Amino acid dipepetide frequency for Novipirellula galeiformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.696AlaAla: 11.696 ± 0.114	1.115AlaCys: 1.115 ± 0.025	5.936AlaAsp: 5.936 ± 0.06	6.536AlaGlu: 6.536 ± 0.079	3.441AlaPhe: 3.441 ± 0.044	7.57AlaGly: 7.57 ± 0.089	1.658AlaHis: 1.658 ± 0.032	6.242AlaIle: 6.242 ± 0.067	4.236AlaLys: 4.236 ± 0.07	8.069AlaLeu: 8.069 ± 0.073	2.9AlaMet: 2.9 ± 0.043	3.483AlaAsn: 3.483 ± 0.044	4.143AlaPro: 4.143 ± 0.056	3.305AlaGln: 3.305 ± 0.049	5.146AlaArg: 5.146 ± 0.066	7.222AlaSer: 7.222 ± 0.076	6.443AlaThr: 6.443 ± 0.071	6.915AlaVal: 6.915 ± 0.063	1.316AlaTrp: 1.316 ± 0.031	2.044AlaTyr: 2.044 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.021	0.233CysCys: 0.233 ± 0.011	0.779CysAsp: 0.779 ± 0.022	0.726CysGlu: 0.726 ± 0.021	0.447CysPhe: 0.447 ± 0.016	1.086CysGly: 1.086 ± 0.032	0.455CysHis: 0.455 ± 0.015	0.484CysIle: 0.484 ± 0.014	0.336CysLys: 0.336 ± 0.015	1.09CysLeu: 1.09 ± 0.028	0.213CysMet: 0.213 ± 0.011	0.359CysAsn: 0.359 ± 0.015	0.591CysPro: 0.591 ± 0.021	0.418CysGln: 0.418 ± 0.015	0.797CysArg: 0.797 ± 0.024	0.731CysSer: 0.731 ± 0.019	0.538CysThr: 0.538 ± 0.017	0.893CysVal: 0.893 ± 0.024	0.174CysTrp: 0.174 ± 0.01	0.281CysTyr: 0.281 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.823AspAla: 6.823 ± 0.074	0.642AspCys: 0.642 ± 0.023	3.919AspAsp: 3.919 ± 0.07	4.011AspGlu: 4.011 ± 0.051	2.347AspPhe: 2.347 ± 0.032	5.197AspGly: 5.197 ± 0.094	1.524AspHis: 1.524 ± 0.028	2.429AspIle: 2.429 ± 0.045	1.655AspLys: 1.655 ± 0.033	5.512AspLeu: 5.512 ± 0.069	0.964AspMet: 0.964 ± 0.024	1.642AspAsn: 1.642 ± 0.037	3.646AspPro: 3.646 ± 0.051	2.524AspGln: 2.524 ± 0.035	4.274AspArg: 4.274 ± 0.052	4.05AspSer: 4.05 ± 0.064	2.835AspThr: 2.835 ± 0.075	4.333AspVal: 4.333 ± 0.061	1.014AspTrp: 1.014 ± 0.021	1.59AspTyr: 1.59 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.808GluAla: 5.808 ± 0.07	0.502GluCys: 0.502 ± 0.018	2.678GluAsp: 2.678 ± 0.039	2.936GluGlu: 2.936 ± 0.046	2.204GluPhe: 2.204 ± 0.034	3.632GluGly: 3.632 ± 0.044	1.438GluHis: 1.438 ± 0.027	3.495GluIle: 3.495 ± 0.048	2.421GluLys: 2.421 ± 0.045	6.476GluLeu: 6.476 ± 0.071	1.634GluMet: 1.634 ± 0.033	2.05GluAsn: 2.05 ± 0.032	2.758GluPro: 2.758 ± 0.048	2.912GluGln: 2.912 ± 0.045	3.994GluArg: 3.994 ± 0.053	4.567GluSer: 4.567 ± 0.051	3.871GluThr: 3.871 ± 0.048	4.115GluVal: 4.115 ± 0.056	0.652GluTrp: 0.652 ± 0.018	1.244GluTyr: 1.244 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.025PheAla: 4.025 ± 0.049	0.508PheCys: 0.508 ± 0.017	2.777PheAsp: 2.777 ± 0.043	2.19PheGlu: 2.19 ± 0.034	1.382PhePhe: 1.382 ± 0.03	3.121PheGly: 3.121 ± 0.041	0.813PheHis: 0.813 ± 0.022	1.472PheIle: 1.472 ± 0.027	1.013PheLys: 1.013 ± 0.023	3.335PheLeu: 3.335 ± 0.049	0.653PheMet: 0.653 ± 0.019	1.187PheAsn: 1.187 ± 0.03	1.667PhePro: 1.667 ± 0.031	1.288PheGln: 1.288 ± 0.028	2.326PheArg: 2.326 ± 0.033	2.436PheSer: 2.436 ± 0.037	2.027PheThr: 2.027 ± 0.043	2.788PheVal: 2.788 ± 0.042	0.526PheTrp: 0.526 ± 0.018	0.964PheTyr: 0.964 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	5.924GlyAla: 5.924 ± 0.076	1.072GlyCys: 1.072 ± 0.031	4.739GlyAsp: 4.739 ± 0.082	4.498GlyGlu: 4.498 ± 0.046	3.022GlyPhe: 3.022 ± 0.046	6.68GlyGly: 6.68 ± 0.12	1.776GlyHis: 1.776 ± 0.03	4.207GlyIle: 4.207 ± 0.049	3.37GlyLys: 3.37 ± 0.058	6.589GlyLeu: 6.589 ± 0.058	1.911GlyMet: 1.911 ± 0.038	2.907GlyAsn: 2.907 ± 0.089	2.923GlyPro: 2.923 ± 0.042	2.808GlyGln: 2.808 ± 0.043	4.715GlyArg: 4.715 ± 0.061	5.158GlySer: 5.158 ± 0.097	4.634GlyThr: 4.634 ± 0.12	5.599GlyVal: 5.599 ± 0.065	1.258GlyTrp: 1.258 ± 0.033	2.083GlyTyr: 2.083 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.28HisAla: 2.28 ± 0.037	0.379HisCys: 0.379 ± 0.014	1.485HisAsp: 1.485 ± 0.028	1.301HisGlu: 1.301 ± 0.026	1.012HisPhe: 1.012 ± 0.025	1.865HisGly: 1.865 ± 0.033	0.773HisHis: 0.773 ± 0.023	0.808HisIle: 0.808 ± 0.019	0.527HisLys: 0.527 ± 0.018	2.2HisLeu: 2.2 ± 0.038	0.337HisMet: 0.337 ± 0.013	0.648HisAsn: 0.648 ± 0.019	1.562HisPro: 1.562 ± 0.03	0.983HisGln: 0.983 ± 0.024	1.814HisArg: 1.814 ± 0.035	1.466HisSer: 1.466 ± 0.031	1.01HisThr: 1.01 ± 0.024	1.519HisVal: 1.519 ± 0.033	0.481HisTrp: 0.481 ± 0.017	0.69HisTyr: 0.69 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.476IleAla: 6.476 ± 0.06	0.601IleCys: 0.601 ± 0.018	4.172IleAsp: 4.172 ± 0.05	4.07IleGlu: 4.07 ± 0.057	1.446IlePhe: 1.446 ± 0.028	4.367IleGly: 4.367 ± 0.057	1.197IleHis: 1.197 ± 0.027	1.886IleIle: 1.886 ± 0.029	1.536IleLys: 1.536 ± 0.029	3.95IleLeu: 3.95 ± 0.054	0.725IleMet: 0.725 ± 0.023	1.634IleAsn: 1.634 ± 0.041	2.578IlePro: 2.578 ± 0.041	2.0IleGln: 2.0 ± 0.034	3.476IleArg: 3.476 ± 0.042	3.179IleSer: 3.179 ± 0.041	2.85IleThr: 2.85 ± 0.078	4.205IleVal: 4.205 ± 0.049	0.544IleTrp: 0.544 ± 0.016	1.112IleTyr: 1.112 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.027LysAla: 3.027 ± 0.053	0.305LysCys: 0.305 ± 0.013	1.599LysAsp: 1.599 ± 0.033	1.764LysGlu: 1.764 ± 0.038	1.09LysPhe: 1.09 ± 0.026	1.966LysGly: 1.966 ± 0.033	0.899LysHis: 0.899 ± 0.022	1.854LysIle: 1.854 ± 0.035	1.666LysLys: 1.666 ± 0.048	3.627LysLeu: 3.627 ± 0.054	0.951LysMet: 0.951 ± 0.023	1.14LysAsn: 1.14 ± 0.027	2.321LysPro: 2.321 ± 0.043	1.805LysGln: 1.805 ± 0.037	2.674LysArg: 2.674 ± 0.046	2.408LysSer: 2.408 ± 0.042	2.258LysThr: 2.258 ± 0.036	2.33LysVal: 2.33 ± 0.033	0.502LysTrp: 0.502 ± 0.016	0.785LysTyr: 0.785 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	10.459LeuAla: 10.459 ± 0.094	1.125LeuCys: 1.125 ± 0.026	5.882LeuAsp: 5.882 ± 0.059	5.214LeuGlu: 5.214 ± 0.064	3.285LeuPhe: 3.285 ± 0.045	6.994LeuGly: 6.994 ± 0.06	2.087LeuHis: 2.087 ± 0.039	4.739LeuIle: 4.739 ± 0.057	3.422LeuLys: 3.422 ± 0.045	9.332LeuLeu: 9.332 ± 0.098	2.088LeuMet: 2.088 ± 0.036	2.926LeuAsn: 2.926 ± 0.045	5.108LeuPro: 5.108 ± 0.06	3.741LeuGln: 3.741 ± 0.047	6.56LeuArg: 6.56 ± 0.065	6.742LeuSer: 6.742 ± 0.063	5.342LeuThr: 5.342 ± 0.082	7.002LeuVal: 7.002 ± 0.062	1.187LeuTrp: 1.187 ± 0.032	1.993LeuTyr: 1.993 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.158MetAla: 2.158 ± 0.037	0.203MetCys: 0.203 ± 0.01	1.063MetAsp: 1.063 ± 0.023	1.04MetGlu: 1.04 ± 0.025	0.78MetPhe: 0.78 ± 0.022	1.471MetGly: 1.471 ± 0.032	0.551MetHis: 0.551 ± 0.016	1.442MetIle: 1.442 ± 0.024	1.049MetLys: 1.049 ± 0.024	2.585MetLeu: 2.585 ± 0.039	0.693MetMet: 0.693 ± 0.02	0.943MetAsn: 0.943 ± 0.025	1.402MetPro: 1.402 ± 0.026	1.074MetGln: 1.074 ± 0.023	1.491MetArg: 1.491 ± 0.03	1.606MetSer: 1.606 ± 0.033	1.567MetThr: 1.567 ± 0.031	1.524MetVal: 1.524 ± 0.027	0.224MetTrp: 0.224 ± 0.011	0.399MetTyr: 0.399 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.398AsnAla: 3.398 ± 0.053	0.346AsnCys: 0.346 ± 0.013	2.161AsnAsp: 2.161 ± 0.057	2.088AsnGlu: 2.088 ± 0.036	1.102AsnPhe: 1.102 ± 0.029	2.66AsnGly: 2.66 ± 0.074	0.879AsnHis: 0.879 ± 0.021	1.265AsnIle: 1.265 ± 0.027	0.847AsnLys: 0.847 ± 0.02	2.92AsnLeu: 2.92 ± 0.04	0.587AsnMet: 0.587 ± 0.017	1.043AsnAsn: 1.043 ± 0.039	2.145AsnPro: 2.145 ± 0.037	1.516AsnGln: 1.516 ± 0.026	2.451AsnArg: 2.451 ± 0.036	1.994AsnSer: 1.994 ± 0.05	1.666AsnThr: 1.666 ± 0.048	2.471AsnVal: 2.471 ± 0.044	0.476AsnTrp: 0.476 ± 0.015	0.83AsnTyr: 0.83 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.119ProAla: 5.119 ± 0.068	0.422ProCys: 0.422 ± 0.016	3.047ProAsp: 3.047 ± 0.044	3.586ProGlu: 3.586 ± 0.044	1.771ProPhe: 1.771 ± 0.033	3.561ProGly: 3.561 ± 0.052	1.181ProHis: 1.181 ± 0.026	2.773ProIle: 2.773 ± 0.042	1.875ProLys: 1.875 ± 0.035	4.725ProLeu: 4.725 ± 0.06	1.257ProMet: 1.257 ± 0.027	1.876ProAsn: 1.876 ± 0.033	2.885ProPro: 2.885 ± 0.056	2.069ProGln: 2.069 ± 0.031	2.891ProArg: 2.891 ± 0.046	3.912ProSer: 3.912 ± 0.049	3.197ProThr: 3.197 ± 0.046	3.612ProVal: 3.612 ± 0.05	0.717ProTrp: 0.717 ± 0.019	1.102ProTyr: 1.102 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.908GlnAla: 3.908 ± 0.052	0.447GlnCys: 0.447 ± 0.016	1.717GlnAsp: 1.717 ± 0.029	1.724GlnGlu: 1.724 ± 0.031	1.561GlnPhe: 1.561 ± 0.028	2.492GlnGly: 2.492 ± 0.039	1.01GlnHis: 1.01 ± 0.026	2.287GlnIle: 2.287 ± 0.033	1.291GlnLys: 1.291 ± 0.028	4.318GlnLeu: 4.318 ± 0.055	1.006GlnMet: 1.006 ± 0.023	1.236GlnAsn: 1.236 ± 0.027	2.195GlnPro: 2.195 ± 0.038	2.111GlnGln: 2.111 ± 0.044	3.221GlnArg: 3.221 ± 0.046	3.027GlnSer: 3.027 ± 0.044	2.611GlnThr: 2.611 ± 0.045	2.666GlnVal: 2.666 ± 0.042	0.769GlnTrp: 0.769 ± 0.019	0.956GlnTyr: 0.956 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.782ArgAla: 4.782 ± 0.06	0.849ArgCys: 0.849 ± 0.024	4.128ArgAsp: 4.128 ± 0.048	4.037ArgGlu: 4.037 ± 0.056	2.945ArgPhe: 2.945 ± 0.04	4.424ArgGly: 4.424 ± 0.056	1.514ArgHis: 1.514 ± 0.03	3.787ArgIle: 3.787 ± 0.044	2.249ArgLys: 2.249 ± 0.04	7.001ArgLeu: 7.001 ± 0.073	1.908ArgMet: 1.908 ± 0.034	2.174ArgAsn: 2.174 ± 0.032	3.006ArgPro: 3.006 ± 0.043	2.742ArgGln: 2.742 ± 0.045	5.221ArgArg: 5.221 ± 0.081	4.515ArgSer: 4.515 ± 0.052	3.146ArgThr: 3.146 ± 0.04	4.715ArgVal: 4.715 ± 0.062	1.278ArgTrp: 1.278 ± 0.028	1.882ArgTyr: 1.882 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.938SerAla: 5.938 ± 0.06	0.648SerCys: 0.648 ± 0.019	4.523SerAsp: 4.523 ± 0.059	4.436SerGlu: 4.436 ± 0.051	2.366SerPhe: 2.366 ± 0.032	6.103SerGly: 6.103 ± 0.11	1.537SerHis: 1.537 ± 0.029	3.656SerIle: 3.656 ± 0.046	2.255SerLys: 2.255 ± 0.034	6.932SerLeu: 6.932 ± 0.068	1.654SerMet: 1.654 ± 0.034	2.323SerAsn: 2.323 ± 0.048	3.715SerPro: 3.715 ± 0.054	2.712SerGln: 2.712 ± 0.039	4.238SerArg: 4.238 ± 0.049	4.776SerSer: 4.776 ± 0.074	3.744SerThr: 3.744 ± 0.061	4.988SerVal: 4.988 ± 0.056	0.856SerTrp: 0.856 ± 0.021	1.453SerTyr: 1.453 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.753ThrAla: 5.753 ± 0.086	0.552ThrCys: 0.552 ± 0.017	3.249ThrAsp: 3.249 ± 0.068	3.026ThrGlu: 3.026 ± 0.044	2.138ThrPhe: 2.138 ± 0.047	4.484ThrGly: 4.484 ± 0.086	1.276ThrHis: 1.276 ± 0.026	3.434ThrIle: 3.434 ± 0.083	1.81ThrLys: 1.81 ± 0.032	6.11ThrLeu: 6.11 ± 0.066	1.27ThrMet: 1.27 ± 0.024	1.758ThrAsn: 1.758 ± 0.058	3.583ThrPro: 3.583 ± 0.045	2.178ThrGln: 2.178 ± 0.03	3.342ThrArg: 3.342 ± 0.041	3.836ThrSer: 3.836 ± 0.051	3.491ThrThr: 3.491 ± 0.08	4.287ThrVal: 4.287 ± 0.085	0.81ThrTrp: 0.81 ± 0.021	1.329ThrTyr: 1.329 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.829ValAla: 7.829 ± 0.066	0.946ValCys: 0.946 ± 0.022	4.713ValAsp: 4.713 ± 0.061	4.204ValGlu: 4.204 ± 0.051	2.572ValPhe: 2.572 ± 0.04	5.275ValGly: 5.275 ± 0.069	1.529ValHis: 1.529 ± 0.029	3.996ValIle: 3.996 ± 0.053	2.203ValLys: 2.203 ± 0.041	6.606ValLeu: 6.606 ± 0.069	1.682ValMet: 1.682 ± 0.03	2.297ValAsn: 2.297 ± 0.046	3.568ValPro: 3.568 ± 0.051	2.578ValGln: 2.578 ± 0.034	4.677ValArg: 4.677 ± 0.059	4.798ValSer: 4.798 ± 0.058	4.456ValThr: 4.456 ± 0.079	5.807ValVal: 5.807 ± 0.066	1.002ValTrp: 1.002 ± 0.023	1.578ValTyr: 1.578 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.04TrpAla: 1.04 ± 0.027	0.196TrpCys: 0.196 ± 0.009	0.804TrpAsp: 0.804 ± 0.022	0.614TrpGlu: 0.614 ± 0.019	0.596TrpPhe: 0.596 ± 0.017	0.942TrpGly: 0.942 ± 0.024	0.39TrpHis: 0.39 ± 0.013	0.919TrpIle: 0.919 ± 0.024	0.601TrpLys: 0.601 ± 0.017	1.552TrpLeu: 1.552 ± 0.032	0.468TrpMet: 0.468 ± 0.016	0.564TrpAsn: 0.564 ± 0.018	0.65TrpPro: 0.65 ± 0.019	0.716TrpGln: 0.716 ± 0.02	0.953TrpArg: 0.953 ± 0.022	1.024TrpSer: 1.024 ± 0.022	0.871TrpThr: 0.871 ± 0.024	0.95TrpVal: 0.95 ± 0.023	0.239TrpTrp: 0.239 ± 0.012	0.32TrpTyr: 0.32 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.194TyrAla: 2.194 ± 0.042	0.317TyrCys: 0.317 ± 0.012	1.557TyrAsp: 1.557 ± 0.033	1.389TyrGlu: 1.389 ± 0.024	0.99TyrPhe: 0.99 ± 0.023	1.982TyrGly: 1.982 ± 0.039	0.652TyrHis: 0.652 ± 0.017	0.826TyrIle: 0.826 ± 0.023	0.608TyrLys: 0.608 ± 0.017	2.3TyrLeu: 2.3 ± 0.043	0.364TyrMet: 0.364 ± 0.013	0.653TyrAsn: 0.653 ± 0.019	1.135TyrPro: 1.135 ± 0.025	1.073TyrGln: 1.073 ± 0.025	2.042TyrArg: 2.042 ± 0.033	1.408TyrSer: 1.408 ± 0.03	1.161TyrThr: 1.161 ± 0.034	1.6TyrVal: 1.6 ± 0.032	0.384TyrTrp: 0.384 ± 0.013	0.669TyrTyr: 0.669 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5747 proteins (2082698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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