Amino acid dipepetide frequency for Thermosyntropha lipolytica DSM 11003

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.124AlaAla: 7.124 ± 0.151	1.118AlaCys: 1.118 ± 0.044	4.007AlaAsp: 4.007 ± 0.088	5.989AlaGlu: 5.989 ± 0.109	3.25AlaPhe: 3.25 ± 0.078	6.933AlaGly: 6.933 ± 0.107	1.322AlaHis: 1.322 ± 0.053	5.042AlaIle: 5.042 ± 0.1	4.331AlaLys: 4.331 ± 0.088	8.485AlaLeu: 8.485 ± 0.128	2.065AlaMet: 2.065 ± 0.071	2.255AlaAsn: 2.255 ± 0.061	2.061AlaPro: 2.061 ± 0.065	2.216AlaGln: 2.216 ± 0.055	4.842AlaArg: 4.842 ± 0.086	3.883AlaSer: 3.883 ± 0.098	2.912AlaThr: 2.912 ± 0.063	6.719AlaVal: 6.719 ± 0.101	0.719AlaTrp: 0.719 ± 0.03	2.909AlaTyr: 2.909 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.724CysAla: 0.724 ± 0.039	0.175CysCys: 0.175 ± 0.018	0.529CysAsp: 0.529 ± 0.027	0.628CysGlu: 0.628 ± 0.032	0.476CysPhe: 0.476 ± 0.031	1.038CysGly: 1.038 ± 0.046	0.259CysHis: 0.259 ± 0.021	0.766CysIle: 0.766 ± 0.038	0.519CysLys: 0.519 ± 0.031	1.131CysLeu: 1.131 ± 0.041	0.285CysMet: 0.285 ± 0.021	0.394CysAsn: 0.394 ± 0.027	0.707CysPro: 0.707 ± 0.037	0.412CysGln: 0.412 ± 0.024	0.713CysArg: 0.713 ± 0.037	0.679CysSer: 0.679 ± 0.033	0.463CysThr: 0.463 ± 0.028	0.539CysVal: 0.539 ± 0.032	0.099CysTrp: 0.099 ± 0.011	0.415CysTyr: 0.415 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.041AspAla: 3.041 ± 0.065	0.414AspCys: 0.414 ± 0.029	2.305AspAsp: 2.305 ± 0.063	4.382AspGlu: 4.382 ± 0.094	2.768AspPhe: 2.768 ± 0.065	3.055AspGly: 3.055 ± 0.081	0.663AspHis: 0.663 ± 0.033	5.357AspIle: 5.357 ± 0.096	3.937AspLys: 3.937 ± 0.087	5.25AspLeu: 5.25 ± 0.094	1.513AspMet: 1.513 ± 0.051	1.922AspAsn: 1.922 ± 0.051	1.936AspPro: 1.936 ± 0.054	0.978AspGln: 0.978 ± 0.035	2.432AspArg: 2.432 ± 0.06	1.871AspSer: 1.871 ± 0.058	1.951AspThr: 1.951 ± 0.059	3.25AspVal: 3.25 ± 0.08	0.477AspTrp: 0.477 ± 0.026	2.576AspTyr: 2.576 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	6.327GluAla: 6.327 ± 0.103	0.527GluCys: 0.527 ± 0.031	4.058GluAsp: 4.058 ± 0.087	9.554GluGlu: 9.554 ± 0.157	2.358GluPhe: 2.358 ± 0.064	5.58GluGly: 5.58 ± 0.103	1.152GluHis: 1.152 ± 0.041	7.282GluIle: 7.282 ± 0.115	8.461GluLys: 8.461 ± 0.15	7.243GluLeu: 7.243 ± 0.117	2.359GluMet: 2.359 ± 0.07	3.782GluAsn: 3.782 ± 0.078	1.899GluPro: 1.899 ± 0.055	2.212GluGln: 2.212 ± 0.06	4.073GluArg: 4.073 ± 0.093	2.395GluSer: 2.395 ± 0.056	2.922GluThr: 2.922 ± 0.079	6.344GluVal: 6.344 ± 0.114	0.671GluTrp: 0.671 ± 0.03	2.709GluTyr: 2.709 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.232PheAla: 3.232 ± 0.081	0.563PheCys: 0.563 ± 0.033	1.903PheAsp: 1.903 ± 0.05	1.934PheGlu: 1.934 ± 0.049	2.048PhePhe: 2.048 ± 0.072	2.376PheGly: 2.376 ± 0.066	0.6PheHis: 0.6 ± 0.034	3.768PheIle: 3.768 ± 0.088	2.857PheLys: 2.857 ± 0.075	4.473PheLeu: 4.473 ± 0.105	1.271PheMet: 1.271 ± 0.048	1.764PheAsn: 1.764 ± 0.055	1.618PhePro: 1.618 ± 0.051	0.859PheGln: 0.859 ± 0.037	1.645PheArg: 1.645 ± 0.046	2.491PheSer: 2.491 ± 0.063	2.274PheThr: 2.274 ± 0.06	2.296PheVal: 2.296 ± 0.06	0.51PheTrp: 0.51 ± 0.033	2.003PheTyr: 2.003 ± 0.062	0.0PheXaa: 0.0 ± 0.0
Gly	5.064GlyAla: 5.064 ± 0.086	0.953GlyCys: 0.953 ± 0.041	3.548GlyAsp: 3.548 ± 0.076	5.924GlyGlu: 5.924 ± 0.097	3.281GlyPhe: 3.281 ± 0.072	5.169GlyGly: 5.169 ± 0.105	1.273GlyHis: 1.273 ± 0.043	6.962GlyIle: 6.962 ± 0.13	5.724GlyLys: 5.724 ± 0.095	6.783GlyLeu: 6.783 ± 0.107	2.131GlyMet: 2.131 ± 0.064	2.567GlyAsn: 2.567 ± 0.062	1.707GlyPro: 1.707 ± 0.049	2.108GlyGln: 2.108 ± 0.057	3.894GlyArg: 3.894 ± 0.086	3.486GlySer: 3.486 ± 0.08	3.418GlyThr: 3.418 ± 0.074	5.321GlyVal: 5.321 ± 0.105	0.744GlyTrp: 0.744 ± 0.04	3.094GlyTyr: 3.094 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.094HisAla: 1.094 ± 0.047	0.174HisCys: 0.174 ± 0.016	0.783HisAsp: 0.783 ± 0.031	1.034HisGlu: 1.034 ± 0.042	0.716HisPhe: 0.716 ± 0.03	1.105HisGly: 1.105 ± 0.043	0.422HisHis: 0.422 ± 0.026	1.519HisIle: 1.519 ± 0.051	0.963HisLys: 0.963 ± 0.04	1.719HisLeu: 1.719 ± 0.052	0.47HisMet: 0.47 ± 0.027	0.719HisAsn: 0.719 ± 0.031	1.014HisPro: 1.014 ± 0.042	0.451HisGln: 0.451 ± 0.027	0.78HisArg: 0.78 ± 0.032	0.784HisSer: 0.784 ± 0.032	0.792HisThr: 0.792 ± 0.038	0.887HisVal: 0.887 ± 0.039	0.13HisTrp: 0.13 ± 0.014	0.73HisTyr: 0.73 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.846IleAla: 6.846 ± 0.116	0.956IleCys: 0.956 ± 0.039	4.479IleAsp: 4.479 ± 0.086	5.946IleGlu: 5.946 ± 0.119	3.128IlePhe: 3.128 ± 0.073	5.445IleGly: 5.445 ± 0.112	0.976IleHis: 0.976 ± 0.041	7.093IleIle: 7.093 ± 0.144	6.711IleLys: 6.711 ± 0.099	7.696IleLeu: 7.696 ± 0.126	2.12IleMet: 2.12 ± 0.061	3.808IleAsn: 3.808 ± 0.092	3.477IlePro: 3.477 ± 0.079	1.686IleGln: 1.686 ± 0.05	3.783IleArg: 3.783 ± 0.08	4.496IleSer: 4.496 ± 0.092	4.275IleThr: 4.275 ± 0.1	5.039IleVal: 5.039 ± 0.103	0.738IleTrp: 0.738 ± 0.036	2.928IleTyr: 2.928 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	5.812LysAla: 5.812 ± 0.11	0.56LysCys: 0.56 ± 0.034	3.687LysAsp: 3.687 ± 0.077	7.493LysGlu: 7.493 ± 0.119	1.913LysPhe: 1.913 ± 0.056	5.65LysGly: 5.65 ± 0.098	0.975LysHis: 0.975 ± 0.039	6.143LysIle: 6.143 ± 0.112	6.122LysLys: 6.122 ± 0.091	6.011LysLeu: 6.011 ± 0.096	2.075LysMet: 2.075 ± 0.057	3.263LysAsn: 3.263 ± 0.086	2.748LysPro: 2.748 ± 0.069	1.88LysGln: 1.88 ± 0.053	3.571LysArg: 3.571 ± 0.07	3.016LysSer: 3.016 ± 0.069	3.101LysThr: 3.101 ± 0.067	5.674LysVal: 5.674 ± 0.096	0.609LysTrp: 0.609 ± 0.032	2.468LysTyr: 2.468 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	9.053LeuAla: 9.053 ± 0.133	1.04LeuCys: 1.04 ± 0.049	4.875LeuAsp: 4.875 ± 0.108	7.658LeuGlu: 7.658 ± 0.121	3.825LeuPhe: 3.825 ± 0.099	7.257LeuGly: 7.257 ± 0.144	1.604LeuHis: 1.604 ± 0.056	6.705LeuIle: 6.705 ± 0.113	8.305LeuLys: 8.305 ± 0.131	10.239LeuLeu: 10.239 ± 0.172	2.35LeuMet: 2.35 ± 0.059	4.159LeuAsn: 4.159 ± 0.075	4.324LeuPro: 4.324 ± 0.087	2.822LeuGln: 2.822 ± 0.086	4.616LeuArg: 4.616 ± 0.09	5.691LeuSer: 5.691 ± 0.104	4.608LeuThr: 4.608 ± 0.088	6.887LeuVal: 6.887 ± 0.105	0.871LeuTrp: 0.871 ± 0.038	3.207LeuTyr: 3.207 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	2.495MetAla: 2.495 ± 0.076	0.236MetCys: 0.236 ± 0.02	1.39MetAsp: 1.39 ± 0.055	2.213MetGlu: 2.213 ± 0.063	0.801MetPhe: 0.801 ± 0.034	1.959MetGly: 1.959 ± 0.068	0.499MetHis: 0.499 ± 0.025	1.736MetIle: 1.736 ± 0.055	1.755MetLys: 1.755 ± 0.057	2.835MetLeu: 2.835 ± 0.066	0.663MetMet: 0.663 ± 0.031	0.879MetAsn: 0.879 ± 0.036	1.361MetPro: 1.361 ± 0.045	1.159MetGln: 1.159 ± 0.045	1.407MetArg: 1.407 ± 0.045	1.35MetSer: 1.35 ± 0.044	1.062MetThr: 1.062 ± 0.045	2.159MetVal: 2.159 ± 0.07	0.231MetTrp: 0.231 ± 0.019	0.724MetTyr: 0.724 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.644AsnAla: 2.644 ± 0.074	0.496AsnCys: 0.496 ± 0.029	1.632AsnAsp: 1.632 ± 0.051	2.354AsnGlu: 2.354 ± 0.063	1.713AsnPhe: 1.713 ± 0.056	2.33AsnGly: 2.33 ± 0.076	0.611AsnHis: 0.611 ± 0.029	3.977AsnIle: 3.977 ± 0.085	2.607AsnLys: 2.607 ± 0.064	4.351AsnLeu: 4.351 ± 0.086	1.153AsnMet: 1.153 ± 0.041	1.801AsnAsn: 1.801 ± 0.059	2.269AsnPro: 2.269 ± 0.067	1.308AsnGln: 1.308 ± 0.044	2.286AsnArg: 2.286 ± 0.06	1.893AsnSer: 1.893 ± 0.057	1.8AsnThr: 1.8 ± 0.055	2.148AsnVal: 2.148 ± 0.053	0.423AsnTrp: 0.423 ± 0.029	1.596AsnTyr: 1.596 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.015ProAla: 3.015 ± 0.086	0.44ProCys: 0.44 ± 0.029	2.393ProAsp: 2.393 ± 0.065	3.892ProGlu: 3.892 ± 0.096	1.761ProPhe: 1.761 ± 0.055	3.419ProGly: 3.419 ± 0.079	0.849ProHis: 0.849 ± 0.039	1.857ProIle: 1.857 ± 0.053	1.648ProLys: 1.648 ± 0.053	3.867ProLeu: 3.867 ± 0.082	0.772ProMet: 0.772 ± 0.032	1.09ProAsn: 1.09 ± 0.041	1.499ProPro: 1.499 ± 0.059	1.246ProGln: 1.246 ± 0.054	1.773ProArg: 1.773 ± 0.051	1.787ProSer: 1.787 ± 0.058	1.392ProThr: 1.392 ± 0.048	3.735ProVal: 3.735 ± 0.087	0.386ProTrp: 0.386 ± 0.023	1.57ProTyr: 1.57 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.503GlnAla: 2.503 ± 0.065	0.195GlnCys: 0.195 ± 0.017	1.328GlnAsp: 1.328 ± 0.049	2.672GlnGlu: 2.672 ± 0.069	0.927GlnPhe: 0.927 ± 0.038	2.046GlnGly: 2.046 ± 0.061	0.473GlnHis: 0.473 ± 0.027	2.235GlnIle: 2.235 ± 0.067	2.523GlnLys: 2.523 ± 0.062	2.367GlnLeu: 2.367 ± 0.065	0.842GlnMet: 0.842 ± 0.034	1.387GlnAsn: 1.387 ± 0.051	0.798GlnPro: 0.798 ± 0.035	0.787GlnGln: 0.787 ± 0.038	1.271GlnArg: 1.271 ± 0.049	1.042GlnSer: 1.042 ± 0.039	1.246GlnThr: 1.246 ± 0.042	2.314GlnVal: 2.314 ± 0.062	0.188GlnTrp: 0.188 ± 0.018	0.88GlnTyr: 0.88 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.393ArgAla: 3.393 ± 0.084	0.516ArgCys: 0.516 ± 0.027	2.728ArgAsp: 2.728 ± 0.075	5.509ArgGlu: 5.509 ± 0.117	2.01ArgPhe: 2.01 ± 0.053	3.377ArgGly: 3.377 ± 0.079	0.829ArgHis: 0.829 ± 0.039	4.588ArgIle: 4.588 ± 0.084	3.721ArgLys: 3.721 ± 0.073	5.206ArgLeu: 5.206 ± 0.1	1.525ArgMet: 1.525 ± 0.053	1.872ArgAsn: 1.872 ± 0.054	1.621ArgPro: 1.621 ± 0.054	1.812ArgGln: 1.812 ± 0.063	2.937ArgArg: 2.937 ± 0.081	2.224ArgSer: 2.224 ± 0.063	1.945ArgThr: 1.945 ± 0.064	3.249ArgVal: 3.249 ± 0.08	0.544ArgTrp: 0.544 ± 0.03	1.981ArgTyr: 1.981 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.067SerAla: 3.067 ± 0.066	0.635SerCys: 0.635 ± 0.032	2.048SerAsp: 2.048 ± 0.055	2.847SerGlu: 2.847 ± 0.078	2.621SerPhe: 2.621 ± 0.067	4.01SerGly: 4.01 ± 0.084	1.032SerHis: 1.032 ± 0.041	3.703SerIle: 3.703 ± 0.081	2.393SerLys: 2.393 ± 0.062	5.891SerLeu: 5.891 ± 0.108	1.173SerMet: 1.173 ± 0.041	1.53SerAsn: 1.53 ± 0.056	2.302SerPro: 2.302 ± 0.068	1.459SerGln: 1.459 ± 0.052	3.188SerArg: 3.188 ± 0.076	3.129SerSer: 3.129 ± 0.093	2.114SerThr: 2.114 ± 0.06	2.691SerVal: 2.691 ± 0.071	0.544SerTrp: 0.544 ± 0.033	2.082SerTyr: 2.082 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.825ThrAla: 3.825 ± 0.087	0.547ThrCys: 0.547 ± 0.032	2.099ThrAsp: 2.099 ± 0.063	2.753ThrGlu: 2.753 ± 0.07	1.655ThrPhe: 1.655 ± 0.049	4.456ThrGly: 4.456 ± 0.087	0.679ThrHis: 0.679 ± 0.034	3.146ThrIle: 3.146 ± 0.082	1.733ThrLys: 1.733 ± 0.059	4.287ThrLeu: 4.287 ± 0.077	0.964ThrMet: 0.964 ± 0.042	1.42ThrAsn: 1.42 ± 0.047	2.187ThrPro: 2.187 ± 0.062	0.998ThrGln: 0.998 ± 0.044	2.469ThrArg: 2.469 ± 0.071	2.424ThrSer: 2.424 ± 0.062	2.049ThrThr: 2.049 ± 0.063	3.48ThrVal: 3.48 ± 0.074	0.428ThrTrp: 0.428 ± 0.032	1.502ThrTyr: 1.502 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.36ValAla: 5.36 ± 0.11	0.845ValCys: 0.845 ± 0.038	3.818ValAsp: 3.818 ± 0.088	5.598ValGlu: 5.598 ± 0.1	3.194ValPhe: 3.194 ± 0.069	4.293ValGly: 4.293 ± 0.1	1.085ValHis: 1.085 ± 0.046	6.153ValIle: 6.153 ± 0.111	5.648ValLys: 5.648 ± 0.104	7.308ValLeu: 7.308 ± 0.104	1.958ValMet: 1.958 ± 0.05	2.886ValAsn: 2.886 ± 0.068	2.747ValPro: 2.747 ± 0.071	1.713ValGln: 1.713 ± 0.054	3.356ValArg: 3.356 ± 0.085	3.594ValSer: 3.594 ± 0.07	2.767ValThr: 2.767 ± 0.078	5.589ValVal: 5.589 ± 0.097	0.628ValTrp: 0.628 ± 0.035	2.636ValTyr: 2.636 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.738TrpAla: 0.738 ± 0.035	0.095TrpCys: 0.095 ± 0.014	0.527TrpAsp: 0.527 ± 0.032	0.883TrpGlu: 0.883 ± 0.039	0.377TrpPhe: 0.377 ± 0.025	0.894TrpGly: 0.894 ± 0.037	0.212TrpHis: 0.212 ± 0.02	0.609TrpIle: 0.609 ± 0.033	0.524TrpLys: 0.524 ± 0.029	1.025TrpLeu: 1.025 ± 0.051	0.274TrpMet: 0.274 ± 0.02	0.299TrpAsn: 0.299 ± 0.022	0.329TrpPro: 0.329 ± 0.022	0.564TrpGln: 0.564 ± 0.026	0.397TrpArg: 0.397 ± 0.023	0.415TrpSer: 0.415 ± 0.024	0.31TrpThr: 0.31 ± 0.021	0.529TrpVal: 0.529 ± 0.027	0.121TrpTrp: 0.121 ± 0.012	0.325TrpTyr: 0.325 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.824TyrAla: 2.824 ± 0.069	0.468TyrCys: 0.468 ± 0.028	1.942TyrAsp: 1.942 ± 0.063	2.643TyrGlu: 2.643 ± 0.065	1.66TyrPhe: 1.66 ± 0.055	2.756TyrGly: 2.756 ± 0.059	0.769TyrHis: 0.769 ± 0.036	2.987TyrIle: 2.987 ± 0.07	2.289TyrLys: 2.289 ± 0.062	3.931TyrLeu: 3.931 ± 0.085	0.95TyrMet: 0.95 ± 0.038	1.596TyrAsn: 1.596 ± 0.048	1.789TyrPro: 1.789 ± 0.051	1.353TyrGln: 1.353 ± 0.052	2.156TyrArg: 2.156 ± 0.066	1.809TyrSer: 1.809 ± 0.061	1.7TyrThr: 1.7 ± 0.05	2.328TyrVal: 2.328 ± 0.064	0.386TyrTrp: 0.386 ± 0.025	1.637TyrTyr: 1.637 ± 0.072	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2141 proteins (645175 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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