Amino acid dipepetide frequency for TM7 phylum sp. oral taxon 348

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.494AlaAla: 6.494 ± 0.202
0.486AlaCys: 0.486 ± 0.04
4.242AlaAsp: 4.242 ± 0.138
4.409AlaGlu: 4.409 ± 0.145
2.366AlaPhe: 2.366 ± 0.114
5.51AlaGly: 5.51 ± 0.132
1.409AlaHis: 1.409 ± 0.069
6.357AlaIle: 6.357 ± 0.154
5.928AlaLys: 5.928 ± 0.157
6.741AlaLeu: 6.741 ± 0.144
1.83AlaMet: 1.83 ± 0.069
3.498AlaAsn: 3.498 ± 0.107
2.472AlaPro: 2.472 ± 0.117
2.7AlaGln: 2.7 ± 0.111
4.041AlaArg: 4.041 ± 0.13
4.785AlaSer: 4.785 ± 0.139
4.071AlaThr: 4.071 ± 0.139
4.876AlaVal: 4.876 ± 0.15
0.672AlaTrp: 0.672 ± 0.057
2.332AlaTyr: 2.332 ± 0.109
0.0AlaXaa: 0.0 ± 0.0
Cys
0.554CysAla: 0.554 ± 0.055
0.049CysCys: 0.049 ± 0.013
0.422CysAsp: 0.422 ± 0.04
0.365CysGlu: 0.365 ± 0.036
0.277CysPhe: 0.277 ± 0.034
0.509CysGly: 0.509 ± 0.045
0.19CysHis: 0.19 ± 0.028
0.463CysIle: 0.463 ± 0.041
0.497CysLys: 0.497 ± 0.044
0.608CysLeu: 0.608 ± 0.05
0.201CysMet: 0.201 ± 0.029
0.323CysAsn: 0.323 ± 0.046
0.338CysPro: 0.338 ± 0.035
0.243CysGln: 0.243 ± 0.029
0.277CysArg: 0.277 ± 0.031
0.513CysSer: 0.513 ± 0.046
0.292CysThr: 0.292 ± 0.029
0.418CysVal: 0.418 ± 0.04
0.118CysTrp: 0.118 ± 0.045
0.315CysTyr: 0.315 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.794AspAla: 3.794 ± 0.126
0.406AspCys: 0.406 ± 0.039
3.805AspAsp: 3.805 ± 0.146
4.253AspGlu: 4.253 ± 0.123
2.844AspPhe: 2.844 ± 0.11
4.071AspGly: 4.071 ± 0.142
0.896AspHis: 0.896 ± 0.061
5.567AspIle: 5.567 ± 0.156
4.774AspLys: 4.774 ± 0.153
4.891AspLeu: 4.891 ± 0.13
1.447AspMet: 1.447 ± 0.058
3.353AspAsn: 3.353 ± 0.112
1.842AspPro: 1.842 ± 0.096
1.899AspGln: 1.899 ± 0.086
2.685AspArg: 2.685 ± 0.115
3.813AspSer: 3.813 ± 0.112
2.879AspThr: 2.879 ± 0.108
3.463AspVal: 3.463 ± 0.127
0.646AspTrp: 0.646 ± 0.055
2.347AspTyr: 2.347 ± 0.095
0.0AspXaa: 0.0 ± 0.0
Glu
4.557GluAla: 4.557 ± 0.149
0.353GluCys: 0.353 ± 0.039
3.125GluAsp: 3.125 ± 0.107
3.862GluGlu: 3.862 ± 0.164
2.267GluPhe: 2.267 ± 0.095
2.958GluGly: 2.958 ± 0.133
0.999GluHis: 0.999 ± 0.062
5.036GluIle: 5.036 ± 0.154
4.823GluLys: 4.823 ± 0.16
6.255GluLeu: 6.255 ± 0.164
1.454GluMet: 1.454 ± 0.082
2.875GluAsn: 2.875 ± 0.111
1.758GluPro: 1.758 ± 0.089
2.279GluGln: 2.279 ± 0.098
3.285GluArg: 3.285 ± 0.114
4.025GluSer: 4.025 ± 0.136
2.719GluThr: 2.719 ± 0.103
3.946GluVal: 3.946 ± 0.132
0.524GluTrp: 0.524 ± 0.043
2.309GluTyr: 2.309 ± 0.101
0.0GluXaa: 0.0 ± 0.0
Phe
3.258PheAla: 3.258 ± 0.113
0.353PheCys: 0.353 ± 0.04
2.514PheAsp: 2.514 ± 0.1
2.017PheGlu: 2.017 ± 0.095
1.534PhePhe: 1.534 ± 0.094
2.89PheGly: 2.89 ± 0.119
0.6PheHis: 0.6 ± 0.048
3.175PheIle: 3.175 ± 0.138
1.971PheLys: 1.971 ± 0.094
3.141PheLeu: 3.141 ± 0.117
0.98PheMet: 0.98 ± 0.071
1.941PheAsn: 1.941 ± 0.108
1.181PhePro: 1.181 ± 0.064
0.809PheGln: 0.809 ± 0.052
1.648PheArg: 1.648 ± 0.075
3.133PheSer: 3.133 ± 0.113
2.457PheThr: 2.457 ± 0.102
2.476PheVal: 2.476 ± 0.108
0.509PheTrp: 0.509 ± 0.051
1.405PheTyr: 1.405 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
4.542GlyAla: 4.542 ± 0.164
0.406GlyCys: 0.406 ± 0.037
3.957GlyAsp: 3.957 ± 0.15
4.09GlyGlu: 4.09 ± 0.132
2.689GlyPhe: 2.689 ± 0.118
4.853GlyGly: 4.853 ± 0.186
1.018GlyHis: 1.018 ± 0.067
5.115GlyIle: 5.115 ± 0.135
4.808GlyLys: 4.808 ± 0.132
5.628GlyLeu: 5.628 ± 0.154
1.618GlyMet: 1.618 ± 0.098
2.936GlyAsn: 2.936 ± 0.108
1.276GlyPro: 1.276 ± 0.069
2.176GlyGln: 2.176 ± 0.102
3.289GlyArg: 3.289 ± 0.112
4.451GlySer: 4.451 ± 0.159
3.163GlyThr: 3.163 ± 0.125
5.226GlyVal: 5.226 ± 0.155
0.873GlyTrp: 0.873 ± 0.058
2.472GlyTyr: 2.472 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
1.113HisAla: 1.113 ± 0.074
0.175HisCys: 0.175 ± 0.026
1.128HisAsp: 1.128 ± 0.076
1.128HisGlu: 1.128 ± 0.065
0.752HisPhe: 0.752 ± 0.054
1.227HisGly: 1.227 ± 0.072
0.528HisHis: 0.528 ± 0.047
1.546HisIle: 1.546 ± 0.083
1.185HisLys: 1.185 ± 0.086
1.595HisLeu: 1.595 ± 0.082
0.486HisMet: 0.486 ± 0.04
1.033HisAsn: 1.033 ± 0.056
0.904HisPro: 0.904 ± 0.065
0.649HisGln: 0.649 ± 0.064
0.847HisArg: 0.847 ± 0.061
1.109HisSer: 1.109 ± 0.071
0.957HisThr: 0.957 ± 0.062
0.999HisVal: 0.999 ± 0.066
0.19HisTrp: 0.19 ± 0.027
0.592HisTyr: 0.592 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
6.638IleAla: 6.638 ± 0.154
0.748IleCys: 0.748 ± 0.051
5.438IleAsp: 5.438 ± 0.166
5.241IleGlu: 5.241 ± 0.166
2.784IlePhe: 2.784 ± 0.122
5.233IleGly: 5.233 ± 0.156
1.329IleHis: 1.329 ± 0.077
7.493IleIle: 7.493 ± 0.228
5.605IleLys: 5.605 ± 0.169
7.204IleLeu: 7.204 ± 0.192
1.694IleMet: 1.694 ± 0.079
4.644IleAsn: 4.644 ± 0.134
2.825IlePro: 2.825 ± 0.116
2.172IleGln: 2.172 ± 0.098
3.558IleArg: 3.558 ± 0.113
6.156IleSer: 6.156 ± 0.158
4.644IleThr: 4.644 ± 0.131
5.317IleVal: 5.317 ± 0.159
0.676IleTrp: 0.676 ± 0.055
2.518IleTyr: 2.518 ± 0.105
0.0IleXaa: 0.0 ± 0.0
Lys
4.329LysAla: 4.329 ± 0.134
0.349LysCys: 0.349 ± 0.039
4.314LysAsp: 4.314 ± 0.137
3.999LysGlu: 3.999 ± 0.165
2.506LysPhe: 2.506 ± 0.095
3.444LysGly: 3.444 ± 0.123
1.173LysHis: 1.173 ± 0.077
6.095LysIle: 6.095 ± 0.151
5.951LysLys: 5.951 ± 0.19
6.646LysLeu: 6.646 ± 0.194
1.804LysMet: 1.804 ± 0.084
4.394LysAsn: 4.394 ± 0.155
2.765LysPro: 2.765 ± 0.121
3.08LysGln: 3.08 ± 0.117
3.536LysArg: 3.536 ± 0.131
5.161LysSer: 5.161 ± 0.137
4.128LysThr: 4.128 ± 0.137
4.162LysVal: 4.162 ± 0.14
0.501LysTrp: 0.501 ± 0.041
2.704LysTyr: 2.704 ± 0.098
0.0LysXaa: 0.0 ± 0.0
Leu
8.07LeuAla: 8.07 ± 0.19
0.604LeuCys: 0.604 ± 0.056
5.362LeuAsp: 5.362 ± 0.14
5.26LeuGlu: 5.26 ± 0.142
3.137LeuPhe: 3.137 ± 0.136
5.522LeuGly: 5.522 ± 0.159
1.785LeuHis: 1.785 ± 0.095
6.809LeuIle: 6.809 ± 0.174
5.917LeuLys: 5.917 ± 0.141
8.45LeuLeu: 8.45 ± 0.222
2.134LeuMet: 2.134 ± 0.081
4.39LeuAsn: 4.39 ± 0.133
4.284LeuPro: 4.284 ± 0.139
3.289LeuGln: 3.289 ± 0.101
5.039LeuArg: 5.039 ± 0.143
6.999LeuSer: 6.999 ± 0.201
4.762LeuThr: 4.762 ± 0.13
5.898LeuVal: 5.898 ± 0.148
0.79LeuTrp: 0.79 ± 0.06
2.814LeuTyr: 2.814 ± 0.115
0.0LeuXaa: 0.0 ± 0.0
Met
1.91MetAla: 1.91 ± 0.089
0.156MetCys: 0.156 ± 0.026
1.17MetAsp: 1.17 ± 0.074
1.018MetGlu: 1.018 ± 0.067
0.79MetPhe: 0.79 ± 0.058
1.306MetGly: 1.306 ± 0.076
0.429MetHis: 0.429 ± 0.036
1.724MetIle: 1.724 ± 0.081
1.53MetLys: 1.53 ± 0.075
2.187MetLeu: 2.187 ± 0.092
0.642MetMet: 0.642 ± 0.051
1.185MetAsn: 1.185 ± 0.066
1.044MetPro: 1.044 ± 0.059
1.014MetGln: 1.014 ± 0.063
1.379MetArg: 1.379 ± 0.072
1.903MetSer: 1.903 ± 0.089
1.306MetThr: 1.306 ± 0.071
1.53MetVal: 1.53 ± 0.075
0.129MetTrp: 0.129 ± 0.02
0.699MetTyr: 0.699 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
3.133AsnAla: 3.133 ± 0.115
0.361AsnCys: 0.361 ± 0.038
2.757AsnAsp: 2.757 ± 0.108
2.917AsnGlu: 2.917 ± 0.105
2.005AsnPhe: 2.005 ± 0.092
3.198AsnGly: 3.198 ± 0.113
0.93AsnHis: 0.93 ± 0.053
4.679AsnIle: 4.679 ± 0.153
3.961AsnLys: 3.961 ± 0.14
4.8AsnLeu: 4.8 ± 0.126
1.082AsnMet: 1.082 ± 0.065
3.471AsnAsn: 3.471 ± 0.155
2.582AsnPro: 2.582 ± 0.1
2.4AsnGln: 2.4 ± 0.116
2.503AsnArg: 2.503 ± 0.103
3.809AsnSer: 3.809 ± 0.138
2.56AsnThr: 2.56 ± 0.099
2.757AsnVal: 2.757 ± 0.105
0.558AsnTrp: 0.558 ± 0.05
2.146AsnTyr: 2.146 ± 0.096
0.0AsnXaa: 0.0 ± 0.0
Pro
2.749ProAla: 2.749 ± 0.122
0.167ProCys: 0.167 ± 0.027
2.468ProAsp: 2.468 ± 0.1
2.837ProGlu: 2.837 ± 0.111
1.417ProPhe: 1.417 ± 0.065
2.453ProGly: 2.453 ± 0.102
0.843ProHis: 0.843 ± 0.049
2.693ProIle: 2.693 ± 0.11
2.575ProLys: 2.575 ± 0.099
2.958ProLeu: 2.958 ± 0.094
0.573ProMet: 0.573 ± 0.044
1.963ProAsn: 1.963 ± 0.086
1.253ProPro: 1.253 ± 0.105
1.443ProGln: 1.443 ± 0.089
1.618ProArg: 1.618 ± 0.084
2.67ProSer: 2.67 ± 0.1
2.092ProThr: 2.092 ± 0.107
2.86ProVal: 2.86 ± 0.122
0.372ProTrp: 0.372 ± 0.039
1.12ProTyr: 1.12 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
3.034GlnAla: 3.034 ± 0.119
0.167GlnCys: 0.167 ± 0.022
1.903GlnAsp: 1.903 ± 0.079
2.009GlnGlu: 2.009 ± 0.11
1.325GlnPhe: 1.325 ± 0.086
1.724GlnGly: 1.724 ± 0.088
0.577GlnHis: 0.577 ± 0.042
2.894GlnIle: 2.894 ± 0.089
2.784GlnLys: 2.784 ± 0.107
3.589GlnLeu: 3.589 ± 0.131
0.866GlnMet: 0.866 ± 0.054
2.085GlnAsn: 2.085 ± 0.099
1.758GlnPro: 1.758 ± 0.122
1.808GlnGln: 1.808 ± 0.136
1.967GlnArg: 1.967 ± 0.099
2.366GlnSer: 2.366 ± 0.102
2.062GlnThr: 2.062 ± 0.099
2.172GlnVal: 2.172 ± 0.09
0.353GlnTrp: 0.353 ± 0.04
1.268GlnTyr: 1.268 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
3.615ArgAla: 3.615 ± 0.112
0.296ArgCys: 0.296 ± 0.032
3.065ArgAsp: 3.065 ± 0.107
3.179ArgGlu: 3.179 ± 0.126
1.979ArgPhe: 1.979 ± 0.098
3.099ArgGly: 3.099 ± 0.115
1.158ArgHis: 1.158 ± 0.068
3.399ArgIle: 3.399 ± 0.118
3.281ArgLys: 3.281 ± 0.124
5.282ArgLeu: 5.282 ± 0.144
1.219ArgMet: 1.219 ± 0.061
2.419ArgAsn: 2.419 ± 0.091
1.777ArgPro: 1.777 ± 0.089
2.62ArgGln: 2.62 ± 0.108
3.505ArgArg: 3.505 ± 0.149
3.293ArgSer: 3.293 ± 0.107
2.355ArgThr: 2.355 ± 0.104
3.33ArgVal: 3.33 ± 0.125
0.395ArgTrp: 0.395 ± 0.034
1.967ArgTyr: 1.967 ± 0.077
0.004ArgXaa: 0.004 ± 0.004
Ser
4.743SerAla: 4.743 ± 0.148
0.471SerCys: 0.471 ± 0.039
4.2SerAsp: 4.2 ± 0.135
4.151SerGlu: 4.151 ± 0.121
2.863SerPhe: 2.863 ± 0.096
5.37SerGly: 5.37 ± 0.148
1.375SerHis: 1.375 ± 0.068
5.548SerIle: 5.548 ± 0.143
4.827SerLys: 4.827 ± 0.141
6.501SerLeu: 6.501 ± 0.193
1.451SerMet: 1.451 ± 0.08
3.817SerAsn: 3.817 ± 0.13
2.548SerPro: 2.548 ± 0.114
2.681SerGln: 2.681 ± 0.122
3.604SerArg: 3.604 ± 0.124
5.45SerSer: 5.45 ± 0.184
3.498SerThr: 3.498 ± 0.105
4.656SerVal: 4.656 ± 0.139
0.729SerTrp: 0.729 ± 0.053
2.195SerTyr: 2.195 ± 0.094
0.0SerXaa: 0.0 ± 0.0
Thr
3.976ThrAla: 3.976 ± 0.128
0.308ThrCys: 0.308 ± 0.038
2.977ThrAsp: 2.977 ± 0.105
2.651ThrGlu: 2.651 ± 0.103
1.815ThrPhe: 1.815 ± 0.079
4.025ThrGly: 4.025 ± 0.124
1.029ThrHis: 1.029 ± 0.066
4.462ThrIle: 4.462 ± 0.153
3.581ThrLys: 3.581 ± 0.126
4.682ThrLeu: 4.682 ± 0.133
1.154ThrMet: 1.154 ± 0.058
2.609ThrAsn: 2.609 ± 0.102
2.867ThrPro: 2.867 ± 0.112
1.622ThrGln: 1.622 ± 0.089
2.263ThrArg: 2.263 ± 0.077
3.604ThrSer: 3.604 ± 0.12
2.92ThrThr: 2.92 ± 0.11
3.824ThrVal: 3.824 ± 0.116
0.448ThrTrp: 0.448 ± 0.042
1.77ThrTyr: 1.77 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
5.613ValAla: 5.613 ± 0.149
0.573ValCys: 0.573 ± 0.05
4.12ValAsp: 4.12 ± 0.119
3.676ValGlu: 3.676 ± 0.131
2.647ValPhe: 2.647 ± 0.111
4.219ValGly: 4.219 ± 0.131
0.965ValHis: 0.965 ± 0.056
5.419ValIle: 5.419 ± 0.161
4.12ValLys: 4.12 ± 0.133
5.837ValLeu: 5.837 ± 0.159
1.447ValMet: 1.447 ± 0.075
3.103ValAsn: 3.103 ± 0.118
2.134ValPro: 2.134 ± 0.084
1.91ValGln: 1.91 ± 0.097
3.467ValArg: 3.467 ± 0.137
4.713ValSer: 4.713 ± 0.153
3.551ValThr: 3.551 ± 0.124
4.925ValVal: 4.925 ± 0.153
0.551ValTrp: 0.551 ± 0.045
2.222ValTyr: 2.222 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.706TrpAla: 0.706 ± 0.05
0.103TrpCys: 0.103 ± 0.019
0.486TrpAsp: 0.486 ± 0.049
0.38TrpGlu: 0.38 ± 0.048
0.49TrpPhe: 0.49 ± 0.045
0.566TrpGly: 0.566 ± 0.053
0.228TrpHis: 0.228 ± 0.03
0.695TrpIle: 0.695 ± 0.056
0.486TrpLys: 0.486 ± 0.048
1.166TrpLeu: 1.166 ± 0.08
0.243TrpMet: 0.243 ± 0.03
0.437TrpAsn: 0.437 ± 0.044
0.254TrpPro: 0.254 ± 0.031
0.646TrpGln: 0.646 ± 0.056
0.76TrpArg: 0.76 ± 0.062
0.558TrpSer: 0.558 ± 0.054
0.365TrpThr: 0.365 ± 0.037
0.52TrpVal: 0.52 ± 0.045
0.197TrpTrp: 0.197 ± 0.034
0.315TrpTyr: 0.315 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.389TyrAla: 2.389 ± 0.096
0.437TyrCys: 0.437 ± 0.058
2.222TyrAsp: 2.222 ± 0.082
1.971TyrGlu: 1.971 ± 0.094
1.504TyrPhe: 1.504 ± 0.066
2.408TyrGly: 2.408 ± 0.093
0.68TyrHis: 0.68 ± 0.044
2.749TyrIle: 2.749 ± 0.097
2.438TyrLys: 2.438 ± 0.102
3.152TyrLeu: 3.152 ± 0.115
0.722TyrMet: 0.722 ± 0.055
2.134TyrAsn: 2.134 ± 0.095
1.261TyrPro: 1.261 ± 0.086
1.272TyrGln: 1.272 ± 0.076
1.967TyrArg: 1.967 ± 0.1
2.172TyrSer: 2.172 ± 0.088
1.808TyrThr: 1.808 ± 0.09
1.857TyrVal: 1.857 ± 0.093
0.368TyrTrp: 0.368 ± 0.04
1.398TyrTyr: 1.398 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.004XaaCys: 0.004 ± 0.004
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.008XaaXaa: 0.008 ± 0.007
Statistics based on 855 proteins (263325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski