Amino acid dipepetide frequency for Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.718AlaAla: 9.718 ± 0.09	1.141AlaCys: 1.141 ± 0.022	4.625AlaAsp: 4.625 ± 0.04	5.085AlaGlu: 5.085 ± 0.056	3.577AlaPhe: 3.577 ± 0.042	5.901AlaGly: 5.901 ± 0.055	2.444AlaHis: 2.444 ± 0.028	4.273AlaIle: 4.273 ± 0.033	3.573AlaLys: 3.573 ± 0.039	9.149AlaLeu: 9.149 ± 0.063	1.982AlaMet: 1.982 ± 0.028	2.821AlaAsn: 2.821 ± 0.033	5.8AlaPro: 5.8 ± 0.07	3.641AlaGln: 3.641 ± 0.043	5.962AlaArg: 5.962 ± 0.056	8.04AlaSer: 8.04 ± 0.062	5.603AlaThr: 5.603 ± 0.05	5.955AlaVal: 5.955 ± 0.048	1.319AlaTrp: 1.319 ± 0.026	2.456AlaTyr: 2.456 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.099CysAla: 1.099 ± 0.02	0.284CysCys: 0.284 ± 0.011	0.623CysAsp: 0.623 ± 0.015	0.563CysGlu: 0.563 ± 0.013	0.489CysPhe: 0.489 ± 0.013	0.971CysGly: 0.971 ± 0.02	0.312CysHis: 0.312 ± 0.01	0.679CysIle: 0.679 ± 0.015	0.422CysLys: 0.422 ± 0.012	1.186CysLeu: 1.186 ± 0.024	0.286CysMet: 0.286 ± 0.01	0.366CysAsn: 0.366 ± 0.012	0.801CysPro: 0.801 ± 0.019	0.373CysGln: 0.373 ± 0.013	0.799CysArg: 0.799 ± 0.017	0.88CysSer: 0.88 ± 0.021	0.745CysThr: 0.745 ± 0.017	0.839CysVal: 0.839 ± 0.019	0.189CysTrp: 0.189 ± 0.009	0.376CysTyr: 0.376 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	5.426AspAla: 5.426 ± 0.046	0.621AspCys: 0.621 ± 0.016	4.158AspAsp: 4.158 ± 0.057	4.23AspGlu: 4.23 ± 0.057	2.064AspPhe: 2.064 ± 0.03	4.318AspGly: 4.318 ± 0.044	1.223AspHis: 1.223 ± 0.023	2.917AspIle: 2.917 ± 0.036	2.055AspLys: 2.055 ± 0.028	4.84AspLeu: 4.84 ± 0.044	1.139AspMet: 1.139 ± 0.019	1.594AspAsn: 1.594 ± 0.025	3.655AspPro: 3.655 ± 0.036	1.56AspGln: 1.56 ± 0.026	3.072AspArg: 3.072 ± 0.043	3.756AspSer: 3.756 ± 0.041	2.937AspThr: 2.937 ± 0.029	4.348AspVal: 4.348 ± 0.045	1.004AspTrp: 1.004 ± 0.02	1.53AspTyr: 1.53 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	5.066GluAla: 5.066 ± 0.057	0.595GluCys: 0.595 ± 0.016	4.209GluAsp: 4.209 ± 0.055	5.029GluGlu: 5.029 ± 0.076	1.889GluPhe: 1.889 ± 0.031	3.697GluGly: 3.697 ± 0.04	1.56GluHis: 1.56 ± 0.023	2.5GluIle: 2.5 ± 0.027	2.8GluLys: 2.8 ± 0.038	5.323GluLeu: 5.323 ± 0.052	1.161GluMet: 1.161 ± 0.02	1.671GluAsn: 1.671 ± 0.025	2.744GluPro: 2.744 ± 0.044	2.199GluGln: 2.199 ± 0.031	4.222GluArg: 4.222 ± 0.047	3.64GluSer: 3.64 ± 0.037	3.032GluThr: 3.032 ± 0.035	3.666GluVal: 3.666 ± 0.04	0.979GluTrp: 0.979 ± 0.02	1.568GluTyr: 1.568 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.39PheAla: 3.39 ± 0.037	0.52PheCys: 0.52 ± 0.015	2.286PheAsp: 2.286 ± 0.029	1.946PheGlu: 1.946 ± 0.028	1.546PhePhe: 1.546 ± 0.027	2.744PheGly: 2.744 ± 0.04	0.891PheHis: 0.891 ± 0.017	1.667PheIle: 1.667 ± 0.027	1.396PheLys: 1.396 ± 0.024	3.545PheLeu: 3.545 ± 0.041	0.766PheMet: 0.766 ± 0.017	1.274PheAsn: 1.274 ± 0.023	2.207PhePro: 2.207 ± 0.03	1.203PheGln: 1.203 ± 0.023	2.122PheArg: 2.122 ± 0.031	3.086PheSer: 3.086 ± 0.034	2.2PheThr: 2.2 ± 0.032	2.642PheVal: 2.642 ± 0.035	0.648PheTrp: 0.648 ± 0.017	1.072PheTyr: 1.072 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	5.643GlyAla: 5.643 ± 0.049	0.894GlyCys: 0.894 ± 0.019	3.566GlyAsp: 3.566 ± 0.039	3.642GlyGlu: 3.642 ± 0.042	2.5GlyPhe: 2.5 ± 0.033	5.347GlyGly: 5.347 ± 0.066	1.847GlyHis: 1.847 ± 0.026	3.183GlyIle: 3.183 ± 0.039	3.145GlyLys: 3.145 ± 0.042	5.734GlyLeu: 5.734 ± 0.049	1.355GlyMet: 1.355 ± 0.025	2.102GlyAsn: 2.102 ± 0.031	3.594GlyPro: 3.594 ± 0.041	2.335GlyGln: 2.335 ± 0.033	4.341GlyArg: 4.341 ± 0.041	5.579GlySer: 5.579 ± 0.055	4.314GlyThr: 4.314 ± 0.044	4.497GlyVal: 4.497 ± 0.046	1.178GlyTrp: 1.178 ± 0.019	1.961GlyTyr: 1.961 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.313HisAla: 2.313 ± 0.025	0.338HisCys: 0.338 ± 0.012	1.439HisAsp: 1.439 ± 0.02	1.341HisGlu: 1.341 ± 0.024	0.955HisPhe: 0.955 ± 0.017	1.78HisGly: 1.78 ± 0.026	0.823HisHis: 0.823 ± 0.023	1.305HisIle: 1.305 ± 0.023	0.848HisLys: 0.848 ± 0.02	2.581HisLeu: 2.581 ± 0.038	0.488HisMet: 0.488 ± 0.011	0.799HisAsn: 0.799 ± 0.017	2.004HisPro: 2.004 ± 0.027	0.857HisGln: 0.857 ± 0.018	1.717HisArg: 1.717 ± 0.026	1.988HisSer: 1.988 ± 0.03	1.571HisThr: 1.571 ± 0.024	1.829HisVal: 1.829 ± 0.027	0.361HisTrp: 0.361 ± 0.011	0.733HisTyr: 0.733 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.334IleAla: 4.334 ± 0.045	0.657IleCys: 0.657 ± 0.017	2.66IleAsp: 2.66 ± 0.034	2.431IleGlu: 2.431 ± 0.037	1.761IlePhe: 1.761 ± 0.026	2.964IleGly: 2.964 ± 0.038	1.162IleHis: 1.162 ± 0.022	2.132IleIle: 2.132 ± 0.031	1.701IleLys: 1.701 ± 0.025	4.329IleLeu: 4.329 ± 0.045	0.888IleMet: 0.888 ± 0.016	1.405IleAsn: 1.405 ± 0.025	3.217IlePro: 3.217 ± 0.033	1.563IleGln: 1.563 ± 0.023	2.748IleArg: 2.748 ± 0.032	3.558IleSer: 3.558 ± 0.036	2.669IleThr: 2.669 ± 0.033	3.381IleVal: 3.381 ± 0.04	0.708IleTrp: 0.708 ± 0.016	1.23IleTyr: 1.23 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.939LysAla: 3.939 ± 0.044	0.437LysCys: 0.437 ± 0.013	2.301LysAsp: 2.301 ± 0.032	2.721LysGlu: 2.721 ± 0.038	1.26LysPhe: 1.26 ± 0.02	2.649LysGly: 2.649 ± 0.032	1.028LysHis: 1.028 ± 0.02	1.727LysIle: 1.727 ± 0.024	2.4LysLys: 2.4 ± 0.048	3.622LysLeu: 3.622 ± 0.041	0.754LysMet: 0.754 ± 0.018	1.218LysAsn: 1.218 ± 0.024	2.335LysPro: 2.335 ± 0.031	1.429LysGln: 1.429 ± 0.026	3.146LysArg: 3.146 ± 0.042	2.637LysSer: 2.637 ± 0.03	2.333LysThr: 2.333 ± 0.03	2.551LysVal: 2.551 ± 0.034	0.642LysTrp: 0.642 ± 0.014	1.189LysTyr: 1.189 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.724LeuAla: 8.724 ± 0.061	1.225LeuCys: 1.225 ± 0.025	5.185LeuAsp: 5.185 ± 0.047	5.328LeuGlu: 5.328 ± 0.048	3.54LeuPhe: 3.54 ± 0.039	5.842LeuGly: 5.842 ± 0.053	2.61LeuHis: 2.61 ± 0.034	3.715LeuIle: 3.715 ± 0.044	3.654LeuLys: 3.654 ± 0.044	8.844LeuLeu: 8.844 ± 0.09	1.646LeuMet: 1.646 ± 0.024	2.881LeuAsn: 2.881 ± 0.032	6.45LeuPro: 6.45 ± 0.052	3.718LeuGln: 3.718 ± 0.045	6.393LeuArg: 6.393 ± 0.061	7.854LeuSer: 7.854 ± 0.058	5.19LeuThr: 5.19 ± 0.046	6.086LeuVal: 6.086 ± 0.054	1.357LeuTrp: 1.357 ± 0.023	2.428LeuTyr: 2.428 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.859MetAla: 1.859 ± 0.025	0.24MetCys: 0.24 ± 0.009	1.136MetAsp: 1.136 ± 0.02	1.032MetGlu: 1.032 ± 0.022	0.754MetPhe: 0.754 ± 0.018	1.204MetGly: 1.204 ± 0.023	0.521MetHis: 0.521 ± 0.013	0.806MetIle: 0.806 ± 0.018	0.802MetLys: 0.802 ± 0.016	1.8MetLeu: 1.8 ± 0.026	0.438MetMet: 0.438 ± 0.015	0.654MetAsn: 0.654 ± 0.017	1.274MetPro: 1.274 ± 0.022	0.742MetGln: 0.742 ± 0.018	1.355MetArg: 1.355 ± 0.022	1.931MetSer: 1.931 ± 0.026	1.165MetThr: 1.165 ± 0.017	1.16MetVal: 1.16 ± 0.022	0.274MetTrp: 0.274 ± 0.01	0.547MetTyr: 0.547 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.181AsnAla: 3.181 ± 0.035	0.374AsnCys: 0.374 ± 0.014	1.611AsnAsp: 1.611 ± 0.027	1.549AsnGlu: 1.549 ± 0.023	1.171AsnPhe: 1.171 ± 0.02	2.524AsnGly: 2.524 ± 0.035	0.727AsnHis: 0.727 ± 0.016	1.718AsnIle: 1.718 ± 0.026	1.127AsnLys: 1.127 ± 0.024	2.802AsnLeu: 2.802 ± 0.037	0.655AsnMet: 0.655 ± 0.014	1.054AsnAsn: 1.054 ± 0.023	2.127AsnPro: 2.127 ± 0.032	0.945AsnGln: 0.945 ± 0.022	1.566AsnArg: 1.566 ± 0.024	2.199AsnSer: 2.199 ± 0.031	1.841AsnThr: 1.841 ± 0.027	2.409AsnVal: 2.409 ± 0.033	0.468AsnTrp: 0.468 ± 0.014	0.837AsnTyr: 0.837 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.279ProAla: 6.279 ± 0.064	0.548ProCys: 0.548 ± 0.016	3.561ProAsp: 3.561 ± 0.034	3.89ProGlu: 3.89 ± 0.036	2.282ProPhe: 2.282 ± 0.031	4.028ProGly: 4.028 ± 0.044	1.688ProHis: 1.688 ± 0.023	2.688ProIle: 2.688 ± 0.029	2.279ProLys: 2.279 ± 0.033	5.481ProLeu: 5.481 ± 0.053	1.094ProMet: 1.094 ± 0.019	2.079ProAsn: 2.079 ± 0.027	6.581ProPro: 6.581 ± 0.101	2.496ProGln: 2.496 ± 0.037	3.947ProArg: 3.947 ± 0.053	7.221ProSer: 7.221 ± 0.092	4.548ProThr: 4.548 ± 0.049	4.092ProVal: 4.092 ± 0.044	0.761ProTrp: 0.761 ± 0.016	1.596ProTyr: 1.596 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.424GlnAla: 3.424 ± 0.035	0.448GlnCys: 0.448 ± 0.013	1.853GlnAsp: 1.853 ± 0.024	2.056GlnGlu: 2.056 ± 0.031	1.198GlnPhe: 1.198 ± 0.021	2.226GlnGly: 2.226 ± 0.034	1.022GlnHis: 1.022 ± 0.021	1.562GlnIle: 1.562 ± 0.027	1.487GlnLys: 1.487 ± 0.027	3.387GlnLeu: 3.387 ± 0.038	0.728GlnMet: 0.728 ± 0.017	1.139GlnAsn: 1.139 ± 0.021	2.396GlnPro: 2.396 ± 0.039	1.877GlnGln: 1.877 ± 0.045	2.569GlnArg: 2.569 ± 0.03	2.753GlnSer: 2.753 ± 0.037	2.143GlnThr: 2.143 ± 0.028	2.164GlnVal: 2.164 ± 0.026	0.627GlnTrp: 0.627 ± 0.014	1.121GlnTyr: 1.121 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.92ArgAla: 5.92 ± 0.057	0.783ArgCys: 0.783 ± 0.022	3.505ArgAsp: 3.505 ± 0.039	3.959ArgGlu: 3.959 ± 0.05	2.278ArgPhe: 2.278 ± 0.031	3.796ArgGly: 3.796 ± 0.051	1.718ArgHis: 1.718 ± 0.026	2.953ArgIle: 2.953 ± 0.035	3.137ArgLys: 3.137 ± 0.037	6.04ArgLeu: 6.04 ± 0.05	1.404ArgMet: 1.404 ± 0.024	1.905ArgAsn: 1.905 ± 0.024	3.954ArgPro: 3.954 ± 0.048	2.354ArgGln: 2.354 ± 0.032	5.634ArgArg: 5.634 ± 0.065	5.034ArgSer: 5.034 ± 0.05	3.884ArgThr: 3.884 ± 0.038	4.069ArgVal: 4.069 ± 0.037	1.093ArgTrp: 1.093 ± 0.021	1.804ArgTyr: 1.804 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.582SerAla: 7.582 ± 0.061	0.914SerCys: 0.914 ± 0.019	4.209SerAsp: 4.209 ± 0.04	3.793SerGlu: 3.793 ± 0.043	2.978SerPhe: 2.978 ± 0.035	5.658SerGly: 5.658 ± 0.051	2.087SerHis: 2.087 ± 0.027	3.656SerIle: 3.656 ± 0.041	2.943SerLys: 2.943 ± 0.034	7.52SerLeu: 7.52 ± 0.064	1.607SerMet: 1.607 ± 0.028	2.37SerAsn: 2.37 ± 0.032	6.441SerPro: 6.441 ± 0.081	2.929SerGln: 2.929 ± 0.04	5.166SerArg: 5.166 ± 0.056	9.11SerSer: 9.11 ± 0.106	5.745SerThr: 5.745 ± 0.052	5.208SerVal: 5.208 ± 0.044	1.131SerTrp: 1.131 ± 0.022	1.939SerTyr: 1.939 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.493ThrAla: 5.493 ± 0.043	0.74ThrCys: 0.74 ± 0.017	2.833ThrAsp: 2.833 ± 0.032	2.728ThrGlu: 2.728 ± 0.03	2.556ThrPhe: 2.556 ± 0.03	4.013ThrGly: 4.013 ± 0.044	1.538ThrHis: 1.538 ± 0.025	2.962ThrIle: 2.962 ± 0.032	2.087ThrLys: 2.087 ± 0.03	6.03ThrLeu: 6.03 ± 0.059	1.1ThrMet: 1.1 ± 0.021	1.843ThrAsn: 1.843 ± 0.027	4.665ThrPro: 4.665 ± 0.052	1.944ThrGln: 1.944 ± 0.025	3.504ThrArg: 3.504 ± 0.035	5.571ThrSer: 5.571 ± 0.054	4.199ThrThr: 4.199 ± 0.053	4.155ThrVal: 4.155 ± 0.044	0.902ThrTrp: 0.902 ± 0.018	1.602ThrTyr: 1.602 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	5.91ValAla: 5.91 ± 0.052	0.946ValCys: 0.946 ± 0.022	4.017ValAsp: 4.017 ± 0.039	3.874ValGlu: 3.874 ± 0.038	2.604ValPhe: 2.604 ± 0.034	4.171ValGly: 4.171 ± 0.039	1.763ValHis: 1.763 ± 0.026	2.939ValIle: 2.939 ± 0.034	2.71ValLys: 2.71 ± 0.036	6.492ValLeu: 6.492 ± 0.048	1.281ValMet: 1.281 ± 0.024	2.148ValAsn: 2.148 ± 0.029	4.536ValPro: 4.536 ± 0.044	2.489ValGln: 2.489 ± 0.03	4.181ValArg: 4.181 ± 0.044	5.108ValSer: 5.108 ± 0.04	3.739ValThr: 3.739 ± 0.043	5.021ValVal: 5.021 ± 0.057	1.12ValTrp: 1.12 ± 0.024	1.871ValTyr: 1.871 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.25TrpAla: 1.25 ± 0.024	0.201TrpCys: 0.201 ± 0.009	1.035TrpAsp: 1.035 ± 0.024	0.867TrpGlu: 0.867 ± 0.017	0.623TrpPhe: 0.623 ± 0.014	0.934TrpGly: 0.934 ± 0.019	0.396TrpHis: 0.396 ± 0.012	0.777TrpIle: 0.777 ± 0.017	0.774TrpLys: 0.774 ± 0.017	1.365TrpLeu: 1.365 ± 0.023	0.372TrpMet: 0.372 ± 0.012	0.586TrpAsn: 0.586 ± 0.016	0.717TrpPro: 0.717 ± 0.017	0.565TrpGln: 0.565 ± 0.016	1.136TrpArg: 1.136 ± 0.021	1.132TrpSer: 1.132 ± 0.02	1.008TrpThr: 1.008 ± 0.02	0.935TrpVal: 0.935 ± 0.022	0.295TrpTrp: 0.295 ± 0.011	0.5TrpTyr: 0.5 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.513TyrAla: 2.513 ± 0.028	0.377TyrCys: 0.377 ± 0.013	1.635TyrAsp: 1.635 ± 0.028	1.485TyrGlu: 1.485 ± 0.024	1.128TyrPhe: 1.128 ± 0.023	1.991TyrGly: 1.991 ± 0.03	0.708TyrHis: 0.708 ± 0.015	1.341TyrIle: 1.341 ± 0.024	0.977TyrLys: 0.977 ± 0.018	2.603TyrLeu: 2.603 ± 0.03	0.551TyrMet: 0.551 ± 0.014	0.975TyrAsn: 0.975 ± 0.021	1.641TyrPro: 1.641 ± 0.025	0.956TyrGln: 0.956 ± 0.017	1.647TyrArg: 1.647 ± 0.027	1.907TyrSer: 1.907 ± 0.034	1.598TyrThr: 1.598 ± 0.025	1.915TyrVal: 1.915 ± 0.026	0.411TyrTrp: 0.411 ± 0.012	0.877TyrTyr: 0.877 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7183 proteins (2842401 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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