Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-3557

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.792AlaAla: 9.792 ± 0.073	1.059AlaCys: 1.059 ± 0.018	4.42AlaAsp: 4.42 ± 0.03	5.428AlaGlu: 5.428 ± 0.043	3.128AlaPhe: 3.128 ± 0.031	6.165AlaGly: 6.165 ± 0.045	1.714AlaHis: 1.714 ± 0.021	4.608AlaIle: 4.608 ± 0.037	4.563AlaLys: 4.563 ± 0.046	7.841AlaLeu: 7.841 ± 0.046	1.993AlaMet: 1.993 ± 0.023	3.114AlaAsn: 3.114 ± 0.025	5.105AlaPro: 5.105 ± 0.05	3.426AlaGln: 3.426 ± 0.031	4.761AlaArg: 4.761 ± 0.04	7.194AlaSer: 7.194 ± 0.048	5.6AlaThr: 5.6 ± 0.036	5.535AlaVal: 5.535 ± 0.038	1.134AlaTrp: 1.134 ± 0.019	2.224AlaTyr: 2.224 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.946CysAla: 0.946 ± 0.017	0.264CysCys: 0.264 ± 0.01	0.656CysAsp: 0.656 ± 0.015	0.611CysGlu: 0.611 ± 0.013	0.517CysPhe: 0.517 ± 0.01	1.005CysGly: 1.005 ± 0.018	0.32CysHis: 0.32 ± 0.009	0.709CysIle: 0.709 ± 0.013	0.523CysLys: 0.523 ± 0.012	1.153CysLeu: 1.153 ± 0.017	0.273CysMet: 0.273 ± 0.008	0.437CysAsn: 0.437 ± 0.01	0.628CysPro: 0.628 ± 0.016	0.421CysGln: 0.421 ± 0.01	0.696CysArg: 0.696 ± 0.013	0.89CysSer: 0.89 ± 0.016	0.712CysThr: 0.712 ± 0.013	0.764CysVal: 0.764 ± 0.013	0.195CysTrp: 0.195 ± 0.006	0.369CysTyr: 0.369 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.863AspAla: 4.863 ± 0.038	0.62AspCys: 0.62 ± 0.012	4.248AspAsp: 4.248 ± 0.051	4.56AspGlu: 4.56 ± 0.045	2.215AspPhe: 2.215 ± 0.022	4.215AspGly: 4.215 ± 0.036	1.102AspHis: 1.102 ± 0.016	3.238AspIle: 3.238 ± 0.03	2.505AspLys: 2.505 ± 0.025	4.901AspLeu: 4.901 ± 0.031	1.269AspMet: 1.269 ± 0.016	2.045AspAsn: 2.045 ± 0.023	3.048AspPro: 3.048 ± 0.027	1.733AspGln: 1.733 ± 0.02	2.817AspArg: 2.817 ± 0.025	4.171AspSer: 4.171 ± 0.033	3.033AspThr: 3.033 ± 0.028	3.688AspVal: 3.688 ± 0.033	0.841AspTrp: 0.841 ± 0.014	1.626AspTyr: 1.626 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.748GluAla: 5.748 ± 0.044	0.625GluCys: 0.625 ± 0.011	4.209GluAsp: 4.209 ± 0.045	5.77GluGlu: 5.77 ± 0.068	1.988GluPhe: 1.988 ± 0.02	4.191GluGly: 4.191 ± 0.036	1.271GluHis: 1.271 ± 0.019	3.21GluIle: 3.21 ± 0.03	3.837GluLys: 3.837 ± 0.044	5.237GluLeu: 5.237 ± 0.043	1.512GluMet: 1.512 ± 0.021	2.334GluAsn: 2.334 ± 0.025	2.7GluPro: 2.7 ± 0.034	2.341GluGln: 2.341 ± 0.032	3.905GluArg: 3.905 ± 0.04	4.348GluSer: 4.348 ± 0.038	3.439GluThr: 3.439 ± 0.03	3.802GluVal: 3.802 ± 0.032	0.884GluTrp: 0.884 ± 0.014	1.723GluTyr: 1.723 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.085PheAla: 3.085 ± 0.032	0.543PheCys: 0.543 ± 0.012	2.219PheAsp: 2.219 ± 0.024	2.202PheGlu: 2.202 ± 0.024	1.545PhePhe: 1.545 ± 0.024	2.916PheGly: 2.916 ± 0.029	0.825PheHis: 0.825 ± 0.013	1.877PheIle: 1.877 ± 0.025	1.635PheLys: 1.635 ± 0.02	3.268PheLeu: 3.268 ± 0.032	0.785PheMet: 0.785 ± 0.014	1.457PheAsn: 1.457 ± 0.019	1.838PhePro: 1.838 ± 0.019	1.36PheGln: 1.36 ± 0.018	1.797PheArg: 1.797 ± 0.021	2.895PheSer: 2.895 ± 0.025	2.15PheThr: 2.15 ± 0.022	2.365PheVal: 2.365 ± 0.024	0.614PheTrp: 0.614 ± 0.013	1.114PheTyr: 1.114 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.875GlyAla: 5.875 ± 0.049	0.903GlyCys: 0.903 ± 0.017	3.891GlyAsp: 3.891 ± 0.031	4.036GlyGlu: 4.036 ± 0.031	2.825GlyPhe: 2.825 ± 0.031	6.577GlyGly: 6.577 ± 0.069	1.637GlyHis: 1.637 ± 0.022	3.691GlyIle: 3.691 ± 0.03	3.832GlyLys: 3.832 ± 0.033	6.092GlyLeu: 6.092 ± 0.04	1.67GlyMet: 1.67 ± 0.022	2.75GlyAsn: 2.75 ± 0.028	3.293GlyPro: 3.293 ± 0.03	2.574GlyGln: 2.574 ± 0.031	4.094GlyArg: 4.094 ± 0.034	5.823GlySer: 5.823 ± 0.047	4.148GlyThr: 4.148 ± 0.037	4.605GlyVal: 4.605 ± 0.037	1.188GlyTrp: 1.188 ± 0.017	2.191GlyTyr: 2.191 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.733HisAla: 1.733 ± 0.02	0.308HisCys: 0.308 ± 0.009	1.21HisAsp: 1.21 ± 0.016	1.226HisGlu: 1.226 ± 0.017	0.868HisPhe: 0.868 ± 0.014	1.663HisGly: 1.663 ± 0.021	0.74HisHis: 0.74 ± 0.016	1.236HisIle: 1.236 ± 0.015	0.926HisLys: 0.926 ± 0.014	2.071HisLeu: 2.071 ± 0.022	0.455HisMet: 0.455 ± 0.009	0.86HisAsn: 0.86 ± 0.015	1.516HisPro: 1.516 ± 0.019	0.897HisGln: 0.897 ± 0.016	1.356HisArg: 1.356 ± 0.018	1.69HisSer: 1.69 ± 0.025	1.251HisThr: 1.251 ± 0.018	1.33HisVal: 1.33 ± 0.017	0.316HisTrp: 0.316 ± 0.009	0.674HisTyr: 0.674 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.504IleAla: 4.504 ± 0.037	0.756IleCys: 0.756 ± 0.014	2.996IleAsp: 2.996 ± 0.029	3.045IleGlu: 3.045 ± 0.028	2.053IlePhe: 2.053 ± 0.025	3.386IleGly: 3.386 ± 0.037	1.141IleHis: 1.141 ± 0.017	2.78IleIle: 2.78 ± 0.03	2.429IleLys: 2.429 ± 0.027	4.596IleLeu: 4.596 ± 0.04	1.096IleMet: 1.096 ± 0.015	1.969IleAsn: 1.969 ± 0.024	3.073IlePro: 3.073 ± 0.027	1.902IleGln: 1.902 ± 0.018	2.713IleArg: 2.713 ± 0.023	4.103IleSer: 4.103 ± 0.032	3.098IleThr: 3.098 ± 0.033	3.268IleVal: 3.268 ± 0.027	0.727IleTrp: 0.727 ± 0.013	1.489IleTyr: 1.489 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.668LysAla: 4.668 ± 0.031	0.534LysCys: 0.534 ± 0.012	2.912LysAsp: 2.912 ± 0.03	3.668LysGlu: 3.668 ± 0.038	1.579LysPhe: 1.579 ± 0.021	3.313LysGly: 3.313 ± 0.029	1.121LysHis: 1.121 ± 0.016	2.432LysIle: 2.432 ± 0.026	3.57LysLys: 3.57 ± 0.052	4.269LysLeu: 4.269 ± 0.034	1.076LysMet: 1.076 ± 0.016	1.847LysAsn: 1.847 ± 0.022	2.81LysPro: 2.81 ± 0.033	1.829LysGln: 1.829 ± 0.023	3.388LysArg: 3.388 ± 0.036	3.769LysSer: 3.769 ± 0.032	2.939LysThr: 2.939 ± 0.025	3.073LysVal: 3.073 ± 0.026	0.716LysTrp: 0.716 ± 0.013	1.435LysTyr: 1.435 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.792LeuAla: 7.792 ± 0.045	1.135LeuCys: 1.135 ± 0.018	4.993LeuAsp: 4.993 ± 0.034	5.485LeuGlu: 5.485 ± 0.046	3.214LeuPhe: 3.214 ± 0.033	5.977LeuGly: 5.977 ± 0.042	2.089LeuHis: 2.089 ± 0.022	4.065LeuIle: 4.065 ± 0.035	4.378LeuLys: 4.378 ± 0.036	8.228LeuLeu: 8.228 ± 0.071	1.719LeuMet: 1.719 ± 0.018	3.135LeuAsn: 3.135 ± 0.026	5.372LeuPro: 5.372 ± 0.041	3.717LeuGln: 3.717 ± 0.033	5.359LeuArg: 5.359 ± 0.039	7.168LeuSer: 7.168 ± 0.041	4.786LeuThr: 4.786 ± 0.031	5.278LeuVal: 5.278 ± 0.041	1.166LeuTrp: 1.166 ± 0.017	2.341LeuTyr: 2.341 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.24MetAla: 2.24 ± 0.024	0.229MetCys: 0.229 ± 0.008	1.262MetAsp: 1.262 ± 0.018	1.343MetGlu: 1.343 ± 0.019	0.745MetPhe: 0.745 ± 0.013	1.547MetGly: 1.547 ± 0.023	0.486MetHis: 0.486 ± 0.011	1.008MetIle: 1.008 ± 0.015	1.076MetLys: 1.076 ± 0.016	1.804MetLeu: 1.804 ± 0.019	0.574MetMet: 0.574 ± 0.013	0.779MetAsn: 0.779 ± 0.014	1.223MetPro: 1.223 ± 0.016	0.822MetGln: 0.822 ± 0.014	1.248MetArg: 1.248 ± 0.017	1.831MetSer: 1.831 ± 0.023	1.244MetThr: 1.244 ± 0.017	1.343MetVal: 1.343 ± 0.019	0.257MetTrp: 0.257 ± 0.008	0.519MetTyr: 0.519 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.248AsnAla: 3.248 ± 0.026	0.468AsnCys: 0.468 ± 0.01	2.012AsnAsp: 2.012 ± 0.022	2.097AsnGlu: 2.097 ± 0.02	1.434AsnPhe: 1.434 ± 0.018	3.21AsnGly: 3.21 ± 0.031	0.842AsnHis: 0.842 ± 0.014	2.22AsnIle: 2.22 ± 0.022	1.634AsnLys: 1.634 ± 0.019	3.216AsnLeu: 3.216 ± 0.028	0.865AsnMet: 0.865 ± 0.012	1.609AsnAsn: 1.609 ± 0.025	2.412AsnPro: 2.412 ± 0.022	1.323AsnGln: 1.323 ± 0.019	1.937AsnArg: 1.937 ± 0.02	2.991AsnSer: 2.991 ± 0.03	2.279AsnThr: 2.279 ± 0.025	2.316AsnVal: 2.316 ± 0.025	0.544AsnTrp: 0.544 ± 0.011	1.143AsnTyr: 1.143 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.205ProAla: 5.205 ± 0.046	0.488ProCys: 0.488 ± 0.011	2.971ProAsp: 2.971 ± 0.029	3.657ProGlu: 3.657 ± 0.037	1.931ProPhe: 1.931 ± 0.023	3.847ProGly: 3.847 ± 0.037	1.237ProHis: 1.237 ± 0.021	2.593ProIle: 2.593 ± 0.025	2.834ProLys: 2.834 ± 0.027	4.655ProLeu: 4.655 ± 0.039	1.032ProMet: 1.032 ± 0.015	2.236ProAsn: 2.236 ± 0.023	4.745ProPro: 4.745 ± 0.065	2.376ProGln: 2.376 ± 0.037	3.218ProArg: 3.218 ± 0.034	5.678ProSer: 5.678 ± 0.05	4.165ProThr: 4.165 ± 0.041	3.483ProVal: 3.483 ± 0.033	0.711ProTrp: 0.711 ± 0.014	1.494ProTyr: 1.494 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.321GlnAla: 3.321 ± 0.033	0.424GlnCys: 0.424 ± 0.011	1.968GlnAsp: 1.968 ± 0.022	2.273GlnGlu: 2.273 ± 0.031	1.255GlnPhe: 1.255 ± 0.016	2.491GlnGly: 2.491 ± 0.024	0.959GlnHis: 0.959 ± 0.016	1.896GlnIle: 1.896 ± 0.02	1.998GlnLys: 1.998 ± 0.025	3.395GlnLeu: 3.395 ± 0.03	0.84GlnMet: 0.84 ± 0.016	1.581GlnAsn: 1.581 ± 0.019	2.38GlnPro: 2.38 ± 0.037	2.383GlnGln: 2.383 ± 0.053	2.467GlnArg: 2.467 ± 0.025	2.99GlnSer: 2.99 ± 0.035	2.237GlnThr: 2.237 ± 0.026	2.059GlnVal: 2.059 ± 0.021	0.554GlnTrp: 0.554 ± 0.013	1.179GlnTyr: 1.179 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.65ArgAla: 4.65 ± 0.031	0.679ArgCys: 0.679 ± 0.013	3.222ArgAsp: 3.222 ± 0.028	3.773ArgGlu: 3.773 ± 0.041	1.954ArgPhe: 1.954 ± 0.022	3.814ArgGly: 3.814 ± 0.035	1.425ArgHis: 1.425 ± 0.018	2.839ArgIle: 2.839 ± 0.024	3.367ArgLys: 3.367 ± 0.033	5.018ArgLeu: 5.018 ± 0.036	1.222ArgMet: 1.222 ± 0.017	2.184ArgAsn: 2.184 ± 0.023	3.199ArgPro: 3.199 ± 0.036	2.481ArgGln: 2.481 ± 0.03	4.714ArgArg: 4.714 ± 0.049	4.413ArgSer: 4.413 ± 0.044	3.137ArgThr: 3.137 ± 0.025	3.231ArgVal: 3.231 ± 0.03	0.828ArgTrp: 0.828 ± 0.013	1.536ArgTyr: 1.536 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.702SerAla: 6.702 ± 0.053	0.893SerCys: 0.893 ± 0.016	4.249SerAsp: 4.249 ± 0.044	4.173SerGlu: 4.173 ± 0.034	2.942SerPhe: 2.942 ± 0.024	5.749SerGly: 5.749 ± 0.042	1.837SerHis: 1.837 ± 0.02	4.187SerIle: 4.187 ± 0.033	3.958SerLys: 3.958 ± 0.03	7.068SerLeu: 7.068 ± 0.043	1.667SerMet: 1.667 ± 0.019	3.144SerAsn: 3.144 ± 0.03	5.299SerPro: 5.299 ± 0.054	3.15SerGln: 3.15 ± 0.033	4.599SerArg: 4.599 ± 0.041	8.176SerSer: 8.176 ± 0.069	5.623SerThr: 5.623 ± 0.041	4.522SerVal: 4.522 ± 0.037	1.077SerTrp: 1.077 ± 0.016	2.099SerTyr: 2.099 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.428ThrAla: 5.428 ± 0.038	0.754ThrCys: 0.754 ± 0.012	2.944ThrAsp: 2.944 ± 0.027	3.254ThrGlu: 3.254 ± 0.028	2.229ThrPhe: 2.229 ± 0.025	4.289ThrGly: 4.289 ± 0.036	1.255ThrHis: 1.255 ± 0.018	3.246ThrIle: 3.246 ± 0.03	2.809ThrLys: 2.809 ± 0.023	5.23ThrLeu: 5.23 ± 0.04	1.247ThrMet: 1.247 ± 0.016	2.223ThrAsn: 2.223 ± 0.024	4.4ThrPro: 4.4 ± 0.041	2.082ThrGln: 2.082 ± 0.025	2.981ThrArg: 2.981 ± 0.028	5.34ThrSer: 5.34 ± 0.042	4.554ThrThr: 4.554 ± 0.043	3.743ThrVal: 3.743 ± 0.03	0.851ThrTrp: 0.851 ± 0.015	1.646ThrTyr: 1.646 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.645ValAla: 5.645 ± 0.036	0.786ValCys: 0.786 ± 0.015	3.796ValAsp: 3.796 ± 0.032	4.049ValGlu: 4.049 ± 0.036	2.348ValPhe: 2.348 ± 0.026	4.241ValGly: 4.241 ± 0.034	1.273ValHis: 1.273 ± 0.017	3.07ValIle: 3.07 ± 0.027	3.092ValLys: 3.092 ± 0.031	5.499ValLeu: 5.499 ± 0.038	1.331ValMet: 1.331 ± 0.021	2.253ValAsn: 2.253 ± 0.025	3.46ValPro: 3.46 ± 0.031	2.212ValGln: 2.212 ± 0.021	3.238ValArg: 3.238 ± 0.026	4.5ValSer: 4.5 ± 0.032	3.54ValThr: 3.54 ± 0.035	4.479ValVal: 4.479 ± 0.037	0.861ValTrp: 0.861 ± 0.014	1.709ValTyr: 1.709 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.179TrpAla: 1.179 ± 0.021	0.196TrpCys: 0.196 ± 0.007	0.892TrpAsp: 0.892 ± 0.015	0.841TrpGlu: 0.841 ± 0.015	0.518TrpPhe: 0.518 ± 0.011	0.968TrpGly: 0.968 ± 0.016	0.329TrpHis: 0.329 ± 0.008	0.747TrpIle: 0.747 ± 0.012	0.779TrpLys: 0.779 ± 0.014	1.261TrpLeu: 1.261 ± 0.018	0.337TrpMet: 0.337 ± 0.008	0.616TrpAsn: 0.616 ± 0.012	0.596TrpPro: 0.596 ± 0.012	0.534TrpGln: 0.534 ± 0.01	0.874TrpArg: 0.874 ± 0.015	1.013TrpSer: 1.013 ± 0.016	0.894TrpThr: 0.894 ± 0.014	0.9TrpVal: 0.9 ± 0.015	0.266TrpTrp: 0.266 ± 0.009	0.414TrpTyr: 0.414 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.178TyrAla: 2.178 ± 0.027	0.426TyrCys: 0.426 ± 0.011	1.669TyrAsp: 1.669 ± 0.019	1.584TyrGlu: 1.584 ± 0.02	1.203TyrPhe: 1.203 ± 0.018	2.132TyrGly: 2.132 ± 0.029	0.721TyrHis: 0.721 ± 0.014	1.472TyrIle: 1.472 ± 0.018	1.205TyrLys: 1.205 ± 0.017	2.593TyrLeu: 2.593 ± 0.024	0.617TyrMet: 0.617 ± 0.012	1.223TyrAsn: 1.223 ± 0.018	1.463TyrPro: 1.463 ± 0.021	1.084TyrGln: 1.084 ± 0.016	1.526TyrArg: 1.526 ± 0.021	2.135TyrSer: 2.135 ± 0.026	1.674TyrThr: 1.674 ± 0.021	1.6TyrVal: 1.6 ± 0.017	0.423TyrTrp: 0.423 ± 0.01	0.954TyrTyr: 0.954 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9480 proteins (4561027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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