Amino acid dipepetide frequency for Penicillium flavigenum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.437AlaAla: 8.437 ± 0.07	1.113AlaCys: 1.113 ± 0.015	4.206AlaAsp: 4.206 ± 0.033	5.051AlaGlu: 5.051 ± 0.042	3.165AlaPhe: 3.165 ± 0.028	5.688AlaGly: 5.688 ± 0.038	1.781AlaHis: 1.781 ± 0.019	4.388AlaIle: 4.388 ± 0.033	3.853AlaLys: 3.853 ± 0.032	7.679AlaLeu: 7.679 ± 0.045	2.033AlaMet: 2.033 ± 0.023	2.97AlaAsn: 2.97 ± 0.026	4.732AlaPro: 4.732 ± 0.045	3.384AlaGln: 3.384 ± 0.034	4.787AlaArg: 4.787 ± 0.033	7.089AlaSer: 7.089 ± 0.041	5.207AlaThr: 5.207 ± 0.03	5.346AlaVal: 5.346 ± 0.035	1.16AlaTrp: 1.16 ± 0.016	2.16AlaTyr: 2.16 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.0CysAla: 1.0 ± 0.016	0.249CysCys: 0.249 ± 0.007	0.691CysAsp: 0.691 ± 0.013	0.62CysGlu: 0.62 ± 0.012	0.579CysPhe: 0.579 ± 0.012	0.952CysGly: 0.952 ± 0.017	0.354CysHis: 0.354 ± 0.009	0.724CysIle: 0.724 ± 0.012	0.497CysLys: 0.497 ± 0.01	1.333CysLeu: 1.333 ± 0.017	0.281CysMet: 0.281 ± 0.008	0.438CysAsn: 0.438 ± 0.01	0.682CysPro: 0.682 ± 0.014	0.487CysGln: 0.487 ± 0.01	0.751CysArg: 0.751 ± 0.012	0.939CysSer: 0.939 ± 0.014	0.697CysThr: 0.697 ± 0.012	0.861CysVal: 0.861 ± 0.018	0.203CysTrp: 0.203 ± 0.006	0.35CysTyr: 0.35 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.484AspAla: 4.484 ± 0.035	0.632AspCys: 0.632 ± 0.011	3.869AspAsp: 3.869 ± 0.043	4.25AspGlu: 4.25 ± 0.039	2.186AspPhe: 2.186 ± 0.019	3.881AspGly: 3.881 ± 0.03	1.342AspHis: 1.342 ± 0.016	3.209AspIle: 3.209 ± 0.026	2.274AspLys: 2.274 ± 0.025	5.212AspLeu: 5.212 ± 0.035	1.329AspMet: 1.329 ± 0.015	1.961AspAsn: 1.961 ± 0.022	3.41AspPro: 3.41 ± 0.027	2.061AspGln: 2.061 ± 0.024	3.102AspArg: 3.102 ± 0.031	4.261AspSer: 4.261 ± 0.029	3.08AspThr: 3.08 ± 0.023	3.604AspVal: 3.604 ± 0.03	0.919AspTrp: 0.919 ± 0.015	1.623AspTyr: 1.623 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.183GluAla: 5.183 ± 0.045	0.665GluCys: 0.665 ± 0.012	4.099GluAsp: 4.099 ± 0.037	5.183GluGlu: 5.183 ± 0.054	1.984GluPhe: 1.984 ± 0.02	3.618GluGly: 3.618 ± 0.032	1.418GluHis: 1.418 ± 0.019	3.178GluIle: 3.178 ± 0.024	3.537GluLys: 3.537 ± 0.034	5.141GluLeu: 5.141 ± 0.037	1.464GluMet: 1.464 ± 0.015	2.419GluAsn: 2.419 ± 0.023	2.88GluPro: 2.88 ± 0.05	2.49GluGln: 2.49 ± 0.024	3.776GluArg: 3.776 ± 0.03	4.454GluSer: 4.454 ± 0.037	3.673GluThr: 3.673 ± 0.03	3.464GluVal: 3.464 ± 0.03	0.888GluTrp: 0.888 ± 0.014	1.69GluTyr: 1.69 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.085PheAla: 3.085 ± 0.028	0.596PheCys: 0.596 ± 0.01	2.351PheAsp: 2.351 ± 0.023	2.173PheGlu: 2.173 ± 0.02	1.726PhePhe: 1.726 ± 0.024	2.891PheGly: 2.891 ± 0.028	0.947PheHis: 0.947 ± 0.013	1.941PheIle: 1.941 ± 0.024	1.472PheLys: 1.472 ± 0.018	3.531PheLeu: 3.531 ± 0.032	0.867PheMet: 0.867 ± 0.015	1.489PheAsn: 1.489 ± 0.019	2.009PhePro: 2.009 ± 0.02	1.482PheGln: 1.482 ± 0.019	1.989PheArg: 1.989 ± 0.023	3.015PheSer: 3.015 ± 0.028	2.168PheThr: 2.168 ± 0.019	2.457PheVal: 2.457 ± 0.025	0.662PheTrp: 0.662 ± 0.012	1.155PheTyr: 1.155 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.212GlyAla: 5.212 ± 0.036	0.903GlyCys: 0.903 ± 0.015	3.601GlyAsp: 3.601 ± 0.028	3.526GlyGlu: 3.526 ± 0.029	2.892GlyPhe: 2.892 ± 0.027	5.307GlyGly: 5.307 ± 0.049	1.731GlyHis: 1.731 ± 0.021	3.642GlyIle: 3.642 ± 0.027	3.265GlyLys: 3.265 ± 0.029	6.188GlyLeu: 6.188 ± 0.039	1.628GlyMet: 1.628 ± 0.022	2.568GlyAsn: 2.568 ± 0.03	3.379GlyPro: 3.379 ± 0.03	2.594GlyGln: 2.594 ± 0.028	3.914GlyArg: 3.914 ± 0.032	5.769GlySer: 5.769 ± 0.036	3.976GlyThr: 3.976 ± 0.029	4.341GlyVal: 4.341 ± 0.036	1.167GlyTrp: 1.167 ± 0.017	2.186GlyTyr: 2.186 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.863HisAla: 1.863 ± 0.019	0.356HisCys: 0.356 ± 0.008	1.336HisAsp: 1.336 ± 0.015	1.381HisGlu: 1.381 ± 0.019	0.957HisPhe: 0.957 ± 0.012	1.76HisGly: 1.76 ± 0.02	0.819HisHis: 0.819 ± 0.016	1.276HisIle: 1.276 ± 0.017	0.891HisLys: 0.891 ± 0.014	2.308HisLeu: 2.308 ± 0.023	0.523HisMet: 0.523 ± 0.01	0.893HisAsn: 0.893 ± 0.015	1.693HisPro: 1.693 ± 0.023	1.006HisGln: 1.006 ± 0.015	1.585HisArg: 1.585 ± 0.019	1.91HisSer: 1.91 ± 0.022	1.333HisThr: 1.333 ± 0.014	1.445HisVal: 1.445 ± 0.019	0.369HisTrp: 0.369 ± 0.01	0.706HisTyr: 0.706 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.331IleAla: 4.331 ± 0.035	0.817IleCys: 0.817 ± 0.014	2.977IleAsp: 2.977 ± 0.025	2.925IleGlu: 2.925 ± 0.027	2.128IlePhe: 2.128 ± 0.026	3.394IleGly: 3.394 ± 0.033	1.273IleHis: 1.273 ± 0.017	2.624IleIle: 2.624 ± 0.028	2.129IleLys: 2.129 ± 0.021	4.71IleLeu: 4.71 ± 0.04	1.081IleMet: 1.081 ± 0.015	1.845IleAsn: 1.845 ± 0.02	3.26IlePro: 3.26 ± 0.027	2.019IleGln: 2.019 ± 0.021	2.798IleArg: 2.798 ± 0.025	4.074IleSer: 4.074 ± 0.029	2.866IleThr: 2.866 ± 0.024	3.264IleVal: 3.264 ± 0.031	0.753IleTrp: 0.753 ± 0.012	1.467IleTyr: 1.467 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.924LysAla: 3.924 ± 0.034	0.529LysCys: 0.529 ± 0.011	2.683LysAsp: 2.683 ± 0.027	3.192LysGlu: 3.192 ± 0.033	1.467LysPhe: 1.467 ± 0.016	2.824LysGly: 2.824 ± 0.024	1.1LysHis: 1.1 ± 0.015	2.232LysIle: 2.232 ± 0.024	2.969LysLys: 2.969 ± 0.046	3.911LysLeu: 3.911 ± 0.033	0.994LysMet: 0.994 ± 0.014	1.744LysAsn: 1.744 ± 0.02	2.679LysPro: 2.679 ± 0.032	1.842LysGln: 1.842 ± 0.021	3.193LysArg: 3.193 ± 0.029	3.479LysSer: 3.479 ± 0.03	2.711LysThr: 2.711 ± 0.023	2.699LysVal: 2.699 ± 0.023	0.682LysTrp: 0.682 ± 0.011	1.349LysTyr: 1.349 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.852LeuAla: 7.852 ± 0.047	1.251LeuCys: 1.251 ± 0.018	5.228LeuAsp: 5.228 ± 0.037	5.508LeuGlu: 5.508 ± 0.043	3.423LeuPhe: 3.423 ± 0.03	6.038LeuGly: 6.038 ± 0.038	2.268LeuHis: 2.268 ± 0.022	4.072LeuIle: 4.072 ± 0.037	3.997LeuLys: 3.997 ± 0.032	8.411LeuLeu: 8.411 ± 0.057	1.884LeuMet: 1.884 ± 0.021	3.272LeuAsn: 3.272 ± 0.026	5.436LeuPro: 5.436 ± 0.039	3.959LeuGln: 3.959 ± 0.033	5.657LeuArg: 5.657 ± 0.041	7.486LeuSer: 7.486 ± 0.045	4.805LeuThr: 4.805 ± 0.035	5.543LeuVal: 5.543 ± 0.039	1.231LeuTrp: 1.231 ± 0.018	2.388LeuTyr: 2.388 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.251MetAla: 2.251 ± 0.02	0.261MetCys: 0.261 ± 0.007	1.332MetAsp: 1.332 ± 0.019	1.345MetGlu: 1.345 ± 0.015	0.812MetPhe: 0.812 ± 0.015	1.547MetGly: 1.547 ± 0.018	0.53MetHis: 0.53 ± 0.009	1.075MetIle: 1.075 ± 0.015	1.001MetLys: 1.001 ± 0.014	1.897MetLeu: 1.897 ± 0.018	0.601MetMet: 0.601 ± 0.012	0.866MetAsn: 0.866 ± 0.015	1.31MetPro: 1.31 ± 0.018	0.933MetGln: 0.933 ± 0.014	1.28MetArg: 1.28 ± 0.017	1.966MetSer: 1.966 ± 0.019	1.359MetThr: 1.359 ± 0.016	1.418MetVal: 1.418 ± 0.018	0.278MetTrp: 0.278 ± 0.009	0.532MetTyr: 0.532 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.15AsnAla: 3.15 ± 0.027	0.463AsnCys: 0.463 ± 0.01	1.982AsnAsp: 1.982 ± 0.021	2.12AsnGlu: 2.12 ± 0.02	1.424AsnPhe: 1.424 ± 0.017	2.914AsnGly: 2.914 ± 0.029	0.861AsnHis: 0.861 ± 0.012	2.16AsnIle: 2.16 ± 0.022	1.545AsnLys: 1.545 ± 0.019	3.329AsnLeu: 3.329 ± 0.03	0.899AsnMet: 0.899 ± 0.014	1.472AsnAsn: 1.472 ± 0.02	2.6AsnPro: 2.6 ± 0.027	1.422AsnGln: 1.422 ± 0.018	1.978AsnArg: 1.978 ± 0.021	2.786AsnSer: 2.786 ± 0.022	2.263AsnThr: 2.263 ± 0.023	2.351AsnVal: 2.351 ± 0.024	0.582AsnTrp: 0.582 ± 0.012	1.081AsnTyr: 1.081 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.159ProAla: 5.159 ± 0.047	0.546ProCys: 0.546 ± 0.011	3.289ProAsp: 3.289 ± 0.024	3.975ProGlu: 3.975 ± 0.048	2.113ProPhe: 2.113 ± 0.022	3.943ProGly: 3.943 ± 0.037	1.369ProHis: 1.369 ± 0.022	2.643ProIle: 2.643 ± 0.021	2.612ProLys: 2.612 ± 0.027	4.726ProLeu: 4.726 ± 0.035	1.18ProMet: 1.18 ± 0.015	2.264ProAsn: 2.264 ± 0.023	4.603ProPro: 4.603 ± 0.058	2.491ProGln: 2.491 ± 0.031	3.391ProArg: 3.391 ± 0.032	6.066ProSer: 6.066 ± 0.043	4.047ProThr: 4.047 ± 0.036	3.727ProVal: 3.727 ± 0.031	0.81ProTrp: 0.81 ± 0.014	1.521ProTyr: 1.521 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.41GlnAla: 3.41 ± 0.028	0.471GlnCys: 0.471 ± 0.01	2.084GlnAsp: 2.084 ± 0.019	2.459GlnGlu: 2.459 ± 0.027	1.377GlnPhe: 1.377 ± 0.018	2.463GlnGly: 2.463 ± 0.025	1.063GlnHis: 1.063 ± 0.017	2.012GlnIle: 2.012 ± 0.021	2.016GlnLys: 2.016 ± 0.023	3.514GlnLeu: 3.514 ± 0.028	0.946GlnMet: 0.946 ± 0.015	1.641GlnAsn: 1.641 ± 0.018	2.612GlnPro: 2.612 ± 0.032	2.179GlnGln: 2.179 ± 0.036	2.609GlnArg: 2.609 ± 0.025	3.338GlnSer: 3.338 ± 0.03	2.445GlnThr: 2.445 ± 0.022	2.244GlnVal: 2.244 ± 0.022	0.611GlnTrp: 0.611 ± 0.011	1.224GlnTyr: 1.224 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.595ArgAla: 4.595 ± 0.031	0.709ArgCys: 0.709 ± 0.014	3.32ArgAsp: 3.32 ± 0.031	3.69ArgGlu: 3.69 ± 0.033	2.158ArgPhe: 2.158 ± 0.022	3.642ArgGly: 3.642 ± 0.031	1.538ArgHis: 1.538 ± 0.02	2.904ArgIle: 2.904 ± 0.024	3.261ArgLys: 3.261 ± 0.026	5.444ArgLeu: 5.444 ± 0.039	1.329ArgMet: 1.329 ± 0.018	2.223ArgAsn: 2.223 ± 0.022	3.444ArgPro: 3.444 ± 0.031	2.565ArgGln: 2.565 ± 0.026	4.821ArgArg: 4.821 ± 0.049	4.753ArgSer: 4.753 ± 0.045	3.251ArgThr: 3.251 ± 0.026	3.418ArgVal: 3.418 ± 0.028	0.949ArgTrp: 0.949 ± 0.015	1.643ArgTyr: 1.643 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.687SerAla: 6.687 ± 0.04	0.911SerCys: 0.911 ± 0.015	4.386SerAsp: 4.386 ± 0.032	4.348SerGlu: 4.348 ± 0.036	3.097SerPhe: 3.097 ± 0.025	5.547SerGly: 5.547 ± 0.038	2.069SerHis: 2.069 ± 0.02	4.122SerIle: 4.122 ± 0.031	3.69SerLys: 3.69 ± 0.027	7.408SerLeu: 7.408 ± 0.039	1.842SerMet: 1.842 ± 0.018	3.076SerAsn: 3.076 ± 0.026	5.587SerPro: 5.587 ± 0.05	3.405SerGln: 3.405 ± 0.026	4.913SerArg: 4.913 ± 0.04	8.522SerSer: 8.522 ± 0.071	5.571SerThr: 5.571 ± 0.038	4.83SerVal: 4.83 ± 0.035	1.202SerTrp: 1.202 ± 0.016	2.111SerTyr: 2.111 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.099ThrAla: 5.099 ± 0.032	0.751ThrCys: 0.751 ± 0.014	2.979ThrAsp: 2.979 ± 0.024	3.349ThrGlu: 3.349 ± 0.032	2.225ThrPhe: 2.225 ± 0.021	4.28ThrGly: 4.28 ± 0.036	1.324ThrHis: 1.324 ± 0.019	3.138ThrIle: 3.138 ± 0.025	2.546ThrLys: 2.546 ± 0.026	5.266ThrLeu: 5.266 ± 0.035	1.26ThrMet: 1.26 ± 0.016	2.141ThrAsn: 2.141 ± 0.02	4.342ThrPro: 4.342 ± 0.042	2.199ThrGln: 2.199 ± 0.023	3.119ThrArg: 3.119 ± 0.024	5.278ThrSer: 5.278 ± 0.04	4.111ThrThr: 4.111 ± 0.036	3.792ThrVal: 3.792 ± 0.031	0.879ThrTrp: 0.879 ± 0.012	1.613ThrTyr: 1.613 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	5.196ValAla: 5.196 ± 0.035	0.861ValCys: 0.861 ± 0.014	3.741ValAsp: 3.741 ± 0.03	3.722ValGlu: 3.722 ± 0.032	2.556ValPhe: 2.556 ± 0.025	4.037ValGly: 4.037 ± 0.034	1.477ValHis: 1.477 ± 0.021	3.152ValIle: 3.152 ± 0.029	2.731ValLys: 2.731 ± 0.026	5.617ValLeu: 5.617 ± 0.039	1.386ValMet: 1.386 ± 0.017	2.303ValAsn: 2.303 ± 0.024	3.657ValPro: 3.657 ± 0.028	2.464ValGln: 2.464 ± 0.022	3.374ValArg: 3.374 ± 0.028	4.889ValSer: 4.889 ± 0.032	3.561ValThr: 3.561 ± 0.028	4.221ValVal: 4.221 ± 0.04	0.858ValTrp: 0.858 ± 0.015	1.765ValTyr: 1.765 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.169TrpAla: 1.169 ± 0.017	0.195TrpCys: 0.195 ± 0.007	0.905TrpAsp: 0.905 ± 0.015	0.865TrpGlu: 0.865 ± 0.013	0.535TrpPhe: 0.535 ± 0.01	0.939TrpGly: 0.939 ± 0.015	0.362TrpHis: 0.362 ± 0.007	0.795TrpIle: 0.795 ± 0.014	0.83TrpLys: 0.83 ± 0.012	1.399TrpLeu: 1.399 ± 0.019	0.414TrpMet: 0.414 ± 0.009	0.653TrpAsn: 0.653 ± 0.012	0.614TrpPro: 0.614 ± 0.009	0.579TrpGln: 0.579 ± 0.011	0.972TrpArg: 0.972 ± 0.014	1.124TrpSer: 1.124 ± 0.017	0.95TrpThr: 0.95 ± 0.014	0.917TrpVal: 0.917 ± 0.014	0.285TrpTrp: 0.285 ± 0.007	0.448TrpTyr: 0.448 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.138TyrAla: 2.138 ± 0.024	0.412TyrCys: 0.412 ± 0.009	1.631TyrAsp: 1.631 ± 0.018	1.522TyrGlu: 1.522 ± 0.015	1.203TyrPhe: 1.203 ± 0.015	2.124TyrGly: 2.124 ± 0.023	0.782TyrHis: 0.782 ± 0.013	1.45TyrIle: 1.45 ± 0.019	1.089TyrLys: 1.089 ± 0.015	2.683TyrLeu: 2.683 ± 0.023	0.651TyrMet: 0.651 ± 0.011	1.144TyrAsn: 1.144 ± 0.017	1.551TyrPro: 1.551 ± 0.021	1.155TyrGln: 1.155 ± 0.015	1.648TyrArg: 1.648 ± 0.019	2.127TyrSer: 2.127 ± 0.02	1.618TyrThr: 1.618 ± 0.021	1.625TyrVal: 1.625 ± 0.017	0.457TyrTrp: 0.457 ± 0.009	0.964TyrTyr: 0.964 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 10875 proteins (5176197 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---