Amino acid dipepetide frequency for Nonomuraea wenchangensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.242AlaAla: 22.242 ± 0.151	1.145AlaCys: 1.145 ± 0.021	7.904AlaAsp: 7.904 ± 0.056	8.851AlaGlu: 8.851 ± 0.072	3.766AlaPhe: 3.766 ± 0.037	14.131AlaGly: 14.131 ± 0.091	2.629AlaHis: 2.629 ± 0.029	3.993AlaIle: 3.993 ± 0.04	2.603AlaLys: 2.603 ± 0.037	14.881AlaLeu: 14.881 ± 0.114	2.776AlaMet: 2.776 ± 0.029	1.982AlaAsn: 1.982 ± 0.026	6.441AlaPro: 6.441 ± 0.057	3.375AlaGln: 3.375 ± 0.042	10.865AlaArg: 10.865 ± 0.074	5.398AlaSer: 5.398 ± 0.044	6.916AlaThr: 6.916 ± 0.051	12.112AlaVal: 12.112 ± 0.078	1.996AlaTrp: 1.996 ± 0.029	2.889AlaTyr: 2.889 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.019	0.106CysCys: 0.106 ± 0.006	0.487CysAsp: 0.487 ± 0.015	0.4CysGlu: 0.4 ± 0.012	0.233CysPhe: 0.233 ± 0.008	0.958CysGly: 0.958 ± 0.02	0.216CysHis: 0.216 ± 0.008	0.134CysIle: 0.134 ± 0.006	0.111CysLys: 0.111 ± 0.006	0.779CysLeu: 0.779 ± 0.016	0.113CysMet: 0.113 ± 0.006	0.133CysAsn: 0.133 ± 0.007	0.504CysPro: 0.504 ± 0.013	0.169CysGln: 0.169 ± 0.008	0.619CysArg: 0.619 ± 0.015	0.415CysSer: 0.415 ± 0.012	0.423CysThr: 0.423 ± 0.014	0.686CysVal: 0.686 ± 0.016	0.122CysTrp: 0.122 ± 0.006	0.182CysTyr: 0.182 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.906AspAla: 6.906 ± 0.052	0.375AspCys: 0.375 ± 0.012	3.557AspAsp: 3.557 ± 0.036	3.741AspGlu: 3.741 ± 0.037	1.508AspPhe: 1.508 ± 0.024	6.062AspGly: 6.062 ± 0.049	1.352AspHis: 1.352 ± 0.022	1.614AspIle: 1.614 ± 0.028	1.035AspLys: 1.035 ± 0.024	6.685AspLeu: 6.685 ± 0.05	0.79AspMet: 0.79 ± 0.017	0.903AspAsn: 0.903 ± 0.023	4.541AspPro: 4.541 ± 0.042	1.55AspGln: 1.55 ± 0.027	4.746AspArg: 4.746 ± 0.043	2.02AspSer: 2.02 ± 0.026	2.541AspThr: 2.541 ± 0.028	4.964AspVal: 4.964 ± 0.039	0.983AspTrp: 0.983 ± 0.021	1.225AspTyr: 1.225 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.189GluAla: 7.189 ± 0.068	0.36GluCys: 0.36 ± 0.011	2.571GluAsp: 2.571 ± 0.03	3.724GluGlu: 3.724 ± 0.043	1.416GluPhe: 1.416 ± 0.022	4.124GluGly: 4.124 ± 0.042	1.647GluHis: 1.647 ± 0.029	2.39GluIle: 2.39 ± 0.032	1.097GluLys: 1.097 ± 0.023	7.381GluLeu: 7.381 ± 0.059	0.891GluMet: 0.891 ± 0.017	0.846GluAsn: 0.846 ± 0.016	3.643GluPro: 3.643 ± 0.039	2.167GluGln: 2.167 ± 0.031	6.07GluArg: 6.07 ± 0.06	2.499GluSer: 2.499 ± 0.033	2.751GluThr: 2.751 ± 0.032	4.784GluVal: 4.784 ± 0.045	0.844GluTrp: 0.844 ± 0.016	0.977GluTyr: 0.977 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.897PheAla: 3.897 ± 0.039	0.267PheCys: 0.267 ± 0.009	1.954PheAsp: 1.954 ± 0.025	1.396PheGlu: 1.396 ± 0.022	0.875PhePhe: 0.875 ± 0.02	3.042PheGly: 3.042 ± 0.034	0.605PheHis: 0.605 ± 0.017	0.722PheIle: 0.722 ± 0.016	0.497PheLys: 0.497 ± 0.014	2.684PheLeu: 2.684 ± 0.036	0.448PheMet: 0.448 ± 0.013	0.552PheAsn: 0.552 ± 0.015	1.429PhePro: 1.429 ± 0.023	0.695PheGln: 0.695 ± 0.015	1.849PheArg: 1.849 ± 0.023	1.391PheSer: 1.391 ± 0.025	1.946PheThr: 1.946 ± 0.026	2.362PheVal: 2.362 ± 0.025	0.46PheTrp: 0.46 ± 0.013	0.632PheTyr: 0.632 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.686GlyAla: 10.686 ± 0.063	0.834GlyCys: 0.834 ± 0.02	5.191GlyAsp: 5.191 ± 0.055	5.472GlyGlu: 5.472 ± 0.044	2.913GlyPhe: 2.913 ± 0.038	9.056GlyGly: 9.056 ± 0.076	2.313GlyHis: 2.313 ± 0.032	3.141GlyIle: 3.141 ± 0.037	2.234GlyLys: 2.234 ± 0.034	10.181GlyLeu: 10.181 ± 0.075	2.051GlyMet: 2.051 ± 0.025	1.658GlyAsn: 1.658 ± 0.03	5.27GlyPro: 5.27 ± 0.053	2.753GlyGln: 2.753 ± 0.036	8.161GlyArg: 8.161 ± 0.065	4.7GlySer: 4.7 ± 0.043	5.587GlyThr: 5.587 ± 0.048	8.153GlyVal: 8.153 ± 0.055	1.798GlyTrp: 1.798 ± 0.025	2.384GlyTyr: 2.384 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.689HisAla: 2.689 ± 0.033	0.205HisCys: 0.205 ± 0.008	1.386HisAsp: 1.386 ± 0.02	1.255HisGlu: 1.255 ± 0.021	0.584HisPhe: 0.584 ± 0.013	2.264HisGly: 2.264 ± 0.028	0.638HisHis: 0.638 ± 0.017	0.607HisIle: 0.607 ± 0.016	0.328HisLys: 0.328 ± 0.01	2.53HisLeu: 2.53 ± 0.032	0.311HisMet: 0.311 ± 0.011	0.374HisAsn: 0.374 ± 0.011	1.714HisPro: 1.714 ± 0.026	0.594HisGln: 0.594 ± 0.014	1.942HisArg: 1.942 ± 0.031	0.833HisSer: 0.833 ± 0.017	1.08HisThr: 1.08 ± 0.02	1.862HisVal: 1.862 ± 0.026	0.362HisTrp: 0.362 ± 0.011	0.487HisTyr: 0.487 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.929IleAla: 4.929 ± 0.04	0.301IleCys: 0.301 ± 0.011	2.251IleAsp: 2.251 ± 0.029	2.107IleGlu: 2.107 ± 0.029	0.829IlePhe: 0.829 ± 0.017	3.534IleGly: 3.534 ± 0.039	0.588IleHis: 0.588 ± 0.015	1.034IleIle: 1.034 ± 0.023	0.756IleLys: 0.756 ± 0.018	2.573IleLeu: 2.573 ± 0.034	0.57IleMet: 0.57 ± 0.015	0.698IleAsn: 0.698 ± 0.021	1.775IlePro: 1.775 ± 0.025	0.74IleGln: 0.74 ± 0.016	2.344IleArg: 2.344 ± 0.028	1.795IleSer: 1.795 ± 0.028	2.242IleThr: 2.242 ± 0.031	3.019IleVal: 3.019 ± 0.036	0.451IleTrp: 0.451 ± 0.012	0.629IleTyr: 0.629 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.53LysAla: 2.53 ± 0.04	0.123LysCys: 0.123 ± 0.007	1.12LysAsp: 1.12 ± 0.021	1.156LysGlu: 1.156 ± 0.021	0.404LysPhe: 0.404 ± 0.012	1.705LysGly: 1.705 ± 0.028	0.415LysHis: 0.415 ± 0.01	0.87LysIle: 0.87 ± 0.021	0.635LysLys: 0.635 ± 0.015	1.949LysLeu: 1.949 ± 0.03	0.337LysMet: 0.337 ± 0.012	0.43LysAsn: 0.43 ± 0.013	1.234LysPro: 1.234 ± 0.025	0.615LysGln: 0.615 ± 0.016	1.384LysArg: 1.384 ± 0.027	0.977LysSer: 0.977 ± 0.02	1.12LysThr: 1.12 ± 0.024	1.899LysVal: 1.899 ± 0.035	0.282LysTrp: 0.282 ± 0.01	0.395LysTyr: 0.395 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.822LeuAla: 16.822 ± 0.111	0.774LeuCys: 0.774 ± 0.016	6.755LeuAsp: 6.755 ± 0.051	4.942LeuGlu: 4.942 ± 0.047	2.713LeuPhe: 2.713 ± 0.039	9.692LeuGly: 9.692 ± 0.072	2.195LeuHis: 2.195 ± 0.031	3.629LeuIle: 3.629 ± 0.041	1.899LeuLys: 1.899 ± 0.03	11.712LeuLeu: 11.712 ± 0.09	1.797LeuMet: 1.797 ± 0.025	1.717LeuAsn: 1.717 ± 0.026	6.711LeuPro: 6.711 ± 0.055	2.123LeuGln: 2.123 ± 0.028	9.294LeuArg: 9.294 ± 0.066	5.488LeuSer: 5.488 ± 0.049	6.853LeuThr: 6.853 ± 0.055	9.403LeuVal: 9.403 ± 0.079	1.372LeuTrp: 1.372 ± 0.025	1.893LeuTyr: 1.893 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.403MetAla: 2.403 ± 0.032	0.121MetCys: 0.121 ± 0.007	0.884MetAsp: 0.884 ± 0.017	0.829MetGlu: 0.829 ± 0.016	0.505MetPhe: 0.505 ± 0.015	1.4MetGly: 1.4 ± 0.021	0.356MetHis: 0.356 ± 0.011	0.83MetIle: 0.83 ± 0.016	0.433MetLys: 0.433 ± 0.012	1.894MetLeu: 1.894 ± 0.027	0.335MetMet: 0.335 ± 0.012	0.454MetAsn: 0.454 ± 0.011	1.152MetPro: 1.152 ± 0.019	0.382MetGln: 0.382 ± 0.012	1.673MetArg: 1.673 ± 0.02	1.365MetSer: 1.365 ± 0.024	1.596MetThr: 1.596 ± 0.023	1.366MetVal: 1.366 ± 0.021	0.237MetTrp: 0.237 ± 0.009	0.313MetTyr: 0.313 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.177AsnAla: 2.177 ± 0.03	0.159AsnCys: 0.159 ± 0.007	0.937AsnAsp: 0.937 ± 0.02	0.788AsnGlu: 0.788 ± 0.018	0.459AsnPhe: 0.459 ± 0.013	1.875AsnGly: 1.875 ± 0.032	0.354AsnHis: 0.354 ± 0.011	0.6AsnIle: 0.6 ± 0.014	0.364AsnLys: 0.364 ± 0.011	1.805AsnLeu: 1.805 ± 0.032	0.282AsnMet: 0.282 ± 0.009	0.411AsnAsn: 0.411 ± 0.014	1.336AsnPro: 1.336 ± 0.024	0.506AsnGln: 0.506 ± 0.015	1.252AsnArg: 1.252 ± 0.023	0.777AsnSer: 0.777 ± 0.02	0.98AsnThr: 0.98 ± 0.023	1.514AsnVal: 1.514 ± 0.023	0.288AsnTrp: 0.288 ± 0.011	0.387AsnTyr: 0.387 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	8.832ProAla: 8.832 ± 0.061	0.381ProCys: 0.381 ± 0.012	4.303ProAsp: 4.303 ± 0.039	4.322ProGlu: 4.322 ± 0.043	1.615ProPhe: 1.615 ± 0.024	6.871ProGly: 6.871 ± 0.063	1.254ProHis: 1.254 ± 0.023	1.655ProIle: 1.655 ± 0.024	1.139ProLys: 1.139 ± 0.021	5.463ProLeu: 5.463 ± 0.046	1.116ProMet: 1.116 ± 0.019	0.905ProAsn: 0.905 ± 0.019	3.994ProPro: 3.994 ± 0.053	1.547ProGln: 1.547 ± 0.031	3.991ProArg: 3.991 ± 0.038	3.185ProSer: 3.185 ± 0.04	2.889ProThr: 2.889 ± 0.04	5.354ProVal: 5.354 ± 0.047	0.97ProTrp: 0.97 ± 0.017	1.514ProTyr: 1.514 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.903GlnAla: 3.903 ± 0.043	0.151GlnCys: 0.151 ± 0.008	1.254GlnAsp: 1.254 ± 0.023	1.438GlnGlu: 1.438 ± 0.021	0.614GlnPhe: 0.614 ± 0.013	2.122GlnGly: 2.122 ± 0.026	0.558GlnHis: 0.558 ± 0.014	1.13GlnIle: 1.13 ± 0.021	0.513GlnLys: 0.513 ± 0.015	2.684GlnLeu: 2.684 ± 0.036	0.449GlnMet: 0.449 ± 0.014	0.459GlnAsn: 0.459 ± 0.015	1.687GlnPro: 1.687 ± 0.038	1.032GlnGln: 1.032 ± 0.03	2.279GlnArg: 2.279 ± 0.027	1.171GlnSer: 1.171 ± 0.02	1.23GlnThr: 1.23 ± 0.02	2.579GlnVal: 2.579 ± 0.03	0.43GlnTrp: 0.43 ± 0.013	0.502GlnTyr: 0.502 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.34ArgAla: 10.34 ± 0.072	0.607ArgCys: 0.607 ± 0.016	4.391ArgAsp: 4.391 ± 0.04	5.044ArgGlu: 5.044 ± 0.05	2.382ArgPhe: 2.382 ± 0.028	5.89ArgGly: 5.89 ± 0.051	2.236ArgHis: 2.236 ± 0.028	2.973ArgIle: 2.973 ± 0.031	1.549ArgLys: 1.549 ± 0.027	10.067ArgLeu: 10.067 ± 0.075	1.92ArgMet: 1.92 ± 0.024	1.355ArgAsn: 1.355 ± 0.023	5.339ArgPro: 5.339 ± 0.051	2.385ArgGln: 2.385 ± 0.029	8.45ArgArg: 8.45 ± 0.072	3.831ArgSer: 3.831 ± 0.037	4.681ArgThr: 4.681 ± 0.04	6.554ArgVal: 6.554 ± 0.047	1.498ArgTrp: 1.498 ± 0.025	1.877ArgTyr: 1.877 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.178SerAla: 6.178 ± 0.052	0.402SerCys: 0.402 ± 0.013	2.429SerAsp: 2.429 ± 0.029	2.266SerGlu: 2.266 ± 0.029	1.546SerPhe: 1.546 ± 0.026	5.698SerGly: 5.698 ± 0.048	0.894SerHis: 0.894 ± 0.015	1.561SerIle: 1.561 ± 0.026	0.916SerLys: 0.916 ± 0.017	4.583SerLeu: 4.583 ± 0.043	1.143SerMet: 1.143 ± 0.021	0.794SerAsn: 0.794 ± 0.017	3.145SerPro: 3.145 ± 0.038	1.167SerGln: 1.167 ± 0.022	3.707SerArg: 3.707 ± 0.038	2.613SerSer: 2.613 ± 0.041	2.677SerThr: 2.677 ± 0.037	3.938SerVal: 3.938 ± 0.038	0.974SerTrp: 0.974 ± 0.02	1.191SerTyr: 1.191 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.724ThrAla: 7.724 ± 0.057	0.47ThrCys: 0.47 ± 0.014	2.907ThrAsp: 2.907 ± 0.035	2.695ThrGlu: 2.695 ± 0.033	1.722ThrPhe: 1.722 ± 0.025	6.32ThrGly: 6.32 ± 0.055	1.083ThrHis: 1.083 ± 0.019	1.947ThrIle: 1.947 ± 0.026	1.033ThrLys: 1.033 ± 0.021	5.859ThrLeu: 5.859 ± 0.043	1.072ThrMet: 1.072 ± 0.019	0.95ThrAsn: 0.95 ± 0.022	4.042ThrPro: 4.042 ± 0.046	1.23ThrGln: 1.23 ± 0.021	3.914ThrArg: 3.914 ± 0.036	2.989ThrSer: 2.989 ± 0.038	3.454ThrThr: 3.454 ± 0.047	5.441ThrVal: 5.441 ± 0.047	0.979ThrTrp: 0.979 ± 0.02	1.33ThrTyr: 1.33 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.891ValAla: 11.891 ± 0.089	0.706ValCys: 0.706 ± 0.016	4.508ValAsp: 4.508 ± 0.041	4.972ValGlu: 4.972 ± 0.04	2.472ValPhe: 2.472 ± 0.029	6.407ValGly: 6.407 ± 0.044	1.85ValHis: 1.85 ± 0.026	3.271ValIle: 3.271 ± 0.038	1.749ValLys: 1.749 ± 0.031	9.88ValLeu: 9.88 ± 0.076	1.529ValMet: 1.529 ± 0.024	1.767ValAsn: 1.767 ± 0.029	5.349ValPro: 5.349 ± 0.05	1.946ValGln: 1.946 ± 0.025	7.344ValArg: 7.344 ± 0.052	4.483ValSer: 4.483 ± 0.038	5.98ValThr: 5.98 ± 0.053	8.29ValVal: 8.29 ± 0.063	1.163ValTrp: 1.163 ± 0.021	1.608ValTyr: 1.608 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.743TrpAla: 1.743 ± 0.022	0.154TrpCys: 0.154 ± 0.009	0.857TrpAsp: 0.857 ± 0.019	0.737TrpGlu: 0.737 ± 0.018	0.517TrpPhe: 0.517 ± 0.015	1.083TrpGly: 1.083 ± 0.022	0.411TrpHis: 0.411 ± 0.011	0.59TrpIle: 0.59 ± 0.016	0.318TrpLys: 0.318 ± 0.011	1.933TrpLeu: 1.933 ± 0.027	0.317TrpMet: 0.317 ± 0.011	0.441TrpAsn: 0.441 ± 0.013	0.913TrpPro: 0.913 ± 0.018	0.583TrpGln: 0.583 ± 0.015	1.563TrpArg: 1.563 ± 0.024	0.969TrpSer: 0.969 ± 0.021	1.056TrpThr: 1.056 ± 0.019	1.019TrpVal: 1.019 ± 0.016	0.381TrpTrp: 0.381 ± 0.012	0.366TrpTyr: 0.366 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.772TyrAla: 2.772 ± 0.032	0.191TyrCys: 0.191 ± 0.008	1.452TyrAsp: 1.452 ± 0.028	1.235TyrGlu: 1.235 ± 0.02	0.633TyrPhe: 0.633 ± 0.014	2.301TyrGly: 2.301 ± 0.031	0.45TyrHis: 0.45 ± 0.013	0.475TyrIle: 0.475 ± 0.013	0.37TyrLys: 0.37 ± 0.013	2.263TyrLeu: 2.263 ± 0.031	0.279TyrMet: 0.279 ± 0.01	0.426TyrAsn: 0.426 ± 0.013	1.084TyrPro: 1.084 ± 0.019	0.624TyrGln: 0.624 ± 0.018	1.921TyrArg: 1.921 ± 0.022	0.922TyrSer: 0.922 ± 0.017	1.156TyrThr: 1.156 ± 0.023	1.866TyrVal: 1.866 ± 0.025	0.362TyrTrp: 0.362 ± 0.012	0.474TyrTyr: 0.474 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 9568 proteins (3041378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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