Amino acid dipepetide frequency for Tengunoibacter tsumagoiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.128AlaAla: 8.128 ± 0.092	0.938AlaCys: 0.938 ± 0.023	4.051AlaAsp: 4.051 ± 0.048	5.066AlaGlu: 5.066 ± 0.058	3.492AlaPhe: 3.492 ± 0.047	6.339AlaGly: 6.339 ± 0.069	2.466AlaHis: 2.466 ± 0.036	5.688AlaIle: 5.688 ± 0.059	2.391AlaLys: 2.391 ± 0.043	11.599AlaLeu: 11.599 ± 0.114	1.951AlaMet: 1.951 ± 0.033	2.923AlaAsn: 2.923 ± 0.047	3.916AlaPro: 3.916 ± 0.054	5.072AlaGln: 5.072 ± 0.062	5.389AlaArg: 5.389 ± 0.063	5.895AlaSer: 5.895 ± 0.052	5.507AlaThr: 5.507 ± 0.088	5.637AlaVal: 5.637 ± 0.063	1.234AlaTrp: 1.234 ± 0.031	2.825AlaTyr: 2.825 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.78CysAla: 0.78 ± 0.02	0.164CysCys: 0.164 ± 0.01	0.447CysAsp: 0.447 ± 0.015	0.46CysGlu: 0.46 ± 0.015	0.401CysPhe: 0.401 ± 0.015	0.832CysGly: 0.832 ± 0.024	0.262CysHis: 0.262 ± 0.012	0.613CysIle: 0.613 ± 0.02	0.253CysLys: 0.253 ± 0.011	1.051CysLeu: 1.051 ± 0.025	0.187CysMet: 0.187 ± 0.01	0.334CysAsn: 0.334 ± 0.014	0.481CysPro: 0.481 ± 0.018	0.483CysGln: 0.483 ± 0.016	0.48CysArg: 0.48 ± 0.018	0.663CysSer: 0.663 ± 0.017	0.573CysThr: 0.573 ± 0.017	0.598CysVal: 0.598 ± 0.018	0.153CysTrp: 0.153 ± 0.01	0.34CysTyr: 0.34 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.222AspAla: 4.222 ± 0.05	0.413AspCys: 0.413 ± 0.016	2.141AspAsp: 2.141 ± 0.037	3.249AspGlu: 3.249 ± 0.049	1.74AspPhe: 1.74 ± 0.028	3.499AspGly: 3.499 ± 0.046	1.152AspHis: 1.152 ± 0.024	2.72AspIle: 2.72 ± 0.048	1.36AspLys: 1.36 ± 0.03	5.458AspLeu: 5.458 ± 0.052	0.922AspMet: 0.922 ± 0.021	1.364AspAsn: 1.364 ± 0.028	2.916AspPro: 2.916 ± 0.037	2.35AspGln: 2.35 ± 0.037	2.502AspArg: 2.502 ± 0.036	2.32AspSer: 2.32 ± 0.037	2.476AspThr: 2.476 ± 0.039	3.09AspVal: 3.09 ± 0.042	0.787AspTrp: 0.787 ± 0.022	1.611AspTyr: 1.611 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.734GluAla: 5.734 ± 0.078	0.41GluCys: 0.41 ± 0.014	2.523GluAsp: 2.523 ± 0.033	4.455GluGlu: 4.455 ± 0.064	1.402GluPhe: 1.402 ± 0.029	3.419GluGly: 3.419 ± 0.042	1.774GluHis: 1.774 ± 0.032	3.587GluIle: 3.587 ± 0.05	2.566GluLys: 2.566 ± 0.045	6.254GluLeu: 6.254 ± 0.072	1.447GluMet: 1.447 ± 0.028	1.791GluAsn: 1.791 ± 0.033	2.383GluPro: 2.383 ± 0.037	4.592GluGln: 4.592 ± 0.083	4.529GluArg: 4.529 ± 0.059	2.741GluSer: 2.741 ± 0.036	3.192GluThr: 3.192 ± 0.045	3.783GluVal: 3.783 ± 0.046	0.718GluTrp: 0.718 ± 0.024	1.622GluTyr: 1.622 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.439PheAla: 3.439 ± 0.044	0.492PheCys: 0.492 ± 0.018	1.952PheAsp: 1.952 ± 0.031	1.953PheGlu: 1.953 ± 0.031	1.827PhePhe: 1.827 ± 0.033	2.76PheGly: 2.76 ± 0.048	0.957PheHis: 0.957 ± 0.024	2.109PheIle: 2.109 ± 0.035	0.968PheLys: 0.968 ± 0.022	4.28PheLeu: 4.28 ± 0.07	0.742PheMet: 0.742 ± 0.018	1.14PheAsn: 1.14 ± 0.027	1.752PhePro: 1.752 ± 0.032	1.764PheGln: 1.764 ± 0.033	1.694PheArg: 1.694 ± 0.031	2.783PheSer: 2.783 ± 0.043	2.433PheThr: 2.433 ± 0.037	2.65PheVal: 2.65 ± 0.041	0.684PheTrp: 0.684 ± 0.017	1.234PheTyr: 1.234 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	5.505GlyAla: 5.505 ± 0.066	0.712GlyCys: 0.712 ± 0.022	3.051GlyAsp: 3.051 ± 0.045	3.812GlyGlu: 3.812 ± 0.052	2.579GlyPhe: 2.579 ± 0.04	5.181GlyGly: 5.181 ± 0.07	1.674GlyHis: 1.674 ± 0.035	4.622GlyIle: 4.622 ± 0.053	3.087GlyLys: 3.087 ± 0.045	7.437GlyLeu: 7.437 ± 0.072	1.708GlyMet: 1.708 ± 0.034	2.489GlyAsn: 2.489 ± 0.05	2.642GlyPro: 2.642 ± 0.033	3.473GlyGln: 3.473 ± 0.048	3.783GlyArg: 3.783 ± 0.052	4.935GlySer: 4.935 ± 0.066	4.343GlyThr: 4.343 ± 0.069	4.72GlyVal: 4.72 ± 0.063	1.233GlyTrp: 1.233 ± 0.027	2.563GlyTyr: 2.563 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.08HisAla: 2.08 ± 0.032	0.309HisCys: 0.309 ± 0.013	1.202HisAsp: 1.202 ± 0.03	1.477HisGlu: 1.477 ± 0.026	1.141HisPhe: 1.141 ± 0.022	1.739HisGly: 1.739 ± 0.034	0.909HisHis: 0.909 ± 0.03	1.519HisIle: 1.519 ± 0.029	0.729HisLys: 0.729 ± 0.017	3.272HisLeu: 3.272 ± 0.052	0.537HisMet: 0.537 ± 0.015	0.767HisAsn: 0.767 ± 0.02	1.67HisPro: 1.67 ± 0.029	1.328HisGln: 1.328 ± 0.025	1.34HisArg: 1.34 ± 0.026	1.516HisSer: 1.516 ± 0.027	1.545HisThr: 1.545 ± 0.03	1.627HisVal: 1.627 ± 0.03	0.446HisTrp: 0.446 ± 0.016	0.954HisTyr: 0.954 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.159IleAla: 6.159 ± 0.058	0.708IleCys: 0.708 ± 0.021	3.141IleAsp: 3.141 ± 0.044	3.798IleGlu: 3.798 ± 0.051	2.307IlePhe: 2.307 ± 0.041	4.492IleGly: 4.492 ± 0.052	1.544IleHis: 1.544 ± 0.029	3.636IleIle: 3.636 ± 0.059	1.815IleLys: 1.815 ± 0.034	6.062IleLeu: 6.062 ± 0.067	1.009IleMet: 1.009 ± 0.023	2.004IleAsn: 2.004 ± 0.033	3.078IlePro: 3.078 ± 0.044	2.774IleGln: 2.774 ± 0.039	2.876IleArg: 2.876 ± 0.036	3.831IleSer: 3.831 ± 0.052	3.591IleThr: 3.591 ± 0.047	4.417IleVal: 4.417 ± 0.059	0.905IleTrp: 0.905 ± 0.025	1.843IleTyr: 1.843 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.982LysAla: 2.982 ± 0.044	0.203LysCys: 0.203 ± 0.011	1.642LysAsp: 1.642 ± 0.032	2.123LysGlu: 2.123 ± 0.037	0.815LysPhe: 0.815 ± 0.019	2.179LysGly: 2.179 ± 0.034	0.804LysHis: 0.804 ± 0.02	1.972LysIle: 1.972 ± 0.035	1.662LysLys: 1.662 ± 0.037	3.074LysLeu: 3.074 ± 0.049	0.839LysMet: 0.839 ± 0.021	1.204LysAsn: 1.204 ± 0.029	1.55LysPro: 1.55 ± 0.029	2.089LysGln: 2.089 ± 0.038	2.319LysArg: 2.319 ± 0.039	1.759LysSer: 1.759 ± 0.032	2.057LysThr: 2.057 ± 0.037	2.192LysVal: 2.192 ± 0.037	0.36LysTrp: 0.36 ± 0.014	0.918LysTyr: 0.918 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	11.083LeuAla: 11.083 ± 0.102	1.274LeuCys: 1.274 ± 0.025	5.12LeuAsp: 5.12 ± 0.051	6.108LeuGlu: 6.108 ± 0.075	4.768LeuPhe: 4.768 ± 0.063	7.109LeuGly: 7.109 ± 0.07	3.045LeuHis: 3.045 ± 0.048	6.36LeuIle: 6.36 ± 0.074	3.733LeuLys: 3.733 ± 0.043	14.428LeuLeu: 14.428 ± 0.14	2.077LeuMet: 2.077 ± 0.035	3.439LeuAsn: 3.439 ± 0.043	6.593LeuPro: 6.593 ± 0.076	5.974LeuGln: 5.974 ± 0.081	6.334LeuArg: 6.334 ± 0.062	7.99LeuSer: 7.99 ± 0.067	6.788LeuThr: 6.788 ± 0.062	7.267LeuVal: 7.267 ± 0.068	1.532LeuTrp: 1.532 ± 0.029	3.263LeuTyr: 3.263 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	1.981MetAla: 1.981 ± 0.038	0.122MetCys: 0.122 ± 0.009	0.916MetAsp: 0.916 ± 0.022	1.1MetGlu: 1.1 ± 0.022	0.587MetPhe: 0.587 ± 0.017	1.435MetGly: 1.435 ± 0.028	0.54MetHis: 0.54 ± 0.017	1.22MetIle: 1.22 ± 0.027	0.862MetLys: 0.862 ± 0.022	2.36MetLeu: 2.36 ± 0.038	0.469MetMet: 0.469 ± 0.015	0.83MetAsn: 0.83 ± 0.018	1.061MetPro: 1.061 ± 0.025	1.219MetGln: 1.219 ± 0.022	1.366MetArg: 1.366 ± 0.028	1.418MetSer: 1.418 ± 0.028	1.344MetThr: 1.344 ± 0.029	1.44MetVal: 1.44 ± 0.026	0.186MetTrp: 0.186 ± 0.009	0.515MetTyr: 0.515 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.997AsnAla: 2.997 ± 0.044	0.291AsnCys: 0.291 ± 0.014	1.659AsnAsp: 1.659 ± 0.031	1.835AsnGlu: 1.835 ± 0.032	1.136AsnPhe: 1.136 ± 0.026	2.655AsnGly: 2.655 ± 0.046	0.756AsnHis: 0.756 ± 0.019	1.943AsnIle: 1.943 ± 0.035	0.996AsnLys: 0.996 ± 0.024	3.293AsnLeu: 3.293 ± 0.042	0.66AsnMet: 0.66 ± 0.017	1.37AsnAsn: 1.37 ± 0.039	1.964AsnPro: 1.964 ± 0.034	1.605AsnGln: 1.605 ± 0.032	1.632AsnArg: 1.632 ± 0.029	1.92AsnSer: 1.92 ± 0.042	2.243AsnThr: 2.243 ± 0.041	2.109AsnVal: 2.109 ± 0.038	0.569AsnTrp: 0.569 ± 0.019	1.12AsnTyr: 1.12 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.706ProAla: 4.706 ± 0.056	0.311ProCys: 0.311 ± 0.014	2.977ProAsp: 2.977 ± 0.043	3.577ProGlu: 3.577 ± 0.05	2.118ProPhe: 2.118 ± 0.033	3.686ProGly: 3.686 ± 0.056	1.311ProHis: 1.311 ± 0.024	2.772ProIle: 2.772 ± 0.04	1.253ProLys: 1.253 ± 0.027	5.812ProLeu: 5.812 ± 0.076	0.853ProMet: 0.853 ± 0.025	1.538ProAsn: 1.538 ± 0.028	2.47ProPro: 2.47 ± 0.048	2.634ProGln: 2.634 ± 0.047	2.321ProArg: 2.321 ± 0.035	3.257ProSer: 3.257 ± 0.067	3.669ProThr: 3.669 ± 0.103	3.483ProVal: 3.483 ± 0.047	0.759ProTrp: 0.759 ± 0.023	1.529ProTyr: 1.529 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.486GlnAla: 5.486 ± 0.071	0.361GlnCys: 0.361 ± 0.012	2.13GlnAsp: 2.13 ± 0.036	3.572GlnGlu: 3.572 ± 0.065	1.556GlnPhe: 1.556 ± 0.031	3.512GlnGly: 3.512 ± 0.044	1.509GlnHis: 1.509 ± 0.031	3.199GlnIle: 3.199 ± 0.047	2.109GlnLys: 2.109 ± 0.038	5.602GlnLeu: 5.602 ± 0.079	1.232GlnMet: 1.232 ± 0.021	1.716GlnAsn: 1.716 ± 0.033	2.881GlnPro: 2.881 ± 0.055	4.186GlnGln: 4.186 ± 0.098	3.806GlnArg: 3.806 ± 0.052	3.334GlnSer: 3.334 ± 0.04	3.247GlnThr: 3.247 ± 0.044	3.492GlnVal: 3.492 ± 0.053	0.753GlnTrp: 0.753 ± 0.021	1.368GlnTyr: 1.368 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.665ArgAla: 4.665 ± 0.062	0.515ArgCys: 0.515 ± 0.018	2.449ArgAsp: 2.449 ± 0.04	3.7ArgGlu: 3.7 ± 0.049	2.265ArgPhe: 2.265 ± 0.029	3.301ArgGly: 3.301 ± 0.046	1.416ArgHis: 1.416 ± 0.028	3.392ArgIle: 3.392 ± 0.043	2.121ArgLys: 2.121 ± 0.036	6.666ArgLeu: 6.666 ± 0.071	1.413ArgMet: 1.413 ± 0.035	1.662ArgAsn: 1.662 ± 0.029	2.756ArgPro: 2.756 ± 0.042	3.269ArgGln: 3.269 ± 0.044	3.906ArgArg: 3.906 ± 0.061	3.632ArgSer: 3.632 ± 0.046	3.236ArgThr: 3.236 ± 0.043	3.468ArgVal: 3.468 ± 0.05	0.997ArgTrp: 0.997 ± 0.02	2.094ArgTyr: 2.094 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.412SerAla: 5.412 ± 0.055	0.589SerCys: 0.589 ± 0.016	3.017SerAsp: 3.017 ± 0.04	3.31SerGlu: 3.31 ± 0.046	2.732SerPhe: 2.732 ± 0.037	4.965SerGly: 4.965 ± 0.066	1.618SerHis: 1.618 ± 0.033	3.95SerIle: 3.95 ± 0.048	1.747SerLys: 1.747 ± 0.032	7.412SerLeu: 7.412 ± 0.072	1.381SerMet: 1.381 ± 0.028	2.154SerAsn: 2.154 ± 0.041	3.343SerPro: 3.343 ± 0.067	3.177SerGln: 3.177 ± 0.044	3.068SerArg: 3.068 ± 0.04	5.016SerSer: 5.016 ± 0.072	4.216SerThr: 4.216 ± 0.06	3.96SerVal: 3.96 ± 0.046	1.088SerTrp: 1.088 ± 0.026	2.204SerTyr: 2.204 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.228ThrAla: 5.228 ± 0.08	0.577ThrCys: 0.577 ± 0.015	2.676ThrAsp: 2.676 ± 0.038	2.89ThrGlu: 2.89 ± 0.046	2.59ThrPhe: 2.59 ± 0.037	4.606ThrGly: 4.606 ± 0.065	1.511ThrHis: 1.511 ± 0.027	4.305ThrIle: 4.305 ± 0.05	1.508ThrLys: 1.508 ± 0.031	7.263ThrLeu: 7.263 ± 0.061	1.19ThrMet: 1.19 ± 0.025	2.165ThrAsn: 2.165 ± 0.042	3.992ThrPro: 3.992 ± 0.104	2.738ThrGln: 2.738 ± 0.049	2.967ThrArg: 2.967 ± 0.037	3.989ThrSer: 3.989 ± 0.054	4.171ThrThr: 4.171 ± 0.059	4.175ThrVal: 4.175 ± 0.065	0.827ThrTrp: 0.827 ± 0.022	2.022ThrTyr: 2.022 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.227ValAla: 6.227 ± 0.071	0.66ValCys: 0.66 ± 0.018	3.013ValAsp: 3.013 ± 0.041	3.882ValGlu: 3.882 ± 0.047	2.408ValPhe: 2.408 ± 0.04	4.658ValGly: 4.658 ± 0.054	1.528ValHis: 1.528 ± 0.028	3.986ValIle: 3.986 ± 0.049	2.138ValLys: 2.138 ± 0.033	7.369ValLeu: 7.369 ± 0.075	1.417ValMet: 1.417 ± 0.027	2.162ValAsn: 2.162 ± 0.04	3.311ValPro: 3.311 ± 0.047	3.37ValGln: 3.37 ± 0.036	3.663ValArg: 3.663 ± 0.046	4.299ValSer: 4.299 ± 0.054	3.981ValThr: 3.981 ± 0.064	4.812ValVal: 4.812 ± 0.062	0.836ValTrp: 0.836 ± 0.026	1.842ValTyr: 1.842 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.927TrpAla: 0.927 ± 0.021	0.143TrpCys: 0.143 ± 0.009	0.623TrpAsp: 0.623 ± 0.02	0.811TrpGlu: 0.811 ± 0.021	0.598TrpPhe: 0.598 ± 0.017	0.9TrpGly: 0.9 ± 0.022	0.425TrpHis: 0.425 ± 0.014	0.818TrpIle: 0.818 ± 0.02	0.558TrpLys: 0.558 ± 0.016	1.974TrpLeu: 1.974 ± 0.035	0.352TrpMet: 0.352 ± 0.013	0.628TrpAsn: 0.628 ± 0.019	0.606TrpPro: 0.606 ± 0.018	1.062TrpGln: 1.062 ± 0.028	0.966TrpArg: 0.966 ± 0.023	1.197TrpSer: 1.197 ± 0.027	0.786TrpThr: 0.786 ± 0.025	0.767TrpVal: 0.767 ± 0.021	0.274TrpTrp: 0.274 ± 0.013	0.49TrpTyr: 0.49 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.765TyrAla: 2.765 ± 0.037	0.362TyrCys: 0.362 ± 0.014	1.562TyrAsp: 1.562 ± 0.036	1.744TyrGlu: 1.744 ± 0.031	1.151TyrPhe: 1.151 ± 0.024	2.279TyrGly: 2.279 ± 0.037	0.906TyrHis: 0.906 ± 0.02	1.581TyrIle: 1.581 ± 0.029	0.886TyrLys: 0.886 ± 0.02	3.617TyrLeu: 3.617 ± 0.047	0.586TyrMet: 0.586 ± 0.018	1.074TyrAsn: 1.074 ± 0.025	1.669TyrPro: 1.669 ± 0.036	1.894TyrGln: 1.894 ± 0.031	1.98TyrArg: 1.98 ± 0.033	1.866TyrSer: 1.866 ± 0.035	1.996TyrThr: 1.996 ± 0.034	1.874TyrVal: 1.874 ± 0.033	0.564TyrTrp: 0.564 ± 0.017	1.13TyrTyr: 1.13 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5981 proteins (2099093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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