Amino acid dipepetide frequency for Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast) (Wangiella dermatitidis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.697AlaAla: 9.697 ± 0.064
1.009AlaCys: 1.009 ± 0.018
4.433AlaAsp: 4.433 ± 0.031
5.502AlaGlu: 5.502 ± 0.047
2.982AlaPhe: 2.982 ± 0.027
6.14AlaGly: 6.14 ± 0.048
1.792AlaHis: 1.792 ± 0.018
4.033AlaIle: 4.033 ± 0.032
4.19AlaLys: 4.19 ± 0.039
7.599AlaLeu: 7.599 ± 0.038
1.951AlaMet: 1.951 ± 0.024
2.999AlaAsn: 2.999 ± 0.025
4.792AlaPro: 4.792 ± 0.045
3.701AlaGln: 3.701 ± 0.035
5.371AlaArg: 5.371 ± 0.034
7.425AlaSer: 7.425 ± 0.054
5.586AlaThr: 5.586 ± 0.041
5.461AlaVal: 5.461 ± 0.036
1.076AlaTrp: 1.076 ± 0.018
2.124AlaTyr: 2.124 ± 0.027
0.0AlaXaa: 0.0 ± 0.0
Cys
0.916CysAla: 0.916 ± 0.016
0.231CysCys: 0.231 ± 0.009
0.605CysAsp: 0.605 ± 0.013
0.547CysGlu: 0.547 ± 0.011
0.492CysPhe: 0.492 ± 0.01
0.873CysGly: 0.873 ± 0.015
0.325CysHis: 0.325 ± 0.009
0.644CysIle: 0.644 ± 0.012
0.471CysLys: 0.471 ± 0.01
1.233CysLeu: 1.233 ± 0.02
0.24CysMet: 0.24 ± 0.008
0.39CysAsn: 0.39 ± 0.011
0.652CysPro: 0.652 ± 0.014
0.431CysGln: 0.431 ± 0.009
0.761CysArg: 0.761 ± 0.014
0.847CysSer: 0.847 ± 0.015
0.636CysThr: 0.636 ± 0.012
0.744CysVal: 0.744 ± 0.013
0.188CysTrp: 0.188 ± 0.007
0.337CysTyr: 0.337 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.652AspAla: 4.652 ± 0.039
0.574AspCys: 0.574 ± 0.011
4.461AspAsp: 4.461 ± 0.051
4.591AspGlu: 4.591 ± 0.042
2.139AspPhe: 2.139 ± 0.023
4.045AspGly: 4.045 ± 0.034
1.336AspHis: 1.336 ± 0.017
2.826AspIle: 2.826 ± 0.025
2.458AspLys: 2.458 ± 0.025
5.072AspLeu: 5.072 ± 0.035
1.251AspMet: 1.251 ± 0.016
1.967AspAsn: 1.967 ± 0.02
3.455AspPro: 3.455 ± 0.031
2.044AspGln: 2.044 ± 0.023
3.193AspArg: 3.193 ± 0.036
4.032AspSer: 4.032 ± 0.029
3.024AspThr: 3.024 ± 0.027
3.673AspVal: 3.673 ± 0.03
0.848AspTrp: 0.848 ± 0.015
1.557AspTyr: 1.557 ± 0.019
0.0AspXaa: 0.0 ± 0.0
Glu
5.59GluAla: 5.59 ± 0.042
0.578GluCys: 0.578 ± 0.012
4.291GluAsp: 4.291 ± 0.041
5.504GluGlu: 5.504 ± 0.058
1.865GluPhe: 1.865 ± 0.018
3.666GluGly: 3.666 ± 0.032
1.454GluHis: 1.454 ± 0.02
2.926GluIle: 2.926 ± 0.029
3.69GluLys: 3.69 ± 0.035
5.109GluLeu: 5.109 ± 0.041
1.387GluMet: 1.387 ± 0.017
2.141GluAsn: 2.141 ± 0.026
2.878GluPro: 2.878 ± 0.031
2.771GluGln: 2.771 ± 0.026
4.046GluArg: 4.046 ± 0.039
4.24GluSer: 4.24 ± 0.03
3.506GluThr: 3.506 ± 0.032
3.624GluVal: 3.624 ± 0.034
0.835GluTrp: 0.835 ± 0.013
1.599GluTyr: 1.599 ± 0.017
0.0GluXaa: 0.0 ± 0.0
Phe
2.96PheAla: 2.96 ± 0.025
0.543PheCys: 0.543 ± 0.011
2.217PheAsp: 2.217 ± 0.024
2.065PheGlu: 2.065 ± 0.022
1.512PhePhe: 1.512 ± 0.021
2.757PheGly: 2.757 ± 0.032
0.863PheHis: 0.863 ± 0.013
1.615PheIle: 1.615 ± 0.021
1.408PheLys: 1.408 ± 0.018
3.341PheLeu: 3.341 ± 0.029
0.727PheMet: 0.727 ± 0.012
1.325PheAsn: 1.325 ± 0.015
1.856PhePro: 1.856 ± 0.02
1.34PheGln: 1.34 ± 0.016
1.942PheArg: 1.942 ± 0.022
2.764PheSer: 2.764 ± 0.025
1.966PheThr: 1.966 ± 0.021
2.316PheVal: 2.316 ± 0.023
0.604PheTrp: 0.604 ± 0.012
1.045PheTyr: 1.045 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
5.342GlyAla: 5.342 ± 0.041
0.779GlyCys: 0.779 ± 0.016
3.591GlyAsp: 3.591 ± 0.031
3.549GlyGlu: 3.549 ± 0.035
2.687GlyPhe: 2.687 ± 0.027
5.98GlyGly: 5.98 ± 0.055
1.804GlyHis: 1.804 ± 0.023
3.343GlyIle: 3.343 ± 0.027
3.375GlyLys: 3.375 ± 0.032
6.048GlyLeu: 6.048 ± 0.041
1.561GlyMet: 1.561 ± 0.021
2.47GlyAsn: 2.47 ± 0.025
3.544GlyPro: 3.544 ± 0.028
2.812GlyGln: 2.812 ± 0.027
4.319GlyArg: 4.319 ± 0.036
5.813GlySer: 5.813 ± 0.046
4.145GlyThr: 4.145 ± 0.033
4.343GlyVal: 4.343 ± 0.035
1.113GlyTrp: 1.113 ± 0.018
2.1GlyTyr: 2.1 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
1.895HisAla: 1.895 ± 0.021
0.318HisCys: 0.318 ± 0.01
1.452HisAsp: 1.452 ± 0.018
1.456HisGlu: 1.456 ± 0.019
0.877HisPhe: 0.877 ± 0.014
1.827HisGly: 1.827 ± 0.024
0.958HisHis: 0.958 ± 0.019
1.166HisIle: 1.166 ± 0.016
0.999HisLys: 0.999 ± 0.016
2.211HisLeu: 2.211 ± 0.025
0.469HisMet: 0.469 ± 0.009
0.887HisAsn: 0.887 ± 0.013
1.699HisPro: 1.699 ± 0.021
1.079HisGln: 1.079 ± 0.017
1.589HisArg: 1.589 ± 0.022
1.888HisSer: 1.888 ± 0.02
1.277HisThr: 1.277 ± 0.018
1.488HisVal: 1.488 ± 0.019
0.345HisTrp: 0.345 ± 0.008
0.69HisTyr: 0.69 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.959IleAla: 3.959 ± 0.033
0.714IleCys: 0.714 ± 0.013
2.691IleAsp: 2.691 ± 0.023
2.719IleGlu: 2.719 ± 0.025
1.822IlePhe: 1.822 ± 0.021
2.973IleGly: 2.973 ± 0.033
1.127IleHis: 1.127 ± 0.016
2.284IleIle: 2.284 ± 0.029
2.109IleLys: 2.109 ± 0.023
4.373IleLeu: 4.373 ± 0.033
0.93IleMet: 0.93 ± 0.012
1.68IleAsn: 1.68 ± 0.019
2.952IlePro: 2.952 ± 0.026
1.792IleGln: 1.792 ± 0.022
2.722IleArg: 2.722 ± 0.026
3.597IleSer: 3.597 ± 0.027
2.636IleThr: 2.636 ± 0.026
3.057IleVal: 3.057 ± 0.03
0.689IleTrp: 0.689 ± 0.013
1.339IleTyr: 1.339 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
4.382LysAla: 4.382 ± 0.041
0.482LysCys: 0.482 ± 0.011
2.812LysAsp: 2.812 ± 0.026
3.398LysGlu: 3.398 ± 0.037
1.386LysPhe: 1.386 ± 0.02
2.875LysGly: 2.875 ± 0.029
1.183LysHis: 1.183 ± 0.016
2.191LysIle: 2.191 ± 0.022
3.339LysLys: 3.339 ± 0.057
3.984LysLeu: 3.984 ± 0.029
1.005LysMet: 1.005 ± 0.016
1.708LysAsn: 1.708 ± 0.021
2.848LysPro: 2.848 ± 0.032
2.036LysGln: 2.036 ± 0.025
3.494LysArg: 3.494 ± 0.035
3.569LysSer: 3.569 ± 0.034
2.857LysThr: 2.857 ± 0.029
2.851LysVal: 2.851 ± 0.032
0.659LysTrp: 0.659 ± 0.014
1.377LysTyr: 1.377 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
7.783LeuAla: 7.783 ± 0.051
1.183LeuCys: 1.183 ± 0.018
5.169LeuAsp: 5.169 ± 0.035
5.458LeuGlu: 5.458 ± 0.039
3.185LeuPhe: 3.185 ± 0.03
5.772LeuGly: 5.772 ± 0.038
2.172LeuHis: 2.172 ± 0.026
3.677LeuIle: 3.677 ± 0.03
4.222LeuLys: 4.222 ± 0.033
8.182LeuLeu: 8.182 ± 0.051
1.706LeuMet: 1.706 ± 0.02
3.069LeuAsn: 3.069 ± 0.024
5.535LeuPro: 5.535 ± 0.036
3.902LeuGln: 3.902 ± 0.033
5.736LeuArg: 5.736 ± 0.041
7.045LeuSer: 7.045 ± 0.044
4.792LeuThr: 4.792 ± 0.032
5.372LeuVal: 5.372 ± 0.041
1.136LeuTrp: 1.136 ± 0.016
2.286LeuTyr: 2.286 ± 0.024
0.0LeuXaa: 0.0 ± 0.0
Met
2.287MetAla: 2.287 ± 0.02
0.233MetCys: 0.233 ± 0.006
1.194MetAsp: 1.194 ± 0.015
1.141MetGlu: 1.141 ± 0.016
0.702MetPhe: 0.702 ± 0.012
1.384MetGly: 1.384 ± 0.018
0.476MetHis: 0.476 ± 0.01
0.918MetIle: 0.918 ± 0.013
0.929MetLys: 0.929 ± 0.014
1.796MetLeu: 1.796 ± 0.019
0.533MetMet: 0.533 ± 0.011
0.754MetAsn: 0.754 ± 0.012
1.287MetPro: 1.287 ± 0.018
0.87MetGln: 0.87 ± 0.015
1.186MetArg: 1.186 ± 0.015
1.845MetSer: 1.845 ± 0.022
1.317MetThr: 1.317 ± 0.018
1.269MetVal: 1.269 ± 0.017
0.229MetTrp: 0.229 ± 0.008
0.504MetTyr: 0.504 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.144AsnAla: 3.144 ± 0.03
0.399AsnCys: 0.399 ± 0.011
1.992AsnAsp: 1.992 ± 0.022
1.968AsnGlu: 1.968 ± 0.021
1.256AsnPhe: 1.256 ± 0.016
2.993AsnGly: 2.993 ± 0.03
0.889AsnHis: 0.889 ± 0.016
1.855AsnIle: 1.855 ± 0.019
1.595AsnLys: 1.595 ± 0.018
3.132AsnLeu: 3.132 ± 0.029
0.789AsnMet: 0.789 ± 0.014
1.642AsnAsn: 1.642 ± 0.026
2.427AsnPro: 2.427 ± 0.024
1.356AsnGln: 1.356 ± 0.019
1.911AsnArg: 1.911 ± 0.023
2.666AsnSer: 2.666 ± 0.025
2.232AsnThr: 2.232 ± 0.023
2.365AsnVal: 2.365 ± 0.025
0.493AsnTrp: 0.493 ± 0.01
0.991AsnTyr: 0.991 ± 0.013
0.0AsnXaa: 0.0 ± 0.0
Pro
5.612ProAla: 5.612 ± 0.05
0.505ProCys: 0.505 ± 0.011
3.346ProAsp: 3.346 ± 0.026
3.957ProGlu: 3.957 ± 0.033
2.004ProPhe: 2.004 ± 0.021
4.124ProGly: 4.124 ± 0.036
1.338ProHis: 1.338 ± 0.018
2.388ProIle: 2.388 ± 0.026
2.713ProLys: 2.713 ± 0.03
4.726ProLeu: 4.726 ± 0.031
1.057ProMet: 1.057 ± 0.017
2.209ProAsn: 2.209 ± 0.026
5.648ProPro: 5.648 ± 0.072
2.724ProGln: 2.724 ± 0.032
3.631ProArg: 3.631 ± 0.031
6.163ProSer: 6.163 ± 0.047
4.207ProThr: 4.207 ± 0.033
3.743ProVal: 3.743 ± 0.032
0.728ProTrp: 0.728 ± 0.014
1.544ProTyr: 1.544 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.725GlnAla: 3.725 ± 0.036
0.435GlnCys: 0.435 ± 0.01
2.216GlnAsp: 2.216 ± 0.023
2.616GlnGlu: 2.616 ± 0.029
1.258GlnPhe: 1.258 ± 0.016
2.551GlnGly: 2.551 ± 0.031
1.269GlnHis: 1.269 ± 0.018
1.929GlnIle: 1.929 ± 0.021
2.106GlnLys: 2.106 ± 0.021
3.471GlnLeu: 3.471 ± 0.028
0.881GlnMet: 0.881 ± 0.015
1.595GlnAsn: 1.595 ± 0.022
2.851GlnPro: 2.851 ± 0.034
3.023GlnGln: 3.023 ± 0.053
2.814GlnArg: 2.814 ± 0.025
3.406GlnSer: 3.406 ± 0.036
2.529GlnThr: 2.529 ± 0.023
2.222GlnVal: 2.222 ± 0.02
0.554GlnTrp: 0.554 ± 0.011
1.198GlnTyr: 1.198 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
4.879ArgAla: 4.879 ± 0.032
0.695ArgCys: 0.695 ± 0.013
3.42ArgAsp: 3.42 ± 0.037
3.876ArgGlu: 3.876 ± 0.036
2.044ArgPhe: 2.044 ± 0.023
3.784ArgGly: 3.784 ± 0.033
1.746ArgHis: 1.746 ± 0.024
2.833ArgIle: 2.833 ± 0.027
3.672ArgLys: 3.672 ± 0.03
5.6ArgLeu: 5.6 ± 0.044
1.275ArgMet: 1.275 ± 0.017
2.274ArgAsn: 2.274 ± 0.023
3.915ArgPro: 3.915 ± 0.036
2.905ArgGln: 2.905 ± 0.032
5.592ArgArg: 5.592 ± 0.053
5.008ArgSer: 5.008 ± 0.046
3.464ArgThr: 3.464 ± 0.031
3.296ArgVal: 3.296 ± 0.024
0.907ArgTrp: 0.907 ± 0.017
1.669ArgTyr: 1.669 ± 0.022
0.0ArgXaa: 0.0 ± 0.0
Ser
6.936SerAla: 6.936 ± 0.054
0.816SerCys: 0.816 ± 0.016
4.137SerAsp: 4.137 ± 0.032
4.112SerGlu: 4.112 ± 0.032
2.814SerPhe: 2.814 ± 0.028
5.708SerGly: 5.708 ± 0.042
1.961SerHis: 1.961 ± 0.023
3.734SerIle: 3.734 ± 0.032
3.716SerLys: 3.716 ± 0.037
6.971SerLeu: 6.971 ± 0.041
1.673SerMet: 1.673 ± 0.021
3.018SerAsn: 3.018 ± 0.027
5.699SerPro: 5.699 ± 0.051
3.484SerGln: 3.484 ± 0.031
5.235SerArg: 5.235 ± 0.048
9.478SerSer: 9.478 ± 0.103
6.17SerThr: 6.17 ± 0.075
4.581SerVal: 4.581 ± 0.038
1.031SerTrp: 1.031 ± 0.014
1.946SerTyr: 1.946 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
5.615ThrAla: 5.615 ± 0.041
0.68ThrCys: 0.68 ± 0.013
2.899ThrAsp: 2.899 ± 0.027
3.109ThrGlu: 3.109 ± 0.029
2.147ThrPhe: 2.147 ± 0.022
4.384ThrGly: 4.384 ± 0.032
1.294ThrHis: 1.294 ± 0.018
2.979ThrIle: 2.979 ± 0.028
2.683ThrLys: 2.683 ± 0.028
5.051ThrLeu: 5.051 ± 0.032
1.221ThrMet: 1.221 ± 0.017
2.22ThrAsn: 2.22 ± 0.022
4.51ThrPro: 4.51 ± 0.042
2.198ThrGln: 2.198 ± 0.025
3.253ThrArg: 3.253 ± 0.028
5.895ThrSer: 5.895 ± 0.071
5.262ThrThr: 5.262 ± 0.087
3.862ThrVal: 3.862 ± 0.034
0.782ThrTrp: 0.782 ± 0.012
1.542ThrTyr: 1.542 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
5.288ValAla: 5.288 ± 0.037
0.8ValCys: 0.8 ± 0.014
3.813ValAsp: 3.813 ± 0.028
3.901ValGlu: 3.901 ± 0.032
2.338ValPhe: 2.338 ± 0.022
4.015ValGly: 4.015 ± 0.034
1.449ValHis: 1.449 ± 0.019
2.767ValIle: 2.767 ± 0.024
2.909ValLys: 2.909 ± 0.031
5.552ValLeu: 5.552 ± 0.044
1.268ValMet: 1.268 ± 0.016
2.146ValAsn: 2.146 ± 0.022
3.753ValPro: 3.753 ± 0.032
2.496ValGln: 2.496 ± 0.021
3.513ValArg: 3.513 ± 0.027
4.638ValSer: 4.638 ± 0.032
3.516ValThr: 3.516 ± 0.028
4.394ValVal: 4.394 ± 0.035
0.852ValTrp: 0.852 ± 0.013
1.66ValTyr: 1.66 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
1.06TrpAla: 1.06 ± 0.018
0.181TrpCys: 0.181 ± 0.007
0.822TrpAsp: 0.822 ± 0.016
0.746TrpGlu: 0.746 ± 0.014
0.505TrpPhe: 0.505 ± 0.011
0.826TrpGly: 0.826 ± 0.017
0.369TrpHis: 0.369 ± 0.01
0.725TrpIle: 0.725 ± 0.013
0.761TrpLys: 0.761 ± 0.013
1.315TrpLeu: 1.315 ± 0.021
0.354TrpMet: 0.354 ± 0.009
0.556TrpAsn: 0.556 ± 0.011
0.59TrpPro: 0.59 ± 0.013
0.58TrpGln: 0.58 ± 0.013
0.947TrpArg: 0.947 ± 0.016
1.016TrpSer: 1.016 ± 0.015
0.905TrpThr: 0.905 ± 0.014
0.806TrpVal: 0.806 ± 0.016
0.259TrpTrp: 0.259 ± 0.009
0.412TrpTyr: 0.412 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.14TyrAla: 2.14 ± 0.022
0.406TyrCys: 0.406 ± 0.009
1.637TyrAsp: 1.637 ± 0.019
1.485TyrGlu: 1.485 ± 0.018
1.149TyrPhe: 1.149 ± 0.016
2.045TyrGly: 2.045 ± 0.025
0.766TyrHis: 0.766 ± 0.014
1.334TyrIle: 1.334 ± 0.017
1.091TyrLys: 1.091 ± 0.015
2.617TyrLeu: 2.617 ± 0.022
0.575TyrMet: 0.575 ± 0.011
1.045TyrAsn: 1.045 ± 0.016
1.476TyrPro: 1.476 ± 0.023
1.106TyrGln: 1.106 ± 0.019
1.598TyrArg: 1.598 ± 0.022
1.884TyrSer: 1.884 ± 0.022
1.557TyrThr: 1.557 ± 0.021
1.6TyrVal: 1.6 ± 0.017
0.407TyrTrp: 0.407 ± 0.01
0.899TyrTyr: 0.899 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9391 proteins (4712771 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski