Amino acid dipepetide frequency for Podila verticillata NRRL 6337

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.658AlaAla: 6.658 ± 0.156
0.996AlaCys: 0.996 ± 0.04
3.204AlaAsp: 3.204 ± 0.071
4.236AlaGlu: 4.236 ± 0.125
2.83AlaPhe: 2.83 ± 0.075
4.238AlaGly: 4.238 ± 0.099
1.905AlaHis: 1.905 ± 0.072
3.917AlaIle: 3.917 ± 0.071
4.037AlaLys: 4.037 ± 0.088
9.72AlaLeu: 9.72 ± 0.379
2.042AlaMet: 2.042 ± 0.054
2.848AlaAsn: 2.848 ± 0.071
4.101AlaPro: 4.101 ± 0.113
3.825AlaGln: 3.825 ± 0.134
3.705AlaArg: 3.705 ± 0.087
6.691AlaSer: 6.691 ± 0.124
5.29AlaThr: 5.29 ± 0.108
4.611AlaVal: 4.611 ± 0.098
0.904AlaTrp: 0.904 ± 0.046
1.905AlaTyr: 1.905 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.771CysAla: 0.771 ± 0.035
0.299CysCys: 0.299 ± 0.028
0.606CysAsp: 0.606 ± 0.034
0.573CysGlu: 0.573 ± 0.026
0.513CysPhe: 0.513 ± 0.025
0.873CysGly: 0.873 ± 0.044
0.411CysHis: 0.411 ± 0.027
0.772CysIle: 0.772 ± 0.038
0.561CysLys: 0.561 ± 0.03
1.182CysLeu: 1.182 ± 0.047
0.338CysMet: 0.338 ± 0.022
0.496CysAsn: 0.496 ± 0.027
0.818CysPro: 0.818 ± 0.051
0.515CysGln: 0.515 ± 0.027
0.669CysArg: 0.669 ± 0.035
0.976CysSer: 0.976 ± 0.046
0.743CysThr: 0.743 ± 0.038
0.74CysVal: 0.74 ± 0.032
0.165CysTrp: 0.165 ± 0.016
0.357CysTyr: 0.357 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.858AspAla: 3.858 ± 0.084
0.668AspCys: 0.668 ± 0.029
4.349AspAsp: 4.349 ± 0.12
3.981AspGlu: 3.981 ± 0.105
1.97AspPhe: 1.97 ± 0.055
3.446AspGly: 3.446 ± 0.082
1.599AspHis: 1.599 ± 0.052
2.967AspIle: 2.967 ± 0.072
2.605AspLys: 2.605 ± 0.071
5.392AspLeu: 5.392 ± 0.117
1.438AspMet: 1.438 ± 0.053
2.668AspAsn: 2.668 ± 0.094
2.847AspPro: 2.847 ± 0.071
2.221AspGln: 2.221 ± 0.061
2.718AspArg: 2.718 ± 0.075
4.111AspSer: 4.111 ± 0.098
2.998AspThr: 2.998 ± 0.07
3.309AspVal: 3.309 ± 0.079
0.689AspTrp: 0.689 ± 0.03
1.584AspTyr: 1.584 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.506GluAla: 5.506 ± 0.168
0.693GluCys: 0.693 ± 0.035
4.16GluAsp: 4.16 ± 0.106
5.006GluGlu: 5.006 ± 0.15
1.945GluPhe: 1.945 ± 0.057
3.105GluGly: 3.105 ± 0.07
1.627GluHis: 1.627 ± 0.056
3.052GluIle: 3.052 ± 0.087
3.359GluLys: 3.359 ± 0.082
5.151GluLeu: 5.151 ± 0.109
1.491GluMet: 1.491 ± 0.048
2.279GluAsn: 2.279 ± 0.064
2.405GluPro: 2.405 ± 0.07
2.716GluGln: 2.716 ± 0.099
3.328GluArg: 3.328 ± 0.093
4.273GluSer: 4.273 ± 0.097
3.265GluThr: 3.265 ± 0.062
3.118GluVal: 3.118 ± 0.079
0.729GluTrp: 0.729 ± 0.034
1.817GluTyr: 1.817 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.498PheAla: 2.498 ± 0.067
0.524PheCys: 0.524 ± 0.028
2.137PheAsp: 2.137 ± 0.057
2.134PheGlu: 2.134 ± 0.064
1.459PhePhe: 1.459 ± 0.055
2.567PheGly: 2.567 ± 0.07
0.959PheHis: 0.959 ± 0.04
1.789PheIle: 1.789 ± 0.053
1.878PheLys: 1.878 ± 0.054
3.334PheLeu: 3.334 ± 0.077
0.994PheMet: 0.994 ± 0.041
1.542PheAsn: 1.542 ± 0.044
1.676PhePro: 1.676 ± 0.052
1.462PheGln: 1.462 ± 0.045
1.717PheArg: 1.717 ± 0.046
3.056PheSer: 3.056 ± 0.063
1.991PheThr: 1.991 ± 0.061
2.381PheVal: 2.381 ± 0.071
0.511PheTrp: 0.511 ± 0.031
1.103PheTyr: 1.103 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
5.233GlyAla: 5.233 ± 0.166
0.815GlyCys: 0.815 ± 0.038
3.65GlyAsp: 3.65 ± 0.1
3.047GlyGlu: 3.047 ± 0.069
2.442GlyPhe: 2.442 ± 0.062
4.673GlyGly: 4.673 ± 0.134
1.909GlyHis: 1.909 ± 0.061
2.99GlyIle: 2.99 ± 0.078
2.93GlyLys: 2.93 ± 0.068
5.298GlyLeu: 5.298 ± 0.094
1.388GlyMet: 1.388 ± 0.055
2.618GlyAsn: 2.618 ± 0.088
2.781GlyPro: 2.781 ± 0.083
2.456GlyGln: 2.456 ± 0.075
3.138GlyArg: 3.138 ± 0.083
5.677GlySer: 5.677 ± 0.124
3.584GlyThr: 3.584 ± 0.08
3.783GlyVal: 3.783 ± 0.092
0.808GlyTrp: 0.808 ± 0.038
2.204GlyTyr: 2.204 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
1.916HisAla: 1.916 ± 0.057
0.394HisCys: 0.394 ± 0.026
1.529HisAsp: 1.529 ± 0.06
1.44HisGlu: 1.44 ± 0.047
1.013HisPhe: 1.013 ± 0.042
1.809HisGly: 1.809 ± 0.06
1.757HisHis: 1.757 ± 0.079
1.294HisIle: 1.294 ± 0.049
1.161HisLys: 1.161 ± 0.054
2.631HisLeu: 2.631 ± 0.078
0.607HisMet: 0.607 ± 0.027
1.125HisAsn: 1.125 ± 0.039
1.915HisPro: 1.915 ± 0.074
1.559HisGln: 1.559 ± 0.061
1.632HisArg: 1.632 ± 0.053
2.432HisSer: 2.432 ± 0.081
1.5HisThr: 1.5 ± 0.051
1.647HisVal: 1.647 ± 0.042
0.329HisTrp: 0.329 ± 0.021
0.849HisTyr: 0.849 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
3.869IleAla: 3.869 ± 0.089
0.744IleCys: 0.744 ± 0.036
2.778IleAsp: 2.778 ± 0.063
3.098IleGlu: 3.098 ± 0.086
1.762IlePhe: 1.762 ± 0.051
3.889IleGly: 3.889 ± 0.149
1.394IleHis: 1.394 ± 0.046
2.437IleIle: 2.437 ± 0.08
2.717IleLys: 2.717 ± 0.064
4.76IleLeu: 4.76 ± 0.101
1.2IleMet: 1.2 ± 0.045
2.19IleAsn: 2.19 ± 0.072
2.838IlePro: 2.838 ± 0.059
2.282IleGln: 2.282 ± 0.053
2.725IleArg: 2.725 ± 0.068
3.94IleSer: 3.94 ± 0.094
2.813IleThr: 2.813 ± 0.069
3.286IleVal: 3.286 ± 0.086
0.645IleTrp: 0.645 ± 0.035
1.381IleTyr: 1.381 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.33LysAla: 4.33 ± 0.092
0.558LysCys: 0.558 ± 0.032
3.165LysAsp: 3.165 ± 0.08
3.513LysGlu: 3.513 ± 0.108
1.524LysPhe: 1.524 ± 0.046
2.745LysGly: 2.745 ± 0.072
1.289LysHis: 1.289 ± 0.044
2.854LysIle: 2.854 ± 0.087
3.696LysLys: 3.696 ± 0.114
4.212LysLeu: 4.212 ± 0.094
1.217LysMet: 1.217 ± 0.043
2.094LysAsn: 2.094 ± 0.058
2.395LysPro: 2.395 ± 0.06
1.984LysGln: 1.984 ± 0.064
3.108LysArg: 3.108 ± 0.073
3.866LysSer: 3.866 ± 0.076
3.847LysThr: 3.847 ± 0.13
3.105LysVal: 3.105 ± 0.068
0.568LysTrp: 0.568 ± 0.027
1.464LysTyr: 1.464 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
8.529LeuAla: 8.529 ± 0.225
1.231LeuCys: 1.231 ± 0.047
5.564LeuAsp: 5.564 ± 0.112
5.995LeuGlu: 5.995 ± 0.133
3.362LeuPhe: 3.362 ± 0.076
5.517LeuGly: 5.517 ± 0.104
2.355LeuHis: 2.355 ± 0.061
4.265LeuIle: 4.265 ± 0.102
5.677LeuLys: 5.677 ± 0.188
7.868LeuLeu: 7.868 ± 0.154
1.969LeuMet: 1.969 ± 0.053
3.737LeuAsn: 3.737 ± 0.095
4.885LeuPro: 4.885 ± 0.099
4.467LeuGln: 4.467 ± 0.105
4.753LeuArg: 4.753 ± 0.099
8.325LeuSer: 8.325 ± 0.117
6.216LeuThr: 6.216 ± 0.167
5.449LeuVal: 5.449 ± 0.128
1.233LeuTrp: 1.233 ± 0.048
2.528LeuTyr: 2.528 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.343MetAla: 2.343 ± 0.067
0.244MetCys: 0.244 ± 0.021
1.556MetAsp: 1.556 ± 0.048
1.505MetGlu: 1.505 ± 0.054
0.892MetPhe: 0.892 ± 0.041
1.471MetGly: 1.471 ± 0.041
0.517MetHis: 0.517 ± 0.029
1.12MetIle: 1.12 ± 0.044
1.076MetLys: 1.076 ± 0.042
2.004MetLeu: 2.004 ± 0.057
0.638MetMet: 0.638 ± 0.03
1.001MetAsn: 1.001 ± 0.038
1.258MetPro: 1.258 ± 0.043
0.852MetGln: 0.852 ± 0.039
1.104MetArg: 1.104 ± 0.042
2.274MetSer: 2.274 ± 0.063
1.565MetThr: 1.565 ± 0.053
1.514MetVal: 1.514 ± 0.05
0.21MetTrp: 0.21 ± 0.017
0.71MetTyr: 0.71 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.789AsnAla: 2.789 ± 0.066
0.497AsnCys: 0.497 ± 0.032
2.063AsnAsp: 2.063 ± 0.05
1.93AsnGlu: 1.93 ± 0.05
1.272AsnPhe: 1.272 ± 0.048
3.379AsnGly: 3.379 ± 0.135
1.149AsnHis: 1.149 ± 0.048
2.242AsnIle: 2.242 ± 0.066
2.168AsnLys: 2.168 ± 0.069
3.991AsnLeu: 3.991 ± 0.123
1.089AsnMet: 1.089 ± 0.04
2.967AsnAsn: 2.967 ± 0.13
2.158AsnPro: 2.158 ± 0.058
1.553AsnGln: 1.553 ± 0.057
1.95AsnArg: 1.95 ± 0.052
5.108AsnSer: 5.108 ± 0.293
2.652AsnThr: 2.652 ± 0.073
2.408AsnVal: 2.408 ± 0.075
0.459AsnTrp: 0.459 ± 0.027
1.106AsnTyr: 1.106 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
4.081ProAla: 4.081 ± 0.1
0.517ProCys: 0.517 ± 0.029
2.485ProAsp: 2.485 ± 0.072
3.276ProGlu: 3.276 ± 0.075
1.865ProPhe: 1.865 ± 0.05
3.138ProGly: 3.138 ± 0.086
1.511ProHis: 1.511 ± 0.052
2.511ProIle: 2.511 ± 0.058
2.638ProLys: 2.638 ± 0.067
4.516ProLeu: 4.516 ± 0.096
1.243ProMet: 1.243 ± 0.044
2.155ProAsn: 2.155 ± 0.062
4.282ProPro: 4.282 ± 0.165
2.36ProGln: 2.36 ± 0.082
2.73ProArg: 2.73 ± 0.065
6.213ProSer: 6.213 ± 0.181
3.978ProThr: 3.978 ± 0.107
3.549ProVal: 3.549 ± 0.091
0.593ProTrp: 0.593 ± 0.03
1.442ProTyr: 1.442 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
3.944GlnAla: 3.944 ± 0.131
0.479GlnCys: 0.479 ± 0.029
2.532GlnAsp: 2.532 ± 0.065
3.177GlnGlu: 3.177 ± 0.085
1.388GlnPhe: 1.388 ± 0.047
2.62GlnGly: 2.62 ± 0.07
1.656GlnHis: 1.656 ± 0.069
1.858GlnIle: 1.858 ± 0.051
2.002GlnLys: 2.002 ± 0.057
3.667GlnLeu: 3.667 ± 0.076
0.94GlnMet: 0.94 ± 0.041
1.582GlnAsn: 1.582 ± 0.054
2.484GlnPro: 2.484 ± 0.099
4.474GlnGln: 4.474 ± 0.317
2.58GlnArg: 2.58 ± 0.07
3.331GlnSer: 3.331 ± 0.095
2.074GlnThr: 2.074 ± 0.055
2.477GlnVal: 2.477 ± 0.063
0.559GlnTrp: 0.559 ± 0.028
1.318GlnTyr: 1.318 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
3.533ArgAla: 3.533 ± 0.079
0.617ArgCys: 0.617 ± 0.03
2.888ArgAsp: 2.888 ± 0.099
3.067ArgGlu: 3.067 ± 0.087
1.932ArgPhe: 1.932 ± 0.052
2.6ArgGly: 2.6 ± 0.072
1.799ArgHis: 1.799 ± 0.056
2.836ArgIle: 2.836 ± 0.069
2.823ArgLys: 2.823 ± 0.067
4.965ArgLeu: 4.965 ± 0.106
1.219ArgMet: 1.219 ± 0.042
2.169ArgAsn: 2.169 ± 0.065
2.956ArgPro: 2.956 ± 0.09
2.396ArgGln: 2.396 ± 0.068
3.744ArgArg: 3.744 ± 0.101
4.578ArgSer: 4.578 ± 0.139
2.977ArgThr: 2.977 ± 0.067
2.934ArgVal: 2.934 ± 0.068
0.667ArgTrp: 0.667 ± 0.025
1.548ArgTyr: 1.548 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
5.951SerAla: 5.951 ± 0.097
0.96SerCys: 0.96 ± 0.048
4.082SerAsp: 4.082 ± 0.084
4.502SerGlu: 4.502 ± 0.116
3.083SerPhe: 3.083 ± 0.069
5.581SerGly: 5.581 ± 0.122
2.302SerHis: 2.302 ± 0.073
5.133SerIle: 5.133 ± 0.142
4.18SerLys: 4.18 ± 0.098
7.922SerLeu: 7.922 ± 0.129
2.091SerMet: 2.091 ± 0.053
4.043SerAsn: 4.043 ± 0.096
5.505SerPro: 5.505 ± 0.177
3.537SerGln: 3.537 ± 0.089
4.502SerArg: 4.502 ± 0.109
11.57SerSer: 11.57 ± 0.374
7.47SerThr: 7.47 ± 0.156
4.741SerVal: 4.741 ± 0.096
0.979SerTrp: 0.979 ± 0.038
2.05SerTyr: 2.05 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.379ThrAla: 4.379 ± 0.102
0.713ThrCys: 0.713 ± 0.034
2.745ThrAsp: 2.745 ± 0.06
2.902ThrGlu: 2.902 ± 0.072
2.292ThrPhe: 2.292 ± 0.056
3.626ThrGly: 3.626 ± 0.087
1.579ThrHis: 1.579 ± 0.05
3.535ThrIle: 3.535 ± 0.067
2.978ThrLys: 2.978 ± 0.075
7.926ThrLeu: 7.926 ± 0.32
1.436ThrMet: 1.436 ± 0.042
3.194ThrAsn: 3.194 ± 0.131
4.334ThrPro: 4.334 ± 0.116
2.113ThrGln: 2.113 ± 0.057
2.913ThrArg: 2.913 ± 0.068
5.928ThrSer: 5.928 ± 0.126
6.038ThrThr: 6.038 ± 0.202
3.847ThrVal: 3.847 ± 0.083
0.71ThrTrp: 0.71 ± 0.034
1.525ThrTyr: 1.525 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.89ValAla: 4.89 ± 0.101
0.798ValCys: 0.798 ± 0.037
3.598ValAsp: 3.598 ± 0.079
3.549ValGlu: 3.549 ± 0.09
2.474ValPhe: 2.474 ± 0.065
3.519ValGly: 3.519 ± 0.081
1.647ValHis: 1.647 ± 0.053
3.005ValIle: 3.005 ± 0.081
2.951ValLys: 2.951 ± 0.073
5.671ValLeu: 5.671 ± 0.11
1.519ValMet: 1.519 ± 0.051
2.275ValAsn: 2.275 ± 0.056
3.471ValPro: 3.471 ± 0.075
2.548ValGln: 2.548 ± 0.071
2.86ValArg: 2.86 ± 0.086
4.671ValSer: 4.671 ± 0.077
3.351ValThr: 3.351 ± 0.068
4.275ValVal: 4.275 ± 0.102
0.667ValTrp: 0.667 ± 0.036
1.707ValTyr: 1.707 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.808TrpAla: 0.808 ± 0.042
0.188TrpCys: 0.188 ± 0.017
0.699TrpAsp: 0.699 ± 0.034
0.692TrpGlu: 0.692 ± 0.034
0.453TrpPhe: 0.453 ± 0.026
0.703TrpGly: 0.703 ± 0.033
0.292TrpHis: 0.292 ± 0.02
0.775TrpIle: 0.775 ± 0.036
0.722TrpLys: 0.722 ± 0.03
1.007TrpLeu: 1.007 ± 0.038
0.345TrpMet: 0.345 ± 0.021
0.603TrpAsn: 0.603 ± 0.028
0.46TrpPro: 0.46 ± 0.029
0.472TrpGln: 0.472 ± 0.03
0.78TrpArg: 0.78 ± 0.029
0.959TrpSer: 0.959 ± 0.036
0.796TrpThr: 0.796 ± 0.038
0.686TrpVal: 0.686 ± 0.035
0.185TrpTrp: 0.185 ± 0.018
0.39TrpTyr: 0.39 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.776TyrAla: 1.776 ± 0.063
0.442TyrCys: 0.442 ± 0.026
1.625TyrAsp: 1.625 ± 0.048
1.401TyrGlu: 1.401 ± 0.049
1.241TyrPhe: 1.241 ± 0.046
1.925TyrGly: 1.925 ± 0.064
0.881TyrHis: 0.881 ± 0.038
1.399TyrIle: 1.399 ± 0.049
1.375TyrLys: 1.375 ± 0.046
2.706TyrLeu: 2.706 ± 0.065
0.651TyrMet: 0.651 ± 0.03
1.344TyrAsn: 1.344 ± 0.055
1.515TyrPro: 1.515 ± 0.057
1.353TyrGln: 1.353 ± 0.047
1.589TyrArg: 1.589 ± 0.054
2.206TyrSer: 2.206 ± 0.065
1.566TyrThr: 1.566 ± 0.055
1.587TyrVal: 1.587 ± 0.05
0.405TyrTrp: 0.405 ± 0.027
1.029TyrTyr: 1.029 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1514 proteins (708146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski