ± 0.737
1.602ProHis: 1.602 ± 0.478
3.844ProIle: 3.844 ± 0.906
2.242ProLys: 2.242 ± 0.64
3.844ProLeu: 3.844 ± 0.786
1.922ProMet: 1.922 ± 0.734
1.922ProAsn: 1.922 ± 1.147
5.125ProPro: 5.125 ± 1.621
3.523ProGln: 3.523 ± 1.117
4.164ProArg: 4.164 ± 1.474
5.125ProSer: 5.125 ± 0.572
4.164ProThr: 4.164 ± 1.965
3.844ProVal: 3.844 ± 1.024
0.32ProTrp: 0.32 ± 0.487
0.961ProTyr: 0.961 ± 0.435
0.0ProXaa: 0.0 ± 0.0
Gln
1.281GlnAla: 1.281 ± 0.74
0.0GlnCys: 0.0 ± 0.0
1.922GlnAsp: 1.922 ± 0.683
2.883GlnGlu: 2.883 ± 0.845
1.922GlnPhe: 1.922 ± 0.455
1.922GlnGly: 1.922 ± 0.581
0.641GlnHis: 0.641 ± 0.265
1.922GlnIle: 1.922 ± 0.737
2.562GlnLys: 2.562 ± 0.452
4.484GlnLeu: 4.484 ± 0.961
0.32GlnMet: 0.32 ± 0.486
3.203GlnAsn: 3.203 ± 0.689
3.203GlnPro: 3.203 ± 0.548
0.32GlnGln: 0.32 ± 0.487
1.281GlnArg: 1.281 ± 0.684
2.562GlnSer: 2.562 ± 0.71
3.844GlnThr: 3.844 ± 0.821
1.602GlnVal: 1.602 ± 0.423
0.641GlnTrp: 0.641 ± 0.515
0.961GlnTyr: 0.961 ± 0.703
0.0GlnXaa: 0.0 ± 0.0
Arg
4.805ArgAla: 4.805 ± 1.087
0.0ArgCys: 0.0 ± 0.0
3.203ArgAsp: 3.203 ± 0.944
3.523ArgGlu: 3.523 ± 0.6
0.961ArgPhe: 0.961 ± 0.671
4.805ArgGly: 4.805 ± 1.473
0.641ArgHis: 0.641 ± 0.469
1.922ArgIle: 1.922 ± 0.665
1.602ArgLys: 1.602 ± 0.967
6.086ArgLeu: 6.086 ± 0.944
1.602ArgMet: 1.602 ± 0.584
4.805ArgAsn: 4.805 ± 0.853
1.602ArgPro: 1.602 ± 0.882
1.281ArgGln: 1.281 ± 0.939
9.289ArgArg: 9.289 ± 5.225
8.008ArgSer: 8.008 ± 1.671
3.203ArgThr: 3.203 ± 1.667
3.203ArgVal: 3.203 ± 0.813
1.281ArgTrp: 1.281 ± 0.675
1.281ArgTyr: 1.281 ± 0.864
0.0ArgXaa: 0.0 ± 0.0
Ser
4.484SerAla: 4.484 ± 1.032
1.281SerCys: 1.281 ± 0.629
4.164SerAsp: 4.164 ± 0.562
4.484SerGlu: 4.484 ± 1.274
3.203SerPhe: 3.203 ± 0.78
5.766SerGly: 5.766 ± 0.937
1.281SerHis: 1.281 ± 0.468
5.125SerIle: 5.125 ± 0.911
5.125SerLys: 5.125 ± 0.721
7.687SerLeu: 7.687 ± 1.474
0.961SerMet: 0.961 ± 0.484
5.445SerAsn: 5.445 ± 1.479
2.883SerPro: 2.883 ± 1.111
2.883SerGln: 2.883 ± 0.89
6.406SerArg: 6.406 ± 1.544
9.93SerSer: 9.93 ± 1.951
6.086SerThr: 6.086 ± 1.295
6.406SerVal: 6.406 ± 2.466
1.922SerTrp: 1.922 ± 0.534
2.242SerTyr: 2.242 ± 0.496
0.0SerXaa: 0.0 ± 0.0
Thr
6.086ThrAla: 6.086 ± 1.017
1.602ThrCys: 1.602 ± 0.573
2.242ThrAsp: 2.242 ± 0.817
3.523ThrGlu: 3.523 ± 0.97
3.844ThrPhe: 3.844 ± 0.581
5.766ThrGly: 5.766 ± 1.432
1.281ThrHis: 1.281 ± 0.764
2.883ThrIle: 2.883 ± 1.157
4.805ThrLys: 4.805 ± 1.72
6.726ThrLeu: 6.726 ± 1.638
1.602ThrMet: 1.602 ± 0.526
1.922ThrAsn: 1.922 ± 1.014
7.687ThrPro: 7.687 ± 1.684
1.602ThrGln: 1.602 ± 0.933
1.281ThrArg: 1.281 ± 0.384
4.805ThrSer: 4.805 ± 1.126
8.648ThrThr: 8.648 ± 2.666
2.562ThrVal: 2.562 ± 0.872
0.961ThrTrp: 0.961 ± 0.438
0.961ThrTyr: 0.961 ± 0.457
0.0ThrXaa: 0.0 ± 0.0
Val
1.281ValAla: 1.281 ± 0.549
1.922ValCys: 1.922 ± 0.953
3.203ValAsp: 3.203 ± 0.459
2.883ValGlu: 2.883 ± 0.828
1.922ValPhe: 1.922 ± 0.51
3.844ValGly: 3.844 ± 0.896
0.961ValHis: 0.961 ± 0.457
4.164ValIle: 4.164 ± 0.857
2.883ValLys: 2.883 ± 1.152
5.445ValLeu: 5.445 ± 1.399
0.961ValMet: 0.961 ± 0.419
3.523ValAsn: 3.523 ± 0.861
2.883ValPro: 2.883 ± 1.0
2.242ValGln: 2.242 ± 0.669
2.242ValArg: 2.242 ± 0.834
5.766ValSer: 5.766 ± 2.128
2.562ValThr: 2.562 ± 0.68
5.766ValVal: 5.766 ± 1.551
0.0ValTrp: 0.0 ± 0.0
1.281ValTyr: 1.281 ± 0.539
0.0ValXaa: 0.0 ± 0.0
Trp
1.281TrpAla: 1.281 ± 0.384
0.32TrpCys: 0.32 ± 0.487
0.0TrpAsp: 0.0 ± 0.0
1.281TrpGlu: 1.281 ± 0.636
0.32TrpPhe: 0.32 ± 0.406
0.641TrpGly: 0.641 ± 0.446
0.641TrpHis: 0.641 ± 0.52
1.602TrpIle: 1.602 ± 0.77
0.641TrpLys: 0.641 ± 0.436
1.281TrpLeu: 1.281 ± 0.937
0.641TrpMet: 0.641 ± 0.318
0.961TrpAsn: 0.961 ± 0.967
0.961TrpPro: 0.961 ± 0.703
0.32TrpGln: 0.32 ± 0.234
1.922TrpArg: 1.922 ± 0.442
0.961TrpSer: 0.961 ± 0.48
2.242TrpThr: 2.242 ± 0.714
0.32TrpVal: 0.32 ± 0.487
0.641TrpTrp: 0.641 ± 0.318
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.602TyrAla: 1.602 ± 0.599
0.0TyrCys: 0.0 ± 0.0
0.961TyrAsp: 0.961 ± 0.416
1.922TyrGlu: 1.922 ± 0.543
2.242TyrPhe: 2.242 ± 0.843
3.523TyrGly: 3.523 ± 0.928
0.0TyrHis: 0.0 ± 0.0
0.641TyrIle: 0.641 ± 0.971
3.203TyrLys: 3.203 ± 1.605
1.922TyrLeu: 1.922 ± 0.609
0.961TyrMet: 0.961 ± 0.435
0.961TyrAsn: 0.961 ± 0.419
1.281TyrPro: 1.281 ± 0.468
0.641TyrGln: 0.641 ± 0.515
2.242TyrArg: 2.242 ± 0.856
1.281TyrSer: 1.281 ± 0.855
3.203TyrThr: 3.203 ± 0.446
0.641TyrVal: 0.641 ± 0.505
0.0TyrTrp: 0.0 ± 0.0
1.922TyrTyr: 1.922 ± 0.946
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.32XaaVal: 0.32 ± 0.273
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3123 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski