Amino acid dipepetide frequency for Nodularia spumigena CCY9414

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.277AlaAla: 7.277 ± 0.104	0.83AlaCys: 0.83 ± 0.022	3.927AlaAsp: 3.927 ± 0.069	5.38AlaGlu: 5.38 ± 0.066	2.787AlaPhe: 2.787 ± 0.044	5.336AlaGly: 5.336 ± 0.08	1.294AlaHis: 1.294 ± 0.029	6.603AlaIle: 6.603 ± 0.072	4.04AlaLys: 4.04 ± 0.06	8.157AlaLeu: 8.157 ± 0.1	1.675AlaMet: 1.675 ± 0.038	3.351AlaAsn: 3.351 ± 0.062	2.845AlaPro: 2.845 ± 0.046	4.131AlaGln: 4.131 ± 0.058	3.423AlaArg: 3.423 ± 0.055	4.632AlaSer: 4.632 ± 0.064	4.494AlaThr: 4.494 ± 0.067	5.525AlaVal: 5.525 ± 0.081	0.997AlaTrp: 0.997 ± 0.029	2.314AlaTyr: 2.314 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.621CysAla: 0.621 ± 0.02	0.178CysCys: 0.178 ± 0.011	0.557CysAsp: 0.557 ± 0.021	0.559CysGlu: 0.559 ± 0.018	0.435CysPhe: 0.435 ± 0.018	0.802CysGly: 0.802 ± 0.025	0.272CysHis: 0.272 ± 0.014	0.559CysIle: 0.559 ± 0.022	0.356CysLys: 0.356 ± 0.017	1.128CysLeu: 1.128 ± 0.028	0.167CysMet: 0.167 ± 0.012	0.402CysAsn: 0.402 ± 0.017	0.545CysPro: 0.545 ± 0.023	0.638CysGln: 0.638 ± 0.021	0.538CysArg: 0.538 ± 0.022	0.589CysSer: 0.589 ± 0.02	0.493CysThr: 0.493 ± 0.018	0.619CysVal: 0.619 ± 0.022	0.136CysTrp: 0.136 ± 0.009	0.349CysTyr: 0.349 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.568AspAla: 3.568 ± 0.051	0.502AspCys: 0.502 ± 0.02	2.094AspAsp: 2.094 ± 0.045	2.951AspGlu: 2.951 ± 0.048	2.378AspPhe: 2.378 ± 0.04	3.038AspGly: 3.038 ± 0.063	0.791AspHis: 0.791 ± 0.027	3.545AspIle: 3.545 ± 0.053	2.296AspLys: 2.296 ± 0.043	5.635AspLeu: 5.635 ± 0.078	0.817AspMet: 0.817 ± 0.025	2.093AspAsn: 2.093 ± 0.043	2.221AspPro: 2.221 ± 0.044	1.858AspGln: 1.858 ± 0.035	2.776AspArg: 2.776 ± 0.052	2.909AspSer: 2.909 ± 0.05	2.456AspThr: 2.456 ± 0.045	3.09AspVal: 3.09 ± 0.054	0.874AspTrp: 0.874 ± 0.023	1.833AspTyr: 1.833 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.163GluAla: 5.163 ± 0.068	0.475GluCys: 0.475 ± 0.019	2.82GluAsp: 2.82 ± 0.044	4.052GluGlu: 4.052 ± 0.072	2.517GluPhe: 2.517 ± 0.041	3.126GluGly: 3.126 ± 0.053	1.047GluHis: 1.047 ± 0.026	5.228GluIle: 5.228 ± 0.066	3.69GluLys: 3.69 ± 0.043	7.214GluLeu: 7.214 ± 0.084	1.419GluMet: 1.419 ± 0.033	3.089GluAsn: 3.089 ± 0.049	2.408GluPro: 2.408 ± 0.04	3.69GluGln: 3.69 ± 0.057	3.362GluArg: 3.362 ± 0.051	3.494GluSer: 3.494 ± 0.054	3.701GluThr: 3.701 ± 0.051	4.189GluVal: 4.189 ± 0.055	0.826GluTrp: 0.826 ± 0.024	1.933GluTyr: 1.933 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.124PheAla: 3.124 ± 0.049	0.542PheCys: 0.542 ± 0.018	2.243PheAsp: 2.243 ± 0.044	2.138PheGlu: 2.138 ± 0.043	1.694PhePhe: 1.694 ± 0.036	2.966PheGly: 2.966 ± 0.049	0.803PheHis: 0.803 ± 0.024	2.448PheIle: 2.448 ± 0.039	1.59PheLys: 1.59 ± 0.037	4.152PheLeu: 4.152 ± 0.068	0.78PheMet: 0.78 ± 0.024	1.831PheAsn: 1.831 ± 0.042	1.933PhePro: 1.933 ± 0.037	1.938PheGln: 1.938 ± 0.034	1.814PheArg: 1.814 ± 0.038	2.907PheSer: 2.907 ± 0.046	2.388PheThr: 2.388 ± 0.049	2.416PheVal: 2.416 ± 0.043	0.691PheTrp: 0.691 ± 0.023	1.357PheTyr: 1.357 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	4.686GlyAla: 4.686 ± 0.081	0.799GlyCys: 0.799 ± 0.027	3.259GlyAsp: 3.259 ± 0.05	4.473GlyGlu: 4.473 ± 0.061	3.023GlyPhe: 3.023 ± 0.051	4.812GlyGly: 4.812 ± 0.091	1.238GlyHis: 1.238 ± 0.033	5.085GlyIle: 5.085 ± 0.067	4.044GlyLys: 4.044 ± 0.064	6.831GlyLeu: 6.831 ± 0.08	1.57GlyMet: 1.57 ± 0.036	2.956GlyAsn: 2.956 ± 0.072	1.215GlyPro: 1.215 ± 0.03	2.769GlyGln: 2.769 ± 0.049	3.31GlyArg: 3.31 ± 0.06	3.936GlySer: 3.936 ± 0.068	3.61GlyThr: 3.61 ± 0.057	4.835GlyVal: 4.835 ± 0.06	1.108GlyTrp: 1.108 ± 0.032	2.289GlyTyr: 2.289 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.06HisAla: 1.06 ± 0.028	0.26HisCys: 0.26 ± 0.013	0.795HisAsp: 0.795 ± 0.025	0.927HisGlu: 0.927 ± 0.026	0.796HisPhe: 0.796 ± 0.024	1.131HisGly: 1.131 ± 0.028	0.645HisHis: 0.645 ± 0.026	1.213HisIle: 1.213 ± 0.03	0.852HisLys: 0.852 ± 0.029	2.308HisLeu: 2.308 ± 0.041	0.25HisMet: 0.25 ± 0.014	0.848HisAsn: 0.848 ± 0.025	1.387HisPro: 1.387 ± 0.031	1.264HisGln: 1.264 ± 0.028	1.124HisArg: 1.124 ± 0.027	1.335HisSer: 1.335 ± 0.039	0.994HisThr: 0.994 ± 0.026	0.798HisVal: 0.798 ± 0.029	0.415HisTrp: 0.415 ± 0.023	0.693HisTyr: 0.693 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.964IleAla: 6.964 ± 0.077	0.765IleCys: 0.765 ± 0.023	3.727IleAsp: 3.727 ± 0.05	4.159IleGlu: 4.159 ± 0.062	2.743IlePhe: 2.743 ± 0.051	4.49IleGly: 4.49 ± 0.062	1.336IleHis: 1.336 ± 0.03	4.19IleIle: 4.19 ± 0.065	3.286IleLys: 3.286 ± 0.054	7.066IleLeu: 7.066 ± 0.082	1.02IleMet: 1.02 ± 0.031	3.269IleAsn: 3.269 ± 0.049	3.819IlePro: 3.819 ± 0.056	3.235IleGln: 3.235 ± 0.05	3.104IleArg: 3.104 ± 0.048	4.752IleSer: 4.752 ± 0.059	3.979IleThr: 3.979 ± 0.052	4.288IleVal: 4.288 ± 0.06	0.881IleTrp: 0.881 ± 0.026	2.115IleTyr: 2.115 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.781LysAla: 3.781 ± 0.063	0.351LysCys: 0.351 ± 0.016	2.056LysAsp: 2.056 ± 0.045	2.725LysGlu: 2.725 ± 0.049	1.992LysPhe: 1.992 ± 0.047	2.547LysGly: 2.547 ± 0.04	0.861LysHis: 0.861 ± 0.025	3.883LysIle: 3.883 ± 0.057	2.4LysLys: 2.4 ± 0.048	5.603LysLeu: 5.603 ± 0.055	1.02LysMet: 1.02 ± 0.027	2.258LysAsn: 2.258 ± 0.044	2.499LysPro: 2.499 ± 0.047	2.69LysGln: 2.69 ± 0.04	2.367LysArg: 2.367 ± 0.048	3.167LysSer: 3.167 ± 0.051	3.022LysThr: 3.022 ± 0.051	3.094LysVal: 3.094 ± 0.049	0.542LysTrp: 0.542 ± 0.02	1.595LysTyr: 1.595 ± 0.037	0.001LysXaa: 0.001 ± 0.001
Leu	9.543LeuAla: 9.543 ± 0.09	1.021LeuCys: 1.021 ± 0.026	5.161LeuAsp: 5.161 ± 0.061	7.351LeuGlu: 7.351 ± 0.082	3.866LeuPhe: 3.866 ± 0.064	7.642LeuGly: 7.642 ± 0.094	1.942LeuHis: 1.942 ± 0.033	6.947LeuIle: 6.947 ± 0.085	5.561LeuLys: 5.561 ± 0.067	11.316LeuLeu: 11.316 ± 0.12	2.146LeuMet: 2.146 ± 0.046	4.8LeuAsn: 4.8 ± 0.06	6.014LeuPro: 6.014 ± 0.077	6.137LeuGln: 6.137 ± 0.075	5.453LeuArg: 5.453 ± 0.063	7.26LeuSer: 7.26 ± 0.078	6.41LeuThr: 6.41 ± 0.063	7.184LeuVal: 7.184 ± 0.072	1.391LeuTrp: 1.391 ± 0.039	2.662LeuTyr: 2.662 ± 0.043	0.001LeuXaa: 0.001 ± 0.001
Met	1.725MetAla: 1.725 ± 0.037	0.153MetCys: 0.153 ± 0.01	0.76MetAsp: 0.76 ± 0.022	1.033MetGlu: 1.033 ± 0.029	0.614MetPhe: 0.614 ± 0.021	1.494MetGly: 1.494 ± 0.04	0.302MetHis: 0.302 ± 0.015	1.205MetIle: 1.205 ± 0.029	0.962MetLys: 0.962 ± 0.03	2.062MetLeu: 2.062 ± 0.041	0.445MetMet: 0.445 ± 0.017	0.9MetAsn: 0.9 ± 0.028	0.941MetPro: 0.941 ± 0.023	1.013MetGln: 1.013 ± 0.03	1.028MetArg: 1.028 ± 0.028	1.358MetSer: 1.358 ± 0.033	1.36MetThr: 1.36 ± 0.034	1.402MetVal: 1.402 ± 0.036	0.164MetTrp: 0.164 ± 0.012	0.408MetTyr: 0.408 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.866AsnAla: 2.866 ± 0.05	0.515AsnCys: 0.515 ± 0.018	1.612AsnAsp: 1.612 ± 0.037	1.868AsnGlu: 1.868 ± 0.046	2.076AsnPhe: 2.076 ± 0.042	2.529AsnGly: 2.529 ± 0.045	1.04AsnHis: 1.04 ± 0.032	3.087AsnIle: 3.087 ± 0.058	1.819AsnLys: 1.819 ± 0.034	5.772AsnLeu: 5.772 ± 0.075	0.707AsnMet: 0.707 ± 0.024	2.153AsnAsn: 2.153 ± 0.058	2.927AsnPro: 2.927 ± 0.048	3.008AsnGln: 3.008 ± 0.06	2.349AsnArg: 2.349 ± 0.045	3.187AsnSer: 3.187 ± 0.053	2.428AsnThr: 2.428 ± 0.047	2.248AsnVal: 2.248 ± 0.044	0.829AsnTrp: 0.829 ± 0.027	1.713AsnTyr: 1.713 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.23ProAla: 3.23 ± 0.051	0.388ProCys: 0.388 ± 0.016	2.964ProAsp: 2.964 ± 0.051	4.259ProGlu: 4.259 ± 0.058	1.675ProPhe: 1.675 ± 0.035	3.12ProGly: 3.12 ± 0.05	1.05ProHis: 1.05 ± 0.026	3.1ProIle: 3.1 ± 0.051	2.199ProLys: 2.199 ± 0.034	4.782ProLeu: 4.782 ± 0.074	0.793ProMet: 0.793 ± 0.025	2.236ProAsn: 2.236 ± 0.039	2.4ProPro: 2.4 ± 0.052	2.87ProGln: 2.87 ± 0.046	1.765ProArg: 1.765 ± 0.039	2.901ProSer: 2.901 ± 0.045	3.061ProThr: 3.061 ± 0.057	3.383ProVal: 3.383 ± 0.052	0.598ProTrp: 0.598 ± 0.02	1.328ProTyr: 1.328 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.718GlnAla: 4.718 ± 0.073	0.341GlnCys: 0.341 ± 0.014	2.249GlnAsp: 2.249 ± 0.044	3.815GlnGlu: 3.815 ± 0.059	1.83GlnPhe: 1.83 ± 0.04	3.502GlnGly: 3.502 ± 0.068	0.889GlnHis: 0.889 ± 0.027	3.964GlnIle: 3.964 ± 0.054	2.994GlnLys: 2.994 ± 0.049	6.146GlnLeu: 6.146 ± 0.078	1.168GlnMet: 1.168 ± 0.027	2.368GlnAsn: 2.368 ± 0.041	2.879GlnPro: 2.879 ± 0.048	3.926GlnGln: 3.926 ± 0.076	2.977GlnArg: 2.977 ± 0.044	2.929GlnSer: 2.929 ± 0.046	3.025GlnThr: 3.025 ± 0.047	3.884GlnVal: 3.884 ± 0.058	0.671GlnTrp: 0.671 ± 0.02	1.258GlnTyr: 1.258 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.949ArgAla: 2.949 ± 0.045	0.532ArgCys: 0.532 ± 0.018	2.39ArgAsp: 2.39 ± 0.046	3.35ArgGlu: 3.35 ± 0.055	2.135ArgPhe: 2.135 ± 0.041	2.983ArgGly: 2.983 ± 0.053	0.998ArgHis: 0.998 ± 0.028	3.256ArgIle: 3.256 ± 0.046	2.235ArgLys: 2.235 ± 0.042	5.896ArgLeu: 5.896 ± 0.07	0.986ArgMet: 0.986 ± 0.028	2.19ArgAsn: 2.19 ± 0.042	2.061ArgPro: 2.061 ± 0.038	3.288ArgGln: 3.288 ± 0.06	3.067ArgArg: 3.067 ± 0.057	3.075ArgSer: 3.075 ± 0.044	2.5ArgThr: 2.5 ± 0.046	3.363ArgVal: 3.363 ± 0.053	0.798ArgTrp: 0.798 ± 0.024	1.85ArgTyr: 1.85 ± 0.039	0.001ArgXaa: 0.001 ± 0.001
Ser	4.404SerAla: 4.404 ± 0.058	0.604SerCys: 0.604 ± 0.02	3.073SerAsp: 3.073 ± 0.052	3.806SerGlu: 3.806 ± 0.057	2.553SerPhe: 2.553 ± 0.045	4.579SerGly: 4.579 ± 0.068	1.468SerHis: 1.468 ± 0.032	3.816SerIle: 3.816 ± 0.053	2.507SerLys: 2.507 ± 0.045	7.354SerLeu: 7.354 ± 0.062	1.231SerMet: 1.231 ± 0.03	2.69SerAsn: 2.69 ± 0.051	3.623SerPro: 3.623 ± 0.051	3.958SerGln: 3.958 ± 0.062	3.249SerArg: 3.249 ± 0.051	4.278SerSer: 4.278 ± 0.069	3.302SerThr: 3.302 ± 0.045	3.977SerVal: 3.977 ± 0.049	0.922SerTrp: 0.922 ± 0.027	1.814SerTyr: 1.814 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.857ThrAla: 4.857 ± 0.065	0.453ThrCys: 0.453 ± 0.018	2.649ThrAsp: 2.649 ± 0.041	3.439ThrGlu: 3.439 ± 0.046	2.1ThrPhe: 2.1 ± 0.035	4.282ThrGly: 4.282 ± 0.063	1.075ThrHis: 1.075 ± 0.023	3.767ThrIle: 3.767 ± 0.048	2.329ThrLys: 2.329 ± 0.046	6.118ThrLeu: 6.118 ± 0.082	0.807ThrMet: 0.807 ± 0.025	2.362ThrAsn: 2.362 ± 0.046	3.664ThrPro: 3.664 ± 0.077	3.044ThrGln: 3.044 ± 0.046	2.362ThrArg: 2.362 ± 0.043	3.443ThrSer: 3.443 ± 0.054	3.432ThrThr: 3.432 ± 0.049	4.082ThrVal: 4.082 ± 0.064	0.736ThrTrp: 0.736 ± 0.024	1.623ThrTyr: 1.623 ± 0.033	0.001ThrXaa: 0.001 ± 0.001
Val	5.608ValAla: 5.608 ± 0.076	0.665ValCys: 0.665 ± 0.024	3.321ValAsp: 3.321 ± 0.037	4.42ValGlu: 4.42 ± 0.07	2.555ValPhe: 2.555 ± 0.042	4.487ValGly: 4.487 ± 0.068	0.986ValHis: 0.986 ± 0.029	4.668ValIle: 4.668 ± 0.06	3.432ValLys: 3.432 ± 0.052	6.646ValLeu: 6.646 ± 0.081	1.524ValMet: 1.524 ± 0.044	3.071ValAsn: 3.071 ± 0.054	2.798ValPro: 2.798 ± 0.044	2.843ValGln: 2.843 ± 0.053	3.151ValArg: 3.151 ± 0.052	4.216ValSer: 4.216 ± 0.056	3.787ValThr: 3.787 ± 0.056	4.732ValVal: 4.732 ± 0.061	0.818ValTrp: 0.818 ± 0.022	1.863ValTyr: 1.863 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.804TrpAla: 0.804 ± 0.026	0.164TrpCys: 0.164 ± 0.011	0.636TrpAsp: 0.636 ± 0.023	0.997TrpGlu: 0.997 ± 0.025	0.607TrpPhe: 0.607 ± 0.023	1.016TrpGly: 1.016 ± 0.028	0.308TrpHis: 0.308 ± 0.015	0.811TrpIle: 0.811 ± 0.024	0.587TrpLys: 0.587 ± 0.018	1.951TrpLeu: 1.951 ± 0.043	0.314TrpMet: 0.314 ± 0.015	0.629TrpAsn: 0.629 ± 0.023	0.272TrpPro: 0.272 ± 0.014	1.152TrpGln: 1.152 ± 0.036	0.878TrpArg: 0.878 ± 0.024	0.89TrpSer: 0.89 ± 0.028	0.571TrpThr: 0.571 ± 0.02	0.902TrpVal: 0.902 ± 0.026	0.226TrpTrp: 0.226 ± 0.015	0.451TrpTyr: 0.451 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.071TyrAla: 2.071 ± 0.041	0.406TyrCys: 0.406 ± 0.016	1.43TyrAsp: 1.43 ± 0.032	1.742TyrGlu: 1.742 ± 0.035	1.38TyrPhe: 1.38 ± 0.032	1.963TyrGly: 1.963 ± 0.04	0.75TyrHis: 0.75 ± 0.021	1.813TyrIle: 1.813 ± 0.038	1.277TyrLys: 1.277 ± 0.031	3.669TyrLeu: 3.669 ± 0.059	0.492TyrMet: 0.492 ± 0.017	1.236TyrAsn: 1.236 ± 0.033	1.648TyrPro: 1.648 ± 0.038	2.08TyrGln: 2.08 ± 0.044	1.804TyrArg: 1.804 ± 0.036	1.953TyrSer: 1.953 ± 0.038	1.612TyrThr: 1.612 ± 0.035	1.579TyrVal: 1.579 ± 0.033	0.544TyrTrp: 0.544 ± 0.023	1.073TyrTyr: 1.073 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5211 proteins (1456987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---