Amino acid dipepetide frequency for Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.669AlaAla: 8.669 ± 0.073	1.019AlaCys: 1.019 ± 0.016	4.247AlaAsp: 4.247 ± 0.032	5.332AlaGlu: 5.332 ± 0.045	3.016AlaPhe: 3.016 ± 0.026	5.685AlaGly: 5.685 ± 0.042	1.769AlaHis: 1.769 ± 0.019	4.102AlaIle: 4.102 ± 0.034	4.061AlaLys: 4.061 ± 0.033	7.64AlaLeu: 7.64 ± 0.045	1.829AlaMet: 1.829 ± 0.02	2.906AlaAsn: 2.906 ± 0.026	4.493AlaPro: 4.493 ± 0.047	3.547AlaGln: 3.547 ± 0.035	5.127AlaArg: 5.127 ± 0.04	7.508AlaSer: 7.508 ± 0.048	5.111AlaThr: 5.111 ± 0.036	5.082AlaVal: 5.082 ± 0.034	1.048AlaTrp: 1.048 ± 0.015	2.053AlaTyr: 2.053 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	0.901CysAla: 0.901 ± 0.015	0.229CysCys: 0.229 ± 0.008	0.634CysAsp: 0.634 ± 0.012	0.63CysGlu: 0.63 ± 0.011	0.53CysPhe: 0.53 ± 0.012	0.885CysGly: 0.885 ± 0.014	0.326CysHis: 0.326 ± 0.009	0.693CysIle: 0.693 ± 0.013	0.52CysLys: 0.52 ± 0.012	1.28CysLeu: 1.28 ± 0.018	0.245CysMet: 0.245 ± 0.008	0.416CysAsn: 0.416 ± 0.009	0.646CysPro: 0.646 ± 0.013	0.464CysGln: 0.464 ± 0.011	0.769CysArg: 0.769 ± 0.013	0.936CysSer: 0.936 ± 0.016	0.672CysThr: 0.672 ± 0.012	0.754CysVal: 0.754 ± 0.015	0.201CysTrp: 0.201 ± 0.006	0.346CysTyr: 0.346 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.545AspAla: 4.545 ± 0.038	0.631AspCys: 0.631 ± 0.011	4.039AspAsp: 4.039 ± 0.05	4.472AspGlu: 4.472 ± 0.042	2.177AspPhe: 2.177 ± 0.023	3.973AspGly: 3.973 ± 0.039	1.349AspHis: 1.349 ± 0.018	3.033AspIle: 3.033 ± 0.024	2.333AspLys: 2.333 ± 0.026	5.176AspLeu: 5.176 ± 0.038	1.226AspMet: 1.226 ± 0.015	1.832AspAsn: 1.832 ± 0.018	3.311AspPro: 3.311 ± 0.027	2.106AspGln: 2.106 ± 0.023	3.249AspArg: 3.249 ± 0.032	4.247AspSer: 4.247 ± 0.032	2.956AspThr: 2.956 ± 0.028	3.598AspVal: 3.598 ± 0.033	0.844AspTrp: 0.844 ± 0.015	1.514AspTyr: 1.514 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.588GluAla: 5.588 ± 0.043	0.664GluCys: 0.664 ± 0.012	4.446GluAsp: 4.446 ± 0.043	5.834GluGlu: 5.834 ± 0.079	1.795GluPhe: 1.795 ± 0.019	3.901GluGly: 3.901 ± 0.035	1.485GluHis: 1.485 ± 0.018	3.139GluIle: 3.139 ± 0.023	3.97GluLys: 3.97 ± 0.048	5.2GluLeu: 5.2 ± 0.041	1.504GluMet: 1.504 ± 0.018	2.396GluAsn: 2.396 ± 0.024	2.705GluPro: 2.705 ± 0.029	2.657GluGln: 2.657 ± 0.025	4.299GluArg: 4.299 ± 0.035	4.398GluSer: 4.398 ± 0.036	3.38GluThr: 3.38 ± 0.027	3.637GluVal: 3.637 ± 0.031	0.86GluTrp: 0.86 ± 0.013	1.651GluTyr: 1.651 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.877PheAla: 2.877 ± 0.026	0.548PheCys: 0.548 ± 0.01	2.21PheAsp: 2.21 ± 0.021	2.177PheGlu: 2.177 ± 0.024	1.459PhePhe: 1.459 ± 0.02	2.561PheGly: 2.561 ± 0.027	0.871PheHis: 0.871 ± 0.013	1.629PheIle: 1.629 ± 0.02	1.444PheLys: 1.444 ± 0.018	3.336PheLeu: 3.336 ± 0.034	0.697PheMet: 0.697 ± 0.012	1.336PheAsn: 1.336 ± 0.018	1.842PhePro: 1.842 ± 0.02	1.416PheGln: 1.416 ± 0.015	2.054PheArg: 2.054 ± 0.021	2.965PheSer: 2.965 ± 0.025	2.008PheThr: 2.008 ± 0.023	2.201PheVal: 2.201 ± 0.025	0.594PheTrp: 0.594 ± 0.011	1.015PheTyr: 1.015 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.045GlyAla: 5.045 ± 0.047	0.819GlyCys: 0.819 ± 0.016	3.532GlyAsp: 3.532 ± 0.033	3.747GlyGlu: 3.747 ± 0.032	2.525GlyPhe: 2.525 ± 0.027	5.67GlyGly: 5.67 ± 0.068	1.666GlyHis: 1.666 ± 0.021	3.311GlyIle: 3.311 ± 0.027	3.546GlyLys: 3.546 ± 0.031	5.836GlyLeu: 5.836 ± 0.039	1.595GlyMet: 1.595 ± 0.019	2.497GlyAsn: 2.497 ± 0.03	3.144GlyPro: 3.144 ± 0.033	2.673GlyGln: 2.673 ± 0.028	4.358GlyArg: 4.358 ± 0.035	5.634GlySer: 5.634 ± 0.044	3.796GlyThr: 3.796 ± 0.029	4.01GlyVal: 4.01 ± 0.03	1.096GlyTrp: 1.096 ± 0.017	1.934GlyTyr: 1.934 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.854HisAla: 1.854 ± 0.021	0.325HisCys: 0.325 ± 0.01	1.38HisAsp: 1.38 ± 0.016	1.455HisGlu: 1.455 ± 0.016	0.937HisPhe: 0.937 ± 0.013	1.704HisGly: 1.704 ± 0.021	0.932HisHis: 0.932 ± 0.018	1.203HisIle: 1.203 ± 0.018	0.994HisLys: 0.994 ± 0.016	2.375HisLeu: 2.375 ± 0.025	0.463HisMet: 0.463 ± 0.01	0.912HisAsn: 0.912 ± 0.015	1.747HisPro: 1.747 ± 0.023	1.151HisGln: 1.151 ± 0.019	1.598HisArg: 1.598 ± 0.022	2.016HisSer: 2.016 ± 0.026	1.315HisThr: 1.315 ± 0.018	1.408HisVal: 1.408 ± 0.017	0.315HisTrp: 0.315 ± 0.008	0.691HisTyr: 0.691 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.046IleAla: 4.046 ± 0.034	0.753IleCys: 0.753 ± 0.012	2.804IleAsp: 2.804 ± 0.024	2.982IleGlu: 2.982 ± 0.022	1.913IlePhe: 1.913 ± 0.023	2.974IleGly: 2.974 ± 0.026	1.231IleHis: 1.231 ± 0.017	2.337IleIle: 2.337 ± 0.026	2.169IleLys: 2.169 ± 0.024	4.56IleLeu: 4.56 ± 0.036	0.964IleMet: 0.964 ± 0.015	1.772IleAsn: 1.772 ± 0.018	2.989IlePro: 2.989 ± 0.021	1.902IleGln: 1.902 ± 0.019	2.961IleArg: 2.961 ± 0.029	4.142IleSer: 4.142 ± 0.031	2.804IleThr: 2.804 ± 0.025	2.963IleVal: 2.963 ± 0.027	0.706IleTrp: 0.706 ± 0.015	1.34IleTyr: 1.34 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.354LysAla: 4.354 ± 0.043	0.514LysCys: 0.514 ± 0.012	2.918LysAsp: 2.918 ± 0.028	3.602LysGlu: 3.602 ± 0.039	1.397LysPhe: 1.397 ± 0.016	3.004LysGly: 3.004 ± 0.028	1.214LysHis: 1.214 ± 0.018	2.356LysIle: 2.356 ± 0.027	3.417LysLys: 3.417 ± 0.075	4.089LysLeu: 4.089 ± 0.037	1.103LysMet: 1.103 ± 0.016	1.738LysAsn: 1.738 ± 0.019	2.726LysPro: 2.726 ± 0.029	1.976LysGln: 1.976 ± 0.021	3.644LysArg: 3.644 ± 0.031	3.723LysSer: 3.723 ± 0.03	2.835LysThr: 2.835 ± 0.028	2.791LysVal: 2.791 ± 0.027	0.651LysTrp: 0.651 ± 0.011	1.317LysTyr: 1.317 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.721LeuAla: 7.721 ± 0.049	1.25LeuCys: 1.25 ± 0.019	5.197LeuAsp: 5.197 ± 0.039	5.702LeuGlu: 5.702 ± 0.043	3.116LeuPhe: 3.116 ± 0.032	5.703LeuGly: 5.703 ± 0.035	2.394LeuHis: 2.394 ± 0.028	3.865LeuIle: 3.865 ± 0.033	4.317LeuLys: 4.317 ± 0.034	8.702LeuLeu: 8.702 ± 0.069	1.687LeuMet: 1.687 ± 0.016	3.239LeuAsn: 3.239 ± 0.027	5.604LeuPro: 5.604 ± 0.041	4.169LeuGln: 4.169 ± 0.036	6.028LeuArg: 6.028 ± 0.04	7.584LeuSer: 7.584 ± 0.043	4.904LeuThr: 4.904 ± 0.035	5.131LeuVal: 5.131 ± 0.041	1.183LeuTrp: 1.183 ± 0.022	2.277LeuTyr: 2.277 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.057MetAla: 2.057 ± 0.02	0.219MetCys: 0.219 ± 0.007	1.195MetAsp: 1.195 ± 0.016	1.316MetGlu: 1.316 ± 0.018	0.672MetPhe: 0.672 ± 0.012	1.359MetGly: 1.359 ± 0.018	0.48MetHis: 0.48 ± 0.011	0.972MetIle: 0.972 ± 0.015	1.071MetLys: 1.071 ± 0.016	1.869MetLeu: 1.869 ± 0.023	0.518MetMet: 0.518 ± 0.011	0.794MetAsn: 0.794 ± 0.013	1.265MetPro: 1.265 ± 0.016	0.907MetGln: 0.907 ± 0.016	1.231MetArg: 1.231 ± 0.017	1.809MetSer: 1.809 ± 0.018	1.259MetThr: 1.259 ± 0.018	1.253MetVal: 1.253 ± 0.016	0.246MetTrp: 0.246 ± 0.007	0.465MetTyr: 0.465 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.208AsnAla: 3.208 ± 0.028	0.417AsnCys: 0.417 ± 0.009	2.035AsnAsp: 2.035 ± 0.025	2.146AsnGlu: 2.146 ± 0.025	1.324AsnPhe: 1.324 ± 0.015	2.922AsnGly: 2.922 ± 0.034	0.962AsnHis: 0.962 ± 0.014	2.022AsnIle: 2.022 ± 0.019	1.542AsnLys: 1.542 ± 0.019	3.347AsnLeu: 3.347 ± 0.028	0.772AsnMet: 0.772 ± 0.015	1.523AsnAsn: 1.523 ± 0.022	2.467AsnPro: 2.467 ± 0.026	1.449AsnGln: 1.449 ± 0.018	2.079AsnArg: 2.079 ± 0.021	2.882AsnSer: 2.882 ± 0.024	2.232AsnThr: 2.232 ± 0.024	2.307AsnVal: 2.307 ± 0.023	0.498AsnTrp: 0.498 ± 0.011	0.953AsnTyr: 0.953 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.074ProAla: 5.074 ± 0.053	0.522ProCys: 0.522 ± 0.012	3.14ProAsp: 3.14 ± 0.03	3.592ProGlu: 3.592 ± 0.034	1.971ProPhe: 1.971 ± 0.021	3.672ProGly: 3.672 ± 0.033	1.386ProHis: 1.386 ± 0.019	2.522ProIle: 2.522 ± 0.026	2.639ProLys: 2.639 ± 0.028	4.873ProLeu: 4.873 ± 0.038	0.997ProMet: 0.997 ± 0.015	2.251ProAsn: 2.251 ± 0.023	5.483ProPro: 5.483 ± 0.071	2.656ProGln: 2.656 ± 0.029	3.565ProArg: 3.565 ± 0.033	6.439ProSer: 6.439 ± 0.054	4.144ProThr: 4.144 ± 0.038	3.26ProVal: 3.26 ± 0.031	0.664ProTrp: 0.664 ± 0.013	1.484ProTyr: 1.484 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	3.63GlnAla: 3.63 ± 0.031	0.436GlnCys: 0.436 ± 0.01	2.282GlnAsp: 2.282 ± 0.024	2.644GlnGlu: 2.644 ± 0.03	1.255GlnPhe: 1.255 ± 0.017	2.515GlnGly: 2.515 ± 0.029	1.237GlnHis: 1.237 ± 0.019	2.049GlnIle: 2.049 ± 0.023	2.204GlnLys: 2.204 ± 0.024	3.54GlnLeu: 3.54 ± 0.031	0.911GlnMet: 0.911 ± 0.016	1.738GlnAsn: 1.738 ± 0.021	2.739GlnPro: 2.739 ± 0.034	2.763GlnGln: 2.763 ± 0.063	2.908GlnArg: 2.908 ± 0.024	3.515GlnSer: 3.515 ± 0.031	2.436GlnThr: 2.436 ± 0.024	2.138GlnVal: 2.138 ± 0.021	0.554GlnTrp: 0.554 ± 0.01	1.166GlnTyr: 1.166 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.856ArgAla: 4.856 ± 0.038	0.739ArgCys: 0.739 ± 0.014	3.491ArgAsp: 3.491 ± 0.029	4.052ArgGlu: 4.052 ± 0.037	2.146ArgPhe: 2.146 ± 0.021	3.878ArgGly: 3.878 ± 0.037	1.674ArgHis: 1.674 ± 0.019	3.012ArgIle: 3.012 ± 0.023	3.818ArgLys: 3.818 ± 0.032	5.795ArgLeu: 5.795 ± 0.046	1.387ArgMet: 1.387 ± 0.019	2.43ArgAsn: 2.43 ± 0.024	3.669ArgPro: 3.669 ± 0.036	2.88ArgGln: 2.88 ± 0.026	5.484ArgArg: 5.484 ± 0.043	5.412ArgSer: 5.412 ± 0.038	3.569ArgThr: 3.569 ± 0.032	3.295ArgVal: 3.295 ± 0.027	0.969ArgTrp: 0.969 ± 0.016	1.717ArgTyr: 1.717 ± 0.023	0.001ArgXaa: 0.001 ± 0.0
Ser	6.867SerAla: 6.867 ± 0.046	0.901SerCys: 0.901 ± 0.015	4.3SerAsp: 4.3 ± 0.034	4.464SerGlu: 4.464 ± 0.037	3.006SerPhe: 3.006 ± 0.027	5.604SerGly: 5.604 ± 0.046	2.085SerHis: 2.085 ± 0.021	4.202SerIle: 4.202 ± 0.032	3.998SerLys: 3.998 ± 0.034	7.497SerLeu: 7.497 ± 0.048	1.798SerMet: 1.798 ± 0.021	3.312SerAsn: 3.312 ± 0.028	5.878SerPro: 5.878 ± 0.059	3.608SerGln: 3.608 ± 0.034	5.43SerArg: 5.43 ± 0.037	9.777SerSer: 9.777 ± 0.083	6.156SerThr: 6.156 ± 0.044	4.477SerVal: 4.477 ± 0.036	1.068SerTrp: 1.068 ± 0.016	2.061SerTyr: 2.061 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.146ThrAla: 5.146 ± 0.04	0.709ThrCys: 0.709 ± 0.012	2.78ThrAsp: 2.78 ± 0.021	3.124ThrGlu: 3.124 ± 0.025	2.217ThrPhe: 2.217 ± 0.024	3.893ThrGly: 3.893 ± 0.035	1.251ThrHis: 1.251 ± 0.016	3.094ThrIle: 3.094 ± 0.031	2.682ThrLys: 2.682 ± 0.027	5.297ThrLeu: 5.297 ± 0.037	1.158ThrMet: 1.158 ± 0.014	2.253ThrAsn: 2.253 ± 0.024	4.261ThrPro: 4.261 ± 0.036	2.144ThrGln: 2.144 ± 0.021	3.362ThrArg: 3.362 ± 0.035	5.981ThrSer: 5.981 ± 0.046	4.457ThrThr: 4.457 ± 0.044	3.463ThrVal: 3.463 ± 0.033	0.786ThrTrp: 0.786 ± 0.012	1.522ThrTyr: 1.522 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.783ValAla: 4.783 ± 0.032	0.766ValCys: 0.766 ± 0.013	3.56ValAsp: 3.56 ± 0.029	3.918ValGlu: 3.918 ± 0.03	2.195ValPhe: 2.195 ± 0.023	3.769ValGly: 3.769 ± 0.031	1.355ValHis: 1.355 ± 0.018	2.753ValIle: 2.753 ± 0.021	2.83ValLys: 2.83 ± 0.028	5.395ValLeu: 5.395 ± 0.041	1.21ValMet: 1.21 ± 0.016	2.124ValAsn: 2.124 ± 0.022	3.351ValPro: 3.351 ± 0.031	2.487ValGln: 2.487 ± 0.028	3.521ValArg: 3.521 ± 0.027	4.499ValSer: 4.499 ± 0.032	3.217ValThr: 3.217 ± 0.029	4.017ValVal: 4.017 ± 0.035	0.783ValTrp: 0.783 ± 0.014	1.517ValTyr: 1.517 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.037TrpAla: 1.037 ± 0.017	0.189TrpCys: 0.189 ± 0.006	0.82TrpAsp: 0.82 ± 0.014	0.816TrpGlu: 0.816 ± 0.013	0.491TrpPhe: 0.491 ± 0.011	0.807TrpGly: 0.807 ± 0.012	0.358TrpHis: 0.358 ± 0.009	0.736TrpIle: 0.736 ± 0.012	0.787TrpLys: 0.787 ± 0.013	1.332TrpLeu: 1.332 ± 0.02	0.35TrpMet: 0.35 ± 0.008	0.584TrpAsn: 0.584 ± 0.01	0.553TrpPro: 0.553 ± 0.011	0.581TrpGln: 0.581 ± 0.011	0.978TrpArg: 0.978 ± 0.016	1.035TrpSer: 1.035 ± 0.015	0.835TrpThr: 0.835 ± 0.016	0.792TrpVal: 0.792 ± 0.012	0.252TrpTrp: 0.252 ± 0.008	0.39TrpTyr: 0.39 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.986TyrAla: 1.986 ± 0.024	0.429TyrCys: 0.429 ± 0.012	1.598TyrAsp: 1.598 ± 0.02	1.504TyrGlu: 1.504 ± 0.018	1.098TyrPhe: 1.098 ± 0.017	1.955TyrGly: 1.955 ± 0.027	0.751TyrHis: 0.751 ± 0.013	1.28TyrIle: 1.28 ± 0.018	1.027TyrLys: 1.027 ± 0.014	2.631TyrLeu: 2.631 ± 0.024	0.544TyrMet: 0.544 ± 0.01	1.034TyrAsn: 1.034 ± 0.015	1.462TyrPro: 1.462 ± 0.019	1.121TyrGln: 1.121 ± 0.016	1.629TyrArg: 1.629 ± 0.019	1.987TyrSer: 1.987 ± 0.022	1.493TyrThr: 1.493 ± 0.019	1.476TyrVal: 1.476 ± 0.019	0.407TyrTrp: 0.407 ± 0.009	0.818TyrTyr: 0.818 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.259XaaXaa: 0.259 ± 0.075

Statistics based on 9228 proteins (4890347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---