Amino acid dipepetide frequency for Culex quinquefasciatus (Southern house mosquito) (Culex pungens)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.398AlaAla: 7.398 ± 0.057	1.182AlaCys: 1.182 ± 0.018	3.425AlaAsp: 3.425 ± 0.025	4.393AlaGlu: 4.393 ± 0.029	2.403AlaPhe: 2.403 ± 0.018	4.751AlaGly: 4.751 ± 0.032	1.471AlaHis: 1.471 ± 0.014	3.596AlaIle: 3.596 ± 0.024	4.105AlaLys: 4.105 ± 0.028	6.024AlaLeu: 6.024 ± 0.037	1.608AlaMet: 1.608 ± 0.015	2.962AlaAsn: 2.962 ± 0.019	3.479AlaPro: 3.479 ± 0.033	2.622AlaGln: 2.622 ± 0.021	3.458AlaArg: 3.458 ± 0.025	5.474AlaSer: 5.474 ± 0.041	4.431AlaThr: 4.431 ± 0.031	4.806AlaVal: 4.806 ± 0.026	0.602AlaTrp: 0.602 ± 0.01	1.694AlaTyr: 1.694 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.236CysAla: 1.236 ± 0.016	0.554CysCys: 0.554 ± 0.01	1.207CysAsp: 1.207 ± 0.018	1.211CysGlu: 1.211 ± 0.017	0.906CysPhe: 0.906 ± 0.023	1.564CysGly: 1.564 ± 0.026	0.521CysHis: 0.521 ± 0.008	0.936CysIle: 0.936 ± 0.016	1.024CysLys: 1.024 ± 0.013	1.777CysLeu: 1.777 ± 0.019	0.393CysMet: 0.393 ± 0.007	0.894CysAsn: 0.894 ± 0.015	1.179CysPro: 1.179 ± 0.027	0.786CysGln: 0.786 ± 0.015	1.27CysArg: 1.27 ± 0.023	1.657CysSer: 1.657 ± 0.022	1.075CysThr: 1.075 ± 0.016	1.294CysVal: 1.294 ± 0.02	0.258CysTrp: 0.258 ± 0.006	0.625CysTyr: 0.625 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.28AspAla: 3.28 ± 0.022	1.075AspCys: 1.075 ± 0.016	3.985AspAsp: 3.985 ± 0.036	4.359AspGlu: 4.359 ± 0.031	2.274AspPhe: 2.274 ± 0.02	3.638AspGly: 3.638 ± 0.026	1.262AspHis: 1.262 ± 0.013	2.754AspIle: 2.754 ± 0.018	2.739AspLys: 2.739 ± 0.025	4.836AspLeu: 4.836 ± 0.026	1.16AspMet: 1.16 ± 0.013	2.129AspAsn: 2.129 ± 0.02	2.67AspPro: 2.67 ± 0.025	2.042AspGln: 2.042 ± 0.016	2.963AspArg: 2.963 ± 0.023	4.052AspSer: 4.052 ± 0.027	2.384AspThr: 2.384 ± 0.019	3.469AspVal: 3.469 ± 0.022	0.627AspTrp: 0.627 ± 0.011	1.752AspTyr: 1.752 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.264GluAla: 4.264 ± 0.033	1.265GluCys: 1.265 ± 0.024	4.058GluAsp: 4.058 ± 0.029	5.867GluGlu: 5.867 ± 0.059	2.347GluPhe: 2.347 ± 0.018	3.183GluGly: 3.183 ± 0.025	1.501GluHis: 1.501 ± 0.014	3.43GluIle: 3.43 ± 0.026	4.297GluLys: 4.297 ± 0.036	6.07GluLeu: 6.07 ± 0.03	1.594GluMet: 1.594 ± 0.015	2.929GluAsn: 2.929 ± 0.023	2.932GluPro: 2.932 ± 0.027	3.128GluGln: 3.128 ± 0.03	3.841GluArg: 3.841 ± 0.029	4.436GluSer: 4.436 ± 0.036	3.249GluThr: 3.249 ± 0.025	3.969GluVal: 3.969 ± 0.026	0.605GluTrp: 0.605 ± 0.011	1.84GluTyr: 1.84 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.477PheAla: 2.477 ± 0.018	0.889PheCys: 0.889 ± 0.01	2.237PheAsp: 2.237 ± 0.019	2.382PheGlu: 2.382 ± 0.017	1.692PhePhe: 1.692 ± 0.019	2.696PheGly: 2.696 ± 0.021	0.985PheHis: 0.985 ± 0.012	1.948PheIle: 1.948 ± 0.018	2.238PheLys: 2.238 ± 0.025	3.596PheLeu: 3.596 ± 0.025	1.029PheMet: 1.029 ± 0.023	1.887PheAsn: 1.887 ± 0.017	1.79PhePro: 1.79 ± 0.017	1.566PheGln: 1.566 ± 0.015	2.337PheArg: 2.337 ± 0.018	2.891PheSer: 2.891 ± 0.02	2.086PheThr: 2.086 ± 0.019	2.746PheVal: 2.746 ± 0.023	0.525PheTrp: 0.525 ± 0.011	1.48PheTyr: 1.48 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.102GlyAla: 4.102 ± 0.029	1.138GlyCys: 1.138 ± 0.017	3.104GlyAsp: 3.104 ± 0.025	3.444GlyGlu: 3.444 ± 0.026	2.481GlyPhe: 2.481 ± 0.02	6.46GlyGly: 6.46 ± 0.061	1.607GlyHis: 1.607 ± 0.015	2.934GlyIle: 2.934 ± 0.023	3.488GlyLys: 3.488 ± 0.026	4.794GlyLeu: 4.794 ± 0.034	1.382GlyMet: 1.382 ± 0.015	2.665GlyAsn: 2.665 ± 0.024	2.659GlyPro: 2.659 ± 0.03	2.403GlyGln: 2.403 ± 0.021	3.361GlyArg: 3.361 ± 0.028	5.467GlySer: 5.467 ± 0.035	3.645GlyThr: 3.645 ± 0.026	3.763GlyVal: 3.763 ± 0.024	0.739GlyTrp: 0.739 ± 0.01	1.908GlyTyr: 1.908 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.386HisAla: 1.386 ± 0.013	0.589HisCys: 0.589 ± 0.009	1.121HisAsp: 1.121 ± 0.01	1.383HisGlu: 1.383 ± 0.015	1.067HisPhe: 1.067 ± 0.013	1.499HisGly: 1.499 ± 0.015	1.395HisHis: 1.395 ± 0.026	1.21HisIle: 1.21 ± 0.013	1.236HisLys: 1.236 ± 0.013	2.421HisLeu: 2.421 ± 0.021	0.62HisMet: 0.62 ± 0.009	1.068HisAsn: 1.068 ± 0.013	1.472HisPro: 1.472 ± 0.015	1.432HisGln: 1.432 ± 0.019	1.592HisArg: 1.592 ± 0.015	1.853HisSer: 1.853 ± 0.017	1.219HisThr: 1.219 ± 0.013	1.553HisVal: 1.553 ± 0.015	0.285HisTrp: 0.285 ± 0.005	0.846HisTyr: 0.846 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.528IleAla: 3.528 ± 0.023	1.274IleCys: 1.274 ± 0.018	2.785IleAsp: 2.785 ± 0.02	3.175IleGlu: 3.175 ± 0.021	2.247IlePhe: 2.247 ± 0.025	2.821IleGly: 2.821 ± 0.022	1.216IleHis: 1.216 ± 0.013	2.594IleIle: 2.594 ± 0.023	2.889IleLys: 2.889 ± 0.021	4.471IleLeu: 4.471 ± 0.03	1.091IleMet: 1.091 ± 0.012	2.393IleAsn: 2.393 ± 0.022	2.791IlePro: 2.791 ± 0.021	2.071IleGln: 2.071 ± 0.022	2.904IleArg: 2.904 ± 0.021	3.772IleSer: 3.772 ± 0.026	2.854IleThr: 2.854 ± 0.024	3.599IleVal: 3.599 ± 0.025	0.535IleTrp: 0.535 ± 0.01	1.578IleTyr: 1.578 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.59LysAla: 3.59 ± 0.026	1.25LysCys: 1.25 ± 0.019	2.91LysAsp: 2.91 ± 0.023	3.874LysGlu: 3.874 ± 0.033	2.182LysPhe: 2.182 ± 0.017	2.564LysGly: 2.564 ± 0.027	1.499LysHis: 1.499 ± 0.017	3.249LysIle: 3.249 ± 0.023	4.563LysLys: 4.563 ± 0.045	5.614LysLeu: 5.614 ± 0.032	1.466LysMet: 1.466 ± 0.014	2.627LysAsn: 2.627 ± 0.025	3.124LysPro: 3.124 ± 0.03	2.748LysGln: 2.748 ± 0.025	3.67LysArg: 3.67 ± 0.028	4.441LysSer: 4.441 ± 0.035	3.257LysThr: 3.257 ± 0.028	3.598LysVal: 3.598 ± 0.025	0.577LysTrp: 0.577 ± 0.009	1.85LysTyr: 1.85 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	6.588LeuAla: 6.588 ± 0.037	1.795LeuCys: 1.795 ± 0.026	4.905LeuAsp: 4.905 ± 0.03	6.045LeuGlu: 6.045 ± 0.042	3.432LeuPhe: 3.432 ± 0.027	4.799LeuGly: 4.799 ± 0.031	2.237LeuHis: 2.237 ± 0.021	4.266LeuIle: 4.266 ± 0.025	5.619LeuLys: 5.619 ± 0.032	8.768LeuLeu: 8.768 ± 0.051	2.036LeuMet: 2.036 ± 0.017	4.259LeuAsn: 4.259 ± 0.025	4.683LeuPro: 4.683 ± 0.029	4.472LeuGln: 4.472 ± 0.031	5.325LeuArg: 5.325 ± 0.034	6.396LeuSer: 6.396 ± 0.032	4.881LeuThr: 4.881 ± 0.027	5.758LeuVal: 5.758 ± 0.034	0.923LeuTrp: 0.923 ± 0.013	2.543LeuTyr: 2.543 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	1.792MetAla: 1.792 ± 0.014	0.418MetCys: 0.418 ± 0.008	1.32MetAsp: 1.32 ± 0.013	1.449MetGlu: 1.449 ± 0.014	1.073MetPhe: 1.073 ± 0.025	1.198MetGly: 1.198 ± 0.015	0.539MetHis: 0.539 ± 0.008	1.211MetIle: 1.211 ± 0.012	1.428MetLys: 1.428 ± 0.014	2.144MetLeu: 2.144 ± 0.019	0.704MetMet: 0.704 ± 0.011	1.068MetAsn: 1.068 ± 0.012	1.08MetPro: 1.08 ± 0.013	0.948MetGln: 0.948 ± 0.013	1.209MetArg: 1.209 ± 0.013	1.702MetSer: 1.702 ± 0.016	1.288MetThr: 1.288 ± 0.013	1.461MetVal: 1.461 ± 0.015	0.229MetTrp: 0.229 ± 0.005	0.662MetTyr: 0.662 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.915AsnAla: 2.915 ± 0.023	0.963AsnCys: 0.963 ± 0.014	2.288AsnAsp: 2.288 ± 0.018	2.677AsnGlu: 2.677 ± 0.021	1.889AsnPhe: 1.889 ± 0.016	3.284AsnGly: 3.284 ± 0.033	1.183AsnHis: 1.183 ± 0.015	2.382AsnIle: 2.382 ± 0.019	2.311AsnLys: 2.311 ± 0.027	4.424AsnLeu: 4.424 ± 0.032	1.024AsnMet: 1.024 ± 0.01	2.813AsnAsn: 2.813 ± 0.033	2.406AsnPro: 2.406 ± 0.02	1.948AsnGln: 1.948 ± 0.022	2.616AsnArg: 2.616 ± 0.02	3.663AsnSer: 3.663 ± 0.029	2.186AsnThr: 2.186 ± 0.018	3.053AsnVal: 3.053 ± 0.02	0.502AsnTrp: 0.502 ± 0.009	1.506AsnTyr: 1.506 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	4.28ProAla: 4.28 ± 0.035	0.785ProCys: 0.785 ± 0.027	2.646ProAsp: 2.646 ± 0.023	3.725ProGlu: 3.725 ± 0.037	1.838ProPhe: 1.838 ± 0.016	3.082ProGly: 3.082 ± 0.036	1.12ProHis: 1.12 ± 0.016	2.4ProIle: 2.4 ± 0.02	3.11ProLys: 3.11 ± 0.028	4.051ProLeu: 4.051 ± 0.023	1.075ProMet: 1.075 ± 0.013	2.324ProAsn: 2.324 ± 0.021	4.463ProPro: 4.463 ± 0.057	2.334ProGln: 2.334 ± 0.028	2.58ProArg: 2.58 ± 0.023	4.37ProSer: 4.37 ± 0.032	3.386ProThr: 3.386 ± 0.029	3.738ProVal: 3.738 ± 0.032	0.489ProTrp: 0.489 ± 0.008	1.442ProTyr: 1.442 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	2.612GlnAla: 2.612 ± 0.021	0.871GlnCys: 0.871 ± 0.016	1.934GlnAsp: 1.934 ± 0.016	2.818GlnGlu: 2.818 ± 0.035	1.666GlnPhe: 1.666 ± 0.017	1.865GlnGly: 1.865 ± 0.017	1.486GlnHis: 1.486 ± 0.019	2.454GlnIle: 2.454 ± 0.026	2.52GlnLys: 2.52 ± 0.029	4.464GlnLeu: 4.464 ± 0.029	1.092GlnMet: 1.092 ± 0.014	2.062GlnAsn: 2.062 ± 0.021	2.526GlnPro: 2.526 ± 0.029	4.946GlnGln: 4.946 ± 0.084	2.617GlnArg: 2.617 ± 0.018	2.994GlnSer: 2.994 ± 0.024	2.295GlnThr: 2.295 ± 0.02	2.453GlnVal: 2.453 ± 0.02	0.428GlnTrp: 0.428 ± 0.007	1.334GlnTyr: 1.334 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	3.342ArgAla: 3.342 ± 0.023	1.259ArgCys: 1.259 ± 0.021	2.868ArgAsp: 2.868 ± 0.022	3.499ArgGlu: 3.499 ± 0.023	2.466ArgPhe: 2.466 ± 0.018	3.001ArgGly: 3.001 ± 0.024	1.552ArgHis: 1.552 ± 0.017	2.95ArgIle: 2.95 ± 0.018	4.003ArgLys: 4.003 ± 0.028	4.984ArgLeu: 4.984 ± 0.034	1.371ArgMet: 1.371 ± 0.015	2.906ArgAsn: 2.906 ± 0.024	2.749ArgPro: 2.749 ± 0.035	2.489ArgGln: 2.489 ± 0.019	4.244ArgArg: 4.244 ± 0.03	4.361ArgSer: 4.361 ± 0.035	3.083ArgThr: 3.083 ± 0.023	3.213ArgVal: 3.213 ± 0.027	0.692ArgTrp: 0.692 ± 0.01	1.815ArgTyr: 1.815 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	5.499SerAla: 5.499 ± 0.032	1.539SerCys: 1.539 ± 0.022	4.025SerAsp: 4.025 ± 0.028	4.382SerGlu: 4.382 ± 0.033	2.987SerPhe: 2.987 ± 0.022	5.449SerGly: 5.449 ± 0.032	1.715SerHis: 1.715 ± 0.016	3.721SerIle: 3.721 ± 0.022	4.18SerLys: 4.18 ± 0.032	6.497SerLeu: 6.497 ± 0.037	1.646SerMet: 1.646 ± 0.016	3.751SerAsn: 3.751 ± 0.033	4.33SerPro: 4.33 ± 0.038	2.919SerGln: 2.919 ± 0.028	4.12SerArg: 4.12 ± 0.034	9.503SerSer: 9.503 ± 0.088	5.101SerThr: 5.101 ± 0.039	4.804SerVal: 4.804 ± 0.029	0.817SerTrp: 0.817 ± 0.011	2.25SerTyr: 2.25 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	4.333ThrAla: 4.333 ± 0.029	1.134ThrCys: 1.134 ± 0.019	2.657ThrAsp: 2.657 ± 0.018	3.299ThrGlu: 3.299 ± 0.037	2.2ThrPhe: 2.2 ± 0.02	3.498ThrGly: 3.498 ± 0.027	1.219ThrHis: 1.219 ± 0.012	3.174ThrIle: 3.174 ± 0.022	3.023ThrLys: 3.023 ± 0.025	5.031ThrLeu: 5.031 ± 0.033	1.247ThrMet: 1.247 ± 0.012	2.54ThrAsn: 2.54 ± 0.02	3.465ThrPro: 3.465 ± 0.032	1.924ThrGln: 1.924 ± 0.015	2.731ThrArg: 2.731 ± 0.02	4.868ThrSer: 4.868 ± 0.041	4.727ThrThr: 4.727 ± 0.058	4.139ThrVal: 4.139 ± 0.031	0.531ThrTrp: 0.531 ± 0.009	1.481ThrTyr: 1.481 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	4.872ValAla: 4.872 ± 0.027	1.453ValCys: 1.453 ± 0.019	3.63ValAsp: 3.63 ± 0.022	4.364ValGlu: 4.364 ± 0.034	2.502ValPhe: 2.502 ± 0.021	3.667ValGly: 3.667 ± 0.024	1.605ValHis: 1.605 ± 0.016	3.297ValIle: 3.297 ± 0.025	3.669ValLys: 3.669 ± 0.024	6.001ValLeu: 6.001 ± 0.041	1.431ValMet: 1.431 ± 0.013	2.68ValAsn: 2.68 ± 0.025	3.611ValPro: 3.611 ± 0.028	2.893ValGln: 2.893 ± 0.024	3.474ValArg: 3.474 ± 0.023	4.381ValSer: 4.381 ± 0.026	3.877ValThr: 3.877 ± 0.035	4.781ValVal: 4.781 ± 0.032	0.68ValTrp: 0.68 ± 0.01	1.841ValTyr: 1.841 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.561TrpAla: 0.561 ± 0.01	0.212TrpCys: 0.212 ± 0.005	0.577TrpAsp: 0.577 ± 0.01	0.58TrpGlu: 0.58 ± 0.009	0.478TrpPhe: 0.478 ± 0.011	0.564TrpGly: 0.564 ± 0.011	0.279TrpHis: 0.279 ± 0.006	0.673TrpIle: 0.673 ± 0.01	0.676TrpLys: 0.676 ± 0.012	0.987TrpLeu: 0.987 ± 0.011	0.308TrpMet: 0.308 ± 0.006	0.618TrpAsn: 0.618 ± 0.009	0.463TrpPro: 0.463 ± 0.009	0.423TrpGln: 0.423 ± 0.007	0.688TrpArg: 0.688 ± 0.009	0.773TrpSer: 0.773 ± 0.012	0.648TrpThr: 0.648 ± 0.011	0.558TrpVal: 0.558 ± 0.009	0.182TrpTrp: 0.182 ± 0.005	0.343TrpTyr: 0.343 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.827TyrAla: 1.827 ± 0.015	0.721TyrCys: 0.721 ± 0.013	1.769TyrAsp: 1.769 ± 0.018	1.876TyrGlu: 1.876 ± 0.016	1.346TyrPhe: 1.346 ± 0.014	1.962TyrGly: 1.962 ± 0.02	0.854TyrHis: 0.854 ± 0.01	1.407TyrIle: 1.407 ± 0.015	1.534TyrLys: 1.534 ± 0.015	2.779TyrLeu: 2.779 ± 0.02	0.644TyrMet: 0.644 ± 0.01	1.463TyrAsn: 1.463 ± 0.016	1.364TyrPro: 1.364 ± 0.016	1.342TyrGln: 1.342 ± 0.016	1.848TyrArg: 1.848 ± 0.017	2.182TyrSer: 2.182 ± 0.021	1.552TyrThr: 1.552 ± 0.014	1.956TyrVal: 1.956 ± 0.026	0.366TyrTrp: 0.366 ± 0.008	1.187TyrTyr: 1.187 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.024XaaXaa: 0.024 ± 0.013

Statistics based on 19204 proteins (8459113 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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