Amino acid dipepetide frequency for Haloarchaeobius iranensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.152AlaAla: 14.152 ± 0.189
0.772AlaCys: 0.772 ± 0.028
9.965AlaAsp: 9.965 ± 0.121
8.513AlaGlu: 8.513 ± 0.102
3.854AlaPhe: 3.854 ± 0.067
10.097AlaGly: 10.097 ± 0.13
1.812AlaHis: 1.812 ± 0.044
4.051AlaIle: 4.051 ± 0.066
1.725AlaLys: 1.725 ± 0.044
10.388AlaLeu: 10.388 ± 0.133
2.161AlaMet: 2.161 ± 0.043
2.427AlaAsn: 2.427 ± 0.045
4.169AlaPro: 4.169 ± 0.068
2.187AlaGln: 2.187 ± 0.05
6.275AlaArg: 6.275 ± 0.092
5.619AlaSer: 5.619 ± 0.083
7.639AlaThr: 7.639 ± 0.102
11.554AlaVal: 11.554 ± 0.138
1.211AlaTrp: 1.211 ± 0.033
2.642AlaTyr: 2.642 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.604CysAla: 0.604 ± 0.024
0.101CysCys: 0.101 ± 0.01
0.666CysAsp: 0.666 ± 0.025
0.636CysGlu: 0.636 ± 0.024
0.221CysPhe: 0.221 ± 0.015
0.891CysGly: 0.891 ± 0.035
0.166CysHis: 0.166 ± 0.014
0.266CysIle: 0.266 ± 0.014
0.109CysLys: 0.109 ± 0.01
0.623CysLeu: 0.623 ± 0.022
0.109CysMet: 0.109 ± 0.01
0.203CysAsn: 0.203 ± 0.012
0.55CysPro: 0.55 ± 0.026
0.181CysGln: 0.181 ± 0.015
0.485CysArg: 0.485 ± 0.022
0.441CysSer: 0.441 ± 0.018
0.44CysThr: 0.44 ± 0.02
0.53CysVal: 0.53 ± 0.023
0.108CysTrp: 0.108 ± 0.01
0.232CysTyr: 0.232 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
10.535AspAla: 10.535 ± 0.13
0.814AspCys: 0.814 ± 0.033
8.487AspAsp: 8.487 ± 0.117
8.492AspGlu: 8.492 ± 0.114
1.895AspPhe: 1.895 ± 0.049
9.193AspGly: 9.193 ± 0.11
1.785AspHis: 1.785 ± 0.051
3.121AspIle: 3.121 ± 0.063
0.86AspLys: 0.86 ± 0.027
6.635AspLeu: 6.635 ± 0.093
1.261AspMet: 1.261 ± 0.038
1.23AspAsn: 1.23 ± 0.04
4.612AspPro: 4.612 ± 0.068
1.682AspGln: 1.682 ± 0.044
6.302AspArg: 6.302 ± 0.077
3.846AspSer: 3.846 ± 0.068
4.217AspThr: 4.217 ± 0.07
7.578AspVal: 7.578 ± 0.094
1.189AspTrp: 1.189 ± 0.038
1.922AspTyr: 1.922 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
8.435GluAla: 8.435 ± 0.119
0.502GluCys: 0.502 ± 0.024
5.509GluAsp: 5.509 ± 0.099
6.121GluGlu: 6.121 ± 0.112
3.147GluPhe: 3.147 ± 0.055
5.358GluGly: 5.358 ± 0.081
2.198GluHis: 2.198 ± 0.053
2.878GluIle: 2.878 ± 0.063
1.638GluLys: 1.638 ± 0.047
7.863GluLeu: 7.863 ± 0.101
1.758GluMet: 1.758 ± 0.042
2.207GluAsn: 2.207 ± 0.049
4.468GluPro: 4.468 ± 0.085
2.739GluGln: 2.739 ± 0.056
7.507GluArg: 7.507 ± 0.103
4.959GluSer: 4.959 ± 0.068
6.262GluThr: 6.262 ± 0.093
5.879GluVal: 5.879 ± 0.084
1.042GluTrp: 1.042 ± 0.031
2.554GluTyr: 2.554 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.715PheAla: 3.715 ± 0.069
0.273PheCys: 0.273 ± 0.017
3.439PheAsp: 3.439 ± 0.061
3.221PheGlu: 3.221 ± 0.059
0.971PhePhe: 0.971 ± 0.03
3.281PheGly: 3.281 ± 0.06
0.613PheHis: 0.613 ± 0.024
0.905PheIle: 0.905 ± 0.031
0.43PheLys: 0.43 ± 0.023
2.834PheLeu: 2.834 ± 0.069
0.485PheMet: 0.485 ± 0.022
0.661PheAsn: 0.661 ± 0.024
1.29PhePro: 1.29 ± 0.033
0.859PheGln: 0.859 ± 0.029
1.761PheArg: 1.761 ± 0.039
1.674PheSer: 1.674 ± 0.034
1.89PheThr: 1.89 ± 0.043
3.442PheVal: 3.442 ± 0.059
0.402PheTrp: 0.402 ± 0.021
0.819PheTyr: 0.819 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.203GlyAla: 8.203 ± 0.123
0.8GlyCys: 0.8 ± 0.027
7.335GlyAsp: 7.335 ± 0.111
7.109GlyGlu: 7.109 ± 0.09
3.183GlyPhe: 3.183 ± 0.063
8.169GlyGly: 8.169 ± 0.12
1.738GlyHis: 1.738 ± 0.044
3.868GlyIle: 3.868 ± 0.066
1.596GlyLys: 1.596 ± 0.041
7.755GlyLeu: 7.755 ± 0.116
1.693GlyMet: 1.693 ± 0.042
1.945GlyAsn: 1.945 ± 0.046
3.436GlyPro: 3.436 ± 0.056
2.192GlyGln: 2.192 ± 0.046
5.085GlyArg: 5.085 ± 0.075
5.567GlySer: 5.567 ± 0.081
6.304GlyThr: 6.304 ± 0.087
7.916GlyVal: 7.916 ± 0.117
1.167GlyTrp: 1.167 ± 0.035
2.726GlyTyr: 2.726 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.069HisAla: 2.069 ± 0.044
0.224HisCys: 0.224 ± 0.016
1.954HisAsp: 1.954 ± 0.049
1.84HisGlu: 1.84 ± 0.043
0.53HisPhe: 0.53 ± 0.022
1.97HisGly: 1.97 ± 0.045
0.569HisHis: 0.569 ± 0.023
0.632HisIle: 0.632 ± 0.027
0.267HisLys: 0.267 ± 0.015
1.714HisLeu: 1.714 ± 0.042
0.297HisMet: 0.297 ± 0.019
0.432HisAsn: 0.432 ± 0.02
1.156HisPro: 1.156 ± 0.032
0.451HisGln: 0.451 ± 0.023
1.369HisArg: 1.369 ± 0.033
0.878HisSer: 0.878 ± 0.031
1.02HisThr: 1.02 ± 0.032
2.063HisVal: 2.063 ± 0.044
0.233HisTrp: 0.233 ± 0.015
0.548HisTyr: 0.548 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
3.94IleAla: 3.94 ± 0.06
0.231IleCys: 0.231 ± 0.013
3.122IleAsp: 3.122 ± 0.061
3.476IleGlu: 3.476 ± 0.081
0.814IlePhe: 0.814 ± 0.032
3.13IleGly: 3.13 ± 0.062
0.682IleHis: 0.682 ± 0.023
1.037IleIle: 1.037 ± 0.033
0.573IleLys: 0.573 ± 0.025
2.5IleLeu: 2.5 ± 0.052
0.432IleMet: 0.432 ± 0.022
0.709IleAsn: 0.709 ± 0.03
1.721IlePro: 1.721 ± 0.039
0.982IleGln: 0.982 ± 0.034
2.164IleArg: 2.164 ± 0.049
1.841IleSer: 1.841 ± 0.047
1.929IleThr: 1.929 ± 0.049
3.239IleVal: 3.239 ± 0.061
0.302IleTrp: 0.302 ± 0.016
0.811IleTyr: 0.811 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
1.591LysAla: 1.591 ± 0.047
0.114LysCys: 0.114 ± 0.011
0.947LysAsp: 0.947 ± 0.03
1.142LysGlu: 1.142 ± 0.038
0.492LysPhe: 0.492 ± 0.02
1.232LysGly: 1.232 ± 0.036
0.483LysHis: 0.483 ± 0.022
0.623LysIle: 0.623 ± 0.03
0.461LysLys: 0.461 ± 0.023
1.546LysLeu: 1.546 ± 0.039
0.36LysMet: 0.36 ± 0.018
0.481LysAsn: 0.481 ± 0.024
0.867LysPro: 0.867 ± 0.029
0.723LysGln: 0.723 ± 0.027
1.511LysArg: 1.511 ± 0.039
1.001LysSer: 1.001 ± 0.031
1.18LysThr: 1.18 ± 0.034
1.179LysVal: 1.179 ± 0.038
0.212LysTrp: 0.212 ± 0.015
0.514LysTyr: 0.514 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
11.638LeuAla: 11.638 ± 0.144
0.62LeuCys: 0.62 ± 0.025
7.888LeuAsp: 7.888 ± 0.106
6.014LeuGlu: 6.014 ± 0.094
3.133LeuPhe: 3.133 ± 0.067
7.895LeuGly: 7.895 ± 0.102
1.557LeuHis: 1.557 ± 0.041
2.015LeuIle: 2.015 ± 0.057
1.435LeuLys: 1.435 ± 0.043
8.668LeuLeu: 8.668 ± 0.137
1.228LeuMet: 1.228 ± 0.036
1.754LeuAsn: 1.754 ± 0.048
4.203LeuPro: 4.203 ± 0.063
2.186LeuGln: 2.186 ± 0.053
5.529LeuArg: 5.529 ± 0.073
5.497LeuSer: 5.497 ± 0.076
5.263LeuThr: 5.263 ± 0.072
9.461LeuVal: 9.461 ± 0.123
0.866LeuTrp: 0.866 ± 0.03
2.153LeuTyr: 2.153 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.815MetAla: 1.815 ± 0.048
0.092MetCys: 0.092 ± 0.009
1.319MetAsp: 1.319 ± 0.037
1.122MetGlu: 1.122 ± 0.035
0.513MetPhe: 0.513 ± 0.022
1.376MetGly: 1.376 ± 0.041
0.359MetHis: 0.359 ± 0.016
0.489MetIle: 0.489 ± 0.022
0.441MetLys: 0.441 ± 0.019
1.503MetLeu: 1.503 ± 0.04
0.284MetMet: 0.284 ± 0.017
0.576MetAsn: 0.576 ± 0.025
0.795MetPro: 0.795 ± 0.031
0.589MetGln: 0.589 ± 0.026
1.114MetArg: 1.114 ± 0.03
1.518MetSer: 1.518 ± 0.041
1.528MetThr: 1.528 ± 0.037
1.338MetVal: 1.338 ± 0.038
0.146MetTrp: 0.146 ± 0.011
0.397MetTyr: 0.397 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.447AsnAla: 2.447 ± 0.041
0.244AsnCys: 0.244 ± 0.015
1.631AsnAsp: 1.631 ± 0.044
1.844AsnGlu: 1.844 ± 0.05
0.66AsnPhe: 0.66 ± 0.028
1.942AsnGly: 1.942 ± 0.045
0.466AsnHis: 0.466 ± 0.022
0.837AsnIle: 0.837 ± 0.029
0.386AsnLys: 0.386 ± 0.021
1.846AsnLeu: 1.846 ± 0.042
0.391AsnMet: 0.391 ± 0.02
0.543AsnAsn: 0.543 ± 0.025
1.442AsnPro: 1.442 ± 0.039
0.668AsnGln: 0.668 ± 0.029
1.628AsnArg: 1.628 ± 0.037
1.029AsnSer: 1.029 ± 0.043
1.26AsnThr: 1.26 ± 0.034
2.253AsnVal: 2.253 ± 0.048
0.323AsnTrp: 0.323 ± 0.017
0.637AsnTyr: 0.637 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
5.063ProAla: 5.063 ± 0.087
0.288ProCys: 0.288 ± 0.016
4.831ProAsp: 4.831 ± 0.063
4.496ProGlu: 4.496 ± 0.068
1.596ProPhe: 1.596 ± 0.044
4.062ProGly: 4.062 ± 0.064
0.865ProHis: 0.865 ± 0.031
1.46ProIle: 1.46 ± 0.041
0.802ProLys: 0.802 ± 0.032
3.563ProLeu: 3.563 ± 0.051
0.886ProMet: 0.886 ± 0.028
1.149ProAsn: 1.149 ± 0.038
2.313ProPro: 2.313 ± 0.05
1.009ProGln: 1.009 ± 0.03
2.261ProArg: 2.261 ± 0.048
2.731ProSer: 2.731 ± 0.055
3.467ProThr: 3.467 ± 0.062
4.549ProVal: 4.549 ± 0.069
0.524ProTrp: 0.524 ± 0.024
1.124ProTyr: 1.124 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.538GlnAla: 2.538 ± 0.046
0.178GlnCys: 0.178 ± 0.013
1.466GlnAsp: 1.466 ± 0.041
1.728GlnGlu: 1.728 ± 0.044
1.062GlnPhe: 1.062 ± 0.033
1.806GlnGly: 1.806 ± 0.04
0.586GlnHis: 0.586 ± 0.024
0.904GlnIle: 0.904 ± 0.03
0.503GlnLys: 0.503 ± 0.024
2.435GlnLeu: 2.435 ± 0.05
0.523GlnMet: 0.523 ± 0.024
0.687GlnAsn: 0.687 ± 0.028
1.28GlnPro: 1.28 ± 0.033
1.11GlnGln: 1.11 ± 0.045
2.068GlnArg: 2.068 ± 0.044
1.632GlnSer: 1.632 ± 0.036
1.628GlnThr: 1.628 ± 0.046
2.072GlnVal: 2.072 ± 0.047
0.349GlnTrp: 0.349 ± 0.02
0.86GlnTyr: 0.86 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.453ArgAla: 6.453 ± 0.096
0.468ArgCys: 0.468 ± 0.021
5.142ArgAsp: 5.142 ± 0.086
6.509ArgGlu: 6.509 ± 0.099
2.43ArgPhe: 2.43 ± 0.05
4.411ArgGly: 4.411 ± 0.066
1.296ArgHis: 1.296 ± 0.036
2.625ArgIle: 2.625 ± 0.048
1.313ArgLys: 1.313 ± 0.038
5.976ArgLeu: 5.976 ± 0.075
1.269ArgMet: 1.269 ± 0.03
1.625ArgAsn: 1.625 ± 0.043
2.602ArgPro: 2.602 ± 0.053
1.84ArgGln: 1.84 ± 0.043
5.011ArgArg: 5.011 ± 0.083
3.581ArgSer: 3.581 ± 0.058
4.305ArgThr: 4.305 ± 0.075
5.687ArgVal: 5.687 ± 0.09
0.798ArgTrp: 0.798 ± 0.031
1.955ArgTyr: 1.955 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.322SerAla: 5.322 ± 0.087
0.357SerCys: 0.357 ± 0.019
4.265SerAsp: 4.265 ± 0.076
4.102SerGlu: 4.102 ± 0.067
2.019SerPhe: 2.019 ± 0.047
5.298SerGly: 5.298 ± 0.089
1.053SerHis: 1.053 ± 0.032
2.102SerIle: 2.102 ± 0.045
1.076SerLys: 1.076 ± 0.037
4.911SerLeu: 4.911 ± 0.066
1.117SerMet: 1.117 ± 0.036
1.423SerAsn: 1.423 ± 0.038
2.607SerPro: 2.607 ± 0.048
1.373SerGln: 1.373 ± 0.043
3.305SerArg: 3.305 ± 0.063
3.048SerSer: 3.048 ± 0.077
3.826SerThr: 3.826 ± 0.069
5.396SerVal: 5.396 ± 0.069
0.653SerTrp: 0.653 ± 0.026
1.503SerTyr: 1.503 ± 0.043
0.001SerXaa: 0.001 ± 0.001
Thr
7.536ThrAla: 7.536 ± 0.104
0.39ThrCys: 0.39 ± 0.018
5.8ThrAsp: 5.8 ± 0.085
4.796ThrGlu: 4.796 ± 0.08
2.231ThrPhe: 2.231 ± 0.047
6.008ThrGly: 6.008 ± 0.078
1.196ThrHis: 1.196 ± 0.036
2.319ThrIle: 2.319 ± 0.046
0.992ThrLys: 0.992 ± 0.031
5.912ThrLeu: 5.912 ± 0.081
1.073ThrMet: 1.073 ± 0.031
1.477ThrAsn: 1.477 ± 0.038
3.249ThrPro: 3.249 ± 0.061
1.425ThrGln: 1.425 ± 0.039
3.319ThrArg: 3.319 ± 0.062
2.899ThrSer: 2.899 ± 0.062
4.568ThrThr: 4.568 ± 0.084
7.963ThrVal: 7.963 ± 0.111
0.661ThrTrp: 0.661 ± 0.026
1.778ThrTyr: 1.778 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
11.489ValAla: 11.489 ± 0.124
0.731ValCys: 0.731 ± 0.024
8.407ValAsp: 8.407 ± 0.11
8.478ValGlu: 8.478 ± 0.108
2.998ValPhe: 2.998 ± 0.061
8.47ValGly: 8.47 ± 0.124
1.871ValHis: 1.871 ± 0.044
2.49ValIle: 2.49 ± 0.055
1.394ValLys: 1.394 ± 0.04
8.602ValLeu: 8.602 ± 0.122
1.384ValMet: 1.384 ± 0.038
1.974ValAsn: 1.974 ± 0.046
4.545ValPro: 4.545 ± 0.062
2.115ValGln: 2.115 ± 0.053
5.697ValArg: 5.697 ± 0.071
5.126ValSer: 5.126 ± 0.066
6.587ValThr: 6.587 ± 0.093
10.477ValVal: 10.477 ± 0.137
0.959ValTrp: 0.959 ± 0.029
2.227ValTyr: 2.227 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.0TrpAla: 1.0 ± 0.029
0.12TrpCys: 0.12 ± 0.011
0.841TrpAsp: 0.841 ± 0.031
0.847TrpGlu: 0.847 ± 0.027
0.462TrpPhe: 0.462 ± 0.022
0.811TrpGly: 0.811 ± 0.031
0.252TrpHis: 0.252 ± 0.014
0.333TrpIle: 0.333 ± 0.018
0.262TrpLys: 0.262 ± 0.014
1.331TrpLeu: 1.331 ± 0.039
0.23TrpMet: 0.23 ± 0.013
0.347TrpAsn: 0.347 ± 0.017
0.479TrpPro: 0.479 ± 0.026
0.382TrpGln: 0.382 ± 0.019
0.915TrpArg: 0.915 ± 0.031
0.648TrpSer: 0.648 ± 0.029
0.878TrpThr: 0.878 ± 0.031
0.959TrpVal: 0.959 ± 0.03
0.212TrpTrp: 0.212 ± 0.015
0.409TrpTyr: 0.409 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.667TyrAla: 2.667 ± 0.058
0.244TyrCys: 0.244 ± 0.015
2.642TyrAsp: 2.642 ± 0.048
2.538TyrGlu: 2.538 ± 0.05
0.75TyrPhe: 0.75 ± 0.027
2.386TyrGly: 2.386 ± 0.05
0.67TyrHis: 0.67 ± 0.025
0.679TyrIle: 0.679 ± 0.025
0.401TyrLys: 0.401 ± 0.021
2.4TyrLeu: 2.4 ± 0.053
0.372TyrMet: 0.372 ± 0.016
0.625TyrAsn: 0.625 ± 0.025
1.256TyrPro: 1.256 ± 0.034
0.724TyrGln: 0.724 ± 0.028
1.989TyrArg: 1.989 ± 0.042
1.221TyrSer: 1.221 ± 0.035
1.404TyrThr: 1.404 ± 0.035
2.484TyrVal: 2.484 ± 0.043
0.358TyrTrp: 0.358 ± 0.019
0.839TyrTyr: 0.839 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.003
Statistics based on 3852 proteins (1096490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski