Amino acid dipepetide frequency for Aspergillus thermomutatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.107AlaAla: 9.107 ± 0.061	1.093AlaCys: 1.093 ± 0.017	4.401AlaAsp: 4.401 ± 0.029	5.294AlaGlu: 5.294 ± 0.043	3.194AlaPhe: 3.194 ± 0.029	5.929AlaGly: 5.929 ± 0.038	1.801AlaHis: 1.801 ± 0.02	4.351AlaIle: 4.351 ± 0.033	3.855AlaLys: 3.855 ± 0.03	7.971AlaLeu: 7.971 ± 0.043	1.982AlaMet: 1.982 ± 0.024	2.931AlaAsn: 2.931 ± 0.027	4.591AlaPro: 4.591 ± 0.045	3.499AlaGln: 3.499 ± 0.029	5.11AlaArg: 5.11 ± 0.038	7.373AlaSer: 7.373 ± 0.045	5.25AlaThr: 5.25 ± 0.035	5.677AlaVal: 5.677 ± 0.037	1.186AlaTrp: 1.186 ± 0.018	2.214AlaTyr: 2.214 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.015	0.242CysCys: 0.242 ± 0.007	0.697CysAsp: 0.697 ± 0.013	0.619CysGlu: 0.619 ± 0.011	0.546CysPhe: 0.546 ± 0.01	0.93CysGly: 0.93 ± 0.016	0.323CysHis: 0.323 ± 0.008	0.672CysIle: 0.672 ± 0.014	0.478CysLys: 0.478 ± 0.01	1.335CysLeu: 1.335 ± 0.021	0.276CysMet: 0.276 ± 0.007	0.425CysAsn: 0.425 ± 0.01	0.675CysPro: 0.675 ± 0.014	0.468CysGln: 0.468 ± 0.011	0.78CysArg: 0.78 ± 0.014	0.939CysSer: 0.939 ± 0.016	0.7CysThr: 0.7 ± 0.013	0.811CysVal: 0.811 ± 0.013	0.202CysTrp: 0.202 ± 0.007	0.372CysTyr: 0.372 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.708AspAla: 4.708 ± 0.033	0.657AspCys: 0.657 ± 0.012	3.883AspAsp: 3.883 ± 0.036	4.354AspGlu: 4.354 ± 0.04	2.202AspPhe: 2.202 ± 0.022	3.972AspGly: 3.972 ± 0.031	1.283AspHis: 1.283 ± 0.016	3.019AspIle: 3.019 ± 0.026	2.186AspLys: 2.186 ± 0.022	5.235AspLeu: 5.235 ± 0.036	1.221AspMet: 1.221 ± 0.017	1.805AspAsn: 1.805 ± 0.02	3.425AspPro: 3.425 ± 0.027	1.953AspGln: 1.953 ± 0.019	3.198AspArg: 3.198 ± 0.028	4.14AspSer: 4.14 ± 0.037	2.876AspThr: 2.876 ± 0.025	3.675AspVal: 3.675 ± 0.03	0.889AspTrp: 0.889 ± 0.013	1.664AspTyr: 1.664 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.349GluAla: 5.349 ± 0.043	0.637GluCys: 0.637 ± 0.012	4.151GluAsp: 4.151 ± 0.045	5.497GluGlu: 5.497 ± 0.06	1.996GluPhe: 1.996 ± 0.022	3.673GluGly: 3.673 ± 0.032	1.413GluHis: 1.413 ± 0.02	3.171GluIle: 3.171 ± 0.026	3.582GluLys: 3.582 ± 0.032	5.299GluLeu: 5.299 ± 0.043	1.486GluMet: 1.486 ± 0.018	2.311GluAsn: 2.311 ± 0.023	2.746GluPro: 2.746 ± 0.036	2.557GluGln: 2.557 ± 0.025	4.051GluArg: 4.051 ± 0.038	4.418GluSer: 4.418 ± 0.038	3.584GluThr: 3.584 ± 0.031	3.535GluVal: 3.535 ± 0.031	0.888GluTrp: 0.888 ± 0.016	1.728GluTyr: 1.728 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.104PheAla: 3.104 ± 0.027	0.575PheCys: 0.575 ± 0.012	2.296PheAsp: 2.296 ± 0.022	2.14PheGlu: 2.14 ± 0.023	1.674PhePhe: 1.674 ± 0.019	2.803PheGly: 2.803 ± 0.029	0.938PheHis: 0.938 ± 0.013	1.807PheIle: 1.807 ± 0.02	1.457PheLys: 1.457 ± 0.019	3.656PheLeu: 3.656 ± 0.029	0.78PheMet: 0.78 ± 0.011	1.405PheAsn: 1.405 ± 0.017	2.01PhePro: 2.01 ± 0.021	1.441PheGln: 1.441 ± 0.017	2.089PheArg: 2.089 ± 0.024	3.016PheSer: 3.016 ± 0.025	2.098PheThr: 2.098 ± 0.02	2.436PheVal: 2.436 ± 0.023	0.655PheTrp: 0.655 ± 0.012	1.162PheTyr: 1.162 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.357GlyAla: 5.357 ± 0.038	0.9GlyCys: 0.9 ± 0.015	3.558GlyAsp: 3.558 ± 0.029	3.562GlyGlu: 3.562 ± 0.026	2.822GlyPhe: 2.822 ± 0.027	5.214GlyGly: 5.214 ± 0.044	1.671GlyHis: 1.671 ± 0.019	3.513GlyIle: 3.513 ± 0.03	3.25GlyLys: 3.25 ± 0.029	6.188GlyLeu: 6.188 ± 0.036	1.546GlyMet: 1.546 ± 0.016	2.428GlyAsn: 2.428 ± 0.021	3.322GlyPro: 3.322 ± 0.029	2.625GlyGln: 2.625 ± 0.026	4.079GlyArg: 4.079 ± 0.035	5.667GlySer: 5.667 ± 0.043	3.96GlyThr: 3.96 ± 0.033	4.432GlyVal: 4.432 ± 0.032	1.17GlyTrp: 1.17 ± 0.016	2.144GlyTyr: 2.144 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.901HisAla: 1.901 ± 0.021	0.337HisCys: 0.337 ± 0.008	1.294HisAsp: 1.294 ± 0.016	1.348HisGlu: 1.348 ± 0.017	0.934HisPhe: 0.934 ± 0.016	1.742HisGly: 1.742 ± 0.023	0.823HisHis: 0.823 ± 0.015	1.225HisIle: 1.225 ± 0.014	0.851HisLys: 0.851 ± 0.013	2.311HisLeu: 2.311 ± 0.022	0.483HisMet: 0.483 ± 0.011	0.826HisAsn: 0.826 ± 0.012	1.72HisPro: 1.72 ± 0.02	0.991HisGln: 0.991 ± 0.014	1.641HisArg: 1.641 ± 0.017	1.862HisSer: 1.862 ± 0.022	1.251HisThr: 1.251 ± 0.017	1.427HisVal: 1.427 ± 0.018	0.355HisTrp: 0.355 ± 0.008	0.726HisTyr: 0.726 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.28IleAla: 4.28 ± 0.032	0.785IleCys: 0.785 ± 0.013	2.84IleAsp: 2.84 ± 0.025	2.884IleGlu: 2.884 ± 0.024	2.046IlePhe: 2.046 ± 0.021	3.119IleGly: 3.119 ± 0.03	1.236IleHis: 1.236 ± 0.015	2.472IleIle: 2.472 ± 0.023	2.062IleLys: 2.062 ± 0.02	4.765IleLeu: 4.765 ± 0.035	0.962IleMet: 0.962 ± 0.014	1.759IleAsn: 1.759 ± 0.019	3.145IlePro: 3.145 ± 0.026	1.929IleGln: 1.929 ± 0.022	2.919IleArg: 2.919 ± 0.026	3.841IleSer: 3.841 ± 0.027	2.761IleThr: 2.761 ± 0.022	3.239IleVal: 3.239 ± 0.029	0.733IleTrp: 0.733 ± 0.012	1.452IleTyr: 1.452 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.023LysAla: 4.023 ± 0.032	0.48LysCys: 0.48 ± 0.011	2.645LysAsp: 2.645 ± 0.025	3.268LysGlu: 3.268 ± 0.034	1.364LysPhe: 1.364 ± 0.019	2.831LysGly: 2.831 ± 0.026	1.082LysHis: 1.082 ± 0.016	2.177LysIle: 2.177 ± 0.024	2.971LysLys: 2.971 ± 0.04	3.912LysLeu: 3.912 ± 0.033	0.93LysMet: 0.93 ± 0.013	1.657LysAsn: 1.657 ± 0.021	2.551LysPro: 2.551 ± 0.029	1.819LysGln: 1.819 ± 0.02	3.313LysArg: 3.313 ± 0.032	3.292LysSer: 3.292 ± 0.031	2.657LysThr: 2.657 ± 0.021	2.722LysVal: 2.722 ± 0.022	0.631LysTrp: 0.631 ± 0.011	1.363LysTyr: 1.363 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.159LeuAla: 8.159 ± 0.044	1.273LeuCys: 1.273 ± 0.018	5.25LeuAsp: 5.25 ± 0.04	5.68LeuGlu: 5.68 ± 0.048	3.455LeuPhe: 3.455 ± 0.036	6.054LeuGly: 6.054 ± 0.035	2.315LeuHis: 2.315 ± 0.026	4.094LeuIle: 4.094 ± 0.031	4.131LeuLys: 4.131 ± 0.033	8.892LeuLeu: 8.892 ± 0.066	1.835LeuMet: 1.835 ± 0.02	3.238LeuAsn: 3.238 ± 0.029	5.569LeuPro: 5.569 ± 0.04	3.982LeuGln: 3.982 ± 0.033	6.057LeuArg: 6.057 ± 0.044	7.599LeuSer: 7.599 ± 0.048	4.914LeuThr: 4.914 ± 0.032	5.607LeuVal: 5.607 ± 0.033	1.252LeuTrp: 1.252 ± 0.018	2.484LeuTyr: 2.484 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.146MetAla: 2.146 ± 0.019	0.244MetCys: 0.244 ± 0.008	1.225MetAsp: 1.225 ± 0.015	1.295MetGlu: 1.295 ± 0.017	0.751MetPhe: 0.751 ± 0.014	1.424MetGly: 1.424 ± 0.017	0.474MetHis: 0.474 ± 0.01	1.026MetIle: 1.026 ± 0.014	0.964MetLys: 0.964 ± 0.015	1.872MetLeu: 1.872 ± 0.02	0.561MetMet: 0.561 ± 0.011	0.788MetAsn: 0.788 ± 0.013	1.189MetPro: 1.189 ± 0.017	0.872MetGln: 0.872 ± 0.013	1.248MetArg: 1.248 ± 0.016	1.792MetSer: 1.792 ± 0.019	1.333MetThr: 1.333 ± 0.015	1.333MetVal: 1.333 ± 0.015	0.253MetTrp: 0.253 ± 0.008	0.533MetTyr: 0.533 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.152AsnAla: 3.152 ± 0.027	0.462AsnCys: 0.462 ± 0.01	1.888AsnAsp: 1.888 ± 0.02	2.02AsnGlu: 2.02 ± 0.02	1.331AsnPhe: 1.331 ± 0.016	2.918AsnGly: 2.918 ± 0.026	0.831AsnHis: 0.831 ± 0.013	1.941AsnIle: 1.941 ± 0.022	1.415AsnLys: 1.415 ± 0.018	3.291AsnLeu: 3.291 ± 0.03	0.792AsnMet: 0.792 ± 0.014	1.352AsnAsn: 1.352 ± 0.019	2.441AsnPro: 2.441 ± 0.024	1.356AsnGln: 1.356 ± 0.018	1.999AsnArg: 1.999 ± 0.021	2.635AsnSer: 2.635 ± 0.024	2.057AsnThr: 2.057 ± 0.021	2.293AsnVal: 2.293 ± 0.026	0.557AsnTrp: 0.557 ± 0.011	1.044AsnTyr: 1.044 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.176ProAla: 5.176 ± 0.044	0.537ProCys: 0.537 ± 0.01	3.245ProAsp: 3.245 ± 0.024	3.869ProGlu: 3.869 ± 0.035	2.105ProPhe: 2.105 ± 0.022	3.92ProGly: 3.92 ± 0.032	1.345ProHis: 1.345 ± 0.016	2.437ProIle: 2.437 ± 0.023	2.458ProLys: 2.458 ± 0.025	4.875ProLeu: 4.875 ± 0.034	1.033ProMet: 1.033 ± 0.015	2.079ProAsn: 2.079 ± 0.023	4.626ProPro: 4.626 ± 0.062	2.395ProGln: 2.395 ± 0.028	3.421ProArg: 3.421 ± 0.034	6.106ProSer: 6.106 ± 0.059	3.737ProThr: 3.737 ± 0.031	3.687ProVal: 3.687 ± 0.03	0.791ProTrp: 0.791 ± 0.013	1.524ProTyr: 1.524 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.537GlnAla: 3.537 ± 0.032	0.465GlnCys: 0.465 ± 0.011	2.036GlnAsp: 2.036 ± 0.023	2.503GlnGlu: 2.503 ± 0.027	1.343GlnPhe: 1.343 ± 0.015	2.438GlnGly: 2.438 ± 0.025	1.061GlnHis: 1.061 ± 0.014	1.949GlnIle: 1.949 ± 0.019	1.966GlnLys: 1.966 ± 0.025	3.589GlnLeu: 3.589 ± 0.026	0.904GlnMet: 0.904 ± 0.012	1.542GlnAsn: 1.542 ± 0.019	2.508GlnPro: 2.508 ± 0.034	2.291GlnGln: 2.291 ± 0.038	2.736GlnArg: 2.736 ± 0.023	3.289GlnSer: 3.289 ± 0.028	2.365GlnThr: 2.365 ± 0.021	2.259GlnVal: 2.259 ± 0.02	0.615GlnTrp: 0.615 ± 0.012	1.167GlnTyr: 1.167 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.884ArgAla: 4.884 ± 0.037	0.725ArgCys: 0.725 ± 0.013	3.371ArgAsp: 3.371 ± 0.031	3.986ArgGlu: 3.986 ± 0.034	2.271ArgPhe: 2.271 ± 0.021	3.651ArgGly: 3.651 ± 0.034	1.604ArgHis: 1.604 ± 0.02	2.997ArgIle: 2.997 ± 0.024	3.425ArgLys: 3.425 ± 0.031	5.852ArgLeu: 5.852 ± 0.04	1.322ArgMet: 1.322 ± 0.018	2.286ArgAsn: 2.286 ± 0.022	3.49ArgPro: 3.49 ± 0.036	2.705ArgGln: 2.705 ± 0.024	5.212ArgArg: 5.212 ± 0.05	4.87ArgSer: 4.87 ± 0.044	3.346ArgThr: 3.346 ± 0.028	3.571ArgVal: 3.571 ± 0.033	0.971ArgTrp: 0.971 ± 0.016	1.746ArgTyr: 1.746 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.845SerAla: 6.845 ± 0.047	0.879SerCys: 0.879 ± 0.014	4.301SerAsp: 4.301 ± 0.033	4.259SerGlu: 4.259 ± 0.039	3.024SerPhe: 3.024 ± 0.029	5.52SerGly: 5.52 ± 0.042	2.004SerHis: 2.004 ± 0.022	3.989SerIle: 3.989 ± 0.029	3.562SerLys: 3.562 ± 0.03	7.507SerLeu: 7.507 ± 0.052	1.699SerMet: 1.699 ± 0.019	2.955SerAsn: 2.955 ± 0.025	5.398SerPro: 5.398 ± 0.044	3.411SerGln: 3.411 ± 0.03	5.114SerArg: 5.114 ± 0.046	8.906SerSer: 8.906 ± 0.079	5.562SerThr: 5.562 ± 0.046	4.807SerVal: 4.807 ± 0.033	1.129SerTrp: 1.129 ± 0.016	2.087SerTyr: 2.087 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.341ThrAla: 5.341 ± 0.037	0.735ThrCys: 0.735 ± 0.013	2.92ThrAsp: 2.92 ± 0.027	3.149ThrGlu: 3.149 ± 0.031	2.192ThrPhe: 2.192 ± 0.022	4.226ThrGly: 4.226 ± 0.035	1.259ThrHis: 1.259 ± 0.016	3.052ThrIle: 3.052 ± 0.028	2.422ThrLys: 2.422 ± 0.023	5.305ThrLeu: 5.305 ± 0.032	1.165ThrMet: 1.165 ± 0.016	1.995ThrAsn: 1.995 ± 0.019	4.11ThrPro: 4.11 ± 0.035	2.055ThrGln: 2.055 ± 0.019	3.04ThrArg: 3.04 ± 0.025	5.203ThrSer: 5.203 ± 0.043	4.1ThrThr: 4.1 ± 0.048	3.98ThrVal: 3.98 ± 0.036	0.862ThrTrp: 0.862 ± 0.015	1.644ThrTyr: 1.644 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.334ValAla: 5.334 ± 0.041	0.853ValCys: 0.853 ± 0.015	3.793ValAsp: 3.793 ± 0.029	3.894ValGlu: 3.894 ± 0.032	2.519ValPhe: 2.519 ± 0.024	4.008ValGly: 4.008 ± 0.035	1.45ValHis: 1.45 ± 0.016	3.112ValIle: 3.112 ± 0.031	2.804ValLys: 2.804 ± 0.028	5.812ValLeu: 5.812 ± 0.038	1.343ValMet: 1.343 ± 0.016	2.255ValAsn: 2.255 ± 0.023	3.659ValPro: 3.659 ± 0.028	2.484ValGln: 2.484 ± 0.023	3.557ValArg: 3.557 ± 0.029	4.859ValSer: 4.859 ± 0.033	3.625ValThr: 3.625 ± 0.026	4.358ValVal: 4.358 ± 0.033	0.89ValTrp: 0.89 ± 0.014	1.828ValTyr: 1.828 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.156TrpAla: 1.156 ± 0.015	0.184TrpCys: 0.184 ± 0.007	0.906TrpAsp: 0.906 ± 0.014	0.87TrpGlu: 0.87 ± 0.014	0.55TrpPhe: 0.55 ± 0.012	0.929TrpGly: 0.929 ± 0.015	0.363TrpHis: 0.363 ± 0.009	0.787TrpIle: 0.787 ± 0.015	0.791TrpLys: 0.791 ± 0.013	1.372TrpLeu: 1.372 ± 0.019	0.391TrpMet: 0.391 ± 0.01	0.63TrpAsn: 0.63 ± 0.012	0.604TrpPro: 0.604 ± 0.012	0.586TrpGln: 0.586 ± 0.011	1.012TrpArg: 1.012 ± 0.014	1.051TrpSer: 1.051 ± 0.014	0.946TrpThr: 0.946 ± 0.014	0.906TrpVal: 0.906 ± 0.014	0.274TrpTrp: 0.274 ± 0.009	0.453TrpTyr: 0.453 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.262TyrAla: 2.262 ± 0.022	0.416TyrCys: 0.416 ± 0.01	1.644TyrAsp: 1.644 ± 0.018	1.58TyrGlu: 1.58 ± 0.019	1.223TyrPhe: 1.223 ± 0.014	2.107TyrGly: 2.107 ± 0.024	0.776TyrHis: 0.776 ± 0.011	1.438TyrIle: 1.438 ± 0.021	1.057TyrLys: 1.057 ± 0.016	2.802TyrLeu: 2.802 ± 0.026	0.613TyrMet: 0.613 ± 0.012	1.107TyrAsn: 1.107 ± 0.017	1.586TyrPro: 1.586 ± 0.018	1.145TyrGln: 1.145 ± 0.015	1.708TyrArg: 1.708 ± 0.018	2.096TyrSer: 2.096 ± 0.018	1.633TyrThr: 1.633 ± 0.018	1.683TyrVal: 1.683 ± 0.02	0.46TyrTrp: 0.46 ± 0.01	0.982TyrTyr: 0.982 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9702 proteins (5065008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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