Amino acid dipepetide frequency for Marine Group I thaumarchaeote SCGC AAA799-D07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.605AlaAla: 4.605 ± 0.264
0.792AlaCys: 0.792 ± 0.086
3.17AlaAsp: 3.17 ± 0.23
3.731AlaGlu: 3.731 ± 0.158
2.475AlaPhe: 2.475 ± 0.132
4.172AlaGly: 4.172 ± 0.236
0.822AlaHis: 0.822 ± 0.073
5.742AlaIle: 5.742 ± 0.241
5.54AlaLys: 5.54 ± 0.236
5.405AlaLeu: 5.405 ± 0.231
1.495AlaMet: 1.495 ± 0.13
3.073AlaAsn: 3.073 ± 0.256
1.577AlaPro: 1.577 ± 0.153
1.675AlaGln: 1.675 ± 0.112
2.138AlaArg: 2.138 ± 0.132
4.291AlaSer: 4.291 ± 0.203
3.342AlaThr: 3.342 ± 0.198
3.91AlaVal: 3.91 ± 0.172
0.516AlaTrp: 0.516 ± 0.062
1.734AlaTyr: 1.734 ± 0.113
0.0AlaXaa: 0.0 ± 0.0
Cys
0.553CysAla: 0.553 ± 0.068
0.127CysCys: 0.127 ± 0.027
0.628CysAsp: 0.628 ± 0.07
0.546CysGlu: 0.546 ± 0.06
0.471CysPhe: 0.471 ± 0.062
1.144CysGly: 1.144 ± 0.111
0.247CysHis: 0.247 ± 0.041
0.912CysIle: 0.912 ± 0.089
0.942CysLys: 0.942 ± 0.088
0.845CysLeu: 0.845 ± 0.078
0.202CysMet: 0.202 ± 0.04
0.658CysAsn: 0.658 ± 0.075
0.478CysPro: 0.478 ± 0.06
0.247CysGln: 0.247 ± 0.039
0.336CysArg: 0.336 ± 0.048
0.822CysSer: 0.822 ± 0.088
0.643CysThr: 0.643 ± 0.075
0.71CysVal: 0.71 ± 0.075
0.09CysTrp: 0.09 ± 0.023
0.366CysTyr: 0.366 ± 0.054
0.0CysXaa: 0.0 ± 0.0
Asp
3.768AspAla: 3.768 ± 0.194
0.725AspCys: 0.725 ± 0.078
3.222AspAsp: 3.222 ± 0.183
4.374AspGlu: 4.374 ± 0.207
2.564AspPhe: 2.564 ± 0.173
3.88AspGly: 3.88 ± 0.21
1.002AspHis: 1.002 ± 0.082
4.957AspIle: 4.957 ± 0.194
4.239AspLys: 4.239 ± 0.174
5.173AspLeu: 5.173 ± 0.327
1.42AspMet: 1.42 ± 0.111
2.721AspAsn: 2.721 ± 0.167
2.28AspPro: 2.28 ± 0.131
1.435AspGln: 1.435 ± 0.105
1.734AspArg: 1.734 ± 0.116
3.783AspSer: 3.783 ± 0.183
2.848AspThr: 2.848 ± 0.161
4.172AspVal: 4.172 ± 0.191
0.606AspTrp: 0.606 ± 0.061
2.19AspTyr: 2.19 ± 0.131
0.0AspXaa: 0.0 ± 0.0
Glu
3.103GluAla: 3.103 ± 0.157
0.606GluCys: 0.606 ± 0.071
2.848GluAsp: 2.848 ± 0.15
4.209GluGlu: 4.209 ± 0.195
3.319GluPhe: 3.319 ± 0.179
3.14GluGly: 3.14 ± 0.152
1.136GluHis: 1.136 ± 0.09
7.214GluIle: 7.214 ± 0.273
6.99GluLys: 6.99 ± 0.197
6.018GluLeu: 6.018 ± 0.239
1.899GluMet: 1.899 ± 0.123
4.448GluAsn: 4.448 ± 0.204
2.318GluPro: 2.318 ± 0.211
2.026GluGln: 2.026 ± 0.128
2.28GluArg: 2.28 ± 0.129
4.336GluSer: 4.336 ± 0.167
3.095GluThr: 3.095 ± 0.167
3.566GluVal: 3.566 ± 0.164
0.561GluTrp: 0.561 ± 0.067
1.921GluTyr: 1.921 ± 0.125
0.0GluXaa: 0.0 ± 0.0
Phe
2.871PheAla: 2.871 ± 0.153
0.583PheCys: 0.583 ± 0.067
3.349PheAsp: 3.349 ± 0.178
2.848PheGlu: 2.848 ± 0.154
1.794PhePhe: 1.794 ± 0.142
3.252PheGly: 3.252 ± 0.149
0.815PheHis: 0.815 ± 0.082
2.923PheIle: 2.923 ± 0.17
2.647PheLys: 2.647 ± 0.146
4.052PheLeu: 4.052 ± 0.22
0.897PheMet: 0.897 ± 0.08
1.951PheAsn: 1.951 ± 0.123
1.6PhePro: 1.6 ± 0.119
1.226PheGln: 1.226 ± 0.101
1.577PheArg: 1.577 ± 0.116
3.992PheSer: 3.992 ± 0.206
2.497PheThr: 2.497 ± 0.136
3.215PheVal: 3.215 ± 0.163
0.389PheTrp: 0.389 ± 0.057
1.473PheTyr: 1.473 ± 0.107
0.0PheXaa: 0.0 ± 0.0
Gly
4.254GlyAla: 4.254 ± 0.283
0.688GlyCys: 0.688 ± 0.075
3.185GlyAsp: 3.185 ± 0.159
3.357GlyGlu: 3.357 ± 0.17
3.08GlyPhe: 3.08 ± 0.173
4.635GlyGly: 4.635 ± 0.245
1.368GlyHis: 1.368 ± 0.099
6.893GlyIle: 6.893 ± 0.235
6.28GlyLys: 6.28 ± 0.231
5.166GlyLeu: 5.166 ± 0.219
1.944GlyMet: 1.944 ± 0.122
3.02GlyAsn: 3.02 ± 0.164
1.712GlyPro: 1.712 ± 0.108
1.794GlyGln: 1.794 ± 0.126
2.28GlyArg: 2.28 ± 0.125
4.306GlySer: 4.306 ± 0.198
3.917GlyThr: 3.917 ± 0.22
4.149GlyVal: 4.149 ± 0.202
0.867GlyTrp: 0.867 ± 0.08
2.504GlyTyr: 2.504 ± 0.165
0.0GlyXaa: 0.0 ± 0.0
His
1.077HisAla: 1.077 ± 0.097
0.262HisCys: 0.262 ± 0.048
1.219HisAsp: 1.219 ± 0.095
1.114HisGlu: 1.114 ± 0.093
0.65HisPhe: 0.65 ± 0.07
1.323HisGly: 1.323 ± 0.093
0.493HisHis: 0.493 ± 0.064
1.368HisIle: 1.368 ± 0.112
1.241HisLys: 1.241 ± 0.099
1.57HisLeu: 1.57 ± 0.107
0.501HisMet: 0.501 ± 0.062
0.89HisAsn: 0.89 ± 0.075
1.106HisPro: 1.106 ± 0.095
0.486HisGln: 0.486 ± 0.049
0.576HisArg: 0.576 ± 0.07
1.189HisSer: 1.189 ± 0.107
1.211HisThr: 1.211 ± 0.093
1.278HisVal: 1.278 ± 0.118
0.194HisTrp: 0.194 ± 0.035
0.695HisTyr: 0.695 ± 0.069
0.0HisXaa: 0.0 ± 0.0
Ile
5.973IleAla: 5.973 ± 0.256
0.972IleCys: 0.972 ± 0.092
5.547IleAsp: 5.547 ± 0.227
6.145IleGlu: 6.145 ± 0.241
3.962IlePhe: 3.962 ± 0.172
6.041IleGly: 6.041 ± 0.241
1.577IleHis: 1.577 ± 0.098
8.209IleIle: 8.209 ± 0.329
7.14IleLys: 7.14 ± 0.26
8.216IleLeu: 8.216 ± 0.254
2.131IleMet: 2.131 ± 0.136
4.239IleAsn: 4.239 ± 0.191
4.239IlePro: 4.239 ± 0.195
2.669IleGln: 2.669 ± 0.142
3.506IleArg: 3.506 ± 0.168
7.424IleSer: 7.424 ± 0.262
5.36IleThr: 5.36 ± 0.209
5.607IleVal: 5.607 ± 0.21
0.553IleTrp: 0.553 ± 0.055
2.176IleTyr: 2.176 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
3.985LysAla: 3.985 ± 0.183
0.957LysCys: 0.957 ± 0.094
4.104LysAsp: 4.104 ± 0.213
5.981LysGlu: 5.981 ± 0.259
4.119LysPhe: 4.119 ± 0.186
4.06LysGly: 4.06 ± 0.183
1.63LysHis: 1.63 ± 0.116
9.996LysIle: 9.996 ± 0.312
10.063LysLys: 10.063 ± 0.379
7.91LysLeu: 7.91 ± 0.277
2.669LysMet: 2.669 ± 0.153
6.37LysAsn: 6.37 ± 0.268
2.901LysPro: 2.901 ± 0.141
2.789LysGln: 2.789 ± 0.154
3.319LysArg: 3.319 ± 0.222
5.772LysSer: 5.772 ± 0.224
5.091LysThr: 5.091 ± 0.201
4.388LysVal: 4.388 ± 0.192
0.763LysTrp: 0.763 ± 0.082
3.103LysTyr: 3.103 ± 0.171
0.0LysXaa: 0.0 ± 0.0
Leu
6.033LeuAla: 6.033 ± 0.249
0.845LeuCys: 0.845 ± 0.069
5.816LeuAsp: 5.816 ± 0.255
6.235LeuGlu: 6.235 ± 0.261
3.439LeuPhe: 3.439 ± 0.208
6.056LeuGly: 6.056 ± 0.235
1.413LeuHis: 1.413 ± 0.111
6.691LeuIle: 6.691 ± 0.249
7.603LeuLys: 7.603 ± 0.241
7.102LeuLeu: 7.102 ± 0.245
2.19LeuMet: 2.19 ± 0.127
4.224LeuAsn: 4.224 ± 0.181
3.162LeuPro: 3.162 ± 0.157
2.579LeuGln: 2.579 ± 0.138
3.387LeuArg: 3.387 ± 0.172
6.721LeuSer: 6.721 ± 0.312
4.934LeuThr: 4.934 ± 0.266
5.816LeuVal: 5.816 ± 0.198
0.643LeuTrp: 0.643 ± 0.08
2.564LeuTyr: 2.564 ± 0.142
0.0LeuXaa: 0.0 ± 0.0
Met
1.473MetAla: 1.473 ± 0.112
0.232MetCys: 0.232 ± 0.047
1.323MetAsp: 1.323 ± 0.102
1.458MetGlu: 1.458 ± 0.102
0.867MetPhe: 0.867 ± 0.085
1.63MetGly: 1.63 ± 0.129
0.576MetHis: 0.576 ± 0.061
2.377MetIle: 2.377 ± 0.142
2.647MetLys: 2.647 ± 0.142
2.564MetLeu: 2.564 ± 0.125
0.635MetMet: 0.635 ± 0.065
1.293MetAsn: 1.293 ± 0.111
1.099MetPro: 1.099 ± 0.092
0.83MetGln: 0.83 ± 0.087
0.837MetArg: 0.837 ± 0.075
1.645MetSer: 1.645 ± 0.117
1.577MetThr: 1.577 ± 0.11
1.548MetVal: 1.548 ± 0.104
0.194MetTrp: 0.194 ± 0.04
0.763MetTyr: 0.763 ± 0.082
0.0MetXaa: 0.0 ± 0.0
Asn
3.514AsnAla: 3.514 ± 0.253
0.591AsnCys: 0.591 ± 0.068
2.938AsnAsp: 2.938 ± 0.165
3.432AsnGlu: 3.432 ± 0.176
2.587AsnPhe: 2.587 ± 0.144
3.103AsnGly: 3.103 ± 0.152
1.009AsnHis: 1.009 ± 0.09
4.695AsnIle: 4.695 ± 0.204
4.134AsnLys: 4.134 ± 0.159
5.271AsnLeu: 5.271 ± 0.402
1.413AsnMet: 1.413 ± 0.111
2.878AsnAsn: 2.878 ± 0.174
2.497AsnPro: 2.497 ± 0.152
1.742AsnGln: 1.742 ± 0.127
1.637AsnArg: 1.637 ± 0.113
3.663AsnSer: 3.663 ± 0.204
3.005AsnThr: 3.005 ± 0.147
3.327AsnVal: 3.327 ± 0.17
0.478AsnTrp: 0.478 ± 0.067
1.749AsnTyr: 1.749 ± 0.138
0.0AsnXaa: 0.0 ± 0.0
Pro
1.929ProAla: 1.929 ± 0.14
0.284ProCys: 0.284 ± 0.047
2.46ProAsp: 2.46 ± 0.152
3.005ProGlu: 3.005 ± 0.15
1.533ProPhe: 1.533 ± 0.112
2.362ProGly: 2.362 ± 0.149
0.763ProHis: 0.763 ± 0.073
3.23ProIle: 3.23 ± 0.153
3.185ProLys: 3.185 ± 0.178
2.669ProLeu: 2.669 ± 0.117
0.748ProMet: 0.748 ± 0.07
1.869ProAsn: 1.869 ± 0.111
1.174ProPro: 1.174 ± 0.102
1.009ProGln: 1.009 ± 0.101
1.293ProArg: 1.293 ± 0.098
2.347ProSer: 2.347 ± 0.137
2.161ProThr: 2.161 ± 0.128
2.908ProVal: 2.908 ± 0.177
0.336ProTrp: 0.336 ± 0.049
1.166ProTyr: 1.166 ± 0.095
0.0ProXaa: 0.0 ± 0.0
Gln
1.824GlnAla: 1.824 ± 0.132
0.232GlnCys: 0.232 ± 0.046
1.383GlnAsp: 1.383 ± 0.119
1.876GlnGlu: 1.876 ± 0.125
1.278GlnPhe: 1.278 ± 0.101
1.45GlnGly: 1.45 ± 0.107
0.606GlnHis: 0.606 ± 0.069
3.125GlnIle: 3.125 ± 0.146
3.267GlnLys: 3.267 ± 0.162
2.415GlnLeu: 2.415 ± 0.155
0.755GlnMet: 0.755 ± 0.087
1.697GlnAsn: 1.697 ± 0.113
0.748GlnPro: 0.748 ± 0.07
0.994GlnGln: 0.994 ± 0.099
1.054GlnArg: 1.054 ± 0.095
1.697GlnSer: 1.697 ± 0.116
1.63GlnThr: 1.63 ± 0.118
1.749GlnVal: 1.749 ± 0.106
0.179GlnTrp: 0.179 ± 0.037
0.89GlnTyr: 0.89 ± 0.073
0.0GlnXaa: 0.0 ± 0.0
Arg
1.891ArgAla: 1.891 ± 0.146
0.351ArgCys: 0.351 ± 0.059
1.884ArgAsp: 1.884 ± 0.123
2.176ArgGlu: 2.176 ± 0.137
1.645ArgPhe: 1.645 ± 0.112
2.31ArgGly: 2.31 ± 0.131
0.523ArgHis: 0.523 ± 0.061
3.491ArgIle: 3.491 ± 0.18
3.529ArgLys: 3.529 ± 0.183
3.245ArgLeu: 3.245 ± 0.166
0.875ArgMet: 0.875 ± 0.084
1.944ArgAsn: 1.944 ± 0.147
1.136ArgPro: 1.136 ± 0.101
0.987ArgGln: 0.987 ± 0.099
1.585ArgArg: 1.585 ± 0.117
2.19ArgSer: 2.19 ± 0.142
1.727ArgThr: 1.727 ± 0.108
2.31ArgVal: 2.31 ± 0.138
0.344ArgTrp: 0.344 ± 0.052
1.062ArgTyr: 1.062 ± 0.097
0.0ArgXaa: 0.0 ± 0.0
Ser
3.768SerAla: 3.768 ± 0.188
0.68SerCys: 0.68 ± 0.071
4.231SerAsp: 4.231 ± 0.205
4.62SerGlu: 4.62 ± 0.201
2.796SerPhe: 2.796 ± 0.171
5.144SerGly: 5.144 ± 0.229
1.376SerHis: 1.376 ± 0.103
6.347SerIle: 6.347 ± 0.239
6.721SerLys: 6.721 ± 0.254
6.579SerLeu: 6.579 ± 0.269
1.734SerMet: 1.734 ± 0.103
3.873SerAsn: 3.873 ± 0.23
2.243SerPro: 2.243 ± 0.122
2.213SerGln: 2.213 ± 0.114
2.37SerArg: 2.37 ± 0.11
4.822SerSer: 4.822 ± 0.216
3.686SerThr: 3.686 ± 0.221
4.486SerVal: 4.486 ± 0.187
0.628SerTrp: 0.628 ± 0.065
1.944SerTyr: 1.944 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
3.185ThrAla: 3.185 ± 0.181
0.68ThrCys: 0.68 ± 0.074
3.14ThrAsp: 3.14 ± 0.173
3.514ThrGlu: 3.514 ± 0.153
2.534ThrPhe: 2.534 ± 0.157
4.411ThrGly: 4.411 ± 0.246
1.092ThrHis: 1.092 ± 0.083
5.173ThrIle: 5.173 ± 0.197
5.196ThrLys: 5.196 ± 0.223
4.553ThrLeu: 4.553 ± 0.206
1.301ThrMet: 1.301 ± 0.095
2.968ThrAsn: 2.968 ± 0.175
2.176ThrPro: 2.176 ± 0.128
1.346ThrGln: 1.346 ± 0.107
1.764ThrArg: 1.764 ± 0.114
3.85ThrSer: 3.85 ± 0.169
3.05ThrThr: 3.05 ± 0.199
3.723ThrVal: 3.723 ± 0.237
0.396ThrTrp: 0.396 ± 0.059
1.592ThrTyr: 1.592 ± 0.096
0.0ThrXaa: 0.0 ± 0.0
Val
3.992ValAla: 3.992 ± 0.196
0.837ValCys: 0.837 ± 0.075
3.783ValAsp: 3.783 ± 0.182
4.052ValGlu: 4.052 ± 0.193
3.08ValPhe: 3.08 ± 0.146
4.418ValGly: 4.418 ± 0.182
1.144ValHis: 1.144 ± 0.082
5.622ValIle: 5.622 ± 0.171
5.652ValLys: 5.652 ± 0.218
5.166ValLeu: 5.166 ± 0.182
1.719ValMet: 1.719 ± 0.111
3.155ValAsn: 3.155 ± 0.163
2.422ValPro: 2.422 ± 0.141
1.503ValGln: 1.503 ± 0.116
1.996ValArg: 1.996 ± 0.129
4.65ValSer: 4.65 ± 0.195
3.783ValThr: 3.783 ± 0.167
4.418ValVal: 4.418 ± 0.209
0.621ValTrp: 0.621 ± 0.07
1.921ValTyr: 1.921 ± 0.123
0.0ValXaa: 0.0 ± 0.0
Trp
0.598TrpAla: 0.598 ± 0.067
0.082TrpCys: 0.082 ± 0.025
0.531TrpAsp: 0.531 ± 0.06
0.531TrpGlu: 0.531 ± 0.058
0.464TrpPhe: 0.464 ± 0.06
0.538TrpGly: 0.538 ± 0.067
0.209TrpHis: 0.209 ± 0.036
0.845TrpIle: 0.845 ± 0.085
0.695TrpLys: 0.695 ± 0.069
0.68TrpLeu: 0.68 ± 0.075
0.277TrpMet: 0.277 ± 0.047
0.65TrpAsn: 0.65 ± 0.071
0.292TrpPro: 0.292 ± 0.044
0.254TrpGln: 0.254 ± 0.051
0.381TrpArg: 0.381 ± 0.053
0.478TrpSer: 0.478 ± 0.054
0.359TrpThr: 0.359 ± 0.055
0.561TrpVal: 0.561 ± 0.065
0.232TrpTrp: 0.232 ± 0.043
0.307TrpTyr: 0.307 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.809TyrAla: 1.809 ± 0.114
0.441TyrCys: 0.441 ± 0.065
2.333TyrAsp: 2.333 ± 0.156
1.832TyrGlu: 1.832 ± 0.121
1.293TyrPhe: 1.293 ± 0.099
2.333TyrGly: 2.333 ± 0.148
0.643TyrHis: 0.643 ± 0.083
1.876TyrIle: 1.876 ± 0.128
2.258TyrLys: 2.258 ± 0.135
2.856TyrLeu: 2.856 ± 0.183
0.755TyrMet: 0.755 ± 0.074
1.749TyrAsn: 1.749 ± 0.135
1.271TyrPro: 1.271 ± 0.098
1.047TyrGln: 1.047 ± 0.083
1.151TyrArg: 1.151 ± 0.073
2.28TyrSer: 2.28 ± 0.128
1.727TyrThr: 1.727 ± 0.114
2.093TyrVal: 2.093 ± 0.125
0.374TyrTrp: 0.374 ± 0.057
1.151TyrTyr: 1.151 ± 0.106
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 562 proteins (133761 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski