Amino acid dipepetide frequency for Babesia ovata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.023AlaAla: 7.023 ± 0.059	1.215AlaCys: 1.215 ± 0.02	4.308AlaAsp: 4.308 ± 0.039	4.95AlaGlu: 4.95 ± 0.049	2.975AlaPhe: 2.975 ± 0.03	4.03AlaGly: 4.03 ± 0.037	1.694AlaHis: 1.694 ± 0.038	4.215AlaIle: 4.215 ± 0.044	4.515AlaLys: 4.515 ± 0.044	7.958AlaLeu: 7.958 ± 0.051	1.491AlaMet: 1.491 ± 0.026	2.992AlaAsn: 2.992 ± 0.058	3.229AlaPro: 3.229 ± 0.054	2.693AlaGln: 2.693 ± 0.033	3.257AlaArg: 3.257 ± 0.055	5.535AlaSer: 5.535 ± 0.052	4.132AlaThr: 4.132 ± 0.042	5.692AlaVal: 5.692 ± 0.048	0.542AlaTrp: 0.542 ± 0.012	2.122AlaTyr: 2.122 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.421CysAla: 1.421 ± 0.023	0.488CysCys: 0.488 ± 0.014	1.463CysAsp: 1.463 ± 0.025	1.041CysGlu: 1.041 ± 0.019	0.633CysPhe: 0.633 ± 0.015	1.602CysGly: 1.602 ± 0.027	0.703CysHis: 0.703 ± 0.016	0.921CysIle: 0.921 ± 0.02	1.273CysLys: 1.273 ± 0.026	1.963CysLeu: 1.963 ± 0.029	0.369CysMet: 0.369 ± 0.013	1.13CysAsn: 1.13 ± 0.024	0.908CysPro: 0.908 ± 0.018	0.806CysGln: 0.806 ± 0.02	1.261CysArg: 1.261 ± 0.022	1.725CysSer: 1.725 ± 0.027	0.969CysThr: 0.969 ± 0.019	1.191CysVal: 1.191 ± 0.022	0.214CysTrp: 0.214 ± 0.009	0.49CysTyr: 0.49 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.67AspAla: 5.67 ± 0.045	1.202AspCys: 1.202 ± 0.017	4.35AspAsp: 4.35 ± 0.051	4.273AspGlu: 4.273 ± 0.053	2.145AspPhe: 2.145 ± 0.03	4.44AspGly: 4.44 ± 0.043	1.419AspHis: 1.419 ± 0.022	3.507AspIle: 3.507 ± 0.033	3.903AspLys: 3.903 ± 0.058	5.773AspLeu: 5.773 ± 0.062	1.296AspMet: 1.296 ± 0.021	2.527AspAsn: 2.527 ± 0.029	2.552AspPro: 2.552 ± 0.044	1.819AspGln: 1.819 ± 0.023	2.51AspArg: 2.51 ± 0.038	4.257AspSer: 4.257 ± 0.043	3.226AspThr: 3.226 ± 0.031	5.004AspVal: 5.004 ± 0.049	0.643AspTrp: 0.643 ± 0.015	1.672AspTyr: 1.672 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.345GluAla: 5.345 ± 0.057	1.246GluCys: 1.246 ± 0.018	3.645GluAsp: 3.645 ± 0.041	4.653GluGlu: 4.653 ± 0.063	2.069GluPhe: 2.069 ± 0.028	3.624GluGly: 3.624 ± 0.042	1.706GluHis: 1.706 ± 0.027	3.538GluIle: 3.538 ± 0.042	4.638GluLys: 4.638 ± 0.058	6.513GluLeu: 6.513 ± 0.054	1.346GluMet: 1.346 ± 0.023	2.745GluAsn: 2.745 ± 0.034	2.284GluPro: 2.284 ± 0.04	2.648GluGln: 2.648 ± 0.031	3.373GluArg: 3.373 ± 0.053	4.474GluSer: 4.474 ± 0.053	3.32GluThr: 3.32 ± 0.039	3.97GluVal: 3.97 ± 0.04	0.587GluTrp: 0.587 ± 0.015	1.738GluTyr: 1.738 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	2.568PheAla: 2.568 ± 0.031	0.811PheCys: 0.811 ± 0.017	2.487PheAsp: 2.487 ± 0.031	2.109PheGlu: 2.109 ± 0.031	1.209PhePhe: 1.209 ± 0.024	2.286PheGly: 2.286 ± 0.036	0.911PheHis: 0.911 ± 0.019	1.451PheIle: 1.451 ± 0.023	2.141PheLys: 2.141 ± 0.03	3.578PheLeu: 3.578 ± 0.04	0.812PheMet: 0.812 ± 0.018	1.761PheAsn: 1.761 ± 0.026	1.145PhePro: 1.145 ± 0.019	1.082PheGln: 1.082 ± 0.019	1.751PheArg: 1.751 ± 0.032	2.608PheSer: 2.608 ± 0.031	2.307PheThr: 2.307 ± 0.029	2.361PheVal: 2.361 ± 0.036	0.368PheTrp: 0.368 ± 0.01	1.244PheTyr: 1.244 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	4.153GlyAla: 4.153 ± 0.043	1.283GlyCys: 1.283 ± 0.021	4.071GlyAsp: 4.071 ± 0.037	4.247GlyGlu: 4.247 ± 0.044	2.796GlyPhe: 2.796 ± 0.033	4.773GlyGly: 4.773 ± 0.072	1.769GlyHis: 1.769 ± 0.031	3.371GlyIle: 3.371 ± 0.037	4.421GlyLys: 4.421 ± 0.06	5.392GlyLeu: 5.392 ± 0.049	1.265GlyMet: 1.265 ± 0.022	2.843GlyAsn: 2.843 ± 0.031	2.0GlyPro: 2.0 ± 0.057	2.337GlyGln: 2.337 ± 0.037	3.275GlyArg: 3.275 ± 0.042	4.827GlySer: 4.827 ± 0.048	3.398GlyThr: 3.398 ± 0.043	4.548GlyVal: 4.548 ± 0.05	0.816GlyTrp: 0.816 ± 0.016	1.95GlyTyr: 1.95 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	1.729HisAla: 1.729 ± 0.031	0.583HisCys: 0.583 ± 0.013	1.561HisAsp: 1.561 ± 0.024	1.42HisGlu: 1.42 ± 0.021	1.063HisPhe: 1.063 ± 0.017	2.07HisGly: 2.07 ± 0.043	0.767HisHis: 0.767 ± 0.017	1.62HisIle: 1.62 ± 0.022	1.467HisLys: 1.467 ± 0.023	2.928HisLeu: 2.928 ± 0.033	0.527HisMet: 0.527 ± 0.015	1.272HisAsn: 1.272 ± 0.024	1.41HisPro: 1.41 ± 0.03	0.979HisGln: 0.979 ± 0.019	1.558HisArg: 1.558 ± 0.023	2.19HisSer: 2.19 ± 0.04	1.362HisThr: 1.362 ± 0.026	1.834HisVal: 1.834 ± 0.029	0.249HisTrp: 0.249 ± 0.01	0.864HisTyr: 0.864 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	3.756IleAla: 3.756 ± 0.032	1.073IleCys: 1.073 ± 0.019	3.417IleAsp: 3.417 ± 0.035	3.275IleGlu: 3.275 ± 0.037	1.612IlePhe: 1.612 ± 0.027	2.948IleGly: 2.948 ± 0.034	1.201IleHis: 1.201 ± 0.016	2.162IleIle: 2.162 ± 0.03	4.067IleLys: 4.067 ± 0.061	4.104IleLeu: 4.104 ± 0.042	0.947IleMet: 0.947 ± 0.018	2.444IleAsn: 2.444 ± 0.035	2.04IlePro: 2.04 ± 0.025	1.995IleGln: 1.995 ± 0.028	2.967IleArg: 2.967 ± 0.03	3.574IleSer: 3.574 ± 0.035	3.195IleThr: 3.195 ± 0.039	3.091IleVal: 3.091 ± 0.037	0.383IleTrp: 0.383 ± 0.011	1.456IleTyr: 1.456 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.885LysAla: 4.885 ± 0.051	1.325LysCys: 1.325 ± 0.026	4.192LysAsp: 4.192 ± 0.058	4.472LysGlu: 4.472 ± 0.058	2.153LysPhe: 2.153 ± 0.027	3.858LysGly: 3.858 ± 0.051	1.85LysHis: 1.85 ± 0.027	3.811LysIle: 3.811 ± 0.059	4.444LysLys: 4.444 ± 0.061	6.547LysLeu: 6.547 ± 0.066	1.238LysMet: 1.238 ± 0.023	3.176LysAsn: 3.176 ± 0.049	2.674LysPro: 2.674 ± 0.034	2.837LysGln: 2.837 ± 0.043	3.345LysArg: 3.345 ± 0.038	4.749LysSer: 4.749 ± 0.062	3.653LysThr: 3.653 ± 0.052	4.056LysVal: 4.056 ± 0.043	0.59LysTrp: 0.59 ± 0.015	1.975LysTyr: 1.975 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	5.923LeuAla: 5.923 ± 0.058	2.256LeuCys: 2.256 ± 0.036	5.628LeuAsp: 5.628 ± 0.048	6.303LeuGlu: 6.303 ± 0.051	3.114LeuPhe: 3.114 ± 0.042	5.65LeuGly: 5.65 ± 0.046	3.133LeuHis: 3.133 ± 0.036	3.523LeuIle: 3.523 ± 0.046	7.258LeuLys: 7.258 ± 0.08	9.139LeuLeu: 9.139 ± 0.077	1.824LeuMet: 1.824 ± 0.026	4.553LeuAsn: 4.553 ± 0.046	4.397LeuPro: 4.397 ± 0.051	5.053LeuGln: 5.053 ± 0.053	6.144LeuArg: 6.144 ± 0.048	7.509LeuSer: 7.509 ± 0.059	5.843LeuThr: 5.843 ± 0.066	5.32LeuVal: 5.32 ± 0.065	0.924LeuTrp: 0.924 ± 0.017	3.351LeuTyr: 3.351 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.539MetAla: 1.539 ± 0.025	0.419MetCys: 0.419 ± 0.011	1.293MetAsp: 1.293 ± 0.023	1.238MetGlu: 1.238 ± 0.024	0.747MetPhe: 0.747 ± 0.018	1.172MetGly: 1.172 ± 0.021	0.512MetHis: 0.512 ± 0.014	0.788MetIle: 0.788 ± 0.017	1.312MetLys: 1.312 ± 0.024	2.391MetLeu: 2.391 ± 0.03	0.473MetMet: 0.473 ± 0.014	0.768MetAsn: 0.768 ± 0.015	1.025MetPro: 1.025 ± 0.021	0.925MetGln: 0.925 ± 0.023	1.26MetArg: 1.26 ± 0.024	1.595MetSer: 1.595 ± 0.028	1.006MetThr: 1.006 ± 0.019	1.114MetVal: 1.114 ± 0.021	0.169MetTrp: 0.169 ± 0.007	0.616MetTyr: 0.616 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.739AsnAla: 3.739 ± 0.045	0.973AsnCys: 0.973 ± 0.017	2.808AsnAsp: 2.808 ± 0.04	2.91AsnGlu: 2.91 ± 0.034	1.601AsnPhe: 1.601 ± 0.023	3.327AsnGly: 3.327 ± 0.044	1.153AsnHis: 1.153 ± 0.022	2.641AsnIle: 2.641 ± 0.036	2.78AsnLys: 2.78 ± 0.043	3.881AsnLeu: 3.881 ± 0.041	0.923AsnMet: 0.923 ± 0.018	2.231AsnAsn: 2.231 ± 0.036	1.917AsnPro: 1.917 ± 0.025	1.662AsnGln: 1.662 ± 0.03	2.016AsnArg: 2.016 ± 0.031	3.187AsnSer: 3.187 ± 0.038	2.545AsnThr: 2.545 ± 0.032	3.561AsnVal: 3.561 ± 0.034	0.418AsnTrp: 0.418 ± 0.011	1.206AsnTyr: 1.206 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	3.164ProAla: 3.164 ± 0.076	0.868ProCys: 0.868 ± 0.018	2.368ProAsp: 2.368 ± 0.035	2.757ProGlu: 2.757 ± 0.039	1.42ProPhe: 1.42 ± 0.023	2.814ProGly: 2.814 ± 0.049	1.199ProHis: 1.199 ± 0.024	1.91ProIle: 1.91 ± 0.03	2.751ProLys: 2.751 ± 0.036	4.018ProLeu: 4.018 ± 0.045	1.053ProMet: 1.053 ± 0.024	1.926ProAsn: 1.926 ± 0.028	3.264ProPro: 3.264 ± 0.089	1.789ProGln: 1.789 ± 0.031	2.066ProArg: 2.066 ± 0.034	3.939ProSer: 3.939 ± 0.045	2.718ProThr: 2.718 ± 0.039	2.75ProVal: 2.75 ± 0.043	0.423ProTrp: 0.423 ± 0.013	1.278ProTyr: 1.278 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.761GlnAla: 2.761 ± 0.034	1.125GlnCys: 1.125 ± 0.021	1.829GlnAsp: 1.829 ± 0.029	2.098GlnGlu: 2.098 ± 0.03	1.279GlnPhe: 1.279 ± 0.023	2.252GlnGly: 2.252 ± 0.037	1.281GlnHis: 1.281 ± 0.03	2.095GlnIle: 2.095 ± 0.03	2.67GlnLys: 2.67 ± 0.04	4.517GlnLeu: 4.517 ± 0.047	0.877GlnMet: 0.877 ± 0.019	1.973GlnAsn: 1.973 ± 0.034	2.1GlnPro: 2.1 ± 0.033	2.176GlnGln: 2.176 ± 0.046	2.237GlnArg: 2.237 ± 0.03	2.905GlnSer: 2.905 ± 0.038	2.005GlnThr: 2.005 ± 0.028	2.416GlnVal: 2.416 ± 0.039	0.376GlnTrp: 0.376 ± 0.011	1.131GlnTyr: 1.131 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	3.217ArgAla: 3.217 ± 0.044	1.168ArgCys: 1.168 ± 0.024	3.308ArgAsp: 3.308 ± 0.031	3.292ArgGlu: 3.292 ± 0.053	1.887ArgPhe: 1.887 ± 0.027	3.262ArgGly: 3.262 ± 0.05	1.539ArgHis: 1.539 ± 0.028	2.93ArgIle: 2.93 ± 0.03	2.976ArgLys: 2.976 ± 0.035	5.26ArgLeu: 5.26 ± 0.054	1.264ArgMet: 1.264 ± 0.027	2.44ArgAsn: 2.44 ± 0.035	2.066ArgPro: 2.066 ± 0.053	2.29ArgGln: 2.29 ± 0.034	3.989ArgArg: 3.989 ± 0.063	4.028ArgSer: 4.028 ± 0.049	2.604ArgThr: 2.604 ± 0.029	3.34ArgVal: 3.34 ± 0.044	0.536ArgTrp: 0.536 ± 0.012	1.679ArgTyr: 1.679 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.649SerAla: 5.649 ± 0.055	1.334SerCys: 1.334 ± 0.028	4.881SerAsp: 4.881 ± 0.051	4.254SerGlu: 4.254 ± 0.044	2.506SerPhe: 2.506 ± 0.033	5.291SerGly: 5.291 ± 0.046	2.377SerHis: 2.377 ± 0.034	3.551SerIle: 3.551 ± 0.032	4.52SerLys: 4.52 ± 0.049	7.13SerLeu: 7.13 ± 0.067	1.479SerMet: 1.479 ± 0.027	3.279SerAsn: 3.279 ± 0.03	3.971SerPro: 3.971 ± 0.046	2.992SerGln: 2.992 ± 0.037	3.799SerArg: 3.799 ± 0.053	6.613SerSer: 6.613 ± 0.084	4.662SerThr: 4.662 ± 0.046	4.982SerVal: 4.982 ± 0.048	0.765SerTrp: 0.765 ± 0.021	1.88SerTyr: 1.88 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	4.572ThrAla: 4.572 ± 0.041	1.225ThrCys: 1.225 ± 0.025	3.308ThrAsp: 3.308 ± 0.042	3.389ThrGlu: 3.389 ± 0.035	2.168ThrPhe: 2.168 ± 0.026	3.588ThrGly: 3.588 ± 0.041	1.544ThrHis: 1.544 ± 0.035	2.682ThrIle: 2.682 ± 0.034	3.45ThrLys: 3.45 ± 0.043	5.91ThrLeu: 5.91 ± 0.046	1.015ThrMet: 1.015 ± 0.018	2.31ThrAsn: 2.31 ± 0.031	3.168ThrPro: 3.168 ± 0.046	2.296ThrGln: 2.296 ± 0.032	2.384ThrArg: 2.384 ± 0.031	4.251ThrSer: 4.251 ± 0.036	3.426ThrThr: 3.426 ± 0.051	3.573ThrVal: 3.573 ± 0.037	0.503ThrTrp: 0.503 ± 0.011	1.651ThrTyr: 1.651 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	4.765ValAla: 4.765 ± 0.05	1.272ValCys: 1.272 ± 0.022	4.626ValAsp: 4.626 ± 0.051	4.649ValGlu: 4.649 ± 0.052	2.042ValPhe: 2.042 ± 0.033	4.062ValGly: 4.062 ± 0.048	1.714ValHis: 1.714 ± 0.038	2.935ValIle: 2.935 ± 0.038	4.979ValLys: 4.979 ± 0.066	5.812ValLeu: 5.812 ± 0.058	1.291ValMet: 1.291 ± 0.021	3.0ValAsn: 3.0 ± 0.034	2.883ValPro: 2.883 ± 0.049	2.378ValGln: 2.378 ± 0.033	3.517ValArg: 3.517 ± 0.041	5.045ValSer: 5.045 ± 0.049	4.008ValThr: 4.008 ± 0.041	4.456ValVal: 4.456 ± 0.065	0.471ValTrp: 0.471 ± 0.011	2.069ValTyr: 2.069 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.538TrpAla: 0.538 ± 0.012	0.187TrpCys: 0.187 ± 0.007	0.589TrpAsp: 0.589 ± 0.013	0.5TrpGlu: 0.5 ± 0.013	0.287TrpPhe: 0.287 ± 0.009	0.396TrpGly: 0.396 ± 0.017	0.258TrpHis: 0.258 ± 0.011	0.556TrpIle: 0.556 ± 0.014	0.637TrpLys: 0.637 ± 0.015	1.14TrpLeu: 1.14 ± 0.018	0.239TrpMet: 0.239 ± 0.009	0.471TrpAsn: 0.471 ± 0.012	0.298TrpPro: 0.298 ± 0.01	0.42TrpGln: 0.42 ± 0.012	0.653TrpArg: 0.653 ± 0.015	0.716TrpSer: 0.716 ± 0.016	0.503TrpThr: 0.503 ± 0.012	0.485TrpVal: 0.485 ± 0.012	0.091TrpTrp: 0.091 ± 0.005	0.312TrpTyr: 0.312 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.151TyrAla: 2.151 ± 0.027	0.52TyrCys: 0.52 ± 0.015	2.051TyrAsp: 2.051 ± 0.026	1.63TyrGlu: 1.63 ± 0.024	1.285TyrPhe: 1.285 ± 0.019	2.089TyrGly: 2.089 ± 0.03	0.722TyrHis: 0.722 ± 0.017	1.498TyrIle: 1.498 ± 0.024	1.627TyrLys: 1.627 ± 0.024	2.898TyrLeu: 2.898 ± 0.032	0.636TyrMet: 0.636 ± 0.019	1.637TyrAsn: 1.637 ± 0.026	1.141TyrPro: 1.141 ± 0.019	0.925TyrGln: 0.925 ± 0.017	1.713TyrArg: 1.713 ± 0.03	2.187TyrSer: 2.187 ± 0.029	1.53TyrThr: 1.53 ± 0.022	2.233TyrVal: 2.233 ± 0.026	0.208TyrTrp: 0.208 ± 0.007	1.099TyrTyr: 1.099 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5006 proteins (3226480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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