Amino acid dipepetide frequency for Halorubrum saccharovorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.721AlaAla: 13.721 ± 0.27
0.674AlaCys: 0.674 ± 0.042
10.448AlaAsp: 10.448 ± 0.165
9.253AlaGlu: 9.253 ± 0.161
4.198AlaPhe: 4.198 ± 0.114
9.986AlaGly: 9.986 ± 0.172
1.715AlaHis: 1.715 ± 0.063
5.082AlaIle: 5.082 ± 0.103
1.848AlaLys: 1.848 ± 0.06
10.139AlaLeu: 10.139 ± 0.195
2.082AlaMet: 2.082 ± 0.063
2.415AlaAsn: 2.415 ± 0.061
3.867AlaPro: 3.867 ± 0.089
1.997AlaGln: 1.997 ± 0.055
5.997AlaArg: 5.997 ± 0.112
5.537AlaSer: 5.537 ± 0.091
6.619AlaThr: 6.619 ± 0.112
10.93AlaVal: 10.93 ± 0.17
1.128AlaTrp: 1.128 ± 0.049
2.768AlaTyr: 2.768 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.526CysAla: 0.526 ± 0.032
0.092CysCys: 0.092 ± 0.013
0.53CysAsp: 0.53 ± 0.032
0.542CysGlu: 0.542 ± 0.03
0.209CysPhe: 0.209 ± 0.02
0.785CysGly: 0.785 ± 0.042
0.174CysHis: 0.174 ± 0.018
0.215CysIle: 0.215 ± 0.02
0.13CysLys: 0.13 ± 0.015
0.532CysLeu: 0.532 ± 0.036
0.097CysMet: 0.097 ± 0.014
0.215CysAsn: 0.215 ± 0.021
0.453CysPro: 0.453 ± 0.031
0.15CysGln: 0.15 ± 0.016
0.46CysArg: 0.46 ± 0.027
0.409CysSer: 0.409 ± 0.031
0.361CysThr: 0.361 ± 0.027
0.477CysVal: 0.477 ± 0.033
0.08CysTrp: 0.08 ± 0.01
0.166CysTyr: 0.166 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
11.333AspAla: 11.333 ± 0.187
0.595AspCys: 0.595 ± 0.039
8.846AspAsp: 8.846 ± 0.189
8.868AspGlu: 8.868 ± 0.157
1.927AspPhe: 1.927 ± 0.058
8.925AspGly: 8.925 ± 0.157
1.844AspHis: 1.844 ± 0.065
3.094AspIle: 3.094 ± 0.08
1.039AspLys: 1.039 ± 0.045
7.479AspLeu: 7.479 ± 0.119
1.238AspMet: 1.238 ± 0.048
1.368AspAsn: 1.368 ± 0.058
5.188AspPro: 5.188 ± 0.095
1.627AspGln: 1.627 ± 0.051
7.492AspArg: 7.492 ± 0.14
3.653AspSer: 3.653 ± 0.078
4.07AspThr: 4.07 ± 0.091
7.468AspVal: 7.468 ± 0.132
0.998AspTrp: 0.998 ± 0.042
1.733AspTyr: 1.733 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
9.08GluAla: 9.08 ± 0.159
0.456GluCys: 0.456 ± 0.031
5.477GluAsp: 5.477 ± 0.124
7.397GluGlu: 7.397 ± 0.157
3.173GluPhe: 3.173 ± 0.078
6.18GluGly: 6.18 ± 0.107
1.976GluHis: 1.976 ± 0.063
4.062GluIle: 4.062 ± 0.097
1.846GluLys: 1.846 ± 0.073
7.18GluLeu: 7.18 ± 0.123
2.017GluMet: 2.017 ± 0.066
2.289GluAsn: 2.289 ± 0.069
4.227GluPro: 4.227 ± 0.09
2.352GluGln: 2.352 ± 0.077
7.356GluArg: 7.356 ± 0.14
5.412GluSer: 5.412 ± 0.112
6.668GluThr: 6.668 ± 0.124
6.222GluVal: 6.222 ± 0.111
1.118GluTrp: 1.118 ± 0.047
2.699GluTyr: 2.699 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.786PheAla: 3.786 ± 0.089
0.248PheCys: 0.248 ± 0.018
3.446PheAsp: 3.446 ± 0.082
3.173PheGlu: 3.173 ± 0.074
1.022PhePhe: 1.022 ± 0.048
3.313PheGly: 3.313 ± 0.092
0.602PheHis: 0.602 ± 0.033
1.068PheIle: 1.068 ± 0.052
0.465PheLys: 0.465 ± 0.03
2.998PheLeu: 2.998 ± 0.092
0.518PheMet: 0.518 ± 0.033
0.667PheAsn: 0.667 ± 0.036
1.325PhePro: 1.325 ± 0.05
0.795PheGln: 0.795 ± 0.034
1.834PheArg: 1.834 ± 0.048
1.728PheSer: 1.728 ± 0.052
1.769PheThr: 1.769 ± 0.054
3.287PheVal: 3.287 ± 0.088
0.374PheTrp: 0.374 ± 0.027
0.815PheTyr: 0.815 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
8.52GlyAla: 8.52 ± 0.151
0.6GlyCys: 0.6 ± 0.033
7.973GlyAsp: 7.973 ± 0.155
7.74GlyGlu: 7.74 ± 0.143
3.303GlyPhe: 3.303 ± 0.075
8.12GlyGly: 8.12 ± 0.172
1.609GlyHis: 1.609 ± 0.057
4.434GlyIle: 4.434 ± 0.09
1.846GlyLys: 1.846 ± 0.063
7.128GlyLeu: 7.128 ± 0.146
1.629GlyMet: 1.629 ± 0.053
2.017GlyAsn: 2.017 ± 0.062
3.446GlyPro: 3.446 ± 0.088
1.841GlyGln: 1.841 ± 0.057
4.985GlyArg: 4.985 ± 0.1
5.771GlySer: 5.771 ± 0.13
5.489GlyThr: 5.489 ± 0.092
7.993GlyVal: 7.993 ± 0.151
1.024GlyTrp: 1.024 ± 0.041
2.643GlyTyr: 2.643 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
2.084HisAla: 2.084 ± 0.06
0.178HisCys: 0.178 ± 0.017
1.73HisAsp: 1.73 ± 0.063
1.691HisGlu: 1.691 ± 0.055
0.503HisPhe: 0.503 ± 0.027
1.882HisGly: 1.882 ± 0.063
0.491HisHis: 0.491 ± 0.034
0.579HisIle: 0.579 ± 0.036
0.306HisLys: 0.306 ± 0.023
1.568HisLeu: 1.568 ± 0.05
0.297HisMet: 0.297 ± 0.024
0.477HisAsn: 0.477 ± 0.025
1.212HisPro: 1.212 ± 0.046
0.41HisGln: 0.41 ± 0.03
1.253HisArg: 1.253 ± 0.046
0.774HisSer: 0.774 ± 0.035
1.017HisThr: 1.017 ± 0.044
1.817HisVal: 1.817 ± 0.05
0.219HisTrp: 0.219 ± 0.019
0.59HisTyr: 0.59 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.25IleAla: 5.25 ± 0.113
0.231IleCys: 0.231 ± 0.02
4.501IleAsp: 4.501 ± 0.096
4.431IleGlu: 4.431 ± 0.098
0.87IlePhe: 0.87 ± 0.04
4.072IleGly: 4.072 ± 0.097
0.791IleHis: 0.791 ± 0.035
1.262IleIle: 1.262 ± 0.056
0.682IleLys: 0.682 ± 0.033
2.908IleLeu: 2.908 ± 0.08
0.458IleMet: 0.458 ± 0.029
0.99IleAsn: 0.99 ± 0.043
2.118IlePro: 2.118 ± 0.071
1.034IleGln: 1.034 ± 0.045
2.643IleArg: 2.643 ± 0.066
2.063IleSer: 2.063 ± 0.058
2.333IleThr: 2.333 ± 0.066
3.771IleVal: 3.771 ± 0.094
0.309IleTrp: 0.309 ± 0.024
0.795IleTyr: 0.795 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
1.855LysAla: 1.855 ± 0.062
0.13LysCys: 0.13 ± 0.016
0.986LysAsp: 0.986 ± 0.049
1.409LysGlu: 1.409 ± 0.058
0.533LysPhe: 0.533 ± 0.029
1.412LysGly: 1.412 ± 0.048
0.456LysHis: 0.456 ± 0.031
0.79LysIle: 0.79 ± 0.041
0.585LysLys: 0.585 ± 0.042
1.75LysLeu: 1.75 ± 0.055
0.403LysMet: 0.403 ± 0.025
0.509LysAsn: 0.509 ± 0.033
0.904LysPro: 0.904 ± 0.04
0.703LysGln: 0.703 ± 0.038
1.754LysArg: 1.754 ± 0.06
1.193LysSer: 1.193 ± 0.047
1.212LysThr: 1.212 ± 0.056
1.197LysVal: 1.197 ± 0.043
0.234LysTrp: 0.234 ± 0.02
0.532LysTyr: 0.532 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
10.484LeuAla: 10.484 ± 0.18
0.528LeuCys: 0.528 ± 0.033
8.058LeuAsp: 8.058 ± 0.108
6.002LeuGlu: 6.002 ± 0.109
3.094LeuPhe: 3.094 ± 0.102
7.55LeuGly: 7.55 ± 0.132
1.455LeuHis: 1.455 ± 0.052
3.203LeuIle: 3.203 ± 0.102
1.576LeuLys: 1.576 ± 0.06
8.103LeuLeu: 8.103 ± 0.174
1.373LeuMet: 1.373 ± 0.043
1.815LeuAsn: 1.815 ± 0.066
3.949LeuPro: 3.949 ± 0.096
1.827LeuGln: 1.827 ± 0.055
5.771LeuArg: 5.771 ± 0.099
5.518LeuSer: 5.518 ± 0.1
5.024LeuThr: 5.024 ± 0.102
7.981LeuVal: 7.981 ± 0.157
0.874LeuTrp: 0.874 ± 0.043
2.229LeuTyr: 2.229 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
1.8MetAla: 1.8 ± 0.064
0.109MetCys: 0.109 ± 0.015
1.256MetAsp: 1.256 ± 0.052
1.173MetGlu: 1.173 ± 0.047
0.525MetPhe: 0.525 ± 0.034
1.388MetGly: 1.388 ± 0.061
0.328MetHis: 0.328 ± 0.024
0.655MetIle: 0.655 ± 0.036
0.434MetLys: 0.434 ± 0.025
1.451MetLeu: 1.451 ± 0.055
0.333MetMet: 0.333 ± 0.027
0.626MetAsn: 0.626 ± 0.031
0.822MetPro: 0.822 ± 0.038
0.439MetGln: 0.439 ± 0.027
1.05MetArg: 1.05 ± 0.043
1.667MetSer: 1.667 ± 0.05
1.564MetThr: 1.564 ± 0.055
1.251MetVal: 1.251 ± 0.049
0.178MetTrp: 0.178 ± 0.016
0.398MetTyr: 0.398 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.653AsnAla: 2.653 ± 0.069
0.197AsnCys: 0.197 ± 0.019
1.715AsnAsp: 1.715 ± 0.059
1.781AsnGlu: 1.781 ± 0.067
0.622AsnPhe: 0.622 ± 0.033
2.046AsnGly: 2.046 ± 0.067
0.45AsnHis: 0.45 ± 0.03
0.93AsnIle: 0.93 ± 0.04
0.426AsnLys: 0.426 ± 0.03
2.041AsnLeu: 2.041 ± 0.072
0.364AsnMet: 0.364 ± 0.021
0.579AsnAsn: 0.579 ± 0.036
1.499AsnPro: 1.499 ± 0.045
0.653AsnGln: 0.653 ± 0.038
1.675AsnArg: 1.675 ± 0.055
1.019AsnSer: 1.019 ± 0.048
1.303AsnThr: 1.303 ± 0.056
2.337AsnVal: 2.337 ± 0.069
0.279AsnTrp: 0.279 ± 0.021
0.612AsnTyr: 0.612 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.648ProAla: 4.648 ± 0.1
0.238ProCys: 0.238 ± 0.022
5.25ProAsp: 5.25 ± 0.103
4.704ProGlu: 4.704 ± 0.104
1.583ProPhe: 1.583 ± 0.056
3.809ProGly: 3.809 ± 0.081
0.874ProHis: 0.874 ± 0.035
2.019ProIle: 2.019 ± 0.057
0.906ProLys: 0.906 ± 0.039
3.429ProLeu: 3.429 ± 0.083
0.832ProMet: 0.832 ± 0.037
1.221ProAsn: 1.221 ± 0.05
2.113ProPro: 2.113 ± 0.066
0.887ProGln: 0.887 ± 0.042
2.357ProArg: 2.357 ± 0.074
2.634ProSer: 2.634 ± 0.068
3.014ProThr: 3.014 ± 0.079
4.178ProVal: 4.178 ± 0.087
0.492ProTrp: 0.492 ± 0.029
1.097ProTyr: 1.097 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.164GlnAla: 2.164 ± 0.061
0.176GlnCys: 0.176 ± 0.018
1.202GlnAsp: 1.202 ± 0.052
1.588GlnGlu: 1.588 ± 0.056
0.956GlnPhe: 0.956 ± 0.043
1.581GlnGly: 1.581 ± 0.049
0.455GlnHis: 0.455 ± 0.029
1.113GlnIle: 1.113 ± 0.049
0.603GlnLys: 0.603 ± 0.036
2.222GlnLeu: 2.222 ± 0.064
0.501GlnMet: 0.501 ± 0.025
0.648GlnAsn: 0.648 ± 0.032
1.021GlnPro: 1.021 ± 0.042
0.897GlnGln: 0.897 ± 0.051
1.809GlnArg: 1.809 ± 0.061
1.463GlnSer: 1.463 ± 0.052
1.477GlnThr: 1.477 ± 0.052
1.538GlnVal: 1.538 ± 0.049
0.297GlnTrp: 0.297 ± 0.023
0.74GlnTyr: 0.74 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.238ArgAla: 6.238 ± 0.107
0.463ArgCys: 0.463 ± 0.028
5.568ArgAsp: 5.568 ± 0.113
6.935ArgGlu: 6.935 ± 0.139
2.467ArgPhe: 2.467 ± 0.064
4.809ArgGly: 4.809 ± 0.11
1.15ArgHis: 1.15 ± 0.044
3.191ArgIle: 3.191 ± 0.073
1.462ArgLys: 1.462 ± 0.053
6.256ArgLeu: 6.256 ± 0.123
1.34ArgMet: 1.34 ± 0.05
1.711ArgAsn: 1.711 ± 0.055
2.53ArgPro: 2.53 ± 0.07
1.658ArgGln: 1.658 ± 0.053
5.096ArgArg: 5.096 ± 0.13
3.817ArgSer: 3.817 ± 0.082
3.831ArgThr: 3.831 ± 0.086
5.684ArgVal: 5.684 ± 0.104
0.728ArgTrp: 0.728 ± 0.034
1.865ArgTyr: 1.865 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.431SerAla: 5.431 ± 0.104
0.361SerCys: 0.361 ± 0.03
5.003SerAsp: 5.003 ± 0.107
4.561SerGlu: 4.561 ± 0.097
1.821SerPhe: 1.821 ± 0.051
5.523SerGly: 5.523 ± 0.107
1.044SerHis: 1.044 ± 0.045
2.354SerIle: 2.354 ± 0.068
1.243SerLys: 1.243 ± 0.046
4.588SerLeu: 4.588 ± 0.087
1.022SerMet: 1.022 ± 0.042
1.268SerAsn: 1.268 ± 0.05
2.735SerPro: 2.735 ± 0.07
1.321SerGln: 1.321 ± 0.055
3.462SerArg: 3.462 ± 0.081
3.017SerSer: 3.017 ± 0.091
3.484SerThr: 3.484 ± 0.085
5.21SerVal: 5.21 ± 0.108
0.61SerTrp: 0.61 ± 0.036
1.321SerTyr: 1.321 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
6.656ThrAla: 6.656 ± 0.107
0.359ThrCys: 0.359 ± 0.026
5.397ThrAsp: 5.397 ± 0.104
4.697ThrGlu: 4.697 ± 0.099
2.174ThrPhe: 2.174 ± 0.06
5.677ThrGly: 5.677 ± 0.113
1.198ThrHis: 1.198 ± 0.043
2.617ThrIle: 2.617 ± 0.063
1.041ThrLys: 1.041 ± 0.044
5.569ThrLeu: 5.569 ± 0.089
0.954ThrMet: 0.954 ± 0.041
1.385ThrAsn: 1.385 ± 0.05
3.075ThrPro: 3.075 ± 0.081
1.198ThrGln: 1.198 ± 0.042
3.402ThrArg: 3.402 ± 0.081
2.759ThrSer: 2.759 ± 0.07
3.853ThrThr: 3.853 ± 0.098
6.909ThrVal: 6.909 ± 0.121
0.581ThrTrp: 0.581 ± 0.033
1.674ThrTyr: 1.674 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
10.499ValAla: 10.499 ± 0.161
0.682ValCys: 0.682 ± 0.034
8.145ValAsp: 8.145 ± 0.132
7.939ValGlu: 7.939 ± 0.142
3.031ValPhe: 3.031 ± 0.088
7.95ValGly: 7.95 ± 0.164
1.626ValHis: 1.626 ± 0.051
3.576ValIle: 3.576 ± 0.078
1.409ValLys: 1.409 ± 0.047
7.609ValLeu: 7.609 ± 0.141
1.368ValMet: 1.368 ± 0.053
2.019ValAsn: 2.019 ± 0.054
4.181ValPro: 4.181 ± 0.092
1.701ValGln: 1.701 ± 0.064
5.667ValArg: 5.667 ± 0.109
5.185ValSer: 5.185 ± 0.109
6.002ValThr: 6.002 ± 0.093
9.104ValVal: 9.104 ± 0.179
0.826ValTrp: 0.826 ± 0.044
2.118ValTyr: 2.118 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.892TrpAla: 0.892 ± 0.04
0.101TrpCys: 0.101 ± 0.013
0.728TrpAsp: 0.728 ± 0.035
0.855TrpGlu: 0.855 ± 0.038
0.422TrpPhe: 0.422 ± 0.03
0.858TrpGly: 0.858 ± 0.038
0.203TrpHis: 0.203 ± 0.02
0.586TrpIle: 0.586 ± 0.036
0.262TrpLys: 0.262 ± 0.019
1.089TrpLeu: 1.089 ± 0.046
0.203TrpMet: 0.203 ± 0.02
0.356TrpAsn: 0.356 ± 0.023
0.451TrpPro: 0.451 ± 0.028
0.303TrpGln: 0.303 ± 0.024
0.786TrpArg: 0.786 ± 0.037
0.593TrpSer: 0.593 ± 0.034
0.725TrpThr: 0.725 ± 0.038
0.865TrpVal: 0.865 ± 0.039
0.173TrpTrp: 0.173 ± 0.019
0.376TrpTyr: 0.376 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.781TyrAla: 2.781 ± 0.082
0.186TyrCys: 0.186 ± 0.018
2.53TyrAsp: 2.53 ± 0.071
2.45TyrGlu: 2.45 ± 0.062
0.803TyrPhe: 0.803 ± 0.037
2.244TyrGly: 2.244 ± 0.058
0.636TyrHis: 0.636 ± 0.034
0.68TyrIle: 0.68 ± 0.035
0.439TyrLys: 0.439 ± 0.029
2.376TyrLeu: 2.376 ± 0.058
0.415TyrMet: 0.415 ± 0.026
0.605TyrAsn: 0.605 ± 0.033
1.168TyrPro: 1.168 ± 0.047
0.656TyrGln: 0.656 ± 0.034
1.952TyrArg: 1.952 ± 0.061
1.168TyrSer: 1.168 ± 0.04
1.362TyrThr: 1.362 ± 0.053
2.414TyrVal: 2.414 ± 0.068
0.304TyrTrp: 0.304 ± 0.026
0.776TyrTyr: 0.776 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2334 proteins (584998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski