Amino acid dipepetide frequency for Nocardia mexicana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.617AlaAla: 21.617 ± 0.151	0.955AlaCys: 0.955 ± 0.021	8.843AlaAsp: 8.843 ± 0.065	8.612AlaGlu: 8.612 ± 0.07	3.303AlaPhe: 3.303 ± 0.038	12.073AlaGly: 12.073 ± 0.082	2.707AlaHis: 2.707 ± 0.038	4.719AlaIle: 4.719 ± 0.045	2.436AlaLys: 2.436 ± 0.032	13.208AlaLeu: 13.208 ± 0.093	2.692AlaMet: 2.692 ± 0.035	2.246AlaAsn: 2.246 ± 0.034	6.676AlaPro: 6.676 ± 0.071	3.901AlaGln: 3.901 ± 0.038	9.69AlaArg: 9.69 ± 0.076	5.264AlaSer: 5.264 ± 0.047	7.486AlaThr: 7.486 ± 0.059	12.158AlaVal: 12.158 ± 0.095	1.72AlaTrp: 1.72 ± 0.029	2.388AlaTyr: 2.388 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.024	0.102CysCys: 0.102 ± 0.006	0.481CysAsp: 0.481 ± 0.014	0.376CysGlu: 0.376 ± 0.011	0.214CysPhe: 0.214 ± 0.009	0.913CysGly: 0.913 ± 0.025	0.182CysHis: 0.182 ± 0.01	0.213CysIle: 0.213 ± 0.008	0.106CysLys: 0.106 ± 0.007	0.697CysLeu: 0.697 ± 0.016	0.118CysMet: 0.118 ± 0.007	0.129CysAsn: 0.129 ± 0.008	0.468CysPro: 0.468 ± 0.014	0.15CysGln: 0.15 ± 0.007	0.595CysArg: 0.595 ± 0.017	0.42CysSer: 0.42 ± 0.012	0.473CysThr: 0.473 ± 0.015	0.596CysVal: 0.596 ± 0.015	0.13CysTrp: 0.13 ± 0.007	0.157CysTyr: 0.157 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.42AspAla: 7.42 ± 0.063	0.417AspCys: 0.417 ± 0.013	3.852AspAsp: 3.852 ± 0.045	3.83AspGlu: 3.83 ± 0.044	1.737AspPhe: 1.737 ± 0.028	5.964AspGly: 5.964 ± 0.066	1.495AspHis: 1.495 ± 0.027	2.545AspIle: 2.545 ± 0.03	1.178AspLys: 1.178 ± 0.026	6.409AspLeu: 6.409 ± 0.058	0.967AspMet: 0.967 ± 0.021	1.178AspAsn: 1.178 ± 0.021	4.857AspPro: 4.857 ± 0.049	1.626AspGln: 1.626 ± 0.027	5.555AspArg: 5.555 ± 0.054	3.101AspSer: 3.101 ± 0.04	3.418AspThr: 3.418 ± 0.037	4.487AspVal: 4.487 ± 0.047	0.98AspTrp: 0.98 ± 0.02	1.4AspTyr: 1.4 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.919GluAla: 5.919 ± 0.057	0.369GluCys: 0.369 ± 0.012	2.286GluAsp: 2.286 ± 0.032	2.455GluGlu: 2.455 ± 0.04	2.037GluPhe: 2.037 ± 0.028	3.278GluGly: 3.278 ± 0.035	1.613GluHis: 1.613 ± 0.029	2.754GluIle: 2.754 ± 0.035	1.138GluLys: 1.138 ± 0.024	7.122GluLeu: 7.122 ± 0.081	1.049GluMet: 1.049 ± 0.024	1.104GluAsn: 1.104 ± 0.023	3.442GluPro: 3.442 ± 0.044	2.472GluGln: 2.472 ± 0.036	5.099GluArg: 5.099 ± 0.047	3.084GluSer: 3.084 ± 0.037	2.95GluThr: 2.95 ± 0.036	4.352GluVal: 4.352 ± 0.045	0.817GluTrp: 0.817 ± 0.019	1.234GluTyr: 1.234 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.107PheAla: 4.107 ± 0.046	0.263PheCys: 0.263 ± 0.01	2.476PheAsp: 2.476 ± 0.037	1.59PheGlu: 1.59 ± 0.027	0.852PhePhe: 0.852 ± 0.022	3.5PheGly: 3.5 ± 0.043	0.626PheHis: 0.626 ± 0.016	0.832PheIle: 0.832 ± 0.02	0.372PheLys: 0.372 ± 0.013	2.538PheLeu: 2.538 ± 0.034	0.411PheMet: 0.411 ± 0.014	0.55PheAsn: 0.55 ± 0.013	1.455PhePro: 1.455 ± 0.023	0.697PheGln: 0.697 ± 0.016	1.908PheArg: 1.908 ± 0.023	1.445PheSer: 1.445 ± 0.028	2.017PheThr: 2.017 ± 0.027	2.477PheVal: 2.477 ± 0.036	0.404PheTrp: 0.404 ± 0.012	0.623PheTyr: 0.623 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.7GlyAla: 10.7 ± 0.089	0.812GlyCys: 0.812 ± 0.02	5.141GlyAsp: 5.141 ± 0.058	4.61GlyGlu: 4.61 ± 0.047	3.0GlyPhe: 3.0 ± 0.039	8.153GlyGly: 8.153 ± 0.076	2.042GlyHis: 2.042 ± 0.029	4.183GlyIle: 4.183 ± 0.045	2.185GlyLys: 2.185 ± 0.035	8.699GlyLeu: 8.699 ± 0.069	2.093GlyMet: 2.093 ± 0.031	1.959GlyAsn: 1.959 ± 0.03	4.931GlyPro: 4.931 ± 0.05	2.577GlyGln: 2.577 ± 0.035	7.098GlyArg: 7.098 ± 0.055	5.326GlySer: 5.326 ± 0.062	5.711GlyThr: 5.711 ± 0.053	7.378GlyVal: 7.378 ± 0.054	1.678GlyTrp: 1.678 ± 0.03	2.387GlyTyr: 2.387 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.647HisAla: 2.647 ± 0.035	0.218HisCys: 0.218 ± 0.01	1.386HisAsp: 1.386 ± 0.027	1.163HisGlu: 1.163 ± 0.022	0.668HisPhe: 0.668 ± 0.016	2.211HisGly: 2.211 ± 0.032	0.674HisHis: 0.674 ± 0.019	0.837HisIle: 0.837 ± 0.018	0.312HisLys: 0.312 ± 0.011	2.188HisLeu: 2.188 ± 0.033	0.362HisMet: 0.362 ± 0.011	0.462HisAsn: 0.462 ± 0.014	1.753HisPro: 1.753 ± 0.025	0.577HisGln: 0.577 ± 0.017	2.196HisArg: 2.196 ± 0.037	1.09HisSer: 1.09 ± 0.022	1.317HisThr: 1.317 ± 0.029	1.55HisVal: 1.55 ± 0.025	0.375HisTrp: 0.375 ± 0.011	0.533HisTyr: 0.533 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.154IleAla: 6.154 ± 0.046	0.313IleCys: 0.313 ± 0.012	3.22IleAsp: 3.22 ± 0.038	2.545IleGlu: 2.545 ± 0.032	0.929IlePhe: 0.929 ± 0.022	4.405IleGly: 4.405 ± 0.045	0.763IleHis: 0.763 ± 0.017	1.165IleIle: 1.165 ± 0.023	0.604IleLys: 0.604 ± 0.018	3.058IleLeu: 3.058 ± 0.04	0.548IleMet: 0.548 ± 0.016	0.815IleAsn: 0.815 ± 0.02	2.383IlePro: 2.383 ± 0.031	0.854IleGln: 0.854 ± 0.021	2.827IleArg: 2.827 ± 0.032	2.002IleSer: 2.002 ± 0.029	2.623IleThr: 2.623 ± 0.037	3.629IleVal: 3.629 ± 0.04	0.41IleTrp: 0.41 ± 0.014	0.697IleTyr: 0.697 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.144LysAla: 2.144 ± 0.033	0.111LysCys: 0.111 ± 0.007	0.927LysAsp: 0.927 ± 0.022	0.79LysGlu: 0.79 ± 0.022	0.59LysPhe: 0.59 ± 0.015	1.319LysGly: 1.319 ± 0.03	0.423LysHis: 0.423 ± 0.014	0.863LysIle: 0.863 ± 0.021	0.546LysLys: 0.546 ± 0.018	1.919LysLeu: 1.919 ± 0.035	0.41LysMet: 0.41 ± 0.013	0.422LysAsn: 0.422 ± 0.014	1.239LysPro: 1.239 ± 0.027	0.687LysGln: 0.687 ± 0.016	1.348LysArg: 1.348 ± 0.026	1.113LysSer: 1.113 ± 0.023	1.138LysThr: 1.138 ± 0.022	1.591LysVal: 1.591 ± 0.028	0.267LysTrp: 0.267 ± 0.011	0.453LysTyr: 0.453 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.416LeuAla: 14.416 ± 0.109	0.8LeuCys: 0.8 ± 0.021	6.797LeuAsp: 6.797 ± 0.061	4.729LeuGlu: 4.729 ± 0.05	2.706LeuPhe: 2.706 ± 0.037	9.049LeuGly: 9.049 ± 0.079	2.174LeuHis: 2.174 ± 0.03	3.953LeuIle: 3.953 ± 0.045	1.32LeuLys: 1.32 ± 0.027	10.376LeuLeu: 10.376 ± 0.09	1.591LeuMet: 1.591 ± 0.027	1.823LeuAsn: 1.823 ± 0.027	6.205LeuPro: 6.205 ± 0.055	2.462LeuGln: 2.462 ± 0.03	8.644LeuArg: 8.644 ± 0.066	5.545LeuSer: 5.545 ± 0.047	6.361LeuThr: 6.361 ± 0.056	8.428LeuVal: 8.428 ± 0.073	1.221LeuTrp: 1.221 ± 0.023	1.688LeuTyr: 1.688 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.286MetAla: 2.286 ± 0.035	0.141MetCys: 0.141 ± 0.008	0.878MetAsp: 0.878 ± 0.018	0.679MetGlu: 0.679 ± 0.017	0.611MetPhe: 0.611 ± 0.016	1.337MetGly: 1.337 ± 0.029	0.409MetHis: 0.409 ± 0.013	0.866MetIle: 0.866 ± 0.02	0.391MetLys: 0.391 ± 0.013	2.039MetLeu: 2.039 ± 0.029	0.364MetMet: 0.364 ± 0.014	0.52MetAsn: 0.52 ± 0.015	1.2MetPro: 1.2 ± 0.023	0.548MetGln: 0.548 ± 0.018	1.628MetArg: 1.628 ± 0.029	1.515MetSer: 1.515 ± 0.024	1.667MetThr: 1.667 ± 0.024	1.543MetVal: 1.543 ± 0.028	0.226MetTrp: 0.226 ± 0.01	0.352MetTyr: 0.352 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.314AsnAla: 2.314 ± 0.031	0.157AsnCys: 0.157 ± 0.007	1.058AsnAsp: 1.058 ± 0.02	0.869AsnGlu: 0.869 ± 0.022	0.592AsnPhe: 0.592 ± 0.016	1.904AsnGly: 1.904 ± 0.035	0.443AsnHis: 0.443 ± 0.013	0.825AsnIle: 0.825 ± 0.017	0.387AsnLys: 0.387 ± 0.011	1.925AsnLeu: 1.925 ± 0.027	0.384AsnMet: 0.384 ± 0.012	0.47AsnAsn: 0.47 ± 0.015	1.673AsnPro: 1.673 ± 0.034	0.593AsnGln: 0.593 ± 0.014	1.516AsnArg: 1.516 ± 0.024	1.131AsnSer: 1.131 ± 0.027	1.229AsnThr: 1.229 ± 0.023	1.429AsnVal: 1.429 ± 0.025	0.318AsnTrp: 0.318 ± 0.011	0.489AsnTyr: 0.489 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.892ProAla: 7.892 ± 0.067	0.291ProCys: 0.291 ± 0.011	4.806ProAsp: 4.806 ± 0.06	4.381ProGlu: 4.381 ± 0.051	1.534ProPhe: 1.534 ± 0.023	6.503ProGly: 6.503 ± 0.065	1.317ProHis: 1.317 ± 0.025	2.138ProIle: 2.138 ± 0.027	1.187ProLys: 1.187 ± 0.025	4.952ProLeu: 4.952 ± 0.054	1.21ProMet: 1.21 ± 0.026	1.251ProAsn: 1.251 ± 0.023	3.767ProPro: 3.767 ± 0.089	1.884ProGln: 1.884 ± 0.038	3.871ProArg: 3.871 ± 0.046	3.046ProSer: 3.046 ± 0.039	3.404ProThr: 3.404 ± 0.044	5.306ProVal: 5.306 ± 0.048	0.843ProTrp: 0.843 ± 0.019	1.114ProTyr: 1.114 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.57GlnAla: 3.57 ± 0.039	0.192GlnCys: 0.192 ± 0.009	1.178GlnAsp: 1.178 ± 0.023	1.161GlnGlu: 1.161 ± 0.024	0.849GlnPhe: 0.849 ± 0.021	2.0GlnGly: 2.0 ± 0.032	0.753GlnHis: 0.753 ± 0.022	1.299GlnIle: 1.299 ± 0.022	0.482GlnLys: 0.482 ± 0.013	3.472GlnLeu: 3.472 ± 0.046	0.585GlnMet: 0.585 ± 0.016	0.534GlnAsn: 0.534 ± 0.016	1.915GlnPro: 1.915 ± 0.039	1.442GlnGln: 1.442 ± 0.032	2.852GlnArg: 2.852 ± 0.036	1.393GlnSer: 1.393 ± 0.026	1.369GlnThr: 1.369 ± 0.027	2.527GlnVal: 2.527 ± 0.037	0.563GlnTrp: 0.563 ± 0.016	0.619GlnTyr: 0.619 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.532ArgAla: 9.532 ± 0.081	0.602ArgCys: 0.602 ± 0.016	4.599ArgAsp: 4.599 ± 0.051	4.508ArgGlu: 4.508 ± 0.055	2.542ArgPhe: 2.542 ± 0.027	5.679ArgGly: 5.679 ± 0.05	1.98ArgHis: 1.98 ± 0.03	3.966ArgIle: 3.966 ± 0.042	1.654ArgLys: 1.654 ± 0.028	8.21ArgLeu: 8.21 ± 0.07	2.035ArgMet: 2.035 ± 0.029	1.701ArgAsn: 1.701 ± 0.029	4.652ArgPro: 4.652 ± 0.044	2.36ArgGln: 2.36 ± 0.034	7.622ArgArg: 7.622 ± 0.074	4.362ArgSer: 4.362 ± 0.044	5.042ArgThr: 5.042 ± 0.05	5.824ArgVal: 5.824 ± 0.05	1.484ArgTrp: 1.484 ± 0.023	1.992ArgTyr: 1.992 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.968SerAla: 6.968 ± 0.063	0.379SerCys: 0.379 ± 0.012	3.193SerAsp: 3.193 ± 0.043	2.748SerGlu: 2.748 ± 0.035	1.539SerPhe: 1.539 ± 0.027	6.199SerGly: 6.199 ± 0.061	0.988SerHis: 0.988 ± 0.021	1.995SerIle: 1.995 ± 0.028	1.003SerLys: 1.003 ± 0.02	4.472SerLeu: 4.472 ± 0.047	1.246SerMet: 1.246 ± 0.021	1.024SerAsn: 1.024 ± 0.023	3.055SerPro: 3.055 ± 0.042	1.252SerGln: 1.252 ± 0.023	3.727SerArg: 3.727 ± 0.038	2.827SerSer: 2.827 ± 0.039	3.255SerThr: 3.255 ± 0.038	4.24SerVal: 4.24 ± 0.047	0.851SerTrp: 0.851 ± 0.021	1.183SerTyr: 1.183 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.63ThrAla: 8.63 ± 0.069	0.388ThrCys: 0.388 ± 0.013	3.85ThrAsp: 3.85 ± 0.044	3.358ThrGlu: 3.358 ± 0.037	1.7ThrPhe: 1.7 ± 0.029	6.348ThrGly: 6.348 ± 0.048	1.202ThrHis: 1.202 ± 0.023	2.254ThrIle: 2.254 ± 0.03	1.045ThrLys: 1.045 ± 0.028	5.588ThrLeu: 5.588 ± 0.056	1.11ThrMet: 1.11 ± 0.02	1.062ThrAsn: 1.062 ± 0.021	3.909ThrPro: 3.909 ± 0.046	1.36ThrGln: 1.36 ± 0.027	4.022ThrArg: 4.022 ± 0.045	3.007ThrSer: 3.007 ± 0.039	3.943ThrThr: 3.943 ± 0.053	6.047ThrVal: 6.047 ± 0.05	0.811ThrTrp: 0.811 ± 0.018	1.244ThrTyr: 1.244 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	11.325ValAla: 11.325 ± 0.092	0.729ValCys: 0.729 ± 0.017	5.354ValAsp: 5.354 ± 0.053	4.405ValGlu: 4.405 ± 0.055	2.506ValPhe: 2.506 ± 0.035	6.83ValGly: 6.83 ± 0.056	1.889ValHis: 1.889 ± 0.028	3.286ValIle: 3.286 ± 0.042	1.308ValLys: 1.308 ± 0.024	9.258ValLeu: 9.258 ± 0.085	1.396ValMet: 1.396 ± 0.024	1.662ValAsn: 1.662 ± 0.024	5.107ValPro: 5.107 ± 0.051	2.102ValGln: 2.102 ± 0.031	6.697ValArg: 6.697 ± 0.052	4.394ValSer: 4.394 ± 0.047	5.377ValThr: 5.377 ± 0.052	8.193ValVal: 8.193 ± 0.076	1.064ValTrp: 1.064 ± 0.023	1.518ValTyr: 1.518 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.58TrpAla: 1.58 ± 0.029	0.154TrpCys: 0.154 ± 0.008	0.786TrpAsp: 0.786 ± 0.02	0.711TrpGlu: 0.711 ± 0.018	0.528TrpPhe: 0.528 ± 0.014	0.986TrpGly: 0.986 ± 0.02	0.375TrpHis: 0.375 ± 0.014	0.613TrpIle: 0.613 ± 0.016	0.328TrpLys: 0.328 ± 0.012	1.77TrpLeu: 1.77 ± 0.032	0.315TrpMet: 0.315 ± 0.012	0.377TrpAsn: 0.377 ± 0.014	0.78TrpPro: 0.78 ± 0.019	0.602TrpGln: 0.602 ± 0.015	1.35TrpArg: 1.35 ± 0.023	0.953TrpSer: 0.953 ± 0.021	0.931TrpThr: 0.931 ± 0.02	1.093TrpVal: 1.093 ± 0.023	0.349TrpTrp: 0.349 ± 0.012	0.307TrpTyr: 0.307 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.029	0.205TyrCys: 0.205 ± 0.009	1.304TyrAsp: 1.304 ± 0.024	1.056TyrGlu: 1.056 ± 0.021	0.707TyrPhe: 0.707 ± 0.016	2.011TyrGly: 2.011 ± 0.03	0.461TyrHis: 0.461 ± 0.014	0.64TyrIle: 0.64 ± 0.017	0.318TyrLys: 0.318 ± 0.011	2.392TyrLeu: 2.392 ± 0.034	0.313TyrMet: 0.313 ± 0.011	0.418TyrAsn: 0.418 ± 0.013	1.231TyrPro: 1.231 ± 0.027	0.61TyrGln: 0.61 ± 0.015	2.101TyrArg: 2.101 ± 0.033	1.129TyrSer: 1.129 ± 0.021	1.165TyrThr: 1.165 ± 0.022	1.55TyrVal: 1.55 ± 0.031	0.377TyrTrp: 0.377 ± 0.012	0.478TyrTyr: 0.478 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8181 proteins (2651363 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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