Amino acid dipepetide frequency for Nitrincola lacisaponensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.335AlaAla: 10.335 ± 0.138
1.178AlaCys: 1.178 ± 0.034
5.709AlaAsp: 5.709 ± 0.079
7.03AlaGlu: 7.03 ± 0.093
3.561AlaPhe: 3.561 ± 0.062
7.533AlaGly: 7.533 ± 0.106
1.966AlaHis: 1.966 ± 0.045
5.377AlaIle: 5.377 ± 0.076
2.632AlaLys: 2.632 ± 0.061
12.193AlaLeu: 12.193 ± 0.13
2.695AlaMet: 2.695 ± 0.054
2.576AlaAsn: 2.576 ± 0.055
3.317AlaPro: 3.317 ± 0.076
4.615AlaGln: 4.615 ± 0.082
5.732AlaArg: 5.732 ± 0.09
5.593AlaSer: 5.593 ± 0.087
4.419AlaThr: 4.419 ± 0.072
6.868AlaVal: 6.868 ± 0.094
1.195AlaTrp: 1.195 ± 0.034
2.367AlaTyr: 2.367 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.864CysAla: 0.864 ± 0.032
0.157CysCys: 0.157 ± 0.013
0.595CysAsp: 0.595 ± 0.023
0.557CysGlu: 0.557 ± 0.025
0.428CysPhe: 0.428 ± 0.021
0.846CysGly: 0.846 ± 0.03
0.337CysHis: 0.337 ± 0.021
0.558CysIle: 0.558 ± 0.023
0.303CysLys: 0.303 ± 0.018
1.146CysLeu: 1.146 ± 0.036
0.234CysMet: 0.234 ± 0.014
0.296CysAsn: 0.296 ± 0.019
0.471CysPro: 0.471 ± 0.021
0.581CysGln: 0.581 ± 0.028
0.657CysArg: 0.657 ± 0.03
0.607CysSer: 0.607 ± 0.026
0.464CysThr: 0.464 ± 0.02
0.724CysVal: 0.724 ± 0.023
0.134CysTrp: 0.134 ± 0.012
0.343CysTyr: 0.343 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.371AspAla: 5.371 ± 0.078
0.511AspCys: 0.511 ± 0.021
2.81AspAsp: 2.81 ± 0.063
3.647AspGlu: 3.647 ± 0.058
2.168AspPhe: 2.168 ± 0.055
3.458AspGly: 3.458 ± 0.081
1.186AspHis: 1.186 ± 0.035
3.117AspIle: 3.117 ± 0.059
1.847AspLys: 1.847 ± 0.04
6.242AspLeu: 6.242 ± 0.084
1.373AspMet: 1.373 ± 0.035
1.669AspAsn: 1.669 ± 0.046
2.855AspPro: 2.855 ± 0.055
2.97AspGln: 2.97 ± 0.056
3.121AspArg: 3.121 ± 0.063
3.024AspSer: 3.024 ± 0.052
2.829AspThr: 2.829 ± 0.058
3.444AspVal: 3.444 ± 0.056
1.007AspTrp: 1.007 ± 0.033
1.771AspTyr: 1.771 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.435GluAla: 6.435 ± 0.084
0.452GluCys: 0.452 ± 0.022
2.657GluAsp: 2.657 ± 0.054
3.284GluGlu: 3.284 ± 0.068
2.063GluPhe: 2.063 ± 0.046
3.894GluGly: 3.894 ± 0.057
1.568GluHis: 1.568 ± 0.036
3.484GluIle: 3.484 ± 0.062
2.392GluLys: 2.392 ± 0.059
7.122GluLeu: 7.122 ± 0.091
1.683GluMet: 1.683 ± 0.04
1.832GluAsn: 1.832 ± 0.045
2.41GluPro: 2.41 ± 0.066
4.354GluGln: 4.354 ± 0.083
4.331GluArg: 4.331 ± 0.079
3.406GluSer: 3.406 ± 0.056
3.282GluThr: 3.282 ± 0.063
4.24GluVal: 4.24 ± 0.073
0.778GluTrp: 0.778 ± 0.026
1.471GluTyr: 1.471 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.483PheAla: 3.483 ± 0.067
0.486PheCys: 0.486 ± 0.022
2.447PheAsp: 2.447 ± 0.049
2.244PheGlu: 2.244 ± 0.041
1.593PhePhe: 1.593 ± 0.043
2.886PheGly: 2.886 ± 0.06
0.764PheHis: 0.764 ± 0.03
2.337PheIle: 2.337 ± 0.055
1.247PheLys: 1.247 ± 0.037
3.361PheLeu: 3.361 ± 0.072
1.074PheMet: 1.074 ± 0.035
1.57PheAsn: 1.57 ± 0.041
1.551PhePro: 1.551 ± 0.039
1.46PheGln: 1.46 ± 0.036
2.069PheArg: 2.069 ± 0.047
2.967PheSer: 2.967 ± 0.059
2.011PheThr: 2.011 ± 0.047
2.461PheVal: 2.461 ± 0.053
0.54PheTrp: 0.54 ± 0.028
1.185PheTyr: 1.185 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.742GlyAla: 5.742 ± 0.089
0.9GlyCys: 0.9 ± 0.032
3.76GlyAsp: 3.76 ± 0.071
4.175GlyGlu: 4.175 ± 0.076
3.342GlyPhe: 3.342 ± 0.056
5.036GlyGly: 5.036 ± 0.12
1.731GlyHis: 1.731 ± 0.047
4.549GlyIle: 4.549 ± 0.073
2.84GlyLys: 2.84 ± 0.065
8.054GlyLeu: 8.054 ± 0.099
2.263GlyMet: 2.263 ± 0.054
2.17GlyAsn: 2.17 ± 0.062
2.041GlyPro: 2.041 ± 0.047
3.558GlyGln: 3.558 ± 0.064
4.288GlyArg: 4.288 ± 0.072
4.17GlySer: 4.17 ± 0.078
3.367GlyThr: 3.367 ± 0.07
5.561GlyVal: 5.561 ± 0.081
1.15GlyTrp: 1.15 ± 0.038
2.518GlyTyr: 2.518 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.123HisAla: 2.123 ± 0.042
0.333HisCys: 0.333 ± 0.019
1.073HisAsp: 1.073 ± 0.039
1.235HisGlu: 1.235 ± 0.039
1.046HisPhe: 1.046 ± 0.034
1.474HisGly: 1.474 ± 0.042
0.718HisHis: 0.718 ± 0.027
1.184HisIle: 1.184 ± 0.034
0.711HisLys: 0.711 ± 0.027
2.839HisLeu: 2.839 ± 0.056
0.514HisMet: 0.514 ± 0.023
0.748HisAsn: 0.748 ± 0.027
1.51HisPro: 1.51 ± 0.039
1.537HisGln: 1.537 ± 0.041
1.353HisArg: 1.353 ± 0.037
1.28HisSer: 1.28 ± 0.038
1.194HisThr: 1.194 ± 0.034
1.159HisVal: 1.159 ± 0.038
0.508HisTrp: 0.508 ± 0.025
0.886HisTyr: 0.886 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.664IleAla: 5.664 ± 0.087
0.636IleCys: 0.636 ± 0.025
3.571IleAsp: 3.571 ± 0.056
4.021IleGlu: 4.021 ± 0.071
1.83IlePhe: 1.83 ± 0.045
4.188IleGly: 4.188 ± 0.067
1.293IleHis: 1.293 ± 0.037
2.876IleIle: 2.876 ± 0.063
1.83IleLys: 1.83 ± 0.054
5.391IleLeu: 5.391 ± 0.082
1.16IleMet: 1.16 ± 0.036
2.275IleAsn: 2.275 ± 0.051
2.601IlePro: 2.601 ± 0.046
2.522IleGln: 2.522 ± 0.045
3.708IleArg: 3.708 ± 0.063
3.845IleSer: 3.845 ± 0.059
3.29IleThr: 3.29 ± 0.059
3.258IleVal: 3.258 ± 0.075
0.646IleTrp: 0.646 ± 0.024
1.461IleTyr: 1.461 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.38LysAla: 3.38 ± 0.072
0.2LysCys: 0.2 ± 0.015
1.683LysAsp: 1.683 ± 0.049
1.74LysGlu: 1.74 ± 0.054
0.811LysPhe: 0.811 ± 0.031
2.405LysGly: 2.405 ± 0.049
0.823LysHis: 0.823 ± 0.035
1.821LysIle: 1.821 ± 0.052
1.437LysLys: 1.437 ± 0.052
3.437LysLeu: 3.437 ± 0.062
0.834LysMet: 0.834 ± 0.028
1.039LysAsn: 1.039 ± 0.036
1.785LysPro: 1.785 ± 0.038
1.871LysGln: 1.871 ± 0.051
2.284LysArg: 2.284 ± 0.052
1.878LysSer: 1.878 ± 0.048
1.947LysThr: 1.947 ± 0.047
2.411LysVal: 2.411 ± 0.047
0.312LysTrp: 0.312 ± 0.019
0.711LysTyr: 0.711 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
11.74LeuAla: 11.74 ± 0.115
1.221LeuCys: 1.221 ± 0.041
6.337LeuAsp: 6.337 ± 0.089
6.838LeuGlu: 6.838 ± 0.09
4.229LeuPhe: 4.229 ± 0.078
7.787LeuGly: 7.787 ± 0.101
2.52LeuHis: 2.52 ± 0.051
6.739LeuIle: 6.739 ± 0.103
4.504LeuLys: 4.504 ± 0.078
14.416LeuLeu: 14.416 ± 0.203
3.152LeuMet: 3.152 ± 0.065
4.323LeuAsn: 4.323 ± 0.059
6.1LeuPro: 6.1 ± 0.084
6.018LeuGln: 6.018 ± 0.096
6.65LeuArg: 6.65 ± 0.085
8.214LeuSer: 8.214 ± 0.109
6.251LeuThr: 6.251 ± 0.085
7.56LeuVal: 7.56 ± 0.111
1.274LeuTrp: 1.274 ± 0.04
2.638LeuTyr: 2.638 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.717MetAla: 2.717 ± 0.059
0.183MetCys: 0.183 ± 0.014
1.303MetAsp: 1.303 ± 0.035
1.285MetGlu: 1.285 ± 0.032
0.798MetPhe: 0.798 ± 0.031
1.81MetGly: 1.81 ± 0.052
0.545MetHis: 0.545 ± 0.023
1.503MetIle: 1.503 ± 0.041
1.071MetLys: 1.071 ± 0.034
3.119MetLeu: 3.119 ± 0.064
0.706MetMet: 0.706 ± 0.026
0.923MetAsn: 0.923 ± 0.033
1.336MetPro: 1.336 ± 0.035
1.415MetGln: 1.415 ± 0.038
1.55MetArg: 1.55 ± 0.034
1.803MetSer: 1.803 ± 0.042
1.712MetThr: 1.712 ± 0.039
1.692MetVal: 1.692 ± 0.042
0.152MetTrp: 0.152 ± 0.012
0.4MetTyr: 0.4 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.985AsnAla: 2.985 ± 0.06
0.299AsnCys: 0.299 ± 0.017
1.603AsnAsp: 1.603 ± 0.046
1.653AsnGlu: 1.653 ± 0.043
1.161AsnPhe: 1.161 ± 0.036
2.08AsnGly: 2.08 ± 0.05
0.752AsnHis: 0.752 ± 0.024
1.887AsnIle: 1.887 ± 0.051
1.0AsnLys: 1.0 ± 0.036
3.625AsnLeu: 3.625 ± 0.062
0.764AsnMet: 0.764 ± 0.029
1.05AsnAsn: 1.05 ± 0.035
2.158AsnPro: 2.158 ± 0.054
1.66AsnGln: 1.66 ± 0.047
2.172AsnArg: 2.172 ± 0.053
1.724AsnSer: 1.724 ± 0.037
1.849AsnThr: 1.849 ± 0.047
1.761AsnVal: 1.761 ± 0.048
0.449AsnTrp: 0.449 ± 0.023
0.836AsnTyr: 0.836 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
4.53ProAla: 4.53 ± 0.067
0.363ProCys: 0.363 ± 0.018
3.292ProAsp: 3.292 ± 0.055
4.018ProGlu: 4.018 ± 0.072
1.689ProPhe: 1.689 ± 0.036
3.611ProGly: 3.611 ± 0.058
0.948ProHis: 0.948 ± 0.03
2.023ProIle: 2.023 ± 0.051
1.273ProLys: 1.273 ± 0.038
5.122ProLeu: 5.122 ± 0.08
1.122ProMet: 1.122 ± 0.031
1.241ProAsn: 1.241 ± 0.036
1.626ProPro: 1.626 ± 0.05
1.87ProGln: 1.87 ± 0.051
2.041ProArg: 2.041 ± 0.054
2.378ProSer: 2.378 ± 0.049
1.832ProThr: 1.832 ± 0.051
4.196ProVal: 4.196 ± 0.068
0.675ProTrp: 0.675 ± 0.023
1.108ProTyr: 1.108 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.7GlnAla: 5.7 ± 0.091
0.428GlnCys: 0.428 ± 0.021
2.288GlnAsp: 2.288 ± 0.045
2.347GlnGlu: 2.347 ± 0.055
1.528GlnPhe: 1.528 ± 0.037
3.979GlnGly: 3.979 ± 0.062
1.5GlnHis: 1.5 ± 0.041
2.658GlnIle: 2.658 ± 0.048
1.388GlnLys: 1.388 ± 0.036
6.845GlnLeu: 6.845 ± 0.099
1.251GlnMet: 1.251 ± 0.036
1.221GlnAsn: 1.221 ± 0.036
2.584GlnPro: 2.584 ± 0.058
4.531GlnGln: 4.531 ± 0.111
3.904GlnArg: 3.904 ± 0.068
2.886GlnSer: 2.886 ± 0.059
2.479GlnThr: 2.479 ± 0.049
4.037GlnVal: 4.037 ± 0.07
0.695GlnTrp: 0.695 ± 0.025
1.083GlnTyr: 1.083 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
4.79ArgAla: 4.79 ± 0.076
0.606ArgCys: 0.606 ± 0.028
3.247ArgAsp: 3.247 ± 0.057
3.92ArgGlu: 3.92 ± 0.058
2.856ArgPhe: 2.856 ± 0.049
3.38ArgGly: 3.38 ± 0.066
1.651ArgHis: 1.651 ± 0.044
3.936ArgIle: 3.936 ± 0.07
2.112ArgLys: 2.112 ± 0.058
7.825ArgLeu: 7.825 ± 0.094
1.725ArgMet: 1.725 ± 0.04
1.961ArgAsn: 1.961 ± 0.044
2.401ArgPro: 2.401 ± 0.05
3.805ArgGln: 3.805 ± 0.074
3.817ArgArg: 3.817 ± 0.077
3.422ArgSer: 3.422 ± 0.061
2.563ArgThr: 2.563 ± 0.051
4.376ArgVal: 4.376 ± 0.073
0.969ArgTrp: 0.969 ± 0.03
2.131ArgTyr: 2.131 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.915SerAla: 5.915 ± 0.091
0.593SerCys: 0.593 ± 0.025
3.281SerAsp: 3.281 ± 0.067
3.489SerGlu: 3.489 ± 0.069
2.394SerPhe: 2.394 ± 0.05
5.336SerGly: 5.336 ± 0.084
1.446SerHis: 1.446 ± 0.039
3.356SerIle: 3.356 ± 0.057
1.656SerLys: 1.656 ± 0.053
7.335SerLeu: 7.335 ± 0.086
1.638SerMet: 1.638 ± 0.036
1.716SerAsn: 1.716 ± 0.046
2.598SerPro: 2.598 ± 0.057
2.778SerGln: 2.778 ± 0.059
3.797SerArg: 3.797 ± 0.067
3.625SerSer: 3.625 ± 0.066
2.806SerThr: 2.806 ± 0.055
4.461SerVal: 4.461 ± 0.074
0.868SerTrp: 0.868 ± 0.03
1.594SerTyr: 1.594 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.04ThrAla: 5.04 ± 0.067
0.469ThrCys: 0.469 ± 0.022
2.998ThrAsp: 2.998 ± 0.057
3.27ThrGlu: 3.27 ± 0.058
1.751ThrPhe: 1.751 ± 0.049
4.549ThrGly: 4.549 ± 0.09
1.233ThrHis: 1.233 ± 0.035
2.127ThrIle: 2.127 ± 0.052
0.964ThrLys: 0.964 ± 0.034
7.481ThrLeu: 7.481 ± 0.09
0.788ThrMet: 0.788 ± 0.029
1.245ThrAsn: 1.245 ± 0.039
2.943ThrPro: 2.943 ± 0.058
2.443ThrGln: 2.443 ± 0.065
3.205ThrArg: 3.205 ± 0.056
2.719ThrSer: 2.719 ± 0.054
2.532ThrThr: 2.532 ± 0.058
3.107ThrVal: 3.107 ± 0.058
0.594ThrTrp: 0.594 ± 0.029
1.162ThrTyr: 1.162 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.784ValAla: 6.784 ± 0.083
0.82ValCys: 0.82 ± 0.029
3.802ValAsp: 3.802 ± 0.061
4.404ValGlu: 4.404 ± 0.077
2.785ValPhe: 2.785 ± 0.06
4.321ValGly: 4.321 ± 0.081
1.362ValHis: 1.362 ± 0.039
4.384ValIle: 4.384 ± 0.067
2.369ValLys: 2.369 ± 0.06
7.638ValLeu: 7.638 ± 0.094
2.069ValMet: 2.069 ± 0.057
2.38ValAsn: 2.38 ± 0.049
2.734ValPro: 2.734 ± 0.053
2.686ValGln: 2.686 ± 0.056
3.983ValArg: 3.983 ± 0.063
4.805ValSer: 4.805 ± 0.07
3.849ValThr: 3.849 ± 0.071
5.056ValVal: 5.056 ± 0.092
0.845ValTrp: 0.845 ± 0.032
1.774ValTyr: 1.774 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.835TrpAla: 0.835 ± 0.026
0.168TrpCys: 0.168 ± 0.013
0.533TrpAsp: 0.533 ± 0.025
0.544TrpGlu: 0.544 ± 0.023
0.562TrpPhe: 0.562 ± 0.023
0.778TrpGly: 0.778 ± 0.031
0.387TrpHis: 0.387 ± 0.019
0.827TrpIle: 0.827 ± 0.032
0.459TrpLys: 0.459 ± 0.02
2.12TrpLeu: 2.12 ± 0.055
0.424TrpMet: 0.424 ± 0.022
0.391TrpAsn: 0.391 ± 0.02
0.589TrpPro: 0.589 ± 0.024
1.07TrpGln: 1.07 ± 0.039
0.84TrpArg: 0.84 ± 0.026
0.817TrpSer: 0.817 ± 0.03
0.558TrpThr: 0.558 ± 0.023
0.944TrpVal: 0.944 ± 0.03
0.207TrpTrp: 0.207 ± 0.016
0.35TrpTyr: 0.35 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.459TyrAla: 2.459 ± 0.056
0.3TyrCys: 0.3 ± 0.016
1.431TyrAsp: 1.431 ± 0.038
1.438TyrGlu: 1.438 ± 0.039
1.141TyrPhe: 1.141 ± 0.035
1.865TyrGly: 1.865 ± 0.045
0.69TyrHis: 0.69 ± 0.024
1.323TyrIle: 1.323 ± 0.041
0.775TyrLys: 0.775 ± 0.03
3.197TyrLeu: 3.197 ± 0.064
0.554TyrMet: 0.554 ± 0.021
0.842TyrAsn: 0.842 ± 0.033
1.348TyrPro: 1.348 ± 0.04
1.587TyrGln: 1.587 ± 0.043
1.989TyrArg: 1.989 ± 0.045
1.522TyrSer: 1.522 ± 0.041
1.386TyrThr: 1.386 ± 0.04
1.535TyrVal: 1.535 ± 0.043
0.407TyrTrp: 0.407 ± 0.023
0.864TyrTyr: 0.864 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3092 proteins (1040077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski