Amino acid dipepetide frequency for Halorubrum sp. J07HR59

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.859AlaAla: 12.859 ± 0.259	0.777AlaCys: 0.777 ± 0.042	9.361AlaAsp: 9.361 ± 0.195	7.916AlaGlu: 7.916 ± 0.164	3.163AlaPhe: 3.163 ± 0.095	9.789AlaGly: 9.789 ± 0.186	1.887AlaHis: 1.887 ± 0.063	4.772AlaIle: 4.772 ± 0.114	1.868AlaLys: 1.868 ± 0.069	8.621AlaLeu: 8.621 ± 0.182	1.898AlaMet: 1.898 ± 0.069	2.534AlaAsn: 2.534 ± 0.073	3.944AlaPro: 3.944 ± 0.095	2.691AlaGln: 2.691 ± 0.082	6.219AlaArg: 6.219 ± 0.148	5.808AlaSer: 5.808 ± 0.135	6.779AlaThr: 6.779 ± 0.145	9.863AlaVal: 9.863 ± 0.206	0.976AlaTrp: 0.976 ± 0.047	2.321AlaTyr: 2.321 ± 0.078	0.03AlaXaa: 0.03 ± 0.01
Cys	0.645CysAla: 0.645 ± 0.041	0.116CysCys: 0.116 ± 0.017	0.624CysAsp: 0.624 ± 0.039	0.684CysGlu: 0.684 ± 0.043	0.224CysPhe: 0.224 ± 0.022	0.985CysGly: 0.985 ± 0.055	0.282CysHis: 0.282 ± 0.032	0.282CysIle: 0.282 ± 0.024	0.113CysLys: 0.113 ± 0.015	0.627CysLeu: 0.627 ± 0.041	0.166CysMet: 0.166 ± 0.02	0.24CysAsn: 0.24 ± 0.026	0.613CysPro: 0.613 ± 0.038	0.296CysGln: 0.296 ± 0.025	0.74CysArg: 0.74 ± 0.043	0.592CysSer: 0.592 ± 0.04	0.451CysThr: 0.451 ± 0.035	0.673CysVal: 0.673 ± 0.042	0.102CysTrp: 0.102 ± 0.016	0.213CysTyr: 0.213 ± 0.021	0.002CysXaa: 0.002 ± 0.002
Asp	8.201AspAla: 8.201 ± 0.165	0.666AspCys: 0.666 ± 0.046	6.291AspAsp: 6.291 ± 0.153	6.686AspGlu: 6.686 ± 0.162	1.944AspPhe: 1.944 ± 0.059	7.241AspGly: 7.241 ± 0.155	1.984AspHis: 1.984 ± 0.064	3.611AspIle: 3.611 ± 0.102	1.087AspLys: 1.087 ± 0.057	6.057AspLeu: 6.057 ± 0.141	1.306AspMet: 1.306 ± 0.062	1.628AspAsn: 1.628 ± 0.063	4.619AspPro: 4.619 ± 0.112	2.536AspGln: 2.536 ± 0.077	6.499AspArg: 6.499 ± 0.15	5.019AspSer: 5.019 ± 0.12	4.985AspThr: 4.985 ± 0.119	6.111AspVal: 6.111 ± 0.134	0.948AspTrp: 0.948 ± 0.043	1.595AspTyr: 1.595 ± 0.075	0.021AspXaa: 0.021 ± 0.007
Glu	7.713GluAla: 7.713 ± 0.149	0.59GluCys: 0.59 ± 0.045	4.508GluAsp: 4.508 ± 0.123	5.153GluGlu: 5.153 ± 0.132	2.936GluPhe: 2.936 ± 0.079	4.619GluGly: 4.619 ± 0.109	1.57GluHis: 1.57 ± 0.056	3.838GluIle: 3.838 ± 0.111	1.609GluLys: 1.609 ± 0.069	6.839GluLeu: 6.839 ± 0.136	1.773GluMet: 1.773 ± 0.073	1.91GluAsn: 1.91 ± 0.074	3.699GluPro: 3.699 ± 0.096	3.211GluGln: 3.211 ± 0.099	5.459GluArg: 5.459 ± 0.11	5.81GluSer: 5.81 ± 0.127	6.964GluThr: 6.964 ± 0.142	5.144GluVal: 5.144 ± 0.128	1.04GluTrp: 1.04 ± 0.051	2.596GluTyr: 2.596 ± 0.087	0.002GluXaa: 0.002 ± 0.002
Phe	3.267PheAla: 3.267 ± 0.103	0.307PheCys: 0.307 ± 0.03	3.075PheAsp: 3.075 ± 0.091	2.589PheGlu: 2.589 ± 0.083	0.959PhePhe: 0.959 ± 0.052	3.177PheGly: 3.177 ± 0.09	0.68PheHis: 0.68 ± 0.039	1.144PheIle: 1.144 ± 0.054	0.479PheLys: 0.479 ± 0.035	2.712PheLeu: 2.712 ± 0.097	0.497PheMet: 0.497 ± 0.033	0.733PheAsn: 0.733 ± 0.042	1.276PhePro: 1.276 ± 0.056	0.969PheGln: 0.969 ± 0.048	1.861PheArg: 1.861 ± 0.065	1.794PheSer: 1.794 ± 0.066	1.907PheThr: 1.907 ± 0.074	2.684PheVal: 2.684 ± 0.072	0.409PheTrp: 0.409 ± 0.034	0.781PheTyr: 0.781 ± 0.044	0.002PheXaa: 0.002 ± 0.002
Gly	8.023GlyAla: 8.023 ± 0.174	0.853GlyCys: 0.853 ± 0.051	6.247GlyAsp: 6.247 ± 0.129	6.3GlyGlu: 6.3 ± 0.129	3.112GlyPhe: 3.112 ± 0.095	7.255GlyGly: 7.255 ± 0.163	1.799GlyHis: 1.799 ± 0.066	4.663GlyIle: 4.663 ± 0.108	1.859GlyLys: 1.859 ± 0.069	7.165GlyLeu: 7.165 ± 0.163	1.674GlyMet: 1.674 ± 0.064	2.014GlyAsn: 2.014 ± 0.07	3.718GlyPro: 3.718 ± 0.102	2.848GlyGln: 2.848 ± 0.075	5.167GlyArg: 5.167 ± 0.111	5.57GlySer: 5.57 ± 0.112	5.479GlyThr: 5.479 ± 0.118	7.408GlyVal: 7.408 ± 0.146	1.098GlyTrp: 1.098 ± 0.06	2.441GlyTyr: 2.441 ± 0.074	0.016GlyXaa: 0.016 ± 0.006
His	1.958HisAla: 1.958 ± 0.063	0.238HisCys: 0.238 ± 0.025	1.732HisAsp: 1.732 ± 0.068	1.699HisGlu: 1.699 ± 0.054	0.472HisPhe: 0.472 ± 0.035	2.018HisGly: 2.018 ± 0.064	0.596HisHis: 0.596 ± 0.043	0.733HisIle: 0.733 ± 0.04	0.354HisLys: 0.354 ± 0.027	1.711HisLeu: 1.711 ± 0.058	0.331HisMet: 0.331 ± 0.031	0.548HisAsn: 0.548 ± 0.034	1.29HisPro: 1.29 ± 0.057	0.664HisGln: 0.664 ± 0.041	1.537HisArg: 1.537 ± 0.062	1.209HisSer: 1.209 ± 0.06	1.329HisThr: 1.329 ± 0.053	1.732HisVal: 1.732 ± 0.06	0.254HisTrp: 0.254 ± 0.027	0.529HisTyr: 0.529 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.082IleAla: 5.082 ± 0.108	0.414IleCys: 0.414 ± 0.033	4.175IleAsp: 4.175 ± 0.101	4.06IleGlu: 4.06 ± 0.099	0.939IlePhe: 0.939 ± 0.051	4.229IleGly: 4.229 ± 0.11	0.939IleHis: 0.939 ± 0.045	1.623IleIle: 1.623 ± 0.066	0.756IleLys: 0.756 ± 0.042	3.184IleLeu: 3.184 ± 0.093	0.594IleMet: 0.594 ± 0.035	1.096IleAsn: 1.096 ± 0.053	2.381IlePro: 2.381 ± 0.073	1.494IleGln: 1.494 ± 0.065	2.902IleArg: 2.902 ± 0.075	2.631IleSer: 2.631 ± 0.083	2.795IleThr: 2.795 ± 0.085	3.729IleVal: 3.729 ± 0.089	0.305IleTrp: 0.305 ± 0.027	0.781IleTyr: 0.781 ± 0.043	0.002IleXaa: 0.002 ± 0.002
Lys	1.646LysAla: 1.646 ± 0.064	0.123LysCys: 0.123 ± 0.018	1.066LysAsp: 1.066 ± 0.056	1.073LysGlu: 1.073 ± 0.055	0.511LysPhe: 0.511 ± 0.034	1.26LysGly: 1.26 ± 0.061	0.442LysHis: 0.442 ± 0.034	0.835LysIle: 0.835 ± 0.041	0.469LysLys: 0.469 ± 0.031	1.665LysLeu: 1.665 ± 0.063	0.421LysMet: 0.421 ± 0.031	0.613LysAsn: 0.613 ± 0.046	1.04LysPro: 1.04 ± 0.051	0.946LysGln: 0.946 ± 0.05	1.669LysArg: 1.669 ± 0.063	1.246LysSer: 1.246 ± 0.053	1.531LysThr: 1.531 ± 0.058	1.075LysVal: 1.075 ± 0.057	0.192LysTrp: 0.192 ± 0.022	0.599LysTyr: 0.599 ± 0.038	0.002LysXaa: 0.002 ± 0.003
Leu	9.495LeuAla: 9.495 ± 0.185	0.775LeuCys: 0.775 ± 0.041	6.58LeuAsp: 6.58 ± 0.139	6.605LeuGlu: 6.605 ± 0.134	2.925LeuPhe: 2.925 ± 0.088	7.431LeuGly: 7.431 ± 0.138	1.438LeuHis: 1.438 ± 0.057	3.251LeuIle: 3.251 ± 0.096	1.639LeuLys: 1.639 ± 0.059	7.69LeuLeu: 7.69 ± 0.192	1.383LeuMet: 1.383 ± 0.056	2.014LeuAsn: 2.014 ± 0.071	3.997LeuPro: 3.997 ± 0.093	2.596LeuGln: 2.596 ± 0.074	5.482LeuArg: 5.482 ± 0.122	5.951LeuSer: 5.951 ± 0.118	5.385LeuThr: 5.385 ± 0.119	7.278LeuVal: 7.278 ± 0.17	0.807LeuTrp: 0.807 ± 0.047	1.961LeuTyr: 1.961 ± 0.071	0.014LeuXaa: 0.014 ± 0.005
Met	1.815MetAla: 1.815 ± 0.075	0.171MetCys: 0.171 ± 0.022	1.281MetAsp: 1.281 ± 0.062	1.038MetGlu: 1.038 ± 0.054	0.523MetPhe: 0.523 ± 0.041	1.494MetGly: 1.494 ± 0.053	0.294MetHis: 0.294 ± 0.029	0.855MetIle: 0.855 ± 0.042	0.488MetLys: 0.488 ± 0.033	1.461MetLeu: 1.461 ± 0.054	0.342MetMet: 0.342 ± 0.03	0.633MetAsn: 0.633 ± 0.037	0.876MetPro: 0.876 ± 0.042	0.573MetGln: 0.573 ± 0.039	1.114MetArg: 1.114 ± 0.047	1.711MetSer: 1.711 ± 0.058	1.658MetThr: 1.658 ± 0.06	1.267MetVal: 1.267 ± 0.053	0.173MetTrp: 0.173 ± 0.021	0.421MetTyr: 0.421 ± 0.032	0.002MetXaa: 0.002 ± 0.002
Asn	2.409AsnAla: 2.409 ± 0.083	0.261AsnCys: 0.261 ± 0.024	1.533AsnAsp: 1.533 ± 0.063	1.637AsnGlu: 1.637 ± 0.064	0.645AsnPhe: 0.645 ± 0.042	1.882AsnGly: 1.882 ± 0.069	0.666AsnHis: 0.666 ± 0.047	1.091AsnIle: 1.091 ± 0.051	0.458AsnLys: 0.458 ± 0.038	2.15AsnLeu: 2.15 ± 0.071	0.412AsnMet: 0.412 ± 0.034	0.65AsnAsn: 0.65 ± 0.044	1.882AsnPro: 1.882 ± 0.071	0.862AsnGln: 0.862 ± 0.048	2.014AsnArg: 2.014 ± 0.075	1.401AsnSer: 1.401 ± 0.057	1.616AsnThr: 1.616 ± 0.065	2.065AsnVal: 2.065 ± 0.063	0.287AsnTrp: 0.287 ± 0.027	0.573AsnTyr: 0.573 ± 0.039	0.002AsnXaa: 0.002 ± 0.002
Pro	5.382ProAla: 5.382 ± 0.131	0.312ProCys: 0.312 ± 0.029	4.851ProAsp: 4.851 ± 0.115	4.476ProGlu: 4.476 ± 0.108	1.526ProPhe: 1.526 ± 0.06	4.247ProGly: 4.247 ± 0.107	0.985ProHis: 0.985 ± 0.05	1.868ProIle: 1.868 ± 0.063	0.761ProLys: 0.761 ± 0.043	3.669ProLeu: 3.669 ± 0.112	0.888ProMet: 0.888 ± 0.042	1.198ProAsn: 1.198 ± 0.056	2.377ProPro: 2.377 ± 0.085	1.385ProGln: 1.385 ± 0.051	2.751ProArg: 2.751 ± 0.091	3.073ProSer: 3.073 ± 0.083	3.456ProThr: 3.456 ± 0.099	4.476ProVal: 4.476 ± 0.109	0.488ProTrp: 0.488 ± 0.037	1.003ProTyr: 1.003 ± 0.056	0.016ProXaa: 0.016 ± 0.005
Gln	3.059GlnAla: 3.059 ± 0.089	0.243GlnCys: 0.243 ± 0.024	1.824GlnAsp: 1.824 ± 0.077	2.176GlnGlu: 2.176 ± 0.08	1.242GlnPhe: 1.242 ± 0.054	1.896GlnGly: 1.896 ± 0.067	0.668GlnHis: 0.668 ± 0.039	1.699GlnIle: 1.699 ± 0.054	0.705GlnLys: 0.705 ± 0.05	3.304GlnLeu: 3.304 ± 0.085	0.784GlnMet: 0.784 ± 0.041	0.874GlnAsn: 0.874 ± 0.048	1.692GlnPro: 1.692 ± 0.062	1.621GlnGln: 1.621 ± 0.067	2.564GlnArg: 2.564 ± 0.086	2.291GlnSer: 2.291 ± 0.082	2.587GlnThr: 2.587 ± 0.069	2.404GlnVal: 2.404 ± 0.075	0.416GlnTrp: 0.416 ± 0.033	1.001GlnTyr: 1.001 ± 0.05	0.009GlnXaa: 0.009 ± 0.004
Arg	6.284ArgAla: 6.284 ± 0.135	0.647ArgCys: 0.647 ± 0.039	5.267ArgAsp: 5.267 ± 0.125	6.039ArgGlu: 6.039 ± 0.13	2.312ArgPhe: 2.312 ± 0.069	4.751ArgGly: 4.751 ± 0.116	1.378ArgHis: 1.378 ± 0.048	3.087ArgIle: 3.087 ± 0.079	1.47ArgLys: 1.47 ± 0.064	6.7ArgLeu: 6.7 ± 0.151	1.306ArgMet: 1.306 ± 0.054	1.655ArgAsn: 1.655 ± 0.068	2.922ArgPro: 2.922 ± 0.086	2.624ArgGln: 2.624 ± 0.095	5.29ArgArg: 5.29 ± 0.129	4.074ArgSer: 4.074 ± 0.103	3.782ArgThr: 3.782 ± 0.109	5.72ArgVal: 5.72 ± 0.131	0.823ArgTrp: 0.823 ± 0.041	1.836ArgTyr: 1.836 ± 0.07	0.002ArgXaa: 0.002 ± 0.003
Ser	6.013SerAla: 6.013 ± 0.133	0.56SerCys: 0.56 ± 0.039	4.987SerAsp: 4.987 ± 0.132	4.712SerGlu: 4.712 ± 0.119	2.023SerPhe: 2.023 ± 0.077	6.164SerGly: 6.164 ± 0.119	1.452SerHis: 1.452 ± 0.061	2.645SerIle: 2.645 ± 0.077	1.329SerLys: 1.329 ± 0.053	5.357SerLeu: 5.357 ± 0.108	1.193SerMet: 1.193 ± 0.053	1.484SerAsn: 1.484 ± 0.062	3.429SerPro: 3.429 ± 0.096	2.231SerGln: 2.231 ± 0.072	4.668SerArg: 4.668 ± 0.127	3.898SerSer: 3.898 ± 0.118	3.997SerThr: 3.997 ± 0.106	5.748SerVal: 5.748 ± 0.143	0.705SerTrp: 0.705 ± 0.043	1.452SerTyr: 1.452 ± 0.068	0.018SerXaa: 0.018 ± 0.007
Thr	7.861ThrAla: 7.861 ± 0.128	0.46ThrCys: 0.46 ± 0.033	5.9ThrAsp: 5.9 ± 0.131	4.906ThrGlu: 4.906 ± 0.103	1.926ThrPhe: 1.926 ± 0.056	6.219ThrGly: 6.219 ± 0.129	1.496ThrHis: 1.496 ± 0.055	3.015ThrIle: 3.015 ± 0.102	0.916ThrLys: 0.916 ± 0.047	5.817ThrLeu: 5.817 ± 0.111	1.089ThrMet: 1.089 ± 0.052	1.491ThrAsn: 1.491 ± 0.065	3.78ThrPro: 3.78 ± 0.103	1.944ThrGln: 1.944 ± 0.075	4.12ThrArg: 4.12 ± 0.103	3.734ThrSer: 3.734 ± 0.099	4.642ThrThr: 4.642 ± 0.125	6.971ThrVal: 6.971 ± 0.128	0.585ThrTrp: 0.585 ± 0.041	1.463ThrTyr: 1.463 ± 0.062	0.018ThrXaa: 0.018 ± 0.007
Val	9.186ValAla: 9.186 ± 0.175	0.777ValCys: 0.777 ± 0.036	6.645ValAsp: 6.645 ± 0.141	6.407ValGlu: 6.407 ± 0.132	2.786ValPhe: 2.786 ± 0.079	7.317ValGly: 7.317 ± 0.149	1.54ValHis: 1.54 ± 0.067	3.852ValIle: 3.852 ± 0.104	1.387ValLys: 1.387 ± 0.062	6.457ValLeu: 6.457 ± 0.142	1.491ValMet: 1.491 ± 0.058	2.199ValAsn: 2.199 ± 0.073	3.912ValPro: 3.912 ± 0.109	2.185ValGln: 2.185 ± 0.073	5.207ValArg: 5.207 ± 0.115	6.141ValSer: 6.141 ± 0.122	6.733ValThr: 6.733 ± 0.147	7.798ValVal: 7.798 ± 0.17	0.77ValTrp: 0.77 ± 0.047	2.053ValTyr: 2.053 ± 0.062	0.016ValXaa: 0.016 ± 0.006
Trp	0.876TrpAla: 0.876 ± 0.049	0.132TrpCys: 0.132 ± 0.019	0.724TrpAsp: 0.724 ± 0.039	0.784TrpGlu: 0.784 ± 0.046	0.398TrpPhe: 0.398 ± 0.033	0.731TrpGly: 0.731 ± 0.04	0.243TrpHis: 0.243 ± 0.022	0.451TrpIle: 0.451 ± 0.03	0.264TrpLys: 0.264 ± 0.025	1.147TrpLeu: 1.147 ± 0.051	0.24TrpMet: 0.24 ± 0.022	0.319TrpAsn: 0.319 ± 0.027	0.499TrpPro: 0.499 ± 0.033	0.428TrpGln: 0.428 ± 0.032	0.814TrpArg: 0.814 ± 0.047	0.684TrpSer: 0.684 ± 0.043	0.735TrpThr: 0.735 ± 0.036	0.842TrpVal: 0.842 ± 0.045	0.18TrpTrp: 0.18 ± 0.021	0.363TrpTyr: 0.363 ± 0.028	0.002TrpXaa: 0.002 ± 0.003
Tyr	2.282TyrAla: 2.282 ± 0.072	0.25TyrCys: 0.25 ± 0.026	2.351TyrAsp: 2.351 ± 0.081	2.037TyrGlu: 2.037 ± 0.083	0.74TyrPhe: 0.74 ± 0.047	1.995TyrGly: 1.995 ± 0.066	0.594TyrHis: 0.594 ± 0.038	0.784TyrIle: 0.784 ± 0.042	0.407TyrLys: 0.407 ± 0.029	2.337TyrLeu: 2.337 ± 0.071	0.393TyrMet: 0.393 ± 0.027	0.661TyrAsn: 0.661 ± 0.037	1.221TyrPro: 1.221 ± 0.057	0.955TyrGln: 0.955 ± 0.05	1.88TyrArg: 1.88 ± 0.067	1.403TyrSer: 1.403 ± 0.06	1.535TyrThr: 1.535 ± 0.074	1.857TyrVal: 1.857 ± 0.072	0.291TyrTrp: 0.291 ± 0.029	0.668TyrTyr: 0.668 ± 0.042	0.012TyrXaa: 0.012 ± 0.004
Xaa	0.021XaaAla: 0.021 ± 0.005	0.0XaaCys: 0.0 ± 0.0	0.016XaaAsp: 0.016 ± 0.006	0.007XaaGlu: 0.007 ± 0.005	0.0XaaPhe: 0.0 ± 0.0	0.009XaaGly: 0.009 ± 0.005	0.005XaaHis: 0.005 ± 0.003	0.012XaaIle: 0.012 ± 0.005	0.005XaaLys: 0.005 ± 0.003	0.025XaaLeu: 0.025 ± 0.007	0.007XaaMet: 0.007 ± 0.005	0.002XaaAsn: 0.002 ± 0.002	0.018XaaPro: 0.018 ± 0.006	0.0XaaGln: 0.0 ± 0.0	0.014XaaArg: 0.014 ± 0.005	0.025XaaSer: 0.025 ± 0.007	0.007XaaThr: 0.007 ± 0.004	0.014XaaVal: 0.014 ± 0.006	0.005XaaTrp: 0.005 ± 0.003	0.0XaaTyr: 0.0 ± 0.0	1.179XaaXaa: 1.179 ± 0.13

Statistics based on 1832 proteins (432529 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---