Amino acid dipepetide frequency for Phaeomoniella chlamydospora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.313AlaAla: 8.313 ± 0.076	0.847AlaCys: 0.847 ± 0.015	4.232AlaAsp: 4.232 ± 0.033	5.278AlaGlu: 5.278 ± 0.048	3.098AlaPhe: 3.098 ± 0.033	5.553AlaGly: 5.553 ± 0.046	1.633AlaHis: 1.633 ± 0.023	4.438AlaIle: 4.438 ± 0.033	4.36AlaLys: 4.36 ± 0.04	7.343AlaLeu: 7.343 ± 0.045	1.885AlaMet: 1.885 ± 0.022	3.083AlaAsn: 3.083 ± 0.028	4.15AlaPro: 4.15 ± 0.045	3.326AlaGln: 3.326 ± 0.034	4.452AlaArg: 4.452 ± 0.038	7.005AlaSer: 7.005 ± 0.057	5.198AlaThr: 5.198 ± 0.048	5.016AlaVal: 5.016 ± 0.036	1.03AlaTrp: 1.03 ± 0.017	2.14AlaTyr: 2.14 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.774CysAla: 0.774 ± 0.016	0.174CysCys: 0.174 ± 0.007	0.536CysAsp: 0.536 ± 0.013	0.529CysGlu: 0.529 ± 0.013	0.481CysPhe: 0.481 ± 0.011	0.772CysGly: 0.772 ± 0.016	0.257CysHis: 0.257 ± 0.008	0.631CysIle: 0.631 ± 0.013	0.458CysLys: 0.458 ± 0.011	1.085CysLeu: 1.085 ± 0.017	0.213CysMet: 0.213 ± 0.009	0.368CysAsn: 0.368 ± 0.012	0.526CysPro: 0.526 ± 0.013	0.361CysGln: 0.361 ± 0.01	0.558CysArg: 0.558 ± 0.012	0.73CysSer: 0.73 ± 0.018	0.587CysThr: 0.587 ± 0.014	0.662CysVal: 0.662 ± 0.013	0.159CysTrp: 0.159 ± 0.006	0.327CysTyr: 0.327 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.583AspAla: 4.583 ± 0.035	0.533AspCys: 0.533 ± 0.012	4.599AspAsp: 4.599 ± 0.048	4.848AspGlu: 4.848 ± 0.045	2.362AspPhe: 2.362 ± 0.026	3.982AspGly: 3.982 ± 0.034	1.252AspHis: 1.252 ± 0.019	3.392AspIle: 3.392 ± 0.034	2.537AspLys: 2.537 ± 0.029	5.515AspLeu: 5.515 ± 0.041	1.261AspMet: 1.261 ± 0.018	2.045AspAsn: 2.045 ± 0.023	3.44AspPro: 3.44 ± 0.031	2.056AspGln: 2.056 ± 0.023	3.022AspArg: 3.022 ± 0.034	4.296AspSer: 4.296 ± 0.038	3.195AspThr: 3.195 ± 0.032	3.882AspVal: 3.882 ± 0.035	0.858AspTrp: 0.858 ± 0.015	1.672AspTyr: 1.672 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.483GluAla: 5.483 ± 0.049	0.54GluCys: 0.54 ± 0.012	4.631GluAsp: 4.631 ± 0.041	5.916GluGlu: 5.916 ± 0.06	1.971GluPhe: 1.971 ± 0.023	3.976GluGly: 3.976 ± 0.038	1.425GluHis: 1.425 ± 0.022	3.45GluIle: 3.45 ± 0.035	4.118GluLys: 4.118 ± 0.043	5.266GluLeu: 5.266 ± 0.046	1.499GluMet: 1.499 ± 0.021	2.579GluAsn: 2.579 ± 0.029	2.62GluPro: 2.62 ± 0.033	2.614GluGln: 2.614 ± 0.03	3.999GluArg: 3.999 ± 0.037	4.535GluSer: 4.535 ± 0.038	3.707GluThr: 3.707 ± 0.034	3.773GluVal: 3.773 ± 0.032	0.854GluTrp: 0.854 ± 0.016	1.738GluTyr: 1.738 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.974PheAla: 2.974 ± 0.034	0.495PheCys: 0.495 ± 0.012	2.416PheAsp: 2.416 ± 0.024	2.305PheGlu: 2.305 ± 0.026	1.588PhePhe: 1.588 ± 0.023	2.889PheGly: 2.889 ± 0.035	0.859PheHis: 0.859 ± 0.016	1.917PheIle: 1.917 ± 0.025	1.637PheLys: 1.637 ± 0.024	3.401PheLeu: 3.401 ± 0.035	0.774PheMet: 0.774 ± 0.014	1.474PheAsn: 1.474 ± 0.02	1.858PhePro: 1.858 ± 0.023	1.392PheGln: 1.392 ± 0.02	1.829PheArg: 1.829 ± 0.023	3.053PheSer: 3.053 ± 0.031	2.218PheThr: 2.218 ± 0.024	2.311PheVal: 2.311 ± 0.029	0.594PheTrp: 0.594 ± 0.013	1.131PheTyr: 1.131 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	4.981GlyAla: 4.981 ± 0.037	0.717GlyCys: 0.717 ± 0.015	3.707GlyAsp: 3.707 ± 0.032	3.757GlyGlu: 3.757 ± 0.038	2.789GlyPhe: 2.789 ± 0.03	5.77GlyGly: 5.77 ± 0.062	1.595GlyHis: 1.595 ± 0.027	3.796GlyIle: 3.796 ± 0.036	3.797GlyLys: 3.797 ± 0.037	5.995GlyLeu: 5.995 ± 0.045	1.534GlyMet: 1.534 ± 0.025	2.641GlyAsn: 2.641 ± 0.031	3.194GlyPro: 3.194 ± 0.038	2.61GlyGln: 2.61 ± 0.029	3.94GlyArg: 3.94 ± 0.038	5.667GlySer: 5.667 ± 0.044	4.193GlyThr: 4.193 ± 0.041	4.256GlyVal: 4.256 ± 0.037	1.072GlyTrp: 1.072 ± 0.017	2.147GlyTyr: 2.147 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.665HisAla: 1.665 ± 0.024	0.273HisCys: 0.273 ± 0.009	1.318HisAsp: 1.318 ± 0.021	1.35HisGlu: 1.35 ± 0.02	0.912HisPhe: 0.912 ± 0.016	1.641HisGly: 1.641 ± 0.022	0.748HisHis: 0.748 ± 0.016	1.221HisIle: 1.221 ± 0.018	0.96HisLys: 0.96 ± 0.015	2.159HisLeu: 2.159 ± 0.026	0.441HisMet: 0.441 ± 0.011	0.868HisAsn: 0.868 ± 0.016	1.554HisPro: 1.554 ± 0.022	0.939HisGln: 0.939 ± 0.015	1.36HisArg: 1.36 ± 0.021	1.711HisSer: 1.711 ± 0.02	1.246HisThr: 1.246 ± 0.019	1.369HisVal: 1.369 ± 0.019	0.304HisTrp: 0.304 ± 0.009	0.68HisTyr: 0.68 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.388IleAla: 4.388 ± 0.038	0.694IleCys: 0.694 ± 0.013	3.235IleAsp: 3.235 ± 0.033	3.261IleGlu: 3.261 ± 0.033	2.095IlePhe: 2.095 ± 0.029	3.467IleGly: 3.467 ± 0.037	1.242IleHis: 1.242 ± 0.019	2.799IleIle: 2.799 ± 0.029	2.538IleLys: 2.538 ± 0.025	4.858IleLeu: 4.858 ± 0.036	1.053IleMet: 1.053 ± 0.018	2.042IleAsn: 2.042 ± 0.024	3.231IlePro: 3.231 ± 0.034	2.036IleGln: 2.036 ± 0.025	2.869IleArg: 2.869 ± 0.031	4.337IleSer: 4.337 ± 0.039	3.151IleThr: 3.151 ± 0.027	3.31IleVal: 3.31 ± 0.035	0.729IleTrp: 0.729 ± 0.015	1.509IleTyr: 1.509 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.626LysAla: 4.626 ± 0.038	0.451LysCys: 0.451 ± 0.012	3.184LysAsp: 3.184 ± 0.034	3.823LysGlu: 3.823 ± 0.046	1.641LysPhe: 1.641 ± 0.021	3.238LysGly: 3.238 ± 0.033	1.188LysHis: 1.188 ± 0.016	2.7LysIle: 2.7 ± 0.028	3.757LysLys: 3.757 ± 0.061	4.328LysLeu: 4.328 ± 0.038	1.065LysMet: 1.065 ± 0.016	1.886LysAsn: 1.886 ± 0.022	2.782LysPro: 2.782 ± 0.033	2.052LysGln: 2.052 ± 0.026	3.575LysArg: 3.575 ± 0.036	3.977LysSer: 3.977 ± 0.036	3.156LysThr: 3.156 ± 0.026	3.173LysVal: 3.173 ± 0.034	0.705LysTrp: 0.705 ± 0.013	1.502LysTyr: 1.502 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.349LeuAla: 7.349 ± 0.048	1.022LeuCys: 1.022 ± 0.018	5.38LeuAsp: 5.38 ± 0.039	5.724LeuGlu: 5.724 ± 0.049	3.226LeuPhe: 3.226 ± 0.034	5.761LeuGly: 5.761 ± 0.044	2.055LeuHis: 2.055 ± 0.024	4.168LeuIle: 4.168 ± 0.038	4.704LeuLys: 4.704 ± 0.039	8.022LeuLeu: 8.022 ± 0.064	1.7LeuMet: 1.7 ± 0.022	3.338LeuAsn: 3.338 ± 0.03	5.192LeuPro: 5.192 ± 0.042	3.817LeuGln: 3.817 ± 0.041	5.443LeuArg: 5.443 ± 0.045	7.486LeuSer: 7.486 ± 0.048	5.002LeuThr: 5.002 ± 0.042	5.175LeuVal: 5.175 ± 0.043	1.102LeuTrp: 1.102 ± 0.019	2.348LeuTyr: 2.348 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.003MetAla: 2.003 ± 0.025	0.213MetCys: 0.213 ± 0.007	1.247MetAsp: 1.247 ± 0.019	1.254MetGlu: 1.254 ± 0.018	0.736MetPhe: 0.736 ± 0.016	1.427MetGly: 1.427 ± 0.018	0.443MetHis: 0.443 ± 0.012	1.086MetIle: 1.086 ± 0.017	1.107MetLys: 1.107 ± 0.019	1.751MetLeu: 1.751 ± 0.022	0.527MetMet: 0.527 ± 0.013	0.854MetAsn: 0.854 ± 0.016	1.127MetPro: 1.127 ± 0.019	0.851MetGln: 0.851 ± 0.019	1.131MetArg: 1.131 ± 0.019	1.795MetSer: 1.795 ± 0.021	1.293MetThr: 1.293 ± 0.018	1.218MetVal: 1.218 ± 0.019	0.243MetTrp: 0.243 ± 0.009	0.514MetTyr: 0.514 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.244AsnAla: 3.244 ± 0.027	0.372AsnCys: 0.372 ± 0.009	2.223AsnAsp: 2.223 ± 0.023	2.324AsnGlu: 2.324 ± 0.025	1.472AsnPhe: 1.472 ± 0.019	3.166AsnGly: 3.166 ± 0.036	0.893AsnHis: 0.893 ± 0.018	2.301AsnIle: 2.301 ± 0.023	1.746AsnLys: 1.746 ± 0.021	3.439AsnLeu: 3.439 ± 0.036	0.819AsnMet: 0.819 ± 0.016	1.585AsnAsn: 1.585 ± 0.025	2.509AsnPro: 2.509 ± 0.025	1.436AsnGln: 1.436 ± 0.022	1.956AsnArg: 1.956 ± 0.024	2.86AsnSer: 2.86 ± 0.033	2.377AsnThr: 2.377 ± 0.028	2.486AsnVal: 2.486 ± 0.025	0.547AsnTrp: 0.547 ± 0.013	1.129AsnTyr: 1.129 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	4.553ProAla: 4.553 ± 0.041	0.385ProCys: 0.385 ± 0.012	3.133ProAsp: 3.133 ± 0.03	3.788ProGlu: 3.788 ± 0.038	1.982ProPhe: 1.982 ± 0.026	3.577ProGly: 3.577 ± 0.038	1.233ProHis: 1.233 ± 0.018	2.678ProIle: 2.678 ± 0.026	2.785ProLys: 2.785 ± 0.034	4.425ProLeu: 4.425 ± 0.041	0.981ProMet: 0.981 ± 0.018	2.255ProAsn: 2.255 ± 0.026	4.565ProPro: 4.565 ± 0.06	2.359ProGln: 2.359 ± 0.034	2.969ProArg: 2.969 ± 0.036	5.953ProSer: 5.953 ± 0.055	3.932ProThr: 3.932 ± 0.034	3.242ProVal: 3.242 ± 0.026	0.649ProTrp: 0.649 ± 0.014	1.541ProTyr: 1.541 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.384GlnAla: 3.384 ± 0.035	0.361GlnCys: 0.361 ± 0.01	2.146GlnAsp: 2.146 ± 0.025	2.53GlnGlu: 2.53 ± 0.026	1.3GlnPhe: 1.3 ± 0.018	2.375GlnGly: 2.375 ± 0.027	1.022GlnHis: 1.022 ± 0.016	2.165GlnIle: 2.165 ± 0.027	2.242GlnLys: 2.242 ± 0.027	3.425GlnLeu: 3.425 ± 0.032	0.901GlnMet: 0.901 ± 0.018	1.68GlnAsn: 1.68 ± 0.024	2.308GlnPro: 2.308 ± 0.033	2.383GlnGln: 2.383 ± 0.043	2.545GlnArg: 2.545 ± 0.031	3.271GlnSer: 3.271 ± 0.035	2.394GlnThr: 2.394 ± 0.028	2.125GlnVal: 2.125 ± 0.023	0.53GlnTrp: 0.53 ± 0.011	1.222GlnTyr: 1.222 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.3ArgAla: 4.3 ± 0.037	0.556ArgCys: 0.556 ± 0.013	3.222ArgAsp: 3.222 ± 0.037	3.797ArgGlu: 3.797 ± 0.043	2.034ArgPhe: 2.034 ± 0.027	3.535ArgGly: 3.535 ± 0.04	1.379ArgHis: 1.379 ± 0.02	2.942ArgIle: 2.942 ± 0.029	3.671ArgLys: 3.671 ± 0.033	5.131ArgLeu: 5.131 ± 0.04	1.195ArgMet: 1.195 ± 0.02	2.261ArgAsn: 2.261 ± 0.021	3.154ArgPro: 3.154 ± 0.038	2.547ArgGln: 2.547 ± 0.024	4.54ArgArg: 4.54 ± 0.052	4.531ArgSer: 4.531 ± 0.045	3.179ArgThr: 3.179 ± 0.028	3.03ArgVal: 3.03 ± 0.031	0.807ArgTrp: 0.807 ± 0.015	1.605ArgTyr: 1.605 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.5SerAla: 6.5 ± 0.055	0.69SerCys: 0.69 ± 0.016	4.54SerAsp: 4.54 ± 0.047	4.51SerGlu: 4.51 ± 0.035	2.996SerPhe: 2.996 ± 0.031	5.726SerGly: 5.726 ± 0.05	1.918SerHis: 1.918 ± 0.024	4.337SerIle: 4.337 ± 0.039	4.3SerLys: 4.3 ± 0.042	7.245SerLeu: 7.245 ± 0.048	1.627SerMet: 1.627 ± 0.023	3.318SerAsn: 3.318 ± 0.033	5.255SerPro: 5.255 ± 0.052	3.403SerGln: 3.403 ± 0.033	4.651SerArg: 4.651 ± 0.044	9.434SerSer: 9.434 ± 0.094	6.144SerThr: 6.144 ± 0.056	4.553SerVal: 4.553 ± 0.037	1.01SerTrp: 1.01 ± 0.018	2.108SerTyr: 2.108 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.169ThrAla: 5.169 ± 0.047	0.628ThrCys: 0.628 ± 0.013	3.113ThrAsp: 3.113 ± 0.029	3.328ThrGlu: 3.328 ± 0.033	2.378ThrPhe: 2.378 ± 0.027	4.327ThrGly: 4.327 ± 0.043	1.252ThrHis: 1.252 ± 0.019	3.377ThrIle: 3.377 ± 0.03	2.972ThrLys: 2.972 ± 0.033	5.347ThrLeu: 5.347 ± 0.038	1.203ThrMet: 1.203 ± 0.019	2.445ThrAsn: 2.445 ± 0.028	4.201ThrPro: 4.201 ± 0.046	2.135ThrGln: 2.135 ± 0.026	2.984ThrArg: 2.984 ± 0.029	5.976ThrSer: 5.976 ± 0.052	4.71ThrThr: 4.71 ± 0.054	3.777ThrVal: 3.777 ± 0.041	0.812ThrTrp: 0.812 ± 0.015	1.682ThrTyr: 1.682 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.923ValAla: 4.923 ± 0.039	0.701ValCys: 0.701 ± 0.016	3.849ValAsp: 3.849 ± 0.028	3.946ValGlu: 3.946 ± 0.033	2.329ValPhe: 2.329 ± 0.028	3.972ValGly: 3.972 ± 0.029	1.308ValHis: 1.308 ± 0.016	3.156ValIle: 3.156 ± 0.032	3.122ValLys: 3.122 ± 0.029	5.345ValLeu: 5.345 ± 0.045	1.226ValMet: 1.226 ± 0.018	2.354ValAsn: 2.354 ± 0.025	3.341ValPro: 3.341 ± 0.028	2.348ValGln: 2.348 ± 0.027	3.215ValArg: 3.215 ± 0.026	4.587ValSer: 4.587 ± 0.038	3.594ValThr: 3.594 ± 0.035	3.959ValVal: 3.959 ± 0.035	0.778ValTrp: 0.778 ± 0.014	1.677ValTyr: 1.677 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.042TrpAla: 1.042 ± 0.017	0.162TrpCys: 0.162 ± 0.006	0.851TrpAsp: 0.851 ± 0.016	0.814TrpGlu: 0.814 ± 0.016	0.503TrpPhe: 0.503 ± 0.013	0.832TrpGly: 0.832 ± 0.018	0.298TrpHis: 0.298 ± 0.011	0.755TrpIle: 0.755 ± 0.015	0.815TrpLys: 0.815 ± 0.015	1.222TrpLeu: 1.222 ± 0.021	0.331TrpMet: 0.331 ± 0.01	0.612TrpAsn: 0.612 ± 0.013	0.535TrpPro: 0.535 ± 0.013	0.531TrpGln: 0.531 ± 0.013	0.812TrpArg: 0.812 ± 0.014	1.007TrpSer: 1.007 ± 0.019	0.884TrpThr: 0.884 ± 0.016	0.792TrpVal: 0.792 ± 0.016	0.256TrpTrp: 0.256 ± 0.009	0.412TrpTyr: 0.412 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.125TyrAla: 2.125 ± 0.022	0.376TyrCys: 0.376 ± 0.011	1.766TyrAsp: 1.766 ± 0.022	1.611TyrGlu: 1.611 ± 0.019	1.221TyrPhe: 1.221 ± 0.021	2.174TyrGly: 2.174 ± 0.033	0.718TyrHis: 0.718 ± 0.015	1.539TyrIle: 1.539 ± 0.022	1.184TyrLys: 1.184 ± 0.017	2.713TyrLeu: 2.713 ± 0.029	0.586TyrMet: 0.586 ± 0.013	1.198TyrAsn: 1.198 ± 0.02	1.445TyrPro: 1.445 ± 0.019	1.11TyrGln: 1.11 ± 0.018	1.562TyrArg: 1.562 ± 0.021	2.054TyrSer: 2.054 ± 0.028	1.656TyrThr: 1.656 ± 0.023	1.62TyrVal: 1.62 ± 0.023	0.427TyrTrp: 0.427 ± 0.012	0.956TyrTyr: 0.956 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.021XaaXaa: 0.021 ± 0.014

Statistics based on 6907 proteins (3771177 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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