Amino acid dipepetide frequency for Wickerhamiella sorbophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.97AlaAla: 8.97 ± 0.124	0.93AlaCys: 0.93 ± 0.024	4.137AlaAsp: 4.137 ± 0.046	5.32AlaGlu: 5.32 ± 0.079	2.986AlaPhe: 2.986 ± 0.05	4.97AlaGly: 4.97 ± 0.055	1.717AlaHis: 1.717 ± 0.03	4.402AlaIle: 4.402 ± 0.051	4.93AlaLys: 4.93 ± 0.054	8.145AlaLeu: 8.145 ± 0.069	1.925AlaMet: 1.925 ± 0.033	3.226AlaAsn: 3.226 ± 0.035	4.611AlaPro: 4.611 ± 0.093	3.724AlaGln: 3.724 ± 0.085	4.656AlaArg: 4.656 ± 0.066	6.726AlaSer: 6.726 ± 0.102	4.903AlaThr: 4.903 ± 0.064	6.001AlaVal: 6.001 ± 0.058	0.851AlaTrp: 0.851 ± 0.024	2.112AlaTyr: 2.112 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.866CysAla: 0.866 ± 0.021	0.204CysCys: 0.204 ± 0.011	0.674CysAsp: 0.674 ± 0.022	0.633CysGlu: 0.633 ± 0.019	0.498CysPhe: 0.498 ± 0.015	0.847CysGly: 0.847 ± 0.022	0.291CysHis: 0.291 ± 0.013	0.661CysIle: 0.661 ± 0.017	0.512CysLys: 0.512 ± 0.015	1.178CysLeu: 1.178 ± 0.029	0.259CysMet: 0.259 ± 0.011	0.41CysAsn: 0.41 ± 0.015	0.588CysPro: 0.588 ± 0.019	0.463CysGln: 0.463 ± 0.014	0.668CysArg: 0.668 ± 0.017	0.862CysSer: 0.862 ± 0.022	0.633CysThr: 0.633 ± 0.026	0.814CysVal: 0.814 ± 0.017	0.149CysTrp: 0.149 ± 0.008	0.387CysTyr: 0.387 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.384AspAla: 4.384 ± 0.052	0.604AspCys: 0.604 ± 0.021	3.715AspAsp: 3.715 ± 0.069	4.437AspGlu: 4.437 ± 0.065	2.434AspPhe: 2.434 ± 0.036	3.367AspGly: 3.367 ± 0.045	1.158AspHis: 1.158 ± 0.023	3.208AspIle: 3.208 ± 0.042	2.736AspLys: 2.736 ± 0.041	5.772AspLeu: 5.772 ± 0.053	1.304AspMet: 1.304 ± 0.028	2.024AspAsn: 2.024 ± 0.031	3.049AspPro: 3.049 ± 0.046	2.012AspGln: 2.012 ± 0.037	2.905AspArg: 2.905 ± 0.05	4.209AspSer: 4.209 ± 0.05	2.856AspThr: 2.856 ± 0.034	3.913AspVal: 3.913 ± 0.054	0.779AspTrp: 0.779 ± 0.02	1.794AspTyr: 1.794 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.38GluAla: 5.38 ± 0.069	0.604GluCys: 0.604 ± 0.018	3.759GluAsp: 3.759 ± 0.069	4.992GluGlu: 4.992 ± 0.083	2.534GluPhe: 2.534 ± 0.036	3.02GluGly: 3.02 ± 0.042	1.434GluHis: 1.434 ± 0.027	3.623GluIle: 3.623 ± 0.048	3.811GluLys: 3.811 ± 0.058	6.747GluLeu: 6.747 ± 0.069	1.476GluMet: 1.476 ± 0.023	2.693GluAsn: 2.693 ± 0.04	3.26GluPro: 3.26 ± 0.067	2.922GluGln: 2.922 ± 0.047	3.576GluArg: 3.576 ± 0.049	4.685GluSer: 4.685 ± 0.057	3.748GluThr: 3.748 ± 0.056	4.013GluVal: 4.013 ± 0.051	0.825GluTrp: 0.825 ± 0.019	2.038GluTyr: 2.038 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.158PheAla: 3.158 ± 0.041	0.58PheCys: 0.58 ± 0.018	2.664PheAsp: 2.664 ± 0.039	2.581PheGlu: 2.581 ± 0.034	1.586PhePhe: 1.586 ± 0.035	2.897PheGly: 2.897 ± 0.061	0.827PheHis: 0.827 ± 0.021	1.805PheIle: 1.805 ± 0.031	2.009PheLys: 2.009 ± 0.033	3.467PheLeu: 3.467 ± 0.054	0.902PheMet: 0.902 ± 0.02	1.612PheAsn: 1.612 ± 0.029	1.55PhePro: 1.55 ± 0.029	1.343PheGln: 1.343 ± 0.029	1.879PheArg: 1.879 ± 0.034	3.234PheSer: 3.234 ± 0.047	2.144PheThr: 2.144 ± 0.037	2.999PheVal: 2.999 ± 0.039	0.579PheTrp: 0.579 ± 0.018	1.318PheTyr: 1.318 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.655GlyAla: 4.655 ± 0.069	0.695GlyCys: 0.695 ± 0.019	3.22GlyAsp: 3.22 ± 0.042	3.257GlyGlu: 3.257 ± 0.043	2.581GlyPhe: 2.581 ± 0.04	4.122GlyGly: 4.122 ± 0.074	1.454GlyHis: 1.454 ± 0.029	3.332GlyIle: 3.332 ± 0.052	3.238GlyLys: 3.238 ± 0.045	5.568GlyLeu: 5.568 ± 0.058	1.311GlyMet: 1.311 ± 0.03	2.24GlyAsn: 2.24 ± 0.04	2.843GlyPro: 2.843 ± 0.047	2.369GlyGln: 2.369 ± 0.043	3.251GlyArg: 3.251 ± 0.045	5.176GlySer: 5.176 ± 0.097	3.445GlyThr: 3.445 ± 0.051	4.174GlyVal: 4.174 ± 0.054	0.837GlyTrp: 0.837 ± 0.023	2.003GlyTyr: 2.003 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.539HisAla: 1.539 ± 0.024	0.295HisCys: 0.295 ± 0.011	1.128HisAsp: 1.128 ± 0.019	1.336HisGlu: 1.336 ± 0.026	0.913HisPhe: 0.913 ± 0.018	1.34HisGly: 1.34 ± 0.029	0.675HisHis: 0.675 ± 0.02	1.255HisIle: 1.255 ± 0.025	1.076HisLys: 1.076 ± 0.022	2.116HisLeu: 2.116 ± 0.032	0.511HisMet: 0.511 ± 0.014	0.834HisAsn: 0.834 ± 0.022	1.356HisPro: 1.356 ± 0.029	0.903HisGln: 0.903 ± 0.025	1.329HisArg: 1.329 ± 0.026	1.634HisSer: 1.634 ± 0.029	1.188HisThr: 1.188 ± 0.028	1.397HisVal: 1.397 ± 0.025	0.266HisTrp: 0.266 ± 0.011	0.723HisTyr: 0.723 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.374IleAla: 4.374 ± 0.052	0.723IleCys: 0.723 ± 0.02	3.438IleAsp: 3.438 ± 0.043	3.542IleGlu: 3.542 ± 0.044	1.904IlePhe: 1.904 ± 0.037	2.972IleGly: 2.972 ± 0.045	1.091IleHis: 1.091 ± 0.024	2.429IleIle: 2.429 ± 0.037	2.764IleLys: 2.764 ± 0.04	4.525IleLeu: 4.525 ± 0.051	1.109IleMet: 1.109 ± 0.026	2.011IleAsn: 2.011 ± 0.031	2.7IlePro: 2.7 ± 0.046	1.923IleGln: 1.923 ± 0.03	2.635IleArg: 2.635 ± 0.035	4.061IleSer: 4.061 ± 0.045	2.715IleThr: 2.715 ± 0.042	3.769IleVal: 3.769 ± 0.05	0.616IleTrp: 0.616 ± 0.016	1.682IleTyr: 1.682 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.428LysAla: 4.428 ± 0.056	0.522LysCys: 0.522 ± 0.015	2.823LysAsp: 2.823 ± 0.046	3.55LysGlu: 3.55 ± 0.051	1.956LysPhe: 1.956 ± 0.03	2.623LysGly: 2.623 ± 0.035	1.208LysHis: 1.208 ± 0.029	2.777LysIle: 2.777 ± 0.033	3.347LysLys: 3.347 ± 0.063	5.41LysLeu: 5.41 ± 0.064	1.153LysMet: 1.153 ± 0.025	1.973LysAsn: 1.973 ± 0.032	2.844LysPro: 2.844 ± 0.047	2.333LysGln: 2.333 ± 0.035	3.357LysArg: 3.357 ± 0.051	3.919LysSer: 3.919 ± 0.05	3.053LysThr: 3.053 ± 0.047	3.749LysVal: 3.749 ± 0.05	0.678LysTrp: 0.678 ± 0.02	1.843LysTyr: 1.843 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	8.704LeuAla: 8.704 ± 0.071	1.219LeuCys: 1.219 ± 0.028	5.809LeuAsp: 5.809 ± 0.063	6.578LeuGlu: 6.578 ± 0.078	3.744LeuPhe: 3.744 ± 0.044	5.728LeuGly: 5.728 ± 0.063	2.002LeuHis: 2.002 ± 0.032	4.229LeuIle: 4.229 ± 0.051	5.183LeuLys: 5.183 ± 0.052	8.994LeuLeu: 8.994 ± 0.102	2.02LeuMet: 2.02 ± 0.034	3.728LeuAsn: 3.728 ± 0.04	5.015LeuPro: 5.015 ± 0.059	4.009LeuGln: 4.009 ± 0.043	5.58LeuArg: 5.58 ± 0.066	7.555LeuSer: 7.555 ± 0.08	4.999LeuThr: 4.999 ± 0.064	6.817LeuVal: 6.817 ± 0.07	1.139LeuTrp: 1.139 ± 0.029	2.773LeuTyr: 2.773 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.129MetAla: 2.129 ± 0.039	0.247MetCys: 0.247 ± 0.01	1.285MetAsp: 1.285 ± 0.024	1.186MetGlu: 1.186 ± 0.024	0.921MetPhe: 0.921 ± 0.022	1.387MetGly: 1.387 ± 0.028	0.44MetHis: 0.44 ± 0.014	1.097MetIle: 1.097 ± 0.023	0.94MetLys: 0.94 ± 0.019	2.125MetLeu: 2.125 ± 0.034	0.501MetMet: 0.501 ± 0.016	0.838MetAsn: 0.838 ± 0.02	1.313MetPro: 1.313 ± 0.034	0.864MetGln: 0.864 ± 0.022	1.177MetArg: 1.177 ± 0.023	2.077MetSer: 2.077 ± 0.033	1.205MetThr: 1.205 ± 0.033	1.497MetVal: 1.497 ± 0.03	0.26MetTrp: 0.26 ± 0.011	0.614MetTyr: 0.614 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.024AsnAla: 3.024 ± 0.038	0.46AsnCys: 0.46 ± 0.014	2.192AsnAsp: 2.192 ± 0.037	2.426AsnGlu: 2.426 ± 0.037	1.53AsnPhe: 1.53 ± 0.029	2.617AsnGly: 2.617 ± 0.038	0.835AsnHis: 0.835 ± 0.02	2.106AsnIle: 2.106 ± 0.035	1.923AsnLys: 1.923 ± 0.035	3.537AsnLeu: 3.537 ± 0.05	0.936AsnMet: 0.936 ± 0.021	1.54AsnAsn: 1.54 ± 0.037	2.142AsnPro: 2.142 ± 0.034	1.437AsnGln: 1.437 ± 0.032	2.093AsnArg: 2.093 ± 0.036	2.864AsnSer: 2.864 ± 0.044	2.091AsnThr: 2.091 ± 0.044	2.704AsnVal: 2.704 ± 0.036	0.515AsnTrp: 0.515 ± 0.016	1.274AsnTyr: 1.274 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.808ProAla: 4.808 ± 0.082	0.474ProCys: 0.474 ± 0.029	2.919ProAsp: 2.919 ± 0.049	4.239ProGlu: 4.239 ± 0.084	1.865ProPhe: 1.865 ± 0.034	3.148ProGly: 3.148 ± 0.057	1.136ProHis: 1.136 ± 0.024	2.392ProIle: 2.392 ± 0.04	2.825ProLys: 2.825 ± 0.039	4.656ProLeu: 4.656 ± 0.048	1.055ProMet: 1.055 ± 0.023	2.016ProAsn: 2.016 ± 0.032	3.688ProPro: 3.688 ± 0.092	2.451ProGln: 2.451 ± 0.05	2.679ProArg: 2.679 ± 0.047	4.675ProSer: 4.675 ± 0.073	3.286ProThr: 3.286 ± 0.06	3.862ProVal: 3.862 ± 0.058	0.542ProTrp: 0.542 ± 0.016	1.395ProTyr: 1.395 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.701GlnAla: 3.701 ± 0.089	0.421GlnCys: 0.421 ± 0.014	1.919GlnAsp: 1.919 ± 0.031	2.5GlnGlu: 2.5 ± 0.038	1.633GlnPhe: 1.633 ± 0.031	2.109GlnGly: 2.109 ± 0.037	0.902GlnHis: 0.902 ± 0.021	2.224GlnIle: 2.224 ± 0.032	2.09GlnLys: 2.09 ± 0.035	4.374GlnLeu: 4.374 ± 0.048	0.961GlnMet: 0.961 ± 0.022	1.629GlnAsn: 1.629 ± 0.029	2.251GlnPro: 2.251 ± 0.056	2.418GlnGln: 2.418 ± 0.074	2.506GlnArg: 2.506 ± 0.038	3.078GlnSer: 3.078 ± 0.053	2.34GlnThr: 2.34 ± 0.043	2.879GlnVal: 2.879 ± 0.037	0.527GlnTrp: 0.527 ± 0.015	1.227GlnTyr: 1.227 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	4.578ArgAla: 4.578 ± 0.071	0.576ArgCys: 0.576 ± 0.02	2.953ArgAsp: 2.953 ± 0.045	3.501ArgGlu: 3.501 ± 0.05	2.187ArgPhe: 2.187 ± 0.036	2.984ArgGly: 2.984 ± 0.05	1.33ArgHis: 1.33 ± 0.026	2.921ArgIle: 2.921 ± 0.04	3.336ArgLys: 3.336 ± 0.048	5.452ArgLeu: 5.452 ± 0.055	1.235ArgMet: 1.235 ± 0.025	2.105ArgAsn: 2.105 ± 0.03	2.834ArgPro: 2.834 ± 0.041	2.701ArgGln: 2.701 ± 0.037	4.165ArgArg: 4.165 ± 0.059	4.12ArgSer: 4.12 ± 0.058	2.979ArgThr: 2.979 ± 0.039	3.532ArgVal: 3.532 ± 0.043	0.678ArgTrp: 0.678 ± 0.02	1.703ArgTyr: 1.703 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.537SerAla: 6.537 ± 0.085	0.776SerCys: 0.776 ± 0.023	4.388SerAsp: 4.388 ± 0.05	4.814SerGlu: 4.814 ± 0.052	2.975SerPhe: 2.975 ± 0.044	5.202SerGly: 5.202 ± 0.145	1.677SerHis: 1.677 ± 0.027	3.918SerIle: 3.918 ± 0.045	4.256SerLys: 4.256 ± 0.053	7.452SerLeu: 7.452 ± 0.068	1.787SerMet: 1.787 ± 0.034	2.95SerAsn: 2.95 ± 0.046	4.425SerPro: 4.425 ± 0.066	3.351SerGln: 3.351 ± 0.052	4.44SerArg: 4.44 ± 0.051	7.759SerSer: 7.759 ± 0.126	4.871SerThr: 4.871 ± 0.071	5.322SerVal: 5.322 ± 0.067	0.918SerTrp: 0.918 ± 0.021	2.084SerTyr: 2.084 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.839ThrAla: 4.839 ± 0.057	0.666ThrCys: 0.666 ± 0.019	2.752ThrAsp: 2.752 ± 0.044	3.31ThrGlu: 3.31 ± 0.046	2.155ThrPhe: 2.155 ± 0.038	3.675ThrGly: 3.675 ± 0.058	1.146ThrHis: 1.146 ± 0.027	3.037ThrIle: 3.037 ± 0.046	2.946ThrLys: 2.946 ± 0.036	5.261ThrLeu: 5.261 ± 0.057	1.206ThrMet: 1.206 ± 0.026	2.056ThrAsn: 2.056 ± 0.037	3.763ThrPro: 3.763 ± 0.054	2.109ThrGln: 2.109 ± 0.04	2.846ThrArg: 2.846 ± 0.05	4.634ThrSer: 4.634 ± 0.077	3.513ThrThr: 3.513 ± 0.089	4.229ThrVal: 4.229 ± 0.08	0.648ThrTrp: 0.648 ± 0.02	1.444ThrTyr: 1.444 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	5.941ValAla: 5.941 ± 0.073	0.962ValCys: 0.962 ± 0.022	4.326ValAsp: 4.326 ± 0.047	4.436ValGlu: 4.436 ± 0.053	2.886ValPhe: 2.886 ± 0.045	4.019ValGly: 4.019 ± 0.048	1.488ValHis: 1.488 ± 0.029	3.356ValIle: 3.356 ± 0.046	3.51ValLys: 3.51 ± 0.047	6.793ValLeu: 6.793 ± 0.069	1.427ValMet: 1.427 ± 0.028	2.517ValAsn: 2.517 ± 0.035	4.037ValPro: 4.037 ± 0.059	2.695ValGln: 2.695 ± 0.038	3.656ValArg: 3.656 ± 0.047	5.487ValSer: 5.487 ± 0.06	3.791ValThr: 3.791 ± 0.079	5.376ValVal: 5.376 ± 0.068	0.827ValTrp: 0.827 ± 0.021	2.251ValTyr: 2.251 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.97TrpAla: 0.97 ± 0.02	0.181TrpCys: 0.181 ± 0.009	0.74TrpAsp: 0.74 ± 0.021	0.615TrpGlu: 0.615 ± 0.016	0.461TrpPhe: 0.461 ± 0.016	0.73TrpGly: 0.73 ± 0.022	0.283TrpHis: 0.283 ± 0.011	0.636TrpIle: 0.636 ± 0.018	0.688TrpLys: 0.688 ± 0.019	1.215TrpLeu: 1.215 ± 0.024	0.276TrpMet: 0.276 ± 0.011	0.561TrpAsn: 0.561 ± 0.017	0.485TrpPro: 0.485 ± 0.017	0.54TrpGln: 0.54 ± 0.014	0.749TrpArg: 0.749 ± 0.021	0.955TrpSer: 0.955 ± 0.024	0.767TrpThr: 0.767 ± 0.021	0.793TrpVal: 0.793 ± 0.02	0.202TrpTrp: 0.202 ± 0.011	0.393TrpTyr: 0.393 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.257TyrAla: 2.257 ± 0.035	0.456TyrCys: 0.456 ± 0.015	1.815TyrAsp: 1.815 ± 0.032	1.885TyrGlu: 1.885 ± 0.034	1.387TyrPhe: 1.387 ± 0.028	2.013TyrGly: 2.013 ± 0.037	0.72TyrHis: 0.72 ± 0.021	1.576TyrIle: 1.576 ± 0.031	1.428TyrLys: 1.428 ± 0.026	3.037TyrLeu: 3.037 ± 0.046	0.745TyrMet: 0.745 ± 0.022	1.286TyrAsn: 1.286 ± 0.028	1.357TyrPro: 1.357 ± 0.031	1.127TyrGln: 1.127 ± 0.027	1.722TyrArg: 1.722 ± 0.028	2.192TyrSer: 2.192 ± 0.035	1.71TyrThr: 1.71 ± 0.033	1.94TyrVal: 1.94 ± 0.031	0.405TyrTrp: 0.405 ± 0.013	1.058TyrTyr: 1.058 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4707 proteins (2105241 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---