Amino acid dipepetide frequency for Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.41AlaAla: 9.41 ± 0.173	1.232AlaCys: 1.232 ± 0.056	5.119AlaAsp: 5.119 ± 0.102	6.549AlaGlu: 6.549 ± 0.126	3.374AlaPhe: 3.374 ± 0.078	7.935AlaGly: 7.935 ± 0.148	1.349AlaHis: 1.349 ± 0.051	5.144AlaIle: 5.144 ± 0.118	5.184AlaLys: 5.184 ± 0.123	7.998AlaLeu: 7.998 ± 0.145	2.166AlaMet: 2.166 ± 0.068	2.519AlaAsn: 2.519 ± 0.073	2.785AlaPro: 2.785 ± 0.078	1.812AlaGln: 1.812 ± 0.058	3.523AlaArg: 3.523 ± 0.09	4.499AlaSer: 4.499 ± 0.107	3.808AlaThr: 3.808 ± 0.089	7.498AlaVal: 7.498 ± 0.124	0.76AlaTrp: 0.76 ± 0.043	2.58AlaTyr: 2.58 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	1.246CysAla: 1.246 ± 0.052	0.264CysCys: 0.264 ± 0.023	0.8CysAsp: 0.8 ± 0.042	0.737CysGlu: 0.737 ± 0.035	0.544CysPhe: 0.544 ± 0.031	1.9CysGly: 1.9 ± 0.07	0.27CysHis: 0.27 ± 0.024	1.074CysIle: 1.074 ± 0.053	0.572CysLys: 0.572 ± 0.035	1.169CysLeu: 1.169 ± 0.045	0.452CysMet: 0.452 ± 0.028	0.427CysAsn: 0.427 ± 0.03	0.978CysPro: 0.978 ± 0.052	0.323CysGln: 0.323 ± 0.026	0.865CysArg: 0.865 ± 0.043	0.991CysSer: 0.991 ± 0.049	0.798CysThr: 0.798 ± 0.042	1.051CysVal: 1.051 ± 0.046	0.121CysTrp: 0.121 ± 0.016	0.49CysTyr: 0.49 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	5.006AspAla: 5.006 ± 0.119	0.718AspCys: 0.718 ± 0.041	2.905AspAsp: 2.905 ± 0.083	4.323AspGlu: 4.323 ± 0.1	2.032AspPhe: 2.032 ± 0.071	4.12AspGly: 4.12 ± 0.115	1.041AspHis: 1.041 ± 0.039	4.451AspIle: 4.451 ± 0.091	2.624AspLys: 2.624 ± 0.075	5.682AspLeu: 5.682 ± 0.113	1.629AspMet: 1.629 ± 0.055	1.665AspAsn: 1.665 ± 0.059	2.961AspPro: 2.961 ± 0.071	1.196AspGln: 1.196 ± 0.052	2.444AspArg: 2.444 ± 0.072	2.67AspSer: 2.67 ± 0.085	3.175AspThr: 3.175 ± 0.087	4.407AspVal: 4.407 ± 0.115	0.526AspTrp: 0.526 ± 0.031	1.686AspTyr: 1.686 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	5.343GluAla: 5.343 ± 0.14	0.777GluCys: 0.777 ± 0.04	3.236GluAsp: 3.236 ± 0.083	5.228GluGlu: 5.228 ± 0.126	2.394GluPhe: 2.394 ± 0.068	4.413GluGly: 4.413 ± 0.1	1.343GluHis: 1.343 ± 0.047	5.588GluIle: 5.588 ± 0.107	5.089GluLys: 5.089 ± 0.109	6.026GluLeu: 6.026 ± 0.135	2.362GluMet: 2.362 ± 0.072	3.125GluAsn: 3.125 ± 0.087	2.163GluPro: 2.163 ± 0.069	1.887GluGln: 1.887 ± 0.06	3.301GluArg: 3.301 ± 0.091	3.334GluSer: 3.334 ± 0.087	3.956GluThr: 3.956 ± 0.076	4.279GluVal: 4.279 ± 0.104	0.61GluTrp: 0.61 ± 0.032	2.54GluTyr: 2.54 ± 0.071	0.0GluXaa: 0.0 ± 0.0
Phe	3.684PheAla: 3.684 ± 0.081	0.733PheCys: 0.733 ± 0.042	2.331PheAsp: 2.331 ± 0.06	2.241PheGlu: 2.241 ± 0.068	1.711PhePhe: 1.711 ± 0.071	3.653PheGly: 3.653 ± 0.1	0.706PheHis: 0.706 ± 0.037	2.737PheIle: 2.737 ± 0.091	1.311PheLys: 1.311 ± 0.054	3.525PheLeu: 3.525 ± 0.108	0.999PheMet: 0.999 ± 0.05	1.202PheAsn: 1.202 ± 0.055	1.68PhePro: 1.68 ± 0.054	0.953PheGln: 0.953 ± 0.044	1.596PheArg: 1.596 ± 0.059	3.144PheSer: 3.144 ± 0.083	2.58PheThr: 2.58 ± 0.084	2.951PheVal: 2.951 ± 0.078	0.423PheTrp: 0.423 ± 0.026	1.139PheTyr: 1.139 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.843GlyAla: 5.843 ± 0.149	1.462GlyCys: 1.462 ± 0.053	4.189GlyAsp: 4.189 ± 0.106	4.691GlyGlu: 4.691 ± 0.101	3.211GlyPhe: 3.211 ± 0.085	5.722GlyGly: 5.722 ± 0.142	1.401GlyHis: 1.401 ± 0.048	6.832GlyIle: 6.832 ± 0.142	5.14GlyLys: 5.14 ± 0.113	6.44GlyLeu: 6.44 ± 0.14	2.532GlyMet: 2.532 ± 0.069	2.777GlyAsn: 2.777 ± 0.09	2.247GlyPro: 2.247 ± 0.067	1.696GlyGln: 1.696 ± 0.057	3.493GlyArg: 3.493 ± 0.083	4.733GlySer: 4.733 ± 0.09	5.073GlyThr: 5.073 ± 0.124	6.248GlyVal: 6.248 ± 0.119	0.886GlyTrp: 0.886 ± 0.048	3.075GlyTyr: 3.075 ± 0.091	0.0GlyXaa: 0.0 ± 0.0
His	1.648HisAla: 1.648 ± 0.055	0.325HisCys: 0.325 ± 0.027	1.037HisAsp: 1.037 ± 0.043	1.139HisGlu: 1.139 ± 0.049	0.693HisPhe: 0.693 ± 0.039	1.357HisGly: 1.357 ± 0.049	0.425HisHis: 0.425 ± 0.028	1.368HisIle: 1.368 ± 0.057	0.813HisLys: 0.813 ± 0.043	1.83HisLeu: 1.83 ± 0.068	0.513HisMet: 0.513 ± 0.032	0.601HisAsn: 0.601 ± 0.038	1.28HisPro: 1.28 ± 0.052	0.538HisGln: 0.538 ± 0.029	0.848HisArg: 0.848 ± 0.045	0.921HisSer: 0.921 ± 0.04	1.03HisThr: 1.03 ± 0.047	1.208HisVal: 1.208 ± 0.046	0.155HisTrp: 0.155 ± 0.017	0.62HisTyr: 0.62 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.694IleAla: 6.694 ± 0.114	1.299IleCys: 1.299 ± 0.054	4.164IleAsp: 4.164 ± 0.087	4.404IleGlu: 4.404 ± 0.099	2.978IlePhe: 2.978 ± 0.088	5.981IleGly: 5.981 ± 0.125	1.34IleHis: 1.34 ± 0.053	5.604IleIle: 5.604 ± 0.143	3.079IleLys: 3.079 ± 0.077	7.561IleLeu: 7.561 ± 0.167	1.774IleMet: 1.774 ± 0.064	2.488IleAsn: 2.488 ± 0.081	4.197IlePro: 4.197 ± 0.087	2.011IleGln: 2.011 ± 0.068	3.95IleArg: 3.95 ± 0.098	5.374IleSer: 5.374 ± 0.124	4.964IleThr: 4.964 ± 0.107	5.529IleVal: 5.529 ± 0.1	0.61IleTrp: 0.61 ± 0.033	2.306IleTyr: 2.306 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	4.268LysAla: 4.268 ± 0.117	0.748LysCys: 0.748 ± 0.035	3.018LysAsp: 3.018 ± 0.078	4.367LysGlu: 4.367 ± 0.099	1.661LysPhe: 1.661 ± 0.06	3.606LysGly: 3.606 ± 0.099	0.938LysHis: 0.938 ± 0.039	4.599LysIle: 4.599 ± 0.106	4.252LysLys: 4.252 ± 0.113	4.178LysLeu: 4.178 ± 0.095	1.743LysMet: 1.743 ± 0.061	2.767LysAsn: 2.767 ± 0.078	2.197LysPro: 2.197 ± 0.068	1.562LysGln: 1.562 ± 0.066	2.643LysArg: 2.643 ± 0.073	3.054LysSer: 3.054 ± 0.088	3.715LysThr: 3.715 ± 0.085	3.194LysVal: 3.194 ± 0.101	0.436LysTrp: 0.436 ± 0.03	2.096LysTyr: 2.096 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	8.535LeuAla: 8.535 ± 0.136	1.403LeuCys: 1.403 ± 0.06	5.026LeuAsp: 5.026 ± 0.104	5.661LeuGlu: 5.661 ± 0.111	3.868LeuPhe: 3.868 ± 0.099	6.691LeuGly: 6.691 ± 0.14	1.74LeuHis: 1.74 ± 0.067	7.075LeuIle: 7.075 ± 0.147	4.677LeuLys: 4.677 ± 0.093	8.972LeuLeu: 8.972 ± 0.192	2.524LeuMet: 2.524 ± 0.071	3.026LeuAsn: 3.026 ± 0.078	4.314LeuPro: 4.314 ± 0.085	2.274LeuGln: 2.274 ± 0.061	4.417LeuArg: 4.417 ± 0.115	6.581LeuSer: 6.581 ± 0.133	5.464LeuThr: 5.464 ± 0.115	6.155LeuVal: 6.155 ± 0.123	0.752LeuTrp: 0.752 ± 0.044	2.867LeuTyr: 2.867 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	2.101MetAla: 2.101 ± 0.062	0.32MetCys: 0.32 ± 0.025	1.596MetAsp: 1.596 ± 0.056	1.588MetGlu: 1.588 ± 0.055	1.001MetPhe: 1.001 ± 0.042	1.889MetGly: 1.889 ± 0.056	0.647MetHis: 0.647 ± 0.04	2.371MetIle: 2.371 ± 0.091	2.032MetLys: 2.032 ± 0.066	2.406MetLeu: 2.406 ± 0.076	1.035MetMet: 1.035 ± 0.044	1.301MetAsn: 1.301 ± 0.054	1.286MetPro: 1.286 ± 0.05	1.001MetGln: 1.001 ± 0.044	1.454MetArg: 1.454 ± 0.05	1.653MetSer: 1.653 ± 0.054	2.069MetThr: 2.069 ± 0.064	1.801MetVal: 1.801 ± 0.061	0.23MetTrp: 0.23 ± 0.023	0.867MetTyr: 0.867 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	3.206AsnAla: 3.206 ± 0.084	0.45AsnCys: 0.45 ± 0.03	1.841AsnAsp: 1.841 ± 0.067	2.235AsnGlu: 2.235 ± 0.063	1.131AsnPhe: 1.131 ± 0.046	2.938AsnGly: 2.938 ± 0.075	0.628AsnHis: 0.628 ± 0.03	2.853AsnIle: 2.853 ± 0.085	1.604AsnLys: 1.604 ± 0.077	3.343AsnLeu: 3.343 ± 0.096	1.033AsnMet: 1.033 ± 0.046	1.255AsnAsn: 1.255 ± 0.065	2.226AsnPro: 2.226 ± 0.066	0.938AsnGln: 0.938 ± 0.045	1.703AsnArg: 1.703 ± 0.062	1.763AsnSer: 1.763 ± 0.07	2.362AsnThr: 2.362 ± 0.07	2.607AsnVal: 2.607 ± 0.072	0.32AsnTrp: 0.32 ± 0.026	1.181AsnTyr: 1.181 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	3.898ProAla: 3.898 ± 0.099	0.653ProCys: 0.653 ± 0.039	2.934ProAsp: 2.934 ± 0.076	4.059ProGlu: 4.059 ± 0.092	1.92ProPhe: 1.92 ± 0.068	3.378ProGly: 3.378 ± 0.086	0.798ProHis: 0.798 ± 0.036	2.785ProIle: 2.785 ± 0.089	2.496ProLys: 2.496 ± 0.079	3.839ProLeu: 3.839 ± 0.081	0.999ProMet: 0.999 ± 0.048	1.474ProAsn: 1.474 ± 0.055	1.5ProPro: 1.5 ± 0.054	1.02ProGln: 1.02 ± 0.042	1.653ProArg: 1.653 ± 0.058	2.475ProSer: 2.475 ± 0.083	2.371ProThr: 2.371 ± 0.102	4.006ProVal: 4.006 ± 0.103	0.433ProTrp: 0.433 ± 0.029	1.65ProTyr: 1.65 ± 0.064	0.0ProXaa: 0.0 ± 0.0
Gln	1.933GlnAla: 1.933 ± 0.062	0.312GlnCys: 0.312 ± 0.021	1.175GlnAsp: 1.175 ± 0.052	1.646GlnGlu: 1.646 ± 0.053	1.022GlnPhe: 1.022 ± 0.04	1.42GlnGly: 1.42 ± 0.051	0.452GlnHis: 0.452 ± 0.029	2.264GlnIle: 2.264 ± 0.068	1.99GlnLys: 1.99 ± 0.062	1.965GlnLeu: 1.965 ± 0.059	0.989GlnMet: 0.989 ± 0.042	1.305GlnAsn: 1.305 ± 0.048	0.919GlnPro: 0.919 ± 0.043	0.737GlnGln: 0.737 ± 0.051	1.164GlnArg: 1.164 ± 0.056	1.271GlnSer: 1.271 ± 0.052	1.694GlnThr: 1.694 ± 0.061	1.661GlnVal: 1.661 ± 0.054	0.224GlnTrp: 0.224 ± 0.017	0.974GlnTyr: 0.974 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.401ArgAla: 3.401 ± 0.091	0.721ArgCys: 0.721 ± 0.039	2.647ArgAsp: 2.647 ± 0.078	3.835ArgGlu: 3.835 ± 0.101	1.985ArgPhe: 1.985 ± 0.059	3.202ArgGly: 3.202 ± 0.083	0.943ArgHis: 0.943 ± 0.043	3.776ArgIle: 3.776 ± 0.087	2.76ArgLys: 2.76 ± 0.076	4.097ArgLeu: 4.097 ± 0.098	1.472ArgMet: 1.472 ± 0.054	1.669ArgAsn: 1.669 ± 0.057	1.74ArgPro: 1.74 ± 0.068	1.37ArgGln: 1.37 ± 0.057	2.622ArgArg: 2.622 ± 0.074	2.622ArgSer: 2.622 ± 0.07	2.383ArgThr: 2.383 ± 0.071	3.435ArgVal: 3.435 ± 0.098	0.367ArgTrp: 0.367 ± 0.025	1.73ArgTyr: 1.73 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.049SerAla: 5.049 ± 0.116	0.831SerCys: 0.831 ± 0.04	3.332SerAsp: 3.332 ± 0.089	3.659SerGlu: 3.659 ± 0.087	2.364SerPhe: 2.364 ± 0.071	5.816SerGly: 5.816 ± 0.119	1.058SerHis: 1.058 ± 0.047	4.145SerIle: 4.145 ± 0.103	2.674SerLys: 2.674 ± 0.063	5.927SerLeu: 5.927 ± 0.123	1.684SerMet: 1.684 ± 0.062	1.69SerAsn: 1.69 ± 0.061	2.804SerPro: 2.804 ± 0.076	1.397SerGln: 1.397 ± 0.054	2.989SerArg: 2.989 ± 0.071	3.791SerSer: 3.791 ± 0.104	3.269SerThr: 3.269 ± 0.096	5.094SerVal: 5.094 ± 0.105	0.66SerTrp: 0.66 ± 0.034	2.071SerTyr: 2.071 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	5.075ThrAla: 5.075 ± 0.113	0.811ThrCys: 0.811 ± 0.039	3.322ThrAsp: 3.322 ± 0.087	3.799ThrGlu: 3.799 ± 0.087	2.22ThrPhe: 2.22 ± 0.065	5.293ThrGly: 5.293 ± 0.114	1.143ThrHis: 1.143 ± 0.042	4.476ThrIle: 4.476 ± 0.114	2.953ThrLys: 2.953 ± 0.087	5.504ThrLeu: 5.504 ± 0.107	1.416ThrMet: 1.416 ± 0.057	1.964ThrAsn: 1.964 ± 0.066	3.487ThrPro: 3.487 ± 0.111	1.309ThrGln: 1.309 ± 0.059	2.379ThrArg: 2.379 ± 0.066	3.567ThrSer: 3.567 ± 0.087	3.674ThrThr: 3.674 ± 0.125	4.737ThrVal: 4.737 ± 0.115	0.58ThrTrp: 0.58 ± 0.034	2.057ThrTyr: 2.057 ± 0.086	0.0ThrXaa: 0.0 ± 0.0
Val	5.265ValAla: 5.265 ± 0.115	1.414ValCys: 1.414 ± 0.055	3.877ValAsp: 3.877 ± 0.095	4.342ValGlu: 4.342 ± 0.104	3.274ValPhe: 3.274 ± 0.08	5.037ValGly: 5.037 ± 0.122	1.255ValHis: 1.255 ± 0.051	6.268ValIle: 6.268 ± 0.126	3.757ValLys: 3.757 ± 0.096	7.136ValLeu: 7.136 ± 0.128	2.241ValMet: 2.241 ± 0.072	2.599ValAsn: 2.599 ± 0.077	3.659ValPro: 3.659 ± 0.094	1.757ValGln: 1.757 ± 0.062	3.657ValArg: 3.657 ± 0.106	5.385ValSer: 5.385 ± 0.126	4.769ValThr: 4.769 ± 0.108	5.866ValVal: 5.866 ± 0.129	0.71ValTrp: 0.71 ± 0.036	2.492ValTyr: 2.492 ± 0.08	0.0ValXaa: 0.0 ± 0.0
Trp	0.595TrpAla: 0.595 ± 0.03	0.124TrpCys: 0.124 ± 0.017	0.593TrpAsp: 0.593 ± 0.033	0.574TrpGlu: 0.574 ± 0.034	0.438TrpPhe: 0.438 ± 0.034	0.61TrpGly: 0.61 ± 0.037	0.191TrpHis: 0.191 ± 0.022	0.767TrpIle: 0.767 ± 0.037	0.622TrpLys: 0.622 ± 0.038	0.811TrpLeu: 0.811 ± 0.038	0.323TrpMet: 0.323 ± 0.022	0.442TrpAsn: 0.442 ± 0.028	0.172TrpPro: 0.172 ± 0.018	0.302TrpGln: 0.302 ± 0.024	0.473TrpArg: 0.473 ± 0.032	0.509TrpSer: 0.509 ± 0.033	0.54TrpThr: 0.54 ± 0.033	0.603TrpVal: 0.603 ± 0.035	0.107TrpTrp: 0.107 ± 0.014	0.431TrpTyr: 0.431 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.045TyrAla: 3.045 ± 0.074	0.473TyrCys: 0.473 ± 0.035	2.119TyrAsp: 2.119 ± 0.072	1.918TyrGlu: 1.918 ± 0.064	1.479TyrPhe: 1.479 ± 0.06	2.731TyrGly: 2.731 ± 0.071	0.679TyrHis: 0.679 ± 0.04	2.13TyrIle: 2.13 ± 0.071	1.412TyrLys: 1.412 ± 0.061	3.609TyrLeu: 3.609 ± 0.094	0.76TyrMet: 0.76 ± 0.042	1.321TyrAsn: 1.321 ± 0.069	1.745TyrPro: 1.745 ± 0.053	1.033TyrGln: 1.033 ± 0.041	1.602TyrArg: 1.602 ± 0.062	1.965TyrSer: 1.965 ± 0.072	2.075TyrThr: 2.075 ± 0.069	2.432TyrVal: 2.432 ± 0.073	0.322TyrTrp: 0.322 ± 0.026	1.311TyrTyr: 1.311 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1739 proteins (522529 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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